15,189 research outputs found
Link stability estimation based on link connectivity changes in mobile ad-hoc networks
No full textDear Wang,
Re: Link Stability Estimation Based on Link Connectivity Changes in Mobile Ad-hoc Networks
I have not been able to assess if this is an author version peer-reviewed or is it an author version non peer reviewed. Could you please clarify this so I can proceed to add your paper to Spiral. Spiral digital repository only accept peer-reviewed papers.
30/11/12 author has confirmed peer reviewe
The role of urate and xanthine oxidase in vascular oxidative stress:Future directions
No full textVascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high. The search for newer, novel ways of attenuating endothelial dysfunction has yielded several new and exciting possibilities, one of which is the manipulation of urate levels using xanthine oxidase inhibitors. Agents such as allopurinol have shown marked improvements in vascular endothelial function in various cohorts at risk of cardiovascular events. Most of the evidence so far comes from smaller mechanistic studies. The few large randomized controlled trials have failed to show any significant mortality benefit using these agents. This article highlights the potential avenues of further research such as dose-response, and the potential for these agents to regress left ventricular hypertrophy. The role of newer agents such as febuxostat and oxypurinol are discussed as well as potential reasons why some of the current newer agents have failed to live up to the promising early-phase data. It is crucial that these remaining questions surrounding urate, xanthine oxidase and the role of various agents that affect this important oxidative stress-generating system are answered, and therefore these promising agents should not be discarded prematurely
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
No full textOxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout. Allopurinol has also been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency by reducing oxygen consumption in smaller mechanistic studies involving various cohorts at risk of cardiovascular events. This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices
Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration.
No full textOBJECTIVE: To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD). METHODS: Using 0-, 6-, 12-, 18-, 24-, and 36-month MRI scans of controls and subjects with MCI and AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, we calculated volume change of whole brain, hippocampus, and ventricles between all pairs of scans using the boundary shift integral. RESULTS: We found no evidence of acceleration in whole-brain atrophy rates in any group. There was evidence that hippocampal atrophy rates in MCI subjects accelerate by 0.22%/year2 on average (p = 0.037). There was evidence of acceleration in rates of ventricular enlargement in subjects with MCI (p = 0.001) and AD (p < 0.001), with rates estimated to increase by 0.27 mL/year2 (95% confidence interval 0.12, 0.43) and 0.88 mL/year2 (95% confidence interval 0.47, 1.29), respectively. A post hoc analysis suggested that the acceleration of hippocampal loss in MCI subjects was mainly driven by the MCI subjects that were observed to progress to clinical AD within 3 years of baseline, with this group showing hippocampal atrophy rate acceleration of 0.50%/year2 (p = 0.003). CONCLUSIONS: The small acceleration rates suggest a long period of transition to the pathologic losses seen in clinical AD. The acceleration in hippocampal atrophy rates in MCI subjects in the ADNI seems to be driven by those MCI subjects who concurrently progressed to a clinical diagnosis of AD
A Fair and Secure Cluster Formation Process for Ad Hoc Networks
No full textAn efficient approach for organizing large ad hoc networks is to divide the nodes
into multiple clusters and designate, for each cluster, a clusterhead which is responsible for
holding intercluster control information. The role of a clusterhead entails rights and duties.
On the one hand, it has a dominant position in front of the others because it manages the
connectivity and has access to other node¿s sensitive information. But on the other hand, the
clusterhead role also has some associated costs. Hence, in order to prevent malicious nodes
from taking control of the group in a fraudulent way and avoid selfish attacks from suitable
nodes, the clusterhead needs to be elected in a secure way. In this paper we present a novel
solution that guarantees the clusterhead is elected in a cheat-proof manner
Energy efficiency in ad-hoc wireless networks
No full textIn ad-hoc wireless networks, nodes are typically battery-powered, therefore energy limitations are among the critical constraints in ad-hoc wireless networks' development. The approaches investigated in this thesis to achieve energy efficient performance in wireless networks
can be grouped into three main categories.
1. Each wireless network node has four energy consumption states: transmitting, receiving, listening and sleeping states. The power consumed in the listening state is less than the power consumed in the transmitting and receiving states, but significantly greater than that in the sleeping state. Energy efficiency is achieved if as many nodes as possible are put into the sleeping states.
2) Since energy is consumed for transmission nonlinearly in terms of the transmission range, transmission range adjustment is another energy saving approach. In this work, the optimal transmission range is derived and applied to achieve energy efficient performance in a number of scenerios.
