5,465 research outputs found
Edward Sullivan, correspondence with Edward D. “Sandy” Ives
No full textEdward Sullivan, correspondence with Edward D. Sandy Ives dating between 1975 and 1977, about life in Veazie and stories he wrote about the area; photo of Lawrence (Larry) Conners, log driver and lumberman.https://digitalcommons.library.umaine.edu/mf064/1008/thumbnail.jp
Investigating the role of NS5A domain III in protecting the hepatitis C virus replication complex
No full textAs a positive sense RNA virus, the Hepatitis C virus makes use of a membrane enclosed replication complex (RC) to replicate its genome in a protected manner. As part of a separate project attempting to visualise the RC, a fluorescent peptide, clover, and a Dihydrofolate reductase (DHFR) destabilizing domain was inserted into the NS5A coding region of a JFH1 replicon. Unexpectedly it was found that the insertion site significantly influenced RNA replication. Under conditions where the DHFR domain was destabilized, insertion within domain III inhibited replication, while insertion at the carboxyl terminus of the protein was better tolerated. However, any difference in replication resulting from the choice of insertion site was lost when transfected cells were treated with trimethoprim to stabilise the DHFR domain. This suggested that rather than causing mis-folding of domain III, insertion into it disrupted an NS5A function that protects the protein from proteolytic degradation. The aim of this work was therefore to further characterise this activity.In an effort to map the key regions of domain III involved, deletions were introduced into domain III of the replicon construct, within the Clover/DHFR fusion protein linked to the carboxyl terminus. Replication assays identified a 81 amino acid region within domain III of NS5A that seemingly protects these constructs during trimethoprim withdrawal. Further mapping of this region using a series of smaller overlapping deletions further narrowed this to a 61 amino acid sequence.To confirm that this region of interest is indeed protecting NS5A from degradation, domain III was duplicated to be either full length or truncated. Replication assays with this constructs showed that an intact domain III is capable of protecting replicons from DHFR-mediated degradation. By scrambling domain III it was found that this activity if not dependent on the primary sequence, suggesting that it is due to an intrinsic property of domain III.The final part of this work was to investigate potential benefits of domain III to the virus lifecycle, specifically investigating the impact of domain III truncation on IFN sensitivity and antigen presentation. However, several experimental issues hindered this work and it was not possible to confirm or deny a role for domain III in modulating these pathways
The Prince Edward Island teacher
No full textv. :. ill.; 29 cm; Centennial issue, 1967 - Spring issue, 1968.; Ceased in 1968?; Partial Contents: History of education on P.E.I. by Francis Blanchard--Background to Canada's centennial by Rev. Francis W.P. Bolger--Acadian milestone, the Acadian Teachers' Association of Prince Edward Island by Francis Blanchard--The traditional report card-should it be abolished? by Kenneth A. Parker--Mental health in our schools by Russell Ewing.Source type: Electronic(1
Frank Sullivan, Jr.
No full textFrank Sullivan, Jr., was born in South Bend, Indiana. A graduate of Dartmouth College (A.B., 1972) in New Hampshire, Sullivan returned to Indiana to serve as a caucus assistant in the Indiana House of Representatives. He then traveled to Washington, D. C., where he served as a legislative assistant to Representatives Edward Roush (1974) and John Brademas (1974-1979). He returned to Indiana again to attend the Indiana University School of Law, receiving his J. D. in 1982. Sullivan joined the firm of Barnes and Thornburg, in Indianapolis, where he practiced corporate and securities law for the next seven years. In 1989 Governor Evan Bayh appointed Sullivan Indiana State Budget Director, a position he would hold until his appointment as the governor’s fiscal policy adviser in 1992.
On November 1, 1993, Bayh appointed Sullivan the 102nd justice of the Indiana Supreme Court. In addition to his duties on the court, Sullivan has served as Chair of the American Bar Association’s Appellate Judges Conference, and as Chair of the ABA Judicial Clerkship Program. Sullivan has also been the Chair, “and principle steward,” of the state of Indiana’s Judicial Technology and Automation Committee, a committee that was formed to “provide leadership and governance regarding the use of technology in Indiana Courts.”
Always looking for new challenges, Sullivan received a master’s of law degree from the University of Virginia in 2001 and in 2007 began teaching a course on the legal aspects of government finance at the Indiana University McKinney School of Law. Throughout his term on the court Sullivan spoke at public forums and wrote articles on legal issues in scholarly and bar related publications. Sullivan retired from the bench in 2012 and became Professor of Practice at the McKinney School of Law.
Sullivan is currently a member of the Maurer School of Law\u27s Board of Visitors.https://www.repository.law.indiana.edu/notablealumni/1037/thumbnail.jp
Frank Sullivan, Jr.
No full textFrank Sullivan, Jr., was born in South Bend, Indiana. A graduate of Dartmouth College (A.B., 1972) in New Hampshire, Sullivan returned to Indiana to serve as a caucus assistant in the Indiana House of Representatives. He then traveled to Washington, D. C., where he served as a legislative assistant to Representatives Edward Roush (1974) and John Brademas (1974-1979). He returned to Indiana again to attend the Indiana University School of Law, receiving his J. D. in 1982. Sullivan joined the firm of Barnes and Thornburg, in Indianapolis, where he practiced corporate and securities law for the next seven years. In 1989 Governor Evan Bayh appointed Sullivan Indiana State Budget Director, a position he would hold until his appointment as the governor’s fiscal policy adviser in 1992.
