200,478 research outputs found
Jalan terbaik selesaikan kemelut MIC: Palanivel, Subramaniam perlu berundur
No full textPENGUNDURAN dua pemimpin utama MIC yang bertelagah, Datuk Seri G. Palanivel dan Pemangku Presiden, Datuk Sen Dr.S. Subramaniam merupakan jalan terbaik dalam usaha Menyelesaikan krisis yang melanda parti itu
Searching for the Least Invasive Management of Pelvi-Ureteric Junction Obstruction in Children: A Critical Literature Review of Comparative Outcomes
No full textIntroduction: To review the published evidence on the minimally invasive pyeloplasty techniques available currently with particular emphasis on the comparative data about the various minimally invasive alternatives to treat pelvi-ureteric junction obstruction and gauge if one should be favored under certain circumstances. Materials and Methods: Non-systematic review of literature on open and minimally invasive pyeloplasty including various kinds of laparoscopic procedures, the robotic-assisted laparoscopic pyeloplasty, and endourological procedures. Results: Any particular minimally invasive pyeloplasty procedure seems feasible in experienced hands, irrespective of age including infants. Comparative data suggest that the robotic-assisted procedure has gained wider acceptance mainly because it is ergonomically more suited to surgeon well-being and facilitates advanced skills with dexterity thanks to 7 degrees of freedom. However, costs remain the major drawback of robotic surgery. In young children and infants, instead, open surgery can be performed via a relatively small incision and quicker time frame. Conclusions: The best approach for pyeloplasty is still a matter of debate. The robotic approach has gained increasing acceptance over the last years with major advantages of the surgeon well-being and ergonomics and the ease of suturing. Evidence, however, may favor the use of open surgery in infancy
Tridactylophagus Subramaniam 1932
No full textKey to the world species of the males of the genus <i>Tridactylophagus</i> Subramaniam, 1932 <p>1. Hind wings with two detached veins between radius (R) and media (M)......................................... 2</p> <p>- Hind wings with one detached vein between radius (R) and media (M).......................................... 9</p> <p>2(1). Detached vein R 3 shorter than R 2......................................................................... 3</p> <p> - Detached vein R 3 longer than R 2......................................................................... 4</p> <p> 3(2). Antennomere VII almost equal to preceding three segments together in length (Orient)................................................................................................. <i>T. ceylonensis</i> Kifune & Hirashima, 1980</p> <p> - Antennomere VII almost twice as long as preceding segment i.e., antennomere VI (Orient)..................................................................................... <i>T. maculatus</i> Chaudhuri, Ghosh & Das Gupta, 1983</p> <p>4(2). Antennomere IV half length of antennomere V............................................................. 5</p> <p>- Antennomere IV longer than half length of antennomere V.................................................... 7</p> <p> 5(4). R 2 detached vein curved at anterolateral angle of wing (Australasia)................. <i>T. buttonensis</i> Kathirithamby, 1992</p> <p>- R 2 detached vein not curved............................................................................ 6</p> <p> 6(5). R 3 detached vein broader than R 4 (Australasia)................................. <i>T. canberraensis</i> Kathirithamby, 1992</p> <p> - R 3 detached vein as broad as R 4 (Orient)................................................. <i>T. coniferus</i> Yang, 1964</p> <p> 7(4). Antennomere IV swollen on one side........................................................ <i>T. sufflatus</i> <b>sp. n.</b></p> <p>- Antennomere IV not swollen on one side.................................................................. 8</p> <p> 8(7). R 3 vein small, narrow, faint and situated close to R 2 (Orient)................ <i>T. orientalis</i> (Chaudhuri & Das Gupta, 1979)</p> <p> - R 3 vein long, prominent and situated near tip of R 4 (Orient)................... <i>T. aduncus M</i> axumdar & Chaudhuri, 1999</p> <p> 9(1). MA 2 vein present in hind wing (Orient).............................................. <i>T. similis</i> Kinzelbach, 1971</p> <p> - MA 2 vein absent in hind wing.......................................................................... 10</p> <p> 10(9). Postlumbium almost rectangular in shape (Orient).......................................... <i>T. sinensis</i> Yang, 1964</p> <p>- Postlumbium not rectangular in shape................................................................... 11</p> <p> 11(10). Tips of mandibles cross each other (Orient).............................. <i>T. carinatus</i> Mazumdar & Chaudhuri, 1999</p> <p> - Tips of mandibles not cross each other (Orient)................................... <i>T. mysorensis</i> Subramaniam, 1932</p>Published as part of <i>Hui, Poulami, Mukherjee, Bindarika & Hazra, Niladri, 2023, A new species of the genus Tridactylophagus Subramaniam, 1932 from West Bengal India with a tentative phylogeny and world key to known males (Strepsiptera: Halictophagidae), pp. 296-304 in Zootaxa 5230 (3)</i> on page 302, DOI: 10.11646/zootaxa.5230.3.2, <a href="http://zenodo.org/record/7561225">http://zenodo.org/record/7561225</a>
Immune response of bighorn sheep to Mannheimia haemolytica
No full textThesis (Ph.D.), Department of Veterinary Microbiology and Pathology, Washington State UniversityBighorn sheep (BHS; Ovis canadensis) are more susceptible to Mannheimia haemolytica-caused pneumonia, than domestic sheep (DS; Ovis aries). The objective of this study was to elucidate the basis for enhanced susceptibility of BHS, and explore potential strategies to prevent pneumonia in BHS. I hypothesized that enhanced lung pathology in BHS is due to inadequate clearance of M. haemolytica from the lungs. To test this hypothesis, M. haemolytica was inoculated intra-tracheally into groups of BHS and DS that were necropsied at 4, 12, and 18 hours post-inoculation (hpi). DS completely cleared the bacteria from the lungs by 18 hpi, whereas BHS had large number of bacteria still remaining in the lungs. Furthermore, bronchoalveolar lavage fluid from BHS had significantly lower titers of neutralizing antibodies to leukotoxin, the critical virulence factor of M. haemolytica. These findings suggested that enhanced lung pathology in BHS is likely due to inadequate clearance from the lungs, which, at least partly, is due to low titer of leukotoxin-neutralizing antibodies. In another study, serine protease inhibitor B1 of BHS and DS was cloned and expressed to facilitate future studies on the role of protease-anti-protease imbalance in enhanced susceptibility of BHS to M. haemolytica-caused pneumonia. M. haemolytica are more frequently isolated from nasopharynx of DS than that of BHS. Furthermore, most DS isolates are leukotoxin-positive whereas most BHS isolates are leukotoxin-negative, which is likely responsible for the negligibly low titers of leukotoxin-neutralizing antibodies in BHS. A `proof-of-concept' study was designed to determine whether repeated immunization will protect BHS against M. haemolytica challenge. Four BHS were repeatedly inoculated with a vaccine prepared with M. haemolytica A1, A2, and Bibersteinia trehalosi T10 culture supernatant. Upon subsequent challenge with M. haemolytica, all four vaccinated animals survived while all four un-vaccinated animals died within two days, suggesting that BHS are capable of mounting protective immune response against M. haemolytica. This notion was confirmed by another study that showed that MHC class II diversity in BHS is comparable to that of DS. Therefore, induction of immunity to M. haemolytica, particularly to its leukotoxin, is likely to protect BHS against pneumonia caused by this organism.Department of Veterinary Microbiology and Pathology, Washington State Universit
Fluid-mediated sources of granular temperature at finite Reynolds numbers
No full textWe derive analytical solutions for hydrodynamic sources and sinks to granular temperature in moderately dense suspensions of elastic particles at finite Reynolds numbers. Modelling the neighbour-induced drag disturbances with a Langevin equation allows an exact solution for the joint fluctuating acceleration–velocity distribution function P(v′,a′;t). Quadrant-conditioned covariance integrals of P(v′,a′;t) yield the hydrodynamic source and sink that dictate the evolution of granular temperature that can be used in Eulerian two-fluid models. Analytical predictions agree with benchmark data from particle-resolved direct numerical simulations and show promise as a general theory from gas–solid to bubbly flows.This article that has been published by Cambridge University Press as Lattanzi, Aaron M., Vahid Tavanashad, Shankar Subramaniam, and Jesse Capecelatro. "Fluid-mediated sources of granular temperature at finite Reynolds numbers." Journal of Fluid Mechanics 942 (2022): A7. DOI: 10.1017/jfm.2022.351. Copyright 2022 The Author(s). Attribution 4.0 International (CC BY 4.0). Posted with permission
