12,984 research outputs found
Black hole spin constraints on the mass spectrum and number of axionlike fields
No full textAstrophysical observations of spinning BHs, which span , can be used to exclude the existence of certain massive bosons via the superradiance phenomenon. In this work, we explore for the first time how these measurements can be used to constrain properties of statistical distributions for the masses of multiple bosonic fields. Quite generally, our methodology excludes {\rm ax}\gtrsim 30 for certain scenarios of interest realised approximately as mass distributions in M-theory, including the QCD axion, grand unified theories, and fuzzy dark matter
Evolution of cooperation among tumor cells
No full textThe evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103NIH U56 CA113004; to David E. AxelrodR.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.NIH CA69568; to Kenneth J. PientaNIH CA102872; to Kenneth J. PientaNIH CA093900; to Kenneth J. PientaNSF SES-0240852; to Robert AxelrodNJ Commission on Cancer Research 1076-CCR-SO; to David E. AxelrodAlso available in PubMed Central. PMCID: PMC155738
The Arts Interview. Dr. David Pitt : The Truant Years, E. J. Pratt
No full textHost Fred Hollingshurst interviews Dr. David Pitt of Memorial University, who discusses the life and work of Newfoundland poet E. J. Pratt. Pitt is the author of E. J. Pratt: The Truant Years, 1881-1927
Clinical_rehab_frailty_prevalence_supplementary_material – Supplemental material for The prevalence of frailty among acute stroke patients, and evaluation of method of assessment
No full textSupplemental material, Clinical_rehab_frailty_prevalence_supplementary_material for The prevalence of frailty among acute stroke patients, and evaluation of method of assessment by Martin Taylor-Rowan, Gillian Cuthbertson, Ruth Keir, Robert Shaw, Bogna Drozdowska, Emma Elliott, David Stott and Terence J Quinn in Clinical Rehabilitation</p
Fly about round me coursing, swallow sweet birds come near [first line]
No full textstrophicpiano and voiceCover is duplicated in 125.115b.Johns Hopkins University, Levy Sheet Music Collection, Box
125, Item 115aTranslated From the French of Volney L'Hotelier by Samuel J. Gardner, Esq. The Music by Felicien David (Author of "Le Desert").E.G. Warren, Engr
Fly about round me coursing, swallow sweet birds come near [first line]
No full textstrophicpiano and voiceCover is duplicated in 125.115b.Johns Hopkins University, Levy Sheet Music Collection, Box
125, Item 115aTranslated From the French of Volney L'Hotelier by Samuel J. Gardner, Esq. The Music by Felicien David (Author of "Le Desert").E.G. Warren, Engr
Interview with David Dunn on the subject of bark beetle sounds
No full textAnimaliaArthropodaInsectaColeopteraCompressed from .wav format into .mp3 delivery formatComposer and recording engineer David Dunn describes his recordings of bark beetles in New Mexico, and some of the possible causes and consequences of bark beetle infestations devastating pine forests throughout the WestSounds were recorded using a modified transducer inserted into the bark of the tree, and are taken with permission of the author from the compact disc "The Sound of Light in Trees" produced by David Dunn in collaboration with the Acoustic Ecology Institute. Scientists say that bark beetle populations are increasing in large part because of increased drought and milder winters due to global warming
David Martyn Lloyd-Jones 1899-1981 and twentieth-century evangelicalism.
No full textThe purpose of this thesis was to demonstrate the significance of the life and ministry of David Martyn Lloyd-Jones in post-war British evangelicalism and to show that, so far as Protestant churches in England and Wales were concerned, no history of the period can afford to ignore him. It is our contention that despite differences of opinion and self- marginalization Lloyd-Jones was and has remained a major force in evangelical thinking. In order to understand how this developed the thesis has been structured along thematic lines highlighting events, persons and questions. The study begins by setting the stage with a biographical chapter and goes on to examine the kind of impact that Lloyd-Jones's preaching had on Christians of all denominations. He believed preaching to be the greatest need of the day and the position of this thesis is that preaching was Lloyd-Jones's greatest contribution to twentieth- century Christianity. As a preacher he attracted one of London's largest congregations and in chapter three we look at the history and nature of Westminster Chapel comparing it with neighbouring ministries, and establishing the kind of people who went to hear him. Chapters four and five ascertain the factors which shaped Lloyd-Jones's views on the church and show how his Reformed evangelicalism led in a separatist as opposed to an ecumenical direction and finally, to a position which was neither Congregational nor Presbyterian. Our further argument is that while he favoured unity among believers his separatist ecclesiology only exacerbated the situation and left evangelicals more divided than before. Chapters six to eight evaluate Lloyd-Jones's background, the nature of his leadership and the extent of his influence - factors which either shaped or were the outcome of his ministry - and looks at the issues which these questions raise
Calvin Theological Seminary Forum: October 2002
No full textReflection3 - Forgiven—and Forgiving by Ronald J. Feenstra6 - Forgiving Seventy Times Seven by Ronald Nydam8 - Charge to a Young Leader 1 Timothy 6:11-12 by the Rev. John Stott 10 - Prayer for the Students of Calvin Seminary by David RylaarsdamDepartments11 - The Council Room12 - Presidential Inauguration14 - Newshttps://digitalcommons.calvin.edu/cts_forum/1002/thumbnail.jp
- …
