131 research outputs found
Novel Epidermal Growth Factor Receptor Pathway Mediates the Release of Human β-Defensin 3 from Helicobacter pylori-Infected Gastric Epithelial Cells
Get PDF富山大学博士(医学)Article富山大学・富医薬博甲212号・Jibran Sualeh Muhammad・2016/9/28
The results within this thesis were published in two peer-reviewed PubMed indexed medical journals. Details are shown below:
1. Muhammad JS, Zaidi SF, Zhou Y, Sakurai H, Sugiyama T. Novel epidermal growth factor receptor pathway mediates release of human ?-defensin 3 from Helicobacter pylori-infected gastric epithelial cells. Pathog Dis. 2016; 74(3). pii: ftv128. doi: 10.1093/femspd/ftv128.
2. Zaidi SF, Refaat A, Zhou Y, Muhammad JS, Shin MS, Saiki I, Sakurai H, Sugiyama T. Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner. Helicobacter. 2015; 20(5):381-9
Saussurea delavayi Franch. (Franchet 1888
No full textSaussurea delavayi Franch. (Fig. 5) Journal de Botanique (Morot) 2: 355 (Franchet 1888). LECTOTYPE (here designated). — China. Yunnan, in monte Tsangchan, supra Tali, alt. 4000 m, 3.VIII.1884, J.M. Delavay 996 (lecto-, P[P00602833]!; isolecto-, A[A00011748]!, K [K000786464]!, P[P00602834]!). REMARKS Franchet (1888) described S. delavayi without designating any specimen as holotype but cited two specimens (Delavay 691 and Delavay 996) in the protologue, but, since then, no author has designated a lectotype, even inadvertently (Art. 7.11 of ICN, Turland et al. 2018) and all these collections should be regarded as syntypes (ICN; Art. 9.6, Turland et al. 2018). According to Stafleu & Cowan (1976), Franchet worked at P and Delavay’s specimens were deposited in K and P. Eight original materials were traced, two of them “ Delavay 691 ” deposited in P (P00602835, P00602836), and four of them “ Delavay 996 ” in A (A00011748), K (K000786464), and P (P00602833, P00602834). According to Art. 9.12 of ICN (Turland et al. 2018) one of them should be chosen as the lectotype. Among these collections, the one sheet “ Delavay 996 ” in P (P00602833) is a perfect match to the description given in the protologue, thus, this blooming specimen is selected here as the lectotype.Published as part of Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8) on page 122, DOI: 10.5252/adansonia2023v45a8, http://zenodo.org/record/784152
Burden of chronic respiratory disease in Asia, 1990–2023:a systematic analysis for the Global Burden of Disease Study 2023
No full textBackgroundChronic respiratory diseases are an important global issue, particularly in Asia, where burden patterns vary widely across countries. With more than half the world's population living in Asia, understanding the national and regional burden of chronic respiratory diseases is essential; however, research on this area remains inadequate. We aimed to investigate the burden of chronic respiratory diseases in Asia at national and regional levels, and to identify key risk factors.MethodsThe Global Burden of Diseases, Injuries, and Risk Factors Study 2023 provides estimates for assessing the burden of chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD), and pulmonary sarcoidosis. We focused on 34 countries in Asia, encompassing the high-income Asia Pacific region and central, east, south, and southeast Asia. Estimates for age-standardised prevalence and disability-adjusted life-year (DALY) rates per 100 000 population, including 95% uncertainty intervals (UIs), were extracted by location, sex, year, and Socio-demographic Index (SDI). The average annual percentage change was calculated and presented as a percentage with 95% CIs. Estimates of modifiable attributable risk factors for DALYs and mortality were also included.FindingsIn Asia, the age-standardised prevalence and DALY rates for chronic respiratory diseases generally declined