sj-pdf-1-asu-10.1177_0003134820952438 – Supplemental Material for The 5-Factor Modified Frailty Index in the Geriatric Surgical Population
No full textSupplemental Material, sj-pdf-1-asu-10.1177_0003134820952438 for The 5-Factor Modified Frailty Index in the Geriatric Surgical Population by Sneha Subramaniam, Jeffrey J. Aalberg, Rainier P. Soriano and Celia M. Divino in The American Surgeon</p
sj-pdf-1-lrt-10.1177_14771535231172084 – Supplemental material for Development of a multichannel spectral simulation tool and experimental validation with different lighting scenarios
No full textSupplemental material, sj-pdf-1-lrt-10.1177_14771535231172084 for Development of a multichannel spectral simulation tool and experimental validation with different lighting scenarios by M Alwalidi, A Ganji Kheybari, S Subramaniam and S Hoffmann in Lighting Research & Technology</p
Abstracts presented at the European Society for Pediatric Urology (ESPU) meetings (2003-2010): Characteristics and outcome
No full textObjective: To determine the characteristics and outcome of abstracts presented to the meetings of the European Society for Pediatric Urology (ESPU). Material and methods: Abstract books from 2003 to 2010 were reviewed and subsequent publication of presented abstracts determined by MEDLINE/PubMed search. Results: Of 1194 abstracts, 50-78% per year originated from 15 to 20 European countries and 50-22% from 8 to 13 non-European countries; 233 (19%) were basic science and 961 (81%) clinical. Clinical abstracts included 135 (14%) multicenter/prospective/randomized trials. These figures did not change significantly over time. A total of 564 (47%) abstracts were subsequently published, 65% within 1 year of the meeting, mostly in the Journal of Urology (33%) and the Journal of Pediatric Urology (21%). Multicenter/prospective/randomized trials studies (OR 2.03; 95% CI 1.37-2.96) and abstracts originating from outside Europe (OR 1.61; 95% CI 1.26 -2.05) were significantly more likely to be subsequently published in full. Conclusion: The ESPU meetings are a true occasion for international exchange of scientific endeavors. Almost half of the abstracts are subsequently published. The Journal of Urology and the Journal of Pediatric Urology are consistently the two major target journals for publication. Non-European countries, irrespective of whether English-speaking or not, seem significantly more likely to publish their abstracts. (C) 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved
A molecular beacon strategy for real-time monitoring of triplex DNA formation kinetics
No full textWe used a molecular beacon (MB) containing a 15-mer triplex- forming oligonucleotide (TFO) to probe in real-time the kinetics of triplex DNA formation in the left side of the TC1 tract (502-516) of the c-src proto-oncogene in vitro. The metal ions Na+, K+, and Mg2+ Stabilized triplex DNA at this site. The pseudo-first-order rate constant (k(psi)) and the second-order association rate constant (k(1)) for the binding of the MB to the target duplex in 10 mM sodium phosphate buffer, pH 7.3, increased from 3.2+/-0.9 to 15+/-2.8 x 10(-3) s(-1) and 6.4+/- 1.8 to 30+/-5.6 x 10(2) M-1 s(-1), respectively, on increasing the MgCl2 concentration from 1 to 2.5 mM. Similar values were obtained for the triplex DNA stabilized by NaCl (100-250 mM). Surprisingly, the values were around 2 times higher in the presence of KCl. The DeltaG of triplex formation in the presence of 1 mM MgCl2, 150 mM NaCl, and 150 mM KCl were - 7.8+/-0.3, -8.2+/-0.3 and -8.7+/-0.7 kcal/mol respectively, despite significant differences in the values of DeltaH and DeltaS, suggesting enthalpy-entropy compensation in the stabilization of the triplex DNA by these metal ions. These results show the utility of NIBS in probing triplex DNA formation and in evaluating kinetic and thermodynamic parameters important for the design and development of TFOs as triplex DNA-based therapeutic agents
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