1,297 research outputs found
sj-docx-1-wso-10.1177_17474930231216339 – Supplemental material for Cerebral microbleeds and asundexian in non-cardioembolic ischemic stroke: Secondary analyses of the PACIFIC-STROKE randomized trial
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930231216339 for Cerebral microbleeds and asundexian in non-cardioembolic ischemic stroke: Secondary analyses of the PACIFIC-STROKE randomized trial by Pargol Balali, Robert G Hart, Eric E Smith, Feryal Saad, Pablo Colorado, Robin Lemmens, Gian Marco De Marchis, Valeria Caso, Lizhen Xu, Laura Heenan, Stuart J Connolly, Hardi Mundl and Ashkan Shoamanesh in International Journal of Stroke</p
Long-term wind-driven X-ray spectral variability of NGC 1365 with Swift
No full textWe present long-term (months–years) X-ray spectral variability of the Seyfert 1.8 galaxy NGC 1365 as observed by Swift, which provides well-sampled observations over a much longer time-scale (six years) and a much larger flux range than is afforded by other observatories. At very low luminosities, the spectrum is very soft, becoming rapidly harder as the luminosity increases and then, above a particular luminosity, softening again. At a given flux level, the scatter in hardness ratio is not very large, meaning that the spectral shape is largely determined by the luminosity. The spectra were therefore summed in luminosity bins and fitted with a variety of models. The best-fitting model consists of two power laws, one unabsorbed and another, more luminous, which is absorbed. In this model, we find a range of intrinsic 0.5–10.0 keV luminosities of approximately 1.1–3.5 erg s?1, and a very large range of absorbing columns, of approximately 1022–1024 cm?2. Interestingly, we find that the absorbing column decreases with increasing luminosity, but that this result is not due to changes in ionization. We suggest that these observations might be interpreted in terms of a wind model in which the launch radius varies as a function of ionizing flux and disc temperature and therefore moves out with increasing accretion rate, i.e. increasing X-ray luminosity. Thus, depending on the inclination angle of the disc relative to the observer, the absorbing column may decrease as the accretion rate goes up. The weaker, unabsorbed, component may be a scattered component from the wind
Social Behavior and Meningococcal Carriage in British Teenagers
No full textUnderstanding predisposing factors for meningococcal carriage may identify targets for public health interventions. Before mass vaccination with meningococcal group C conjugate vaccine began in autumn 1999, we took pharyngeal swabs from ?14,000 UK teenagers and collected information on potential risk factors. Neisseria meningitidis was cultured from 2,319 (16.7%) of 13,919 swabs. In multivariable analysis, attendance at pubs/clubs, intimate kissing, and cigarette smoking were each independently and strongly associated with increased risk for meningococcal carriage (p<0.001). Carriage in those with none of these risk factors was 7.8%, compared to 32.8% in those with all 3. Passive smoking was also linked to higher risk for carriage, but age, sex, social deprivation, home crowding, or school characteristics had little or no effect. Social behavior, rather than age or sex, can explain the higher frequency of meningococcal carriage among teenagers. A ban on smoking in public places may reduce risk for transmission
Switching patients from warfarin to dabigatran therapy: To RE-LY or not to rely
No full text[No abstract available]Connolly SJ, 2009, NEW ENGL J MED, V361, P1139, DOI 10.1056-NEJMoa0905561; Ezekowitz MD, 2010, CIRCULATION, V122, P2246, DOI 10.1161-CIRCULATIONAHA.110.973735; Shewan LG, 2010, INT J CARDIOL, V144, P1, DOI 10.1016-j.ijcard.2010.07.0300
Rapid hydrolysis of RNA with a CU-II complex
No full textPT: J; CR: ANDERSON B, 1977, J AM CHEM SOC, V99, P2652 BARBIER B, 1992, J AM CHEM SOC, V114, P3511 BASHKIN JK, 1994, J AM CHEM SOC, V116, P5981 BRESLOW R, 1986, J AM CHEM SOC, V108, P2655 BRESLOW R, 1989, P NATL ACAD SCI USA, V86, P1746 BRESLOW R, 1991, P NATL ACAD SCI USA, V88, P4080 CONNOLLY JA, 1994, INORG CHEM, V33, P665 GOBEL MW, 1992, ANGEW CHEM INT EDIT, V31, P207 GOBEL MW, 1992, ANGEW CHEM, V104, P217 GUSTAFSON RL, 1959, J AM CHEM SOC, V81, P525 HENDRY P, 1990, INORG CHEM, V29, P92 JUBIAN V, 1992, J AM CHEM SOC, V114, P1120 KOMIYAMA M, 1992, J CHEM SOC CHEM 0415, P640 MAGDA D, 1994, J AM CHEM SOC, V116, P7439 MATSUMOTO Y, 1990, J CHEM SOC CHEM COMM, P1050 MORROW JR, 1992, J AM CHEM SOC, V114, P1903 SCHNEIDER HJ, 1993, ANGEW CHEM INT EDIT, V32, P1716 SCHNEIDER HJ, 1993, ANGEW CHEM, V105, P1773 SMITH J, 1993, J AM CHEM SOC, V115, P362 STERN MK, 1990, J AM CHEM SOC, V112, P5357 SUMAOKA J, 1994, J CHEM SOC CHEM COMM, P1755 TAKASAKI BK, 1993, J AM CHEM SOC, V115, P9337 TAKASAKI BK, 1994, J AM CHEM SOC, V116, P1121 WAHNON D, 1994, J CHEM SOC CHEM COMM, P1441 WALL M, 1993, ANGEW CHEM INT EDIT, V32, P1633 WALL M, 1993, ANGEW CHEM, V105, P1696; NR: 26; TC: 82; J9: ANGEW CHEM INT ED; PG: 3; GA: QM404Source type: Electronic(1
Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III
