754 research outputs found
Author Lynda Barry Brings Gospel of Creativity to Lawrence University Convocation
No full textAward-winning cartoonist and author Lynda Barry brings her message of tapping into your innate creativity to Lawrence University in the convocation “Crossing the Fox River: From Thought to Action.”
The third presentation in the college’s 2012-13 convocation series, Barry’s address on Thursday, Jan. 24 at 11:10 a.m. in the Lawrence Memorial Chapel, is free and open to the public.
Barry has enjoyed a 35-year career as a cartoonist that began as an undergraduate at Washington State’s Evergreen State College, where she shared her comic strips with Evergreen classmate Matt Groening, the future creator of the TV hit show “The Simpsons,” who secretly slipped them into the school newspaper.
Along the way, she forged a unique path in the art world. Her weekly comic strip “Ernie Pook’s Comeek,” which ran in alternative newspapers from 1979-2008, is widely credited with expanding the literary, thematic and emotional range of American comics.
A truly multidisciplinary artist, Barry is the author of 18 books, has worked as a commentator for NPR and written monthly features for a numerous magazines, among them Esquire, Mother Jones, Mademoiselle and Salon. She recorded a spoken word album called “The Lynda Barry Experience,” adapted her first novel, “The Good Times are Killing Me,” into an off-Broadway play and has been a guest of David Letterman on his television show numerous times.
A Wisconsin native who makes her home today in rural Rock County, Barry conducts more than a dozen writing workshops a year, including some specifically for non-writers in which she coaxes her students to find that part of the brain where the story-telling talent resides.
Barry has been honored with numerous awards for her work, including two Eisner Awards, which honor creative achievement in American comic books. Her illustrated novel “Cruddy” has been translated into French, Italian, German, Catalan and Hebrew and her book “One! Hundred! Demons!” was required reading in 2008 for all incoming Stanford University freshmen
Linda Barry 3-29-2005
No full textDr. Anne Panning and Dr. Alicia Chase interview Linda Barry. Linda Barry is a cartoonist, the creator of "Ernie Pook's Comeek", author of "The Good Times Are Killing Me", "Cruddy", "One! Hundred! Demons!", and "What It Is". In 2004, she won the Lulu Award from the Women Cartoonists Hall of Fame. The interview segment opens with Lynda reading and excerpt from "What It Is". The discussion begins with Lynda's time in college and how she developed her art style. She mentions this time in her life was a period of doing her best to keep her work "serious" so she'd one day become respected as an artist. She explains how she went about submitting comics and what the general public opinion about comic strips was at the time and how that impacted her early work. Lynda talks about where the stories for her comics come from and how she conceptualizes them into comics. Lynda outlines her creative process and how that pushes her work forward. The discussion is closed with Lynda reading an excerpt from "One! Hundred! Demons!".Archived web conten
A flow electrochemistry-enabled synthesis of 2-substituted <i>N</i>-(methyl-<i>d</i>)piperidines
No full textA synthesis of N-monodeuteriomethyl-2-substituted piperidines is described. An efficient and readily scalable anodic methoxylation of N-formylpiperidine in an undivided microfluidic electrolysis cell delivers methoxylated piperidine 3, which is a precursor to a N-formyliminium ion and enables C-nucleophiles to be introduced at the 2-position. The isotopically labelled N-deuteriomethyl group is installed using the Eschweiler-Clarke reaction with formic acid-d2 and unlabelled formaldehyde. Monodeuterated N-methyl groups in these molecular systems possess small isotropic proton chemical shift differences important in the investigation of molecules that are able to support long-lived nuclear spin states in solution nuclear magnetic resonance
The collected letters of Robert Southey, Part Two: 1798-1803
No full textThis project is a new, complete edition of all of the letters written by the controversial author and polemicist Robert Southey (1774-1843). Part Two covers the years 1798-1803.Edited by Ian Packer and Lynda Pratt</p
An Examination of Factors Influencing Small Proton Chemical Shift Differences in Nitrogen-Substituted Monodeuterated Methyl Groups
No full textMonodeuterated methyl groups have previously been demonstrated to provide access to long-lived nuclear spin states. This is possible when the CH2D rotamers have sufficiently different populations and the local environment is chiral, which foments a non-negligible isotropic chemical shift difference between the two CH2D protons. In this article, the focus is on the N-CH2D group of N-CH2D-2-methylpiperidine and other suitable CH2D-piperidine derivatives. We used a combined experimental and computational approach to investigate how rotameric symmetry breaking leads to a 1H CH2D chemical shift difference that can subsequently be tuned by a variety of factors such as temperature, acidity and 2-substituted molecular groups.</jats:p
