3,416 research outputs found
Correction: Rhodium-catalyzed cycloaddition of carbonyl ylides for the synthesis of spiro[furo[2,3-<i>a</i>]xanthene-2,3′-indolin]-2′-one scaffolds
No full textCorrection for ‘Rhodium-catalyzed cycloaddition of carbonyl ylides for the synthesis of spiro[furo[2,3-a]xanthene-2,3′-indolin]-2′-one scaffolds’ by B. V. Subba Reddy et al., RSC Adv., 2016, 6, 50497–50499.</p
Cytotoxic activity and chemical investigations of Alpinia Scabra (Blume) naves / Annushuya a/p Subba Reddy
No full textAlpinia scabra (Blume) Náves belonging to the botanical family Zingiberaceae, is an aromatic, perennial and rhizomatous herb, which is sometimes known by its vernacular name ‘Lengkuas raya’ among the locals. It is a wild species which grows largely on mountains at moderate elevations in Peninsular Malaysia, but it can also survive in lowlands like in the states of Terengganu and Northern Johor. The experimental approach in the present study was based on bioassay-guided fractionation. The methanol and fractionated extracts (hexane, chloroform and water) of A. scabra leaves, rhizomes, roots and pseudo stems were investigated for their cytotoxic effect against selected human cancer cell lines, namely hormone-dependent breast carcinoma cell line (MCF7) and ovarian cancer cell line (SKOV-3) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The identified cytotoxic extracts were then subjected to chemical investigations in order to identify the active ingredients. A normal human lung fibroblast cell line (MRC-5) was used to determine the specificity for cancerous cells. The cytotoxic extracts were also subjected to morphological assessment, DAPI nuclear staining and DNA fragmentation analysis. The leaf (hexane and chloroform) and rhizome (chloroform) extracts showed high inhibitory effect against the tested cell lines. Ten fractions (LC1-LC10) were obtained after purification of the leaf chloroform extract. Fraction LC4 which showed excellent cytotoxic activity was further purified and resulted in seventeen sub-fractions (VLC1-VLC17). Sub-fraction VLC9 showed excellent cytotoxicity against MCF7 and SKOV-3 cells but not toxic against normal MRC-5 cells. Meanwhile, eighteen fractions (RC1-RC18) were obtained after purification of the rhizome chloroform extract, by which fraction RC5 showed cytotoxicity against SKOV-3 cells with high selectivity index. There were marked morphological changes when observed using phase-contrast inverted
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microscope, DAPI nuclear staining and also DNA fragmentation in MCF7 and SKOV-3 cells after treatment with the cytotoxic extracts and fractions which were indicative of cell apoptosis. Methyl palmitate and methyl stearate were identified in the hexane leaf extract by GC-MS analysis. The data obtained from the current study demonstrated that the cytotoxic extracts and fractions of A. scabra inhibited the tested cancer cells mainly through apoptosis induction which were characterized by apoptotic morphological changes and DNA fragmentation. The active ingredients in leaf sub-fraction VLC9 and the rhizome fraction RC5 may lead to the discovery of valuable compounds that have the ability to kill cancer cells but not normal cells
sj-pptx-1-sgo-10.1177_21582440221126885 – Supplemental material for Modeling the Nonlinearities Between Coaching Leadership and Turnover Intention by Artificial Neural Networks
No full textSupplemental material, sj-pptx-1-sgo-10.1177_21582440221126885 for Modeling the Nonlinearities Between Coaching Leadership and Turnover Intention by Artificial Neural Networks by Won Seok Bang, Wee Kuk Hoan, Ju Young Park and Nagireddy gari Subba Reddy in SAGE Open</p
Teacher formative assessment: the missing link in response to intervention
No full textResponse to Intervention (RtI) focuses on the assessment, intervention, and progress monitoring of student academic performance and social behavior. Despite requiring highly-qualified personnel for successful implementation, the implementation of Rtl has not focused on applying its foundational principles towards promoting teacher effectiveness through assessment, intervention, and progress monitoring of teacher classroom practice. Compounding this problem is the lack of availability of reliable and valid teacher assessments to apply in an Rtl model for teacher professional development. This chapter provides a rationale for applying RtI principles to teacher professional development and how teacher formative assessment can improve educator effectiveness, student learning, and social behaviors. The Classroom Strategies Scale (CSS, Reddy & Dudek, 2014), a new multidimensional assessment of instructional and behavioral management practices is discussed as an example of one promising tool for promoting teachers professional development within an Rtl model. We offer a synthesis of the theory, research, and evidence of reliability and validity of the CSS. The application of teacher formative assessment in job-embedded professional development/coaching models for schools is discussed. Finally, implications for practice and research are outlined.Peer reviewe
SOCIAL MEDIA AS A MARKETING TOOL IN MSMEsININDIA–A STUDY
No full textDr. S. Venkata Subba Reddy,Vunnam Hari Bab
Characterization of Red sandalwood by ICP-MS Analysis, Optical absorption and EPR spectroscopic methods
No full textRed sandalwood contains Cd, Fe, Ni, Mn, C, S, H elements. ICP-MS results indicate that the red sandalwood contains Ni (61.877), Cu (281.256), Ba (3722.064) and Sr (6365.482) ppm elements respectively. It has partial semi conducting nature. EPR spectrum of the sample is due to Fe(III) in tetragonal distortion and its ash sample also contains Mn(II) in addition to Fe(III). The g values obtained for Fe(III) in the sample are 6.52, 2.63 and 1.92 respectively. The observed g and A values for Mn (II) are 1.990 and 88.5 G respectively. Mn(II) may be low in concentration in the sample. Optical absorption spectrum clearly indicates the presence of both ferric iron and Ni(II) in octahedral geometry. NIR Spectrum is due to carbonate overtones and harmonics and water fundamentals
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