No full textBackground: LAAOS III (Left Atrial Appendage Occlusion Study III) showed that left atrial appendage (LAA) occlusion reduces the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation undergoing cardiac surgery. This article examines the effect of LAA occlusion on stroke reduction according to variation in the use of oral anticoagulants (OACs). Methods: Information regarding OAC use was collected at every follow-up visit. Adjusted proportional hazards modeling, including using landmarks of hospital discharge, 1 and 2 years after randomization, evaluated the effect of LAA occlusion on the risk of ischemic stroke or systemic embolism, according to OAC use. Adjusted proportional hazard modeling, with OAC use as a time-dependent covariate, was also performed to assess the effect of LAA occlusion, according to OAC use throughout the study. Results: At hospital discharge, 3027 patients (63.5%) were receiving a vitamin K antagonist, and 879 (18.5%) were receiving a non-vitamin K antagonist oral anticoagulant (direct OAC), with no difference in OAC use between treatment arms. There were 2887 (60.5%) patients who received OACs at all follow-up visits, 1401 (29.4%) who received OAC at some visits, and 472 (9.9%) who never received OACs. The effect of LAA occlusion on the risk of ischemic stroke or systemic embolism was consistent after discharge across all 3 groups: hazard ratios of 0.70 (95% CI, 0.51-0.96), 0.63 (95% CI, 0.43-0.94), and 0.76 (95% CI, 0.32-1.79), respectively. An adjusted proportional hazards model with OAC use as a time-dependent covariate showed that the reduction in stroke or systemic embolism with LAA occlusion was similar whether patients were receiving OACs or not. Conclusions: The benefit of LAA occlusion was consistent whether patients were receiving OACs or not. LAA occlusion provides thromboembolism reduction in patients independent of OAC use
A test of stress, cues, and re-exposure to large wins as potential reinstaters of suboptimal decision making in rats
No full textCitation:
Connolly NP, Kim JS, Tunstall BJ and Kearns DN (2015) A test of stress, cues, and re-exposure to large wins as potential reinstaters of suboptimal decision making in rats. Front. Psychol. 6:394.The present experiment investigated potential reinstaters of suboptimal economic deci- sion making in rats. Rats were first trained on a version of the rat Gambling Task under conditions designed to promote choice of a suboptimal option that occasionally resulted in large “wins” (four sucrose pellets). In a second phase, preference for this economically suboptimal option was reduced by substantially increasing the probability of punishment when this option was chosen. Then, three events were tested for their ability to reinstate choice of the suboptimal option. A brief period of re-exposure to a high frequency of large wins significantly increased choice of the suboptimal option. The pharmacological stressor yohimbine did not reinstate suboptimal choice, but did increase impulsive action as indexed by premature responding. Presentation of cues previously associated with large wins did not alter behavior. Results suggest reinstaters of suboptimal choice may differ from reinstaters of extinguished drug- and food-seeking behavior
Cultural resources baseline report
No full textfrom Tom Connolly ; to ODOT Archaeologist & Tribal Liaison.Title from PDF caption (viewed on July 12, 2021).Redactions have been deleted from this version of the document."REDACTED"--Watermark.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 22-24).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Atrial fibrillation is associated with increased mortality: Causation or association?
No full textThis editorial refers to ‘All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995–2008: a Swedish nationwide long-term case–control study’, by T. Andersson et al., on page 1061Darryl P. Leong, John W. Eikelboom, Jeff S. Healey, and Stuart J. Connoll
Reduction in unnecessary ventricular pacing fails to affect hard clinical outcomes in patients with preserved left ventricular function: a meta-analysis
No full textAims:
Several pacing modalities across multiple manufacturers have been introduced to minimize unnecessary right ventricular pacing. We conducted a meta-analysis to assess whether ventricular pacing reduction modalities (VPRM) influence hard clinical outcomes in comparison to standard dual-chamber pacing (DDD).
Methods and results:
An electronic search was performed using Cochrane Central Register, PubMed, Embase, and Scopus. Only randomized controlled trials (RCT) were included in this analysis. Outcomes of interest included: frequency of ventricular pacing (VP), incident persistent/permanent atrial fibrillation (PerAF), all-cause hospitalization and all-cause mortality. Odds ratios (OR) were reported for dichotomous variables. Seven RCTs involving 4119 adult patients were identified. Ventricular pacing reduction modalities were employed in 2069 patients: (MVP, Medtronic Inc.) in 1423 and (SafeR, Sorin CRM, Clamart) in 646 patients. Baseline demographics and clinical characteristics were similar between VPRM and DDD groups. The mean follow-up period was 2.5 ± 0.9 years. Ventricular pacing reduction modalities showed uniform reduction in VP in comparison to DDD groups among all individual studies. The incidence of PerAF was similar between both groups {8 vs. 10%, OR 0.84 [95% confidence interval (CI) 0.57; 1.24], P = 0.38}. Ventricular pacing reduction modalities showed no significant differences in comparison to DDD for all-cause hospitalization or all-cause mortality [9 vs. 11%, OR 0.82 (95% CI 0.65; 1.03), P= 0.09; 6 vs. 6%, OR 0.97 (95% CI 0.74; 1.28), P = 0.84, respectively].
Conclusion:
Novel VPRM measures effectively reduce VP in comparison to standard DDD. When actively programmed, VPRM did not improve clinical outcomes and were not superior to standard DDD programming in reducing incidence of PerAF, all-cause hospitalization, or all-cause mortality
- …
