5,884 research outputs found
Hamilton, Catherine Jane [pseud. Retlaw Spring] (1841–1935), author and journalist
Full text linkHamilton, Catherine Jane [pseud. Retlaw Spring] (1841-1935), author and journalist, was born on 25 January 1841 at Kilmersdon, Somerset, where she was baptized on 12 April 1841, the younger of two daughters of Richard Hamilton (1805?-1859), vicar of Kilmersdon, and his wife Charlotte, née Cooper (1809-1882), the fifth daughter of William Cooper, of Queens County, Ireland. She was of Irish heritage on both sides. Her father belonged to a military family with roots in Strabane (county Tyrone) - his father, John Hamilton, and her father’s four older brothers were all officers in the Fifth Foot – and was a graduate of Trinity College Dublin. He had been a bright scholar with an aptitude for languages, and as a preacher was praised for his powerful sermons and his ability to bring the Bible to life for his parishioners
Dr. Jennifer Erkulwater and Dr. Catherine Bagwell – Faculty Author Interview
No full textFeatured authors are Dr. Catherine Bagwell, Associate Professor of Psychology and Dr. Jennifer Erkulwater, Associate Professor of Political Science. Dr. Rick Mayes is another co-author, but he is unable to join us today due to a research leave project in Peru. Their new book, Medicating Children: ADHD and Pediatric Mental Health, integrates analyses of the clinical, political, historical, educational, social, economic and legal aspects of ADHD and the medications and treatment surrounding the mental disorder
Interview with Catherine McCall
No full textInterview with Dr. Catherine McCall, graduate of UNCW's MFA in Creative Writing program and author of Lifeguarding: A Memoir of Secrets, Swimming, and the South
Epidemiology of stroke and its subtypes in Chinese populations
Full text linkBACKGROUND:
Chinese populations have been reported to have a higher stroke
incidence as well as different stroke epidemiology compared with white populations.
However, reliable comparisons have been precluded by a lack of methodologically
robust studies. I aimed to systematically evaluate the incidence of stroke, the
distribution of its main types/subtypes, and risk factor distributions among stroke
types/subtypes in Chinese, and to compare these with data from white populations.
Methods: I performed a series of systematic reviews and meta-analyses of studies
conducted since 1990 which had data on (1) incidence of stroke, (2) pathological
types of stroke or ischaemic stroke subtypes, and (3) frequency of risk factors among
pathological types of stroke or ischaemic stroke (IS) subtypes in Chinese populations,
and in white populations for comparison. I calculated age-standardized stroke
incidence and the proportions of each pathological type and ischaemic subtype. For
each risk factor, I calculated study-specific and pooled odds ratios (ORs) using a
random effects model for intracerebral haemorrhage (ICH) versus IS, for each IS
subtype versus other subtypes, and for overall IS patients, comparing findings for
Chinese versus Whites.
In addition, I conducted individual patient analyses of data from the National Taiwan
University Hospital (NTUH) Stroke Registry, which consecutively recruited 6675
acute stroke patients from 2006-2011, comparing risk factor profiles among stroke
types and subtypes and using logistic regression to adjust for potential confounding
factors.
RESULTS:
From my systematic reviews, I found a younger onset of stroke, a slightly
higher overall stroke incidence and higher proportion of ICH in Chinese versus white
populations. Although the overall proportion of lacunar infarct appeared higher in
Chinese from hospital-based studies than white populations, confirming the different
distributions of ischaemic subtypes will need further comparable population-based
studies.
In my meta-analyses comparing risk factors for ICH versus IS, in Chinese - but not
Whites – hypertension (HTN) and alcohol intake were significantly more frequent,
while mean age was lower in ICH than IS. In IS, the overall prevalence of
hypertension, diabetes, smoking, and alcohol intake were similar between Chinese
and white IS patients, whereas hypercholesterolaemia, ischaemic heart disease (IHD)
and atrial fibrillation (AF) were less common in Chinese IS patients. As for IS
subtypes, the relative frequencies of risk factors were mostly qualitatively similar
(although different in size) in Chinese and white populations. Compared with other
ischaemic subtypes: large artery atherosclerosis (LAA) strokes were associated with
diabetes; cardioembolic (CE) strokes were associated with AF and IHD; small vessel
disease (SVD) strokes or lacunar strokes were associated with hypertension and
diabetes.