from 1990 to 2023; however, the trend varied substantially by disease and country. In 2023, the age-standardised prevalence rate of COPD was highest in south Asia (3044·18 [95% UI 2748·67–3303·04] per 100 000 population), while the age-standardised asthma prevalence rate was highest in the high-income Asia Pacific region (4870·24 [4046·70–5962·78] per 100 000 population) and southeast Asia (4778·18 [3970·25–5735·61] per 100 000 population). Despite southeast Asia and the high-income Asia Pacific region having a similar age-standardised asthma prevalence rate, southeast Asia had a higher age-standardised DALY rate (508·67 [95% UI 394·89–669·92] per 100 000 population) compared with the high-income Asia Pacific region (204·40 [129·23–290·41] per 100 000 population). A decrease in the age-standardised DALY rate for chronic respiratory diseases was observed with increasing SDI, contrasting with its prevalence patterns. Age-standardised DALY rates of COPD decreased in all Asian countries except for Georgia (average annual percentage change 1·37 [95% CI 1·26–1·48]) and Kazakhstan (0·73 [0·55–0·93]), and age-standardised DALY rates of asthma decreased in all countries. Smoking and ambient particulate matter pollution were identified as leading attributable risk factors for chronic respiratory diseases across Asia. Household air pollution from solid fuels was a regionally pronounced risk factor for chronic respiratory diseases, particularly in south Asia (age-standardised DALY rate 657·58 [95% UI 485·04–880·45] per 100 000 population). Although smoking was a major risk factor in males, ambient particulate matter pollution and secondhand smoke emerged as important attributable risk factors for chronic respiratory diseases in females.InterpretationCountries with lower SDI had markedly higher DALY rates, highlighting the need to address socioeconomic and health-care inequities. Household air pollution from solid fuels continues to impose a substantial but preventable burden in south Asia, calling for clean energy adoption and improved ventilation.FundingGates Foundation
Novel Epidermal Growth Factor Receptor Pathway Mediates the Release of Human β-Defensin 3 from Helicobacter pylori-Infected Gastric Epithelial Cells
No full textGenetics and Epigenetics Mechanism in the Pathogenesis of Behçet\u27s Disease
No full textBackground: Behçet\u27s Disease (BD) is characterized by numerous systemic manifestations and is known for its ability to affect both, arteries and the veins. However, the etiology of BD is only partially understood, and previous studies have demonstrated a role for genetic and epigenetic factors that contribute to disease pathophysiology. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. Furthermore, during disease exacerbations adenosine deaminase has an important role in activating lymphocyte proliferation, maturation, and differentiation in BD. This article presents a review of the published literature mainly from the last 20 years. The topics of main concern were the role of genetic and epigenetic factors as contributing factors in disease pathophysiology.
Result & Conclusion: The authors used MeSH terms Behçet\u27s disease with pathophysiology, pathogenesis, genetic or epigenetic to search the PubMed database. All the relevant studies identified were included and are described according to the aforementioned subheadings
DNA methylation as an epigenetic regulator of gallbladder cancer: An overview
