916 research outputs found
Atypical fibroxanthoma arising in a tracheostomy scar: A rare cicatricial neoplasm
No full textDear Editor,
Atypical fibroxanthoma (AFX) is a cutaneous neoplasm that classically occurs in heavily sun‐damaged skin on the head and neck of elderly patients.1 We report the case of a 70‐year‐old man who presented with a 1‐year history of a slowly enlarging, nodular lesion on his anterior neck (Fig. 1). The lesion was asymptomatic, apart from scant straw‐yellow discharge that had emanated from the lesion since its onset. The lesion was at the site of a scar from a tracheostomy, which was performed 40 years earlier following a motor vehicle accident. On examination, a nontender, flesh‐coloured nodule was found at the superior aspect of the scar, with a central pit and serous crusting. The lesion was mobile with deglutition due to cicatricial tethering to the trachea. A punch biopsy revealed a pleomorphic tumour with immunohistochemistry consistent with AFX, and the excision specimen supported this diagnosis (Fig. 2a–c).No Full Tex
Skin surface topography grading is a valid measure of skin photoaging
No full textThe technique of grading the surface topography of sun-exposed skin using silicone impressions of the skin surface is a simple, non-invasive method for measuring skin damage because of sun exposure, but it has never been validated in a community setting
Collective Improvisation: The Practice and Vision of Ingemar Lindh
No full textIngemar Lindh's research on the principles of collective improvisation and performance conceived as process announce an important development in the 20th-century tradition of the actor's work. After early studies with Étienne Decroux and working collaborations with Jerzy Grotowski, Eugenio Barba, and Yves Lebreton, Lindh founded the first laboratory theatre in Sweden in 1971, the Institutet för Scenkonst. His practice of collective improvisation is viewed in light of postdramatic concerns such as its resistance to fixed scores, directorial montage, and choreography as an organizing principle
Corrigendum: Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth
No full textIn the published article, there was an error in the author list, and the consortium the PRECISE Network was not credited with authorship. The corrected author list appears below. Stanley Onyango1,2*, Jia Dai Mi3, Angela Koech2, Patricia Okiro1, Marleen Temmerman2, Peter von Dadelszen3, Rachel M Tribe3†, Geoffrey Omuse1†, and the PRECISE Network The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.</p
Towards the tumble resistant microlight
No full textThe tumble mode is a pitching departure from controlled flight which leads to a pitch autorotation that is generally unrecoverable – resulting in vertical ground impact, usually preceded by in-flight breakup (the mechanism for which, surprisingly, can sometimes prevent loss of life). This was identified in work led by the British Microlight Aircraft Association beginning in 1997 as a response to a number of fatal accidents in Rogallo winged microlight aeroplanes, although the tumble is also known to occur to hang-gliders. This paper explains how this class of aeroplane is controlled, and how it has been found that they can enter the tumble mode. The mechanism by which the tumble can be entered is described. This has led to work showing how flight testing can be used to establish and demonstrate resistance to tumble entry – particularly important with increasing number of very high performance flexwings. These flight tests will be explained, together with the significance of the results. Recent accident investigation work has also shown a new mechanism of tumble entry, through partial failure of the A-frame structure and the pitch-trimmer mechanism. Also described is a possible relevance to well known historical accidents to flying wing aeroplanes– specifically the YB-49 and dH-108, and discovered data on the characteristics of the BKB-1flying wing glider; are also described
PITX2 and non-canonical Wnt pathway interaction in metastatic prostate cancer
No full textThe non-canonical Wnt pathway, a regulator of cellular motility and morphology, is increasingly implicated in cancer metastasis. In a quantitative PCR array analysis of 84 Wnt pathway associated genes, both non-canonical and canonical pathways were activated in primary and metastatic tumors relative to normal prostate. Expression of the Wnt target gene PITX2 in a prostate cancer (PCa) bone metastasis was strikingly elevated over normal prostate (over 2,000-fold) and primary prostate cancer (over 200-fold). The elevation of PITX2 protein was also evident on tissue microarrays, with strong PITX2 immunostaining in PCa skeletal and, to a lesser degree, soft tissue metastases. PITX2 is associated with cell migration during normal tissue morphogenesis. In our studies, overexpression of individual PITX2A/B/C isoforms stimulated PC-3 PCa cell motility, with the PITX2A isoform imparting a specific motility advantage in the presence of non-canonical Wnt5a stimulation. Furthermore, PITX2 specific shRNA inhibited PC-3 cell migration toward bone cell derived chemoattractant. These experimental results support a pivotal role of PITX2A and non-canonical Wnt signaling in enhancement of PCa cell motility, suggest PITX2 involvement in homing of PCa to the skeleton, and are consistent with a role for PITX2 in PCa metastasis to soft and bone tissues. Our findings, which significantly expand previous evidence that PITX2 is associated with risk of PCa biochemical recurrence, indicate that variation in PITX2 expression accompanies and may promote prostate tumor progression and metastasis
