5,460 research outputs found
β-diversity of deep-sea holothurians and asteroids along a bathymetric gradient (NE Atlantic)
No full textMeasuring and understanding patterns of ?-diversity remain major challenges in community ecology. Recently, ?-diversity has been shown to consist of 2 distinct components: (1) spatial turnover and (2) species loss leading to nestedness. Both components structure deep-sea macrofaunal assemblages but vary in importance among taxa and ocean basins and with energy availability. Here, we present the first evidence for turnover and nestedness along a bathymetric gradient in 2 major megafaunal taxa, holothurians and asteroids. Turnover is the dominant component of ?-diversity throughout bathyal and abyssal zones in both taxa, despite major differences in ?-diversity and trophic composition. High spatial turnover suggests a role for evolutionary adaptation to environmental circumstances within depth bands. This pattern differs fundamentally from those in some macrofaunal groups in low-energy environments where abyssal nestedness is high and diversity low, with diversity maintained partly by source-sink dynamics
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
Social Behavior and Meningococcal Carriage in British Teenagers
No full textUnderstanding predisposing factors for meningococcal carriage may identify targets for public health interventions. Before mass vaccination with meningococcal group C conjugate vaccine began in autumn 1999, we took pharyngeal swabs from ?14,000 UK teenagers and collected information on potential risk factors. Neisseria meningitidis was cultured from 2,319 (16.7%) of 13,919 swabs. In multivariable analysis, attendance at pubs/clubs, intimate kissing, and cigarette smoking were each independently and strongly associated with increased risk for meningococcal carriage (p<0.001). Carriage in those with none of these risk factors was 7.8%, compared to 32.8% in those with all 3. Passive smoking was also linked to higher risk for carriage, but age, sex, social deprivation, home crowding, or school characteristics had little or no effect. Social behavior, rather than age or sex, can explain the higher frequency of meningococcal carriage among teenagers. A ban on smoking in public places may reduce risk for transmission
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
Translation and interpretation: Translation redundancy reconsidered
No full textInterpretation is an integral part of the process of translating. This article raises the question of whether interpretation fo a literary work by a translator should be guided by extratextual factors or not. The discussion is illustrated with examples taken from David Hawkes' translation of a Chinese classic, A Dream of Red Mansions. As the work of a scholar-translator, Hawkes' version is richly supplemented with disclosures concerning the characters and explanations of the cultural environment embodied in the novel. In many cases, however, this translation procedure is redundant and explanatory, enlightening the readers but at the same time robbing them of the pleasure of literary interpretation and cultural exploration. By means of this illustration of translation redundancy, the author points out that there is difference between a scholar who helps the interpretation fo a work and a translator who presents a work close to its original version. It is particularly important to pay attention tot his difference in literary translations in a cross-cultural situation involving two enormously different cultures.Language & LinguisticsA&HCI0ARTICLE1,SI115-12
INTERNATIONAL FINANCIAL REPORTING STANDARDS (IFRS), BAIK BAGI USAHA MIKRO KECIL MENENGAH? (Studi Kasus: UMKM JM KERIPIK)