No full textGallbladder cancer (GBC) is a lethal health issue affecting mostly the women in their middle-age. High incidence of GBC has been reported across the world specifically in Asian countries, India and Pakistan. The exact etiology remains unknown, although several risk factors and genetic aberrations involving mutations or epigenetic changes may be involved in gallbladder carcinogenesis. This article presents a review of the published literature mainly from the year 2003 onwards. The topic of main concerns was epigenetic regulation of GBC. All relevant studies identified were included and are described according to the aforementioned subheadings. In this review, we have discussed the role of DNA methylation in GBC, clinical implication and future prospects of biomarker development for early diagnosis and therapeutic interventions
Saussurea virgata Franch. (Franchet 1894
No full text<i>Saussurea virgata</i> Franch. <p>(Fig. 15)</p> <p> <i>Journal de Botanique (Morot)</i> 2: 340 (1888).</p> <p> LECTOTYPE (here designated). — <b>China</b>. Yunnan, dans les prairies humides au pied du Tsang-Chan, alt. 2800 m, 25.IX.1888, <i>J.M. Delavay 3617</i> (lecto-, P[P00602943]!; isolecto-, P[P00602944, P00602945]!).</p> <p>REMARKS</p> <p> Franchet (1888) described <i>S. virgata</i> without designating any specimen as holotype, but cited two collections (<i>Delavay 3617</i> and <i>Delavay 3201</i>) in the protologue, but, since then, no author has designated a lectotype, even inadvertently (Art. 7.11 of ICN, Turland <i>et al.</i> 2018). Six original materials were traced in P, three of them “ <i>Delavay 3617</i> ” in P (P00602928, P00602929, P00602942), and three of them “ <i>Delavay 3201</i> ” in P (P00602943, P00602944, P00602945). According to Art. 9.6 of ICN (Turland <i>et al.</i> 2018), all these collections should be regarded as syntypes. All the original materials in P bear the informations “ Syntype <i>S. virgata</i> Franch. ” as well as Delavay annotations, from which lectotype could be chosen (Art. 9.12 of ICN, Turland <i>et al.</i> 2018). Herein, we designate the sheet “ <i>Delavay 3617</i> ” in P (P00602943) as the lectotype. The selected herbarium specimen is well preserved and comprises a stem, many leaves with numerous flowers and inflorescence which fully agree with both the description and the current application of the name.</p>Published as part of <i>Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8)</i> on page 136, DOI: 10.5252/adansonia2023v45a8, <a href="http://zenodo.org/record/7841520">http://zenodo.org/record/7841520</a>
Saussurea vestita Franch. (Franchet 1888
No full text<i>Saussurea vestita</i> Franch. <p>(Fig. 14)</p> <p> <i>Journal de Botanique (Morot)</i> 2: 358 (Franchet 1888).</p> <p> LECTOTYPE (here designated). — <b>China</b>. Yunnan, in calcareis ad collum montis Hee-chan-men, prope Lankong, alt. 3000 m, 30.VIII.1886, <i>J.M. Delavay 2145</i> (lecto-, P[P00602923]!; isolecto-, K[K000035680, K000035681]!, P[P00602924]!).</p> <p>REMARKS</p> <p> In the protologue, Franchet (1888) provided the following localities information: “ Yunnan, in calcareis ad collum montis Hee-chan-men, prope Lankong, alt. 3000 m (<i>Delavay 2145</i>); “ad collum Pi-iou-se, supra Tapin-tze (<i>Delavay s.n.</i>); “ad pedem montis Yang-in-chan (<i>Delavay s.n.</i>)” but did not indicate any holotype specimen. Since then, no author has designated a lectotype, even inadvertently (Art. 7.11 of ICN, Turland <i>et al.</i> 2018). We located seven original materials deposited in K & P, and all these collections should be regarded as syntypes (Art. 9.6 of ICN; Turland <i>et al.</i> 2018). After careful examination of all these collections, which have been deposited in P, it is necessary to select one of them as the lectotype in accordance with Art. 9.12 of ICN (Turland <i>et al.</i> 2018). We designate here the blooming specimen “ <i>Delavay 2145</i> ” in P (P00602923) as the lectotype.The selected sheet bears a complete and well-preserved specimen that displays all the morphological diagnostic traits in agreement with the protologue.</p>Published as part of <i>Jibran, Muhammad, Idrees, Muhammad & Zhang, Zhiyong, 2023, Notes on the typification of fourteen names published by A. R. Franchet in Saussurea DC. (Asteraceae), pp. 115-139 in Adansonia (3) (3) 45 (8)</i> on page 131, DOI: 10.5252/adansonia2023v45a8, <a href="http://zenodo.org/record/7841520">http://zenodo.org/record/7841520</a>
