438 research outputs found
The Author of Waverley
No full textMedium: engravingprintssigned and dated."The Author of Waverley" [2017.0032.000.000], Goodall, Edward, Allan, WilliamArtist and Role: Goodall, Edward,Artist and Role: Allan, William, ArtistExtent: shee
William Goodall letter to Z. Eastman, May 1874
No full textThis four-page letter appears to be a serial letter written by William Goodall to Z. Eastman, on the subject of Goodall's acquaintance with Benjamin Lundy and subsequent historical and press coverage of Lundy's life, history, and relationship and contribution to the U.S. anti-slavery and abolitionist movements. Much of the letter describes Goodall's struggle with the composition process -- presumably, perhaps, for the Chicago Anti-Slavery Reunion to be held in June , 1875 -- for a memorial biographical sketch on the life and times of Lundy. Goodall summarizes his paper thus far and provides his opinion on Lundy's legacy and contributions, and Lundy's politics, alongside those of his contemporaries. Large portions of the letter are illegible due to difficult penmanship, damage to the letter material, or folding or tearing of the letter paper. Benjamin Lundy (1789-1839) was a prominent Quaker abolitionist best known for his development of abolitionist periodicals. His Genius of Universal Emancipation was first published in 1821 from his home in Mt. Pleasant, Ohio, and enjoyed a wide circulation across the antebellum United States. In the 1820s, the young William Lloyd Garrison came to work for The Genius. Benjamin Lundy traveled widely seeking subscriptions to The Genius, giving talks about the anti-slavery movement, and observing and documenting the conditions of enslaved people across the Americas. He was also involved in the establishment of freed slave colonies in Mexico
A survey of some fifth- and sixth-formers' perceptions of mathematics
No full textThis Report gives some results of a small but purposive survey of the attitudes of school fifth- and sixth-formers to mathematics as a subject and their opinions as to whether they wished to proceed to further study of mathematics. The survey was conducted by direct face-to-face interviewing of the pupils at their schools during the academic year 1990-1991. The interviewing and the initial analysis of the data were carried out by a fourth-year student, Mr R T Davies, in the Department of Mathematics and Statistics at Brunel University as part of his Final Year Project. The author of this Report was closely involved with the work, as was Dr E J Davis of Henley Management College; both the author and Dr Davis had roles of project supervisors and independent roles concerning survey design and analysis
Regulating Casino Gaming: A Checklist for States Considering It
No full textIn his essay - Regulating Casino Gaming: A Checklist for States Considering It – by Leonard E. Goodall, Professor of Management and Public Administration, College of Business and Econornics, University of Nevada, Las Vegas, Professor Goodall initially states: “Since various states are likely to continue to debate the issue of the establishment of legal casinos, and since states considering legal casinos must also decide how best to regulate them, the author discusses the similarities and contrasts in the regulatory systems already in operation.”
Certainly not all states have solicited casino gaming, or what people generally refer to as gambling, but many have and the list is growing. If casinos are to be, and indications are that many more states will endorse gaming as a source of revenue, then regulating them must follow as a matter of due course says the author. Keep in mind this essay was written in 1988, and the actuality of casino gaming has indeed come to fruition in many states.
“Nevada, having legalized casino gaming in 1931, has over a half-century of experience with the regulatory process,” Professor Goodall informs. “When New Jersey approved the establishment of casinos in Atlantic City in 1976, state officials studied the Nevada system carefully and adopted many of Nevada\u27s procedures.”
Professor Goodall bullet-points at least 7 key elements that states wanting to pursue gaming should, or in the cases of Nevada and New Jersey, have already addressed in regard to regulation of the industry. Goodall parses, in more detail, those essentials.
The ultimate form of regulation is ownership Goodall says. Either state run, or private are the logical options. “The arguments for private ownership have been both pragmatic and political,” Goodall says. “Legislators, like the general public, are skeptical of the ability of state bureaucracies to run big businesses in an efficient manner. Many of them also believe regulation can be more effective if there is at least an arm\u27s-length distance between regulation and ownership,” the professor opines.
