527 research outputs found
Prose Fiction of Radka Denemarkova
Get PDF(in English): This bachelor's thesis focuses on the analysis of the selected novels by Radka Denemarkova. In addition to the determination of the common features in the narrative discourse, thematic and language structure of the Central European trilogy, consisting of the novels A já pořád kdo to tluče, Peníze od Hitlera and Kobold, and the common features of other novels by the author, i.e. Příspěvek k dějinám radosti and MY 2, the thesis deals with changes and shifts in the same areas, from the author's debut until her novel MY 2. The thesis also deals with the image of the author, more specifically, how the novels were primarily received in her home country and how Radka Denemarkova builds her own image as an author of the selected novels. Klíčová slova (anglicky): Radka Denemarkova, Czech literature of the 21st century, prose, novel analysis, author's imag
Language Humour in Advertising
Get PDFTitle: The Language Humour in Andvertising Author: Radka Čimingová Department: Department of czech language and literature Supervisor: PhDr. Radka Holanová, Ph.D. Abstract: The presented work deals with linguistic analysis of means that frame humour in printed advertising. The analysis of the language humour is based on a selected advertising sample. This sample was used to identify, classify and specify individual linguistic means in more detail. Humour is interpreted as a play on words that is built around updating, change, intentional breaking of established rules, incongruity and around the relationship between language and extralinguistic reality. This play resulting in a comic tone of the advertisement concerns meaning as well as graphic form of individual linguistic means, usage of different varieties of lexis, intertextual connection and the relationship between words and pictures. The work covers all these aspects of the linguistic play on words as well as describes the theoretical context in which the play takes place and specifies the basic terms connected to the subject of the thesis, i.e. advertising and humour. Keywords: Advertising, Humour, Languag
Streamlining of the storage system in distribution company RADKA Pardubice Ltd.
No full textPráce se zabývá významem skladů a skladování. V praktické části práce autor analyzoval skladování ve společnosti RADKA spol. s r.o. Pardubice. Na základě provedené analýzy skladování autor identifikoval nedostatky ve skladování společnosti RADKA spol. s r.o. Pardubice. V závěru práce se autor věnoval vytvoření návrhů, které mají za cíl zefektivnit skladování v této společnosti a ekonomickému zhodnocení těchto návrhů.The thesis deals with importance of warehouse and storing. In the practical part of the thesis the author analysed the storage system in the distribution company RADKA Pardubice Ltd. On the basis of the analysis author identified weaknesses of the storage system in the company RADKA Pardubice Ltd. In third part of this thesis author focuses on creation of suggestions on streamlining of the storage system in the distribution company. The last part of the thesis deals with economic evaluation of above mentioned suggestions.Dopravní fakulta Jana PerneraDokončená práce s úspěšnou obhajobo
BOBATH CONCEPT - THE INFLUENCE OF FUNCTIONAL TESTS ON THE MOTIVATION'S IMPROVEMENT OF THE PATIENTS AFTER STROKE
No full text1 UNIVERZITA KARLOVA V PRAZE LÉKAŘSKÁ FAKULTA V HRADCI KRÁLOVÉ BAKALÁŘSKÁ PRÁCE 2014 Radka Horecká 2 UNIVERZITA KARLOVA V PRAZE LÉKAŘSKÁ FAKULTA V HRADCI KRÁLOVÉ REHABILITAČNÍ KLINIKA BOBATH KONCEPT - VLIV FUNKČNÍCH TESTŮ NA ZLEPŠOVÁNÍ MOTIVACE U PACIENTŮ PO CÉVNÍ MOZKOVÉ PŘÍHODĚ BAKALÁŘSKÁ PRÁCE Autor práce: Radka Horecká, DiS. Vedoucí práce: Mgr. Pavlína Savková 2014 3 CHARLES UNIVERSITY IN PRAGUE FACULTY OF MEDICINE IN HRADEC KRÁLOVÉ DEPARTMENT OF REHABILITATION MEDICINE BOBATH CONCEPT - THE INFLUENCE OF FUNCTIONAL TESTS ON THE MOTIVATION'S IMPROVEMENT OF THE PATIENTS AFTER STROKE Bachelor's thesis Author: Radka Horecká, DiS. Supervisor: Mgr. Pavlína Savková 2014 4 Prohlašuji, že předložená práce je mým původním autorským dílem, které jsem vypracovala samostatně. Veškerou literaturu a další zdroje, z nichž jsem při zpracování čerpala, v práci řádně cituji a jsou uvedeny v seznamu použité literatury. V Hradci Králové dne 30.4.2014 ……………………….. 5 Poděkování Děkuji personálu v RÚ Chotěboři, zejména paní Jolaně Sajfertové, vedoucí fyzioterapeutce. Dalším rehabilitačním pracovníkům, kterým jsem občas narušila program s pacienty, paní logopedce, vedení RÚ, které mi umožnilo získání pacientů a potřebných informací k mojí bakalářské práci a konečně děkuji i pacientům, kteří se nebáli podstoupit testování a..