Clinical patterns of seronegative spondyloarthropathies in a tertiary centre in Pakistan
No full textالملخص: أهداف البحث: لالتهاب الفقرات والمفاصل أنماط مختلفة في مناطق مختلفة من العالم. وتعتبر معرفة النمط الإقليمي مهمة للتشخيص الصحيح. تهدف هذه الدراسة لتقييم الأعراض والنمط السريري لالتهاب الفقرات والمفاصل بين شريحة المجتمع المنخفضة اقتصاديا واجتماعيا في الباكستان. طرق البحث: خلال الفترة من يوليو ٢٠١٦ إلى يونيو ٢٠١٧، تم إجراء دراسة ملاحظة سريرية في مستشفى تعليمي جامعي للرعاية الثالثة. وكانت العينة التي تم الاختيار منها ٥٠٠٠ شخص في البداية من عيادة الروماتيزم. وتم اختيار ١١٤ شخص وإدراجهم في هذه الدراسة على النحو المحدد في معايير الاشتمال. كما تم تسجيل جميع المتغيرات الديموغرافية وعمل الفحوصات السريرية الأساسية. وتم تجميع معلومات المريض بناء على المشاهدات الدارجة لالتهاب الفقرات والمفاصل. واستخدمت معايير تشخيص مجموعة الدراسة الأوروبية لالتهاب الفقرات والمفاصل لتشخيص وتصنيف المشاركين بالدراسة. النتائج: من بين ١١٤ حالة تم تشخيصها في هذه الدراسة، ضمت الدراسة ٣٦٪ (٤١) من الإناث و٦٤٪ (٧٣) من الذكور. وكان متوسط العمر للمرضى بين ٢٥-٦٥ عاما. وكان الذكور أكثر تضررا بمرتين تقريبا عن الإناث بمعدل ٢: ١.٤. وكان الذكور في العمر ٣٠-٦٠ عاما الأكثر ضررا. وكانت الأنواع الفرعية الأكثر تشخيصا في كثير من الأحيان التهاب الفقار اللاصق، والتهاب المفاصل التفاعلي والتهاب المفاصل الصدفي. وكانت أكثر الأعراض انتشارا هي التهاب المفصل العجزي الحرقفي، وألم التهاب العمود الفقري والتهاب المفصل الزليلي. الاستنتاجات: وجدت الدراسة الهيمنة الذكورية لالتهاب الفقرات والمفاصل، ومن بين جميع المرضى الذين شملتهم هذه الدراسة؛ تم تشخيص التهاب الفقار اللاصق، والتهاب المفاصل الصدفي والتهاب المفاصل التفاعلي مع الأنواع الفرعية السائدة -لالتهاب الفقرات والمفاصل. Abstract: Objectives: The patterns of spondyloarthropathies (SpA) differ across regions globally, and an understanding of these patterns is important for the correct diagnosis of this condition. The aim of this study was to evaluate the presenting symptoms and clinical patterns of SpA in a community of low socioeconomic status in Pakistan. Methods: This clinical observational study was conducted in a tertiary care teaching hospital from July 2016 to June 2017. Five thousand patients were initially recruited in the rheumatology clinic. A total of 114 patients were finally selected and enrolled in this study, as defined by the inclusion criteria. All demographic variables were recorded and baseline clinical investigations were performed. The European Spondyloarthropathy Study Group (ESSG) diagnostic criteria were used to diagnose the condition and classify the study participants. Results: Of the 114 patients, 64% (73 patients) were men and 36% (41 patients) were women. The mean age of the patients ranged 25–65 years. The men were affected twice as much as women with a ratio of 2:1.4. Men in the age group of 30–60 years constituted a large proportion of the study population. The most frequently diagnosed subtypes were ankylosing spondylitis, reactive arthritis, and psoriatic arthritis. The most common presenting symptoms were sacroiliitis, inflammatory spinal pain, and synovitis. Conclusion: Males had a higher prevalence of SpA. Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis were the most commonly diagnosed subtypes. الكلمات المفتاحية: التهاب الفقرات والمفاصل, التهاب المفاصل الروماتويدي, التهاب المفاصل الصدفي, التهاب الفقار اللاصق, التهاب المفاصل التفاعلي, Keywords: Ankylosing spondylitis, Psoriatic arthritis, Reactive arthritis, Rheumatoid arthritis, Spondyloarthropathie
- …