Additionally important to consider is the purpose of legalization, says Goodall. Are the proceeds earmarked for general funds, or to be used specifically?
Geographic considerations are key, Goodall points out. “This decision will depend partly on a state\u27s reasons for having casinos in the first place,” he expands. “New Jersey\u27s policy, for example, is obviously consistent with its goal of using casinos to reinvigorate Atlantic City.”
“In both states, one of the most important functions of the regulatory agencies is that of licensing, the process of investigating individuals or organizations and then authorizing them to participate in the gaming business,” Goodall provides.
In closing, Goodall says there is no need for ensuing states to reinvent the wheel when it comes to casino gaming regulation. Nevada and New Jersey already provide two good designs from which to emulate and/or build upon
Science amongst the vines - Meeting on signalling systems
No full textCopyright © 2008 by the European Molecular Biology OrganizationStuart M Pitson, Gregory J Goodall and Mark A Guthridg
Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3 ' AU-rich mRNA destabilizing elements
No full text© 2008 BioTechniquesTetracycline-regulated expression systems have been widely used for inducible protein expression in cultured mammalian cells. With these systems, however, leakiness in expression of the target gene in the absence of the inducing agent is a frequent problem. Here we describe a novel approach to overcome this problem that involves the incorporation of AU-rich mRNA destabilizing elements (AREs) into the 3′ untranslated regions of the tetracycline-inducible constructs. Using the inducible expression of sphingosine kinase 1 and 2 in HEK293 cells as model systems, we found this ARE approach to be remarkably successful in ablating expression of these proteins in the absence of doxycycline through decreasing stability of their mRNAs. We show that this undemanding and flexible process results in a substantial decrease in the leakiness of the tetracycline-inducible expression system while maintaining a high level of target protein expression following induction.Duyen H. Pham, Paul A.B. Moretti, Gregory J. Goodall and Stuart M. Pitso
Depression management in primary care: an observational study of management changes related to PHQ-9 score for depression monitoring
No full textBackground:Since 2009 UK GPs have been incentivised to use depression severity scores to monitor patients' response to treatment after 5-12 weeks of treatment.Aim:To examine the association between the severity scores obtained and follow-up questionnaires to monitor depression and subsequent changes made to the treatment of it.Design and setting:A retrospective cohort study utilising routine primary care records was conducted between April 2009 and March 2011 in 13 general practices recruited from within Hampshire, Wiltshire, and Southampton City primary care trusts.Method:Records were examined of 604 patients who had received a new diagnosis of depression since 1 April 2009, and who had completed the nine-item depression scale of the Patient Health Questionnaire (PHQ-9) at initial diagnosis and a subsequent PHQ-9 within 6 months. The main outcome measure was the odds ratio (OR) for a change in depression management. Change in management was defined as change in antidepressant drug prescription, dose, or referral.Results:Controlling for the effects of potentially confounding factors, patients who showed an inadequate response in score change at the time of second assessment were nearly five times as likely to experience a subsequent change to treatment in comparison with those who showed an adequate response (OR 4.72, 95% confidence interval = 2.83 to 7.86).Conclusion:GPs' decisions to change treatment or to make referrals following a second PHQ-9 appear to be in line with guidance from the National Institute for Health and Clinical Excellence for the monitoring of depression in primary care. Although the present study demonstrates an association between a lack of change in questionnaire scores and treatment changes, the extent to which scores influence choice and whether they are associated with improvements in depression outcomes is an important area for further research
Reduced rate of force development under fatigued conditions is associated to the decline in force complexity in adult males