No full textABSTRAKUndang-undang nomor 20 tahun 2008 tentang Usaha Makro Kecil Menengah (UMKM), usaha kecil adalah usaha ekonomi produktif yang berdiri sendiri, yang dilakukan oleh orang perseorangan atau badan usaha yang bukan merupakan anak perusahaan atau bukan cabang perusahaan yang memiliki, dikuasai atau menjadi bagian baik langsung maupun tidak langsung dari usaha menengah atau usaha besar yang memenuhi kriteria. JM Keripik merupakan salah salah UMKM yang bergelut dibidang produksi dan penjualan. IFRS merupakan seperangkat standard yang dikeluarkan oleh Dewan Standard Akuntansi Internasional (IASB). IFRS berguna untuk menyusun laporan keuangan yang dapat diterima di dunia Global.Penulistertarik untukmengetahuipencatatankeuanganJM Keripik dan apakah perlu merekomendasikan IFRS pada UMKM JM Keripik. Metode penelitian yang digunakaan penulis adalah kualitatif yaitu observasi dan wawancara. Dari hasil penelitian banyak terdapat pencatatan-pencatatan yang kurang terperinci, UMKM JM Keripik hanya memilki empat macam pencatatan yaitu pencatatan mengenai: 1.Stock barang, 2.Supliyer, 3.Costumer dan 4.Stock toko, pencatatan ini hanya dapat dimengerti oleh pemilik JM Keripik. Sebaiknya pemilik UMKM JM Keripik mengganti laporan keuangan yang sederhana ke laporan keuangan yang semestinya dan yang berbasis IFRS karena IFRS membawa dampak positif bagi UMKM dan merupakan standar akuntansi keuangan yang digunakan dunia global. Kata Kunci : UMKM, IFRS, JM Keripik ABSTRACT Act number 20 of 2008 concerning the Macro Small and Medium Enterprises, small businesses are productive economic activities that stand alone, carried out by an individual or business entity that is not a subsidiary or not a branch of the company that owns, controlled or become part either directly or indirectly from medium or large businesses that meet the criteria. JM Keripik which deals in the field of production and sales. IFRS is a set of standards issued by the International Accounting Standards Board (IASB). IFRS is useful for preparing financial statements that is acceptable in the global world. Authors interested in knowing the financial records of JM Keripik and whether to recommend IFRS on JM Keripik. The research method is qualitative author of observation and interviews. From the research there are many registries are less detailed, JM Keripik has only four kinds of recording is recording about: 1.Stock goods, 2.Supliyer, 3.Costumer and 4.Stock shop, registration can only be understood by the owner of JM Keripik. JM Keripik owners should replace the simple financial reports to the appropriate financial statements and IFRS-based IFRS for Macro Small and Medium Enterprises had a positive impact and a financial accounting standards global world. Keywords : UMKM, IFRS, JM Keripi
Risk and protective factors for meningococcal disease in adolescents: matched cohort study
No full textObjective: To examine biological and social risk factors for
meningococcal disease in adolescents.
Design: Prospective, population based, matched cohort study
with controls matched for age and sex in 1:1 matching.
Controls were sought from the general practitioner.
Setting: Six contiguous regions of England, which represent
some 65% of the country’s population.
Participants: 15-19 year olds with meningococcal disease
recruited at hospital admission in six regions (representing 65%
of the population of England) from January 1999 to June 2000,
and their matched controls.
Methods: Blood samples and pernasal and throat swabs were
taken from case patients at admission to hospital and from
cases and matched controls at interview. Data on potential risk
factors were gathered by confidential interview. Data were
analysed by using univariate and multivariate conditional
logistic regression.
Results: 144 case control pairs were recruited (74 male (51%);
median age 17.6). 114 cases (79%) were confirmed
microbiologically. Significant independent risk factors for
meningococcal disease were history of preceding illness
(matched odds ratio 2.9, 95% confidence interval 1.4 to 5.9),
intimate kissing with multiple partners (3.7, 1.7 to 8.1), being a
university student (3.4, 1.2 to 10) and preterm birth (3.7, 1.0 to
13.5). Religious observance (0.09, 0.02 to 0.6) and
meningococcal vaccination (0.12, 0.04 to 0.4) were associated
with protection.
Conclusions: Activities and events increasing risk for
meningococcal disease in adolescence are different from in
childhood. Students are at higher risk. Altering personal
behaviours could moderate the risk. However, the development
of further effective meningococcal vaccines remains a key
public health priority
Gridlock: chaos and confusion in our prisons
No full textBehind the headlines and political posturing, the prison system is in crisis, with inhumane conditions and overcrowding making a mockery of justice, argues Peter JM Wayne, who has spent over 20 years inside. Copyright (c) 2008 The Author. Journal compilation (c) 2008 ippr.
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