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Abstract LB065: Prostate cancer molecular immunophenotypes in biopsies with high vs average radiation sensitivity as predicted by post-operative radiation therapy outcomes (PORTOS) scores
No full textAbstract Background: The combination of radiation therapy and immunotherapy has emerged as an exciting field of research with the potential for significant clinical benefit. Using pre-treatment prostate biopsies from two clinical trials we explored the hypothesis that a validated gene expression signature of postoperative radiation therapy outcome score (PORTOS) is associated with differences in tumor molecular immunophenotype. In this study, we compared prostate tumors with high vs average PORTOS scores for expression of 32 molecular immunophenoscores that reflect cancer antigen profiles and the cellular composition of tumor infiltrating lymphocytes. Methods: Gene expression profiles were obtained from microdissected tumor tissue from 242 treatment naïve-prostate biopsy cores obtained from 92 patients enrolled in the University of Miami MAST (NCT02242773) and BLaStM (NCT02307058) clinical trials. For each biopsy the PORTOS score (PMID: 27743920) and 32 tumor molecular immunophenoscores (PMID: 28052254) were determined from Affymetrix Human Exon 1.0 ST microarray data using published methods. Results: 14% of the biopsy cores were predicted by the PORTOS signature to be more responsive to radiation therapy. Compared to the cores with average PORTOS scores, the “high PORTOS” biopsies showed a 2 fold or greater level of the tumor immunoactivation markers Act CD4, Act CD8, EC, HLA DPA1 and Tem CD8 and a 2 fold or lower level of the tumor immunosuppression markers MDSC, SC, TIM3 and T reg (Mann-Whitney P value of <0.0001 for all nine comparisons of medians). Discussion: Preliminary studies suggest that prostate cancers with PORTOS scores that predict greater sensitivity to radiation therapy also have immunophenotype profiles consistent with a higher level of overall immunogenicity. Citation Format: Sandra M. Gaston, Sanoj Punnen, Oleksandr Kryvenko, Alan Pollack, Elai Davicioni, Seagle Liu, Radka Stoyanova. Prostate cancer molecular immunophenotypes in biopsies with high vs average radiation sensitivity as predicted by post-operative radiation therapy outcomes (PORTOS) scores [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB065
Comparative study of early- and mid-ripening peach (Prunus persica L.) varieties: biological activity, macro-, and micro- nutrient profile
Get PDFFruits have always been a constituent in the dietary recommendations, and have
undeniable health promoting properties. Revealing the nutrient profile and
biological activity of different fruit varieties is essential for the utilization of their
potential beneficial activity.