On November 1, 1993, Bayh appointed Sullivan the 102nd justice of the Indiana Supreme Court. In addition to his duties on the court, Sullivan has served as Chair of the American Bar Association’s Appellate Judges Conference, and as Chair of the ABA Judicial Clerkship Program. Sullivan has also been the Chair, “and principle steward,” of the state of Indiana’s Judicial Technology and Automation Committee, a committee that was formed to “provide leadership and governance regarding the use of technology in Indiana Courts.”
Always looking for new challenges, Sullivan received a master’s of law degree from the University of Virginia in 2001 and in 2007 began teaching a course on the legal aspects of government finance at the Indiana University McKinney School of Law. Throughout his term on the court Sullivan spoke at public forums and wrote articles on legal issues in scholarly and bar related publications. Sullivan retired from the bench in 2012 and became Professor of Practice at the McKinney School of Law.
Sullivan is currently a member of the Maurer School of Law\u27s Board of Visitors.https://www.repository.law.indiana.edu/notablealumni/1037/thumbnail.jp
Edward O. Sullivan (May 24, 1972)
No full textSullivan recalled that Nixon had an excellent memory for detail, and they became friends over shared political interests.
Please note that this interview is to be used for personal projects only, with appropriate credit given to the interviewee, and may not be used in commercial or transformative works
'One equal music’: The royal college of music, its inception and the legacy of Sir George Grove 1883-1895
No full textThe establishment of the Royal College of Music (RCM) in 1883 represents the denouement of an eighteenth-century movement to found a conservatoire with a national remit in Britain. Whether motivated by the desire to rival Continental conservatoires to generate and develop an environment in which a worthy successor to Purcell could be nurtured or to create an indigenous musical workforce to obtain direct control of market forces, the RCM was seen as a panacea in the light of the demise of the experimental National Training School for Music (1876-1882) and the ineffectual Royal Academy of Music founded in 1822. The NTSM's financial concerns led Sir Henry Cole to approach the Royal Commission of 1851 for aid. In return for a meagre grant, the Commission insisted the NTSM remodel its management and constitution on pain of eviction from buildings on the Kensington Estate. Cole's approach to 1851 Commissionets precipitated the involvement of the Prince of Wales and other senior members of the Court that led directly to the establishment of the RCM in 1878.Attempts to institute the RCM as a quango to regulate the music profession alongside music education both at elementary school and university level were intended to provide ideal circumstances for inducing comprehensive treasury assistance where the NTSM failed. When this proved elusive, a contingency was provided by George Grove (first RCM Director from 1882) who, at the request of the Prince of Wales, imtiated a capital fund. The introduction of fee-paying students alongside scholars provided financial security that distanced the College & insolvency. Substantial growth in numbers during the first few years forced Grove and the Council to address the issue of a new building. Grove's appointment of an unrivalled professorial staff and the development of a rigorous curriculum, whose inspiration was to be found within the Continental traditions in France and Germany, had paid dividends. By 1894, the results of RCM's pedagogical methods were respected across Europe. The appointment of Grove's neighbour, Alexander Mackenzie, as Principal of the RAM heralded an environment for mutual co-operation between two rival institutions. The institution of local examinations under the Associated Board of the Royal Academy of Music and the Royal College of Music from 1889 marked the conclusion of further attempts to amalgamate the two institutions. The foundation of both the Associated Board was intended to provide a remedy to the shortage of suitably-qualified candidates entering for scholarships and to improve music tuition among school children as set out in the RCM's 1883 charter. The coalition created formidable opposition to Halle's proposal to establish a chartered Royal College of Music in Manchester (RMCM) in 1893 and Parliament's attempts to include music within the provision of the bill for the regulation and registration of teachers. The foundation of the Associated Board allowed Grove to begin implementing the RCM's remit to lead the music profession on both a national and imperial scale. The RCM's national and European reputation established by Grove was consolidated under the directorate of his successor, c. Hubert H. Parry, who confirmed the RCM's global reputation to which other, fledgling institutions, such as New York's Juilliard School of Music, came to aspke. Grove's initiatives, which began the process of emancipating composer and performer alike, went on to transform Britain's international musical reputation within a generation, the ramifications of which continue to affect us more than a century later
Ed Sullivan and Warren Hull interview Navy combat photographers from the Naval Air Station, Anacostia, Maryland, June 18, 1945
No full textEpisode number 609, Navy Combat Photographers, Naval Air Station, WAVES auditorium; Pictured: Lt. Commander John McLain, Lt. Collier Young, Ed Sullivan, Warren Hull, Lt. Dave Hopkins, Harold C. Nyby, Edward Patrick O'Hara
The court of Cupid. [electronic resource] : By the author of the Meretriciad. Containing the eighth edition of the Meretriciad, with great additions. In two volumes.
No full textAuthor of The meretriciad = Edward Thompson.With a final advertisement leaf in volume 2.Price from imprint: price Five Shillings.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
The works of the author of the Night-thoughts. [electronic resource] : In four volumes. Revised and corrected by himself. A new edition.
No full textThe author of the Night Thoughts = Edward Young.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
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