Sins against science : the scientific media hoaxes of Poe, Twain, and others /
No full text"Lynda Walsh explores a provocative era in American history - the proliferation of fake news stories about scientific and technological discoveries from 1830 to 1880. These hoaxes, which fooled thousands of readers, offer a first-hand look at an intriguing guerilla tactic in the historical struggle between arts and sciences in America. Focusing on the hoaxes of Richard Adams Locke, Edgar Allan Poe, Mark Twain, and Dan De Quille, the author combines rhetorical hermeneutics, linguistic pragmatics, and reader-response theory to answer three primary questions: How did the hoaxes work? What were the hoaxers trying to accomplish? And - what is a hoax?"--Jacket.Includes bibliographical references (pages 279-290) and index.A brief natural history of hoaxing -- Method -- Poe's hoaxing and the construction of readerships -- Mark Twain and the social mechanics of laughter -- The hoaxes of Dan de Quille: building and defending the west -- The mechanics of hoaxing."Lynda Walsh explores a provocative era in American history - the proliferation of fake news stories about scientific and technological discoveries from 1830 to 1880. These hoaxes, which fooled thousands of readers, offer a first-hand look at an intriguing guerilla tactic in the historical struggle between arts and sciences in America. Focusing on the hoaxes of Richard Adams Locke, Edgar Allan Poe, Mark Twain, and Dan De Quille, the author combines rhetorical hermeneutics, linguistic pragmatics, and reader-response theory to answer three primary questions: How did the hoaxes work? What were the hoaxers trying to accomplish? And - what is a hoax?"--Jacket
Structure-function analysis of the non-helicase domain of Sgs1, the Bloom Syndrome ortholog from Saccharomyces cerevisiae
No full textBloom’s Syndrome (BS) is a rare human disease characterized by genome instability and cancer predispostion. The gene mutated in BS, BLM, encodes a member of the RecQ family of DNA helicases. BLM is unique among this family because it is the only RecQ member conserved in unicellular eukaryotes. Apart from the DNA helicase domain, BLM/SGS1 orthologs contain a poorly characterized N-terminal domain of about 650 amino acids (aa). In yeast, this domain (Sgs1 1-652) is known to be physiologically important although it’s only known roles are to bind Top3 and Rmi1 through its N-terminal 100 aa, and in vitro single-strand DNA (ssDNA) binding, ssDNA annealing and strand exchange (SE) activities, through its SE domain (Sgs1 103-323) My research consisted of structure/function analyses of Sgs1 in its poorly characterized N-terminus of aa 323-652 and I found a domain that is important to Sgs1’s function. I interrogated this region by doing systematic deletions and tested these sgs1 mutants for complementation of synthetic lethality. The allele with the smallest deletion that did not complement sgs1slx4 synthetic lethality was found to be sgs1-∆386-621, and the allele with the smallest deletion that did not complement sgs1slx5, was found to be sgs1-∆500-621. I found that sgs1-∆386-621 is physiologically important also through the Top3 slow growth assay. Furthermore I believe that the difference in results between sgs1slx4 and sgs1slx5 will prove significant and warrants further investigation. I also used a BLM/GCN4 chimera where the SE domain was replaced with the coiled coil GCN4, and again tested alleles with systematic deletions within aa 323-652 in synthetic lethality assay. I found the smallest essential domain to be sgs1/gcn4-∆500-621 in the sgs1slx4 background, and interestingly the same deletion in sgs1-∆500-621 did grow weakly and complemented synthetic lethality. Therefore I postulate there is some interaction between the SE domain and aa 500-621 that could be physiologically important and again warrants further investigation.M.S.Includes bibliographical referencesby Lynda Tuberty-Vaugha
Long-lived nuclear spin states in monodeuterated methyl groups
No full textIt is possible to access long-lived nuclear singlet order in monodeuterated methyl groups, in the case that a significant chemical shift difference exists between the CH2D protons. This occurs when the local environment is chiral, and the CH2D rotamers have different populations. An experimental demonstration is presented for the case of N-CH2D-2-methylpiperidine. The ratio of the singlet relaxation time constant TS to the longitudinal relaxation time constant T1 is found to be equal to 3.1 ± 0.1 s, over a wide range of temperatures, solvents, and magnetic fields. The longest observed value of TS approaches 1 minute. The relaxation mechanisms of the long-lived state are discussed, and a modified model of the CH2D geometry is proposed to explain the observed ratio of TS to T1
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