3) Since energy can be saved properly arranging the communication algorithms, network topology management or network routing is the third approach which can be utilised in combination with the above two approaches. In this work, Geographical Adaptive Fidelity (GAF) algorithms, clustering algorithms and Geographic Routing (GR) algorithms are all utilised to reduce the energy consumption of wireless networks, such as Sensor Networks and Vehicular Networks.
These three approaches are used in this work to reduce the energy consumption of wireless networks. With the GAF algorithm. We derived the optimal transmission range and optimal grid size in both linear and rectangular networks and as a result we show how the network energy consumptions can be reduced and how the network lifetime can be prolonged. With Geographic Routing algorithms the author
proposed the Optimal Range Forward (ORF) algorithm and Optimal Forward with Energy Balance (OFEB) algorithm to reduce the energy consumption and to prolong the network lifetime. The results show that compared to the traditional GR algorithms (Most Forward within Radius, Nearest Forward Progress), the network lifetime is prolonged. Other approaches have also been considered to improve the networks's energy efficient operation utilising Genetic Algorithms to find the optimal size of the grid or cluster. Furthermore realistic physical layer models, Rayleigh fading and LogNormal fading, are considered in evaluating energy efficiency in a realistic network environment
The impact of mobility models on the performance of mobile Ad Hoc network routing protocol
No full textA mobility model represents nodes distribution and movement over the network. Several research works have shown that a selection of mobility model can affect the outcome of routing performance simulation in Mobile Ad Hoc Networks. Thus, a routing protocol may only be effective in a particular mobility model or scenario but performs inferiorly in another. As a result, analyses of routing protocol performance are often based on inadequate information leading to inaccurate argument and conclusion. In this paper, three different mobility models have been selected, where each of them is highly distinctive in terms of nodes movement behavior. In addition, a new measurement technique called probability of route connectivity is introduced. The technique is used to quantify the success rate of route established by a routing protocol. Extensive simulation runs are done and results are compared between each mobility model
Internet connection method for mobile ad hoc wireless networks
No full textIn recent years, wireless networks with Internet services have become more and
more popular. Technologies which integrate Internet and wireless networks have
extended traditional Internet applications into a more flexible and dynamic
environment. This research work investigates the technology that supports the
connection between a Mobile Ad Hoc Wireless Network (MANET) and the
Internet, which enables the current wireless Internet technologies to provide a
ubiquitous wireless life style.
With detailed analysis of the existing wireless Internet technologies and
MANETs regarding their features and applications, the demand and lack of
research work for an application to provide Internet connection to MANET is
indicated. The primary difficulty for MANET and Internet connection is that the
dynamic features of MANET do not suit the traditional connection methods used
in infrastructure wireless networks. This thesis introduces new concept of the
'Gateway Awareness' (GAW) to the wireless devices in the MANET. GAW is a
new routing protocol designed by the author of this thesis, at the University of
Warwick. Based on GAW, an inclusive definition for the connection method,
which supports the Internet connection and keeps the independency of routing in
MANET, is addressed. Unlike other research work, this method supports the
MANET and Internet communication in both directions. Furthermore, it explores
possible ways of using the Internet as an extension for wireless communications.
The GAW routing method is developed from destination sequenced distance
vector (DSDV) routing protocol. However, it defines a layer of wireless nodes
(known as GAWNs) with exclusive functions for the Internet connection task.
The layer of GAWNs brings a new set of route update and route selection
method. Simulations show that the GAW routing method provides quality
Internet connection performance in different scenarios compared with other
methods. In particular, the connection is completed with minimum effect on the
independent MANET while the routing efficiency and accuracy is guaranteed
Funeral March to the Memory of Cornelius Vanderbilt.
No full textda capo with trio and codapiano[Cornelius Vanderbilt].9273Johns Hopkins University, Levy Sheet Music Collection, Box
057, Item 126aComposed by Ad. Meyer.Ferd. Mayer, Gen'l Lith's, 96 & 98 Fulton St. N.Y
Funeral March to the Memory of Cornelius Vanderbilt.
No full textda capo with trio and codapiano[Cornelius Vanderbilt].9273Johns Hopkins University, Levy Sheet Music Collection, Box
057, Item 126aComposed by Ad. Meyer.Ferd. Mayer, Gen'l Lith's, 96 & 98 Fulton St. N.Y
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