The current study focuses on the detailed comparative analysis of three earlyand two mid-ripening peach varieties: “Filina” (peach), “July Lady” (peach),
“Laskava” (peach), “Gergana” (nectarine), and “Ufo-4” (flat peach). They were
characterized in terms of essential nutrients as carbohydrates (sugars, pectin,
and dietary fibers), proteins (including amino acid content) and lipids as well as
organic acids, fat-soluble vitamins, carotenoids and chlorophyll. Mineral content
was also determined. In addition, polyphenolic compounds and the related
antioxidant activity was studied (FRAP, CUPRAC, DPPH and ABTS methods)
The language and style of Radka Denemark`s novel "Kobold"
No full textThe main purpose of my final paper is the linguistic analysis of two-part novel contemporary Czech writer Radka Denemarková Kobold "Excesses of Tenderness/ Excesses of People". My final paper consists of two basic parts. The theoretical part collect composition, because it is called open work and language instruments. Practical part is divided into the phonetic side, morphological, syntactic and lexical levels. This novel (itself) is not the only one novel which was written by this author but it creates the third part of trilogy about postwar history in the Central Europe. Its relation with bonding elements of the novels "A já pořád kdo to tluče" and "Peníze od Hitlera" will be studied in this thesis
Abstract PO-027: Associations of radiomics features with tumor necrosis following chemotherapy and/or radiation therapy in patients with extremity soft tissue sarcoma
No full textAbstract Introductory sentence: The purpose of this study is to identify MRI radiomic features of sarcomas pre and post treatment with radiation and/or chemotherapy that correlate with the level of necrosis demonstrated on pathology report upon tumor excision. Experimental procedures: Patients with soft tissue upper and lower extremity sarcomas and available pre- and post-treatment MRI exams were included in the study. For the purposes of this study we utilized T2 fat saturated imaging sequences. We employed MINT Lesion radiomics software for extraction of quantitative imaging data. The lesions Regions of Interest (ROIs) were manually contoured MRI scans before and after chemotherapy and/or radiation therapy. Following treatment, patients had their tumors excised with corresponding tumor necrosis data recorded. Using Pearson correlation statistics, the percent necrosis was compared to radiomic changes (delta-radiomics). Summary of data: Fifty-two patients, treated between 2012 and 2020 were included in the study. The clinical characteristics were: male – (56%) and female- (44%); type of sarcomas ranged from Liposarcoma, Leiomyosarcoma, Myxofibrosarcoma, among others; Grade 2-3; Treatment with radiation and/or chemotherapy of different doses and regimens. MRIs were acquired within 3 months before initiation of treatment and within 2 months after treatment. Surgery was subsequently performed within 2 months of last MRI scan. The average necrosis on final pathology was 68% +/- 33% std. Total of 41 radiomic features were extracted from the ROIs. Five of the delta-radiomics parameters were significantly correlated with necrosis (p-value < 0.05) and sixteen were marginally associated (p-value < 0.1). The significantly correlated radiomic features includes first and second order values representing the distribution of voxel intensities within the segmented image regions and the statistical inter-relationships between neighboring voxels, respectively. Conclusions: In this pilot study we identified delta-radiomics features, related to first order radiomic data, or increased voxel intensity, and second order radiomics, or increased vowel heterogeneity, associated with the level of necrosis within sarcomas post radiation and/or chemotherapy. This data will be followed up with larger patient samples and including additional sequences for delta-radiomics analysis, such as Diffusion Weighted Imaging and Dynamic Enhanced Contrast to develop prediction models for necrosis levels. Citation Format: James Grosso, Ty Subhawong, Radka Stoyanova, Raphael Yechieli, Crystal Seldon, Blase Prosperi. Associations of radiomics features with tumor necrosis following chemotherapy and/or radiation therapy in patients with extremity soft tissue sarcoma [abstract]. In: Proceedings of the AACR Virtual Special Conference on Artificial Intelligence, Diagnosis, and Imaging; 2021 Jan 13-14. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(5_Suppl):Abstract nr PO-027
Some electrical and photoelectrical properties of organic semiconductors
No full textTitle: Some electrical and photoelectrical properties of organics semiconductors Author: Radka Chomutová Department: Department of Macromolecular Physics Supervisor: doc. RNDr. Jiří Toušek, CSc., Department of Macromolecular Physics Abstract: The object of this study is to determine some electrical and photoelectrical properties of polymer materials and their importance considering their usage as a solar cell. Especially, thin layers of polythiophene (PT1,PT2) and poly-3-hexylthiophene (P3HT) are measured and determined. Studied parameters are Fermi level by Kelvin method, the concentration of free charge carriers, conductivity, exciton diffusion length and thickness of the space charge region by surface photovoltage method (SPV). Obtained values were then added to older measurements with similar focus for polymer poly[2-methoxy-5-(2-ethylhexyloxy)-1,4- phenylenevinylene] (MEH-PPV). Keywords: sollar cell, diffusion lenght, surface photovoltage method, Kelvin probe, organic laye
Statistical inference based on saddlepoint approximations
No full textTitle: Statistical inference based on saddlepoint approximations Author: Radka Sabolová Abstract: The saddlepoint techniques for M-estimators have proved to be very accurate and robust even for small sample sizes. Based on these results, saddle- point approximations of density of regression quantile and saddlepoint tests on the value of regression quantile were derived, both in parametric and nonpara- metric setup. Among these, a test on the value of regression quantile based on the asymptotic distribution of averaged regression quantiles was also proposed and all these tests were compared in a numerical study to the classical tests. Finally, special case of Kullback-Leibler divergence in exponential family was studied and saddlepoint approximations of the density of maximum likelihood estimator and sufficient statistic were also derived using this divergence.
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