Analyses of NTUH individual patient data showed that HTN and alcohol intake were
independent risk factors for ICH versus IS in a Chinese population in Taiwan,
regardless of age, sex, or other risk factors. The results were consistent with my
previous risk factor meta-analyses for ICH versus IS. In IS analyses, the prevalence
of hypertension, diabetes, AF, and hyperlipidaemia in overall IS patients based in
Taiwan were higher than the pooled results in my risk factor meta-analysis for IS for
all Chinese populations including mainland China. In terms of risk factor
associations with IS subtypes, the findings after controlling for potential confounders
were mostly close to my previous meta-analysis results with the exception of
stronger associations of hypertension and diabetes with SVD (lacunar) strokes.
CONCLUSION:
I have shown a younger onset of stroke, a higher overall stroke
incidence, an around twofold higher proportion of ICH and different distribution of
IS subtypes, as well as some differences in risk factor distributions among
pathological types of stroke and IS subtypes in Chinese compared with white
populations. My results help to inform us of different stroke mechanisms in different
populations, to guide further well-designed research in this area, and to direct better
strategies for stroke prevention in Chinese populations
From Kulim to Singapore: Catherine Lim's literary life
No full textThe publication in 1993 by Heinemann Asia of a volume of stories entitled The Best of Catherine Lim emphasised the significant contribution which this talented author has made to recent Singaporean fiction. The 1993 edition contains work from five of Catherine Lim's previously published collections, from Little Ironies (1978) to Deadline for Love (1992), and reflects the confidence which her publishers usually have in her capacity to draw a strong local reading audience. In fact, a Catherine Lim book is quite capable of attracting sales of 20,00O copies in a first edition
From Kulim to Singapore: Catherine Lim's literary life
No full textThe publication in 1993 by Heinemann Asia of a volume of stories entitled The Best of Catherine Lim emphasised the significant contribution which this talented author has made to recent Singaporean fiction. The 1993 edition
contains work from five of Catherine Lim's previously published collections, from Little Ironies (1978) to Deadline for Love (1992), and reflects the confidence which her publishers usually have in her capacity to draw a strong local reading audience. In fact, a Catherine Lim book is quite capable of attracting sales of 20,000 copies in a first edition
"On Writing with Catherine Wagner"
No full textIncludes descriptive metadata provided by producer in MP3 file: "Catherine Wagner is the author of two books of poems, 'Miss America' and 'Macular Hole,' and co-editor of 'Not for Mothers Only: Contemporary Poems on Child-Getting and Child-Rearing.'" Listen to an interview conducted by Tom Orange
The Family History of Catherine D. Lumley
Full text linkCatherine Lumley authored this family history as part of the course requirements for HIST 550/770: Your Family in History. This course was offered online in Spring 2023 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
Potentially serious incidental findings in the UK Biobank Imaging Study
Full text linkThe increased use of imaging across research, clinical and commercial contexts has
generated debate and calls for evidence on the benefits and harms of incidental findings
(defined as those which are unrelated to the purpose of imaging) to inform policy and
practice. Evidence on clearly non-serious incidental findings is of limited clinical usefulness;
this thesis therefore focuses on potentially serious incidental findings (PSIFs), defined as
those which may indicate the possibility of a condition which, if it was confirmed, would
carry a real prospect of seriously threatening life span, or of having a substantial impact on
major body functions or quality of life.
In 2014, the UK Biobank Imaging Study began performing brain, cardiac and body magnetic
resonance imaging (MRI), dual-energy X-ray absorptiometry and carotid Doppler
ultrasound, and aims to image 100,000 of its population-based participants. The imaging data
can be combined with extensive sociodemographic, lifestyle, physical measures,
biochemical, genetic and linked healthcare data, to generate a research resource which will
facilitate studies into a wide range of diseases. Due to the scale of the UK Biobank Imaging
Study, PSIFs are a particularly pertinent issue. UK Biobank therefore evaluates the impact of
its protocol for handling PSIFs, the data from which form the basis of this thesis.