No full textPurpose: This study aimed to verify whether the slowing of muscle contraction quickness, typically observed in states of fatigue, may worsen force control by decreasing the rate with which force fluctuations are modulated. Therefore, we investigated the relationship between rate of force development (RFD), and force fluctuations' magnitude (Coefficient of variation, CoV) and complexity (Approximate Entropy, ApEn; Detrended fluctuation analysis, DFAα). Methods: Fourteen participants performed intermittent ballistic isometric contractions of the plantar dorsiflexors at 70% of maximal voluntary force until task failure (under 60% twice). Results: Indices of RFD (RFDpeak, RFD50, RFD100, and RFD150) decreased over time by approximately 46, 32, 44, and 39%, respectively (p all ≤ 0.007). DFAα increased by 10% (p < 0.001), and CoV increased by 15% (p < 0.001), indicating decreased force complexity along with increased force fluctuations, respectively. ApEn decreased by just over a quarter (28%, p < 0.001). The linear hierarchical models showed negative associations between RFDpeak and DFAα (β = - 3.6 10-4, p < 0.001), CoV (β = - 1.8 10-3, p < 0.001), while ApEn showed a positive association (β = 8.2 × 10-5, p < 0.001). Conclusion: The results suggest that exercise-induced reductions in contraction speed, lead to smoother force complexity and diminished force control due to slower adjustments around the target force. The fatigued state resulted in worsened force producing capacity and overall force control
Central and peripheral determinants of fatigue in acute hypoxia
No full textThis thesis was submitted for the degree of Docter of Philosophy and awarded by Brunel University on 24th March 2011.Fatigue is defined as an exercise-induced decrease in maximal voluntary force produced by a muscle. Fatigue may arise from central and/or peripheral mechanisms. Supraspinal fatigue (a component of central fatigue) is defined as a suboptimal output from the motor cortex and measured using transcranial magnetic stimulation (TMS). Reductions in O2 supply (hypoxia) exacerbate fatigue and as the severity of hypoxia increases, central mechanisms of fatigue are thought to contribute more to exercise intolerance. In study 1, the feasibility of TMS to measure cortical voluntary activation and supraspinal fatigue of human knee-extensors was determined. TMS produced reliable measurements of cortical voluntary activation within- and between-days, and enabled the assessment of supraspinal fatigue. In study 2, the mechanisms of fatigue during single-limb exercise in normoxia (arterial O2 saturation [SaO2] ~98%), and mild to severe hypoxia (SaO2 93-80%) were determined. Hypoxia did not alter neuromuscular function or cortical voluntary activation of the knee-extensors at rest, despite large reductions in cerebral oxygenation. Maximal force declined by ~30% after single-limb exercise in all conditions, despite reduced exercise time in severe-hypoxia compared to normoxia (15.9 ± 5.4 vs. 24.7 ± 5.5 min; p < 0.05). Peripheral mechanisms of fatigue contributed more to the reduction in force generating capacity of the knee-extensors following single-limb exercise in normoxia and mild- to moderate-hypoxia, whereas supraspinal fatigue played a greater role in severe-hypoxia. In study 3, the effect of constant-load cycling exercise to the limit of tolerance in hypoxia (SaO2 ~80%) and normoxia was investigated. Time to the limit of tolerance was significantly shorter in hypoxia compared to normoxia (3.6 ± 1.3 vs. 8.1 ± 2.9 min; p < 0.001). The reductions in maximal voluntary force and knee-extensor twitch force at task-failure were not different in hypoxia compared to normoxia. However, the level of supraspinal fatigue was exacerbated in hypoxia, and occurred in parallel with reductions in cerebral oxygenation and O2 delivery. Supraspinal fatigue contributes to the decrease in whole-body exercise tolerance in hypoxia, presumably as a consequence of inadequate O2 delivery to the brain
Review of \u3ci\u3eHarvest for Hope\u3c/i\u3e: \u3ci\u3eA Guide to Mindful Eating\u3c/i\u3e by Jane Goodall with Gary McAvoy and Gail Hudson
No full textOne of the world\u27s preeminent experts on primate behavior, author Jane Goodall now invests her boundless energy traveling and speaking about conservation. After years of studying chimpanzees in the Gombe National Park in Tanzania, Goodall found their very existence threatened by poachers, by encroachment of farming into their habitat, and by global forces far from their wild environment. She is now on a mission to inform the public about what is wrong with our society and its impact on the planet. Harvest for Hope catalogs the problems and provides practical solutions
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