8,913 research outputs found

    From Single Cell Data to Mechanistic Insights Into Stem Cell Differentiation

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    The work presented here is motivated by two related questions: 1. How do cells make decisions? ◦ In response to developmental, environmental, and physiological cues. ◦ using signalling, transcription,etc. 2.How can we make mathematical, predictive, and explanatory models of cellular decision making processes? ◦ identifying molecular interaction networks from data and available prior knowledge ◦ building dynamical systems representations for detailed (in)validation and hypothesis evaluation The presentation introduces and discusses work that was introduced in four papers/preprints:1. Chan, T. E., Stumpf, M. P. H., & Babtie, A. C. (2017). Gene Regulatory Network Inference from Single-Cell Data Using Multivariate Information Measures. Cell Systems, 5(3), 251–267.e3. http://doi.org/10.1016/j.cels.2017.08.0142. Stumpf, P. S., Smith, R. C. G., Lenz, M., Schuppert, A., Müller, F.-J., Babtie, A. C., et al. (2017). Stem Cell Differentiation as a Non-Markov Stochastic Process. Cell Systems, 5(3), 268–282.e7. http://doi.org/10.1016/j.cels.2017.08.0093. Brackston, R., Lakatos, E., & Stumpf, M. P. H. (2018). Transition State Characteristics During Cell Differentiation. bioRxiv, 264143. http://doi.org/10.1101/2641434. Chan, T. E., Pallaseni, A., Babtie, A. C., McEwen, K., & Stumpf, M. P. H. (2018). Empirical Bayes Meets Information Theoretical Network Reconstruction from Single Cell Data. bioRxiv, 264853. http://doi.org/10.1101/264853 </div

    E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel)

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    Arsip Kuliah Online 2010: E-book : Industrial Transformation In The Developing World (author: Michael T. Rock & David P. Angel

    E-book : &#34;industrial Transformations In The Developing World (author: Michael T. Rock & David. P Angel)

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    Arsip Kuliah Online 2010: E-book : &#34;industrial Transformations In The Developing World (author: Michael T. Rock & David. P Angel

    Correspondence: George Kephart to Michael Frome

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    This 1960s correspondence, from George S. Kephart to Michael Frome, discusses what the author considers misinformation about his father, Horace Kephart. Horace Kephart (1862-1931) was a noted naturalist, woodsman, journalist, and author and promoter of the Great Smoky Mountains National Park

    P. Michael Politano

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    P. Michael Politano, PhD, MPS, ABPP Dr. P. Michael (Mike) Politano is a professor in the Department of Psychology at the Citadel (Charleston, South Carolina). He holds an undergraduate degree from Duke University, a master’s and PhD from Indiana University in school psychology, a postdoctorate from Indiana University and the Medical College of Virginia in clinical child psychology, and a master’s in religious studies from Loyola, New Orleans. Dr. Politano has taught both undergraduate and graduate research methodology and statistics at various universities for more than 40 years. He also has supervised numerous master’s theses and PhD dissertations. Dr. Politano has published in numerous peer-reviewed journals and presented his work at multiple professional conferences worldwide. He is also the author and illustrator of the children’s book A Pig in a Tree and the novel Tag and Chubs.https://commons.erau.edu/ntas-bios/1017/thumbnail.jp

    [Von den ausgebrannten Wassern]

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    [Michael Puff]Impressum: Datum in der Vorlage erwähnt, Ort und Drucker nach ISTCIn Sack, Freiburg the author is identified as Michael Puff, nicknamed Schrick (H. Walther, Sudhoff's Archiv 54 (1970) p.285)Incunabula: The Printing Revolution in Europe 1455-1500, Unit 15 - Medical Incunabula Part V, MI 62 (Research Publications (Primary Source Media) Reading, 1995

    Early Risk, Attention, and Brain Activation in Adolescents Born Preterm

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    The relations among early cumulative medical risk, cumulative environmental risk, attentional control, and brain activation were assessed in 15 – 16-year-old adolescents who were born preterm. Functional magnetic resonance imaging found frontal, temporal, and parietal cortex activation during an attention task with greater activation of the left superior-temporal and left supramarginal gyri associated with better performance. Individual differences in early cumulative risk are related to patterns of brain activation such that medical risk is related to left parietal cortex activation and environmental risk is related to temporal lobe activation. The findings suggest that early risk is related to less mature patterns of brain activation, including reduced efficiency of processing and responding to stimuli.This is the accepted version of the following article: Carmody, D. P., Bendersky, M., Dunn, S. M., DeMarco, J. K., Hegyi, T., Hiatt, M. and Lewis, M. (2006), Early Risk, Attention, and Brain Activation in Adolescents Born Preterm. Child Development, 77: 384–394, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/j.1467-8624.2006.00877.x/abstract.Peer reviewe

    Sociology

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    Michael Kelly is the author of 68 entries altogether. The New Oxford Companion to Literature in French is far more than a simple revision of the original Oxford Companion to French Literature, published in 1959, and described by The Listener as the 'standard work of reference for English-speaking enquirers into French literature'. As the change in title implies, this completely new work presents an authoritative guide not only to ten centuries of literature produced in the territory now called France, but also to the rich literary output of other French-speaking countries around the world.The scope of the Companion is deliberately open and inclusive, challenging and extending the traditional canon. Literature is understood in a broad sense, ranging from strip cartoon and pamphlet to tragedy and epic, and particular attention is devoted to francophone writing from outside France. Written by an international team of specialists, entries cover individual authors and works - over 3,000 of them - from the troubadours to Césaire, and from La Princesse de Clèves to La Vie mode d'emploi . Each is discussed in detail within their historical, cultural, and intellectual context.Among the new features of the Companion are the substantial essay-entries, reflecting up-to-date scholarship and theoretical debates on topics such as: - literary movements and genres - historical subjects such as chivalry, or Occupation and Resistance in wartime France - movements of thought from Scholasticism to feminism - linguistic topics - the sciences - the arts and media, including opera, cinema, and pres

    Anthropology

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    Michael Kelly is the author of 68 entries altogether. The New Oxford Companion to Literature in French is far more than a simple revision of the original Oxford Companion to French Literature, published in 1959, and described by The Listener as the 'standard work of reference for English-speaking enquirers into French literature'. As the change in title implies, this completely new work presents an authoritative guide not only to ten centuries of literature produced in the territory now called France, but also to the rich literary output of other French-speaking countries around the world.The scope of the Companion is deliberately open and inclusive, challenging and extending the traditional canon. Literature is understood in a broad sense, ranging from strip cartoon and pamphlet to tragedy and epic, and particular attention is devoted to francophone writing from outside France. Written by an international team of specialists, entries cover individual authors and works - over 3,000 of them - from the troubadours to Césaire, and from La Princesse de Clèves to La Vie mode d'emploi. Each is discussed in detail within their historical, cultural, and intellectual context.Among the new features of the Companion are the substantial essay-entries, reflecting up-to-date scholarship and theoretical debates on topics such as:- literary movements and genres- historical subjects such as chivalry, or Occupation and Resistance in wartime France- movements of thought from Scholasticism to feminism- linguistic topics- the sciences- the arts and media, including opera, cinema, and press
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