This thesis aims to provide empirical data on seven themes relating to PSIFs: their
prevalence and nature; follow-up and final diagnoses; factors associated with PSIFs and with
serious final diagnoses; participants’ understanding of consent to feedback of PSIFs; nonmedical
impacts of feedback of PSIFs; opinions of receiving feedback of PSIFs; and the
economic impact of feedback of PSIFs on hospital services.
Chapter 1 outlines the scale of the challenge of incidental findings, and summarises current
literature and gaps in our knowledge relating to each of the seven themes on PSIFs. Chapter
2 reviews systematically and meta-analyses published studies of brain and body MRI of
apparently asymptomatic adults. Chapter 3 introduces the UK Biobank, the UK Biobank
Imaging Study, and the rationale behind and protocol used to handle PSIFs in 100,000
largely asymptomatic participants: radiographer flagging of concerning images for a
radiologist to review. Chapter 4 presents a study comparing two protocols to handle PSIFs in
the first 1,000 imaged UK Biobank participants: radiographer flagging versus systematic
radiologist review of all images. Chapter 5 investigates the factors associated with PSIFs and
with serious final diagnoses. Chapter 6 examines the economic impact of feedback of PSIFs
on hospital services, using linked routinely collected healthcare data. In the systematic review, pooled prevalences of PSIFs on brain, thorax, abdominal and brain
and body MRI were: 1.4–1.7%; 1.3–3.0%; 1.9–4.5%; and 3.9–12.8% respectively, the upper
estimates reflecting the inclusion of indeterminate findings. There was substantial
heterogeneity, but few informative data on potential sources of this. Around half of PSIFs
were suspected malignancies.
Based on the first 7,334 participants in the UK Biobank Imaging Study (283 of whom had
PSIFs), the PSIFs protocol had the largest influence on the prevalence of PSIFs and serious
final diagnoses of any of the investigated factors: systematic radiologist review resulted in
around 13 times more PSIFs and around four times more serious final diagnoses compared to
radiographer flagging. A lower proportion of PSIFs detected by radiologists were finally
diagnosed as serious compared to radiographer flagging (12% and 32% [Chapter 4 and 5]).
Feedback of PSIFs resulted in substantial impacts in terms of: clinical assessments (all
participants visited their general practitioner, and 90% underwent some form of other clinical
assessment, mostly imaging or referral to a specialist [Chapter 4]); non-medical impacts on
participants (including on emotional wellbeing, insurance and finances and work and
activities in 17%, 9% and 6% respectively [Chapter 4]); and hospital service use and cost
(81% of cases with PSIFs generated some hospital use and costs, which had increased
compared to controls, and to cases’ hospital use and costs during the year before feedback of
a PSIF [Chapter 6]). Importantly, as around 80% of PSIFs turned out not to be serious
(Chapters 2, 4 and 5), many of these impacts may be unnecessary.
Despite these negative impacts, the vast majority of participants were glad to have received
feedback of a PSIF and to have taken part in the imaging study (98% and 99% respectively),
although almost a quarter changed their minds over time about whether or not feedback
should always be given. Around a quarter of participants incorrectly thought they could
choose to receive feedback and UK Biobank has improved its consent materials accordingly
(Chapter 4).
Feedback of PSIFs impacts on participants and publicly-funded health services (and in turn
patients in need); most PSIFs turn out not to be serious and many of these impacts may be
unnecessary. Researchers can substantially influence these impacts via IFs policies, which
must be designed to minimise unnecessary harms, and be clearly explained to participants to
facilitate informed consent. These, and other implications of this thesis are further described
in Chapter 7, which also discusses the results in the context of the broader literature, outlines
the strengths and limitations of this thesis, and suggests directions for future work
Changing role of women : Mary Catherine Bateson
No full textHost, Bill Moyers ; guest, Mary Catherine Bateson. Producer/director, Betsy McCarthy.The subject of women and their roles at home and at work is one of the major and continuing stories of the day. Mary Catherine Bateson, anthropologist and author, has written on topics ranging from the social consequences of the AIDS epidemic to life with her celebrated parents, anthropologists Margaret Mead and Gregory Bateson. One of her primary areas of interest is the social consequences of the changing roles of women. In this program with Bill Moyers, she talks about how the idea of "home" as a place to give and receive nurture might become a new metaphor for the workplace. Bateson also discusses how women can create order and sense out of their conflicting commitments
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