293 research outputs found
Sudden Death in Sickle Cell Disease: An Autopsy Diagnosis
No full textABSTRACTSickle cell disease is a common hereditary hemoglobinopathy with high prevalence in the central and northeastern regions of India. A 24-year-old male patient with 3 days’ history of fever was brought dead to the hospital. Morphology showed clogging of blood vessels with sickled red blood cells (RBCs) in all the organs, and an autopsy diagnosis of sickle cell disease was made. As the cause may not be obvious in many cases, most patients remain undiagnosed. It is important to note the circumstances of death, gross finding, and histopathology, with hemoglobin electrophoresis if available, during autopsy to arrive at the diagnosis. This case is presented here to highlight this fact and draw attention to its pathology.How to cite this articleSheshanna N, Sethi G, Raj JA, Prakash SM, Surhonne SP. Sudden Death in Sickle Cell Disease: An Autopsy Diagnosis. J Med Sci 2017;3(4):113-115.</jats:sec
MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications
No full textIn this chapter, the author highlight dysregulated MicroRNAs (miRNA), as potential therapeutic targets in different tumor stromal cells describe their functions in the regulation of the tumor microenvironment. They also discusses the role of tumor-related miRNAs as biomarkers for cancer diagnosis and prognosis. TAMs show the ability to promote the tumor development and progression by enhancing angiogenesis, immune suppression, tumor cell invasion, and metastatic programming of tumor tissue, and thus reducing patient survival. MiRNAs can also be delivered by inorganic nanoparticle–based vectors, such as gold nanoparticles, iron-nanoparticles and silica-based nanoparticles. Tumor stroma plays an essential role during tumor growth, thus targeting tumor stromal cells provides possibilities to inhibit the promotion activities in tumor progression and metastasis. The authors summarizes various miRNA delivery approaches that have been or can potentially be applied to deliver miRNA as therapeutics into the stromal cells
Negotiating modernity: education and translation in nineteenth century Egypt
No full textBetween the French and British occupations, Muhammad Ali Pasha (r. 1805-48) and his successors ruled Egypt as an autonomous Ottoman province. In order to establish and maintain that autonomy from both Ottoman and European imperial interests, Muhammad Ali sought European technical expertise to aid in the rapid modernization of the country – reorganizing the military, building new infrastructure, and reforming the civil service. Establishing a state-of-the- art education system was fundamental to this process, and yet it remains a neglected subject in contemporary historical scholarship on the modernization project initiated under Pasha’s rule.
The dissertation focuses on two institutions that served as the original sites where European knowledge was transmitted and translated: the first student missions to France (1826-49) and the School of Languages in Cairo (1836-51). Using archival documents, correspondence, and published records in both French and Arabic, it uncovers the complicated mediations integral to the acquisition of this expertise through the missions, in the context of defensive modernization against European encroachment. The dissertation further explores how those educated in the student missions used their experiences to choose and localize useful knowledge. It also traces the ways in which Egyptians envisioned a hybridized government and religious education system by advocating for this new knowledge in educational practice and intellectual life through an examination of debates published in the first Egyptian educational journal Rawdat al-Madaris al-Misriyya (The Garden of the Egyptian Schools). By investigating the role played by those in favor of the inclusion of indigenized European knowledge, it highlights the implications of early nineteenth century Egyptian experiments with education on larger literary, religious, philosophical, and political trends in the Middle East in the latter half of the nineteenth century.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-12-01The student, Archana Prakash, accepted the attached license on 2016-11-16 at 15:20.The student, Archana Prakash, submitted this Dissertation for approval on 2016-11-16 at 15:24.This Dissertation was approved for publication on 2016-11-17 at 09:03.DSpace SAF Submission Ingestion Package generated from Vireo submission #10256 on 2017-02-28 at 14:41:33Made available in DSpace on 2017-03-01T17:01:18Z (GMT). No. of bitstreams: 2
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Screening and Identification of Antibiotic Resistant Lactic Acid Bacteria from Fermented Foods
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Molecular Characterisation of Cell –Lytic Bacteriocin Produced by Pediococcus Pentosaceus Cfr SIII
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Molecular Chacterization of Pediocin PA1 Producing Lactic Acid Bacteria Isolated from Food Samples
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Security System using Pir Sensor with Gsm Module for Controlled Atmosphere Storage System.
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Characterization of Bacillus Spp. with Antibacterial Activity Isolated from Fermented Vegetables
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Cooling rates of neutron stars and the young neutron star in the Cassiopeia A supernova remnant
No full textWe explore the thermal state of the neutron star in the Cassiopeia A supernova remnant using the recent result of Ho & Heinke that the thermal radiation of this star is well described by a carbon atmosphere model and the emission comes from the entire stellar surface. Starting from neutron star cooling theory, we formulate a robust method to extract neutrino cooling rates of thermally relaxed stars at the neutrino cooling stage from observations of thermal surface radiation. We show how to compare these rates with the rates of standard candles – stars with non-superfluid nucleon cores cooling slowly via the modified Urca process. We find that the internal temperature of standard candles is a well-defined function of the stellar compactness parameter x=rg/R, irrespective of the equation of state of neutron star matter (R and rg are circumferential and gravitational radii, respectively). We demonstrate that the data on the Cassiopeia A neutron star can be explained in terms of three parameters: f?, the neutrino cooling efficiency with respect to the standard candle; the compactness x; and the amount of light elements in the heat-blanketing envelope. For an ordinary (iron) heat-blanketing envelope or a low-mass (? 10?13 M?) carbon envelope, we find the efficiency f?? 1 (standard cooling) for x? 0.5 and f?? 0.02 (slower cooling) for a maximum compactness x? 0.7. A heat blanket containing the maximum mass (?10?8 M?) of light elements increases f? by a factor of 50. We also examine the (unlikely) possibility that the star is still thermally non-relaxe
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