Architectural disruption in aerospace
No full textThesis (S.M.)--Massachusetts Institute of Technology, System Design and Management Program, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p. 70-71).Distinctive technology and customer / supplier relationships are currently the primary sources of competitive advantage in the Aerospace industry. Modular Open System Architecture (MOSA) requirements represent a significant disruption to this mode of competition. The United States Department of Defense intends to accelerate the rate of aerospace innovation and inject additional competitiveness into the procurement process through the modularization of its products and effective intellectual property management. This combination of architectural disruption and new customer capabilities has the potential to reduce the industry's opportunity to capture value from innovative technologies or a position as first supplier. Historical examples such as Polaroid and IBM demonstrate the organizational paralysis that often results from disruptions in product architecture. The competitive formula becomes ingrained in the processes, resources, and culture of mature companies and is no longer explicit knowledge, which limits the company's ability to develop the capabilities required to compete in its new environment. Competing in a MOSA environment will require the development of new organizational capabilities such as rapid experimentation, fighting standards wars, and protecting system-level knowledge. Defining the disruptive threat and the foundations of current core competencies will enable firms to develop the organizational capabilities essential for this shift in competitive context.(cont.) The author will present several historical examples of architectural disruption, a framework for evaluating the disruptive change, and an identification of organizational anchors that may hinder a particular competitor's ability to respond to MOSA. The goal of the thesis is to start a dialogue within an identified incumbent with in hopes of beginning the organizational transformation required to effectively compete in this new era.by Geoffrey Ashworth.S.M
The mysterious case of Carter Brown: Or, who really killed the Australian author?
No full textConsiders the exporting of intellectual property and the ways Sydney publisher Horwits Publications, author Alan Geoffrey Yates and multinational conglomerate Signet negotiated geographical and cultural boundaries to produce one of Australia's successful literary exports. Evolution of Australian paperback publishers to hardcover publishers; Details of a contract for Yates' Peter Carter Brown novels; Procedure followed in editing novels of Yates submitted to Horwitz and Signet; Marketing campaign for Signet in the U.S.; Impact of the pressure of writing deadlines on the quality of the novels
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Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
No full textIn the version of this Letter initially published, the Acknowledgements section omitted the following note of support from Geoffrey M. Wahl: “Work in the laboratory of G.M.W. was supported, in part, by the Cancer Center Core Grant (CA014195), National Institutes of Health/National Cancer Institute (R35 CA197687), National Institutes of Health Cancer Training Grant (T32 CA009370), the Isacoff Research Foundation Gastrointestinal (ICOF) and the Freeberg Foundation.”
A rare pitfall in the molecular interpretation of BRAF V600E status in melanoma in the setting of BRAF V600E-mutated chronic lymphocytic leukemia/small lymphocytic lymphoma
No full textBRAF mutation status is a critical predictive and prognostic biomarker in guiding management of unresectable and metastatic melanoma. We recently observed a case of BRAF V600E-mutated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) intermixed with BRAF V600E wild-type melanoma reported to harbor BRAF V600E mutation on molecular testing. Our observation underscores the importance of appropriate tumor selection for molecular studies and knowledge of mutational status of co-existing tumors. This article is protected by copyright. All rights reserved
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