133,502 research outputs found
Personal Papers (MS 80-0002)
No full textEnvelope printed with a statement of account in the amount of $5.00 for professional services rendered by E. Y. Stott, D. D. S., sent to D. W. Kempner
Personal Papers (MS 80-0002)
No full textEnvelope printed with a statement of account in the amount of $5.00 for professional services rendered by E. Y. Stott, D. D. S., sent to Mr. D. W. Kempner
D-dimer predicts early clinical progression in ischemic stroke: confirmation using routine clinical assays
No full text<p><b>Background and Purpose:</b> Plasma D-dimer levels, measured using a research laboratory assay, independently predict progressing ischemic stroke. We wished to confirm these findings using commercially available assays and to provide data to allow the design of intervention studies.</p>
<p><b>Methods:</b> We studied 219 consecutive acute ischemic stroke admissions of whom 54 (25%) met criteria for progressing stroke.</p>
<p><b>Results:</b> There were strong correlations between D-dimer results as measured by the Biopool AB, MDA and VIDAS assays; correlation coefficients r=0.91 to 0.94; all P<0.001. In binary logistic regression analyses, D-dimer, as measured by the 3 different assays, was an independent predictor of progressing stroke (odds ratios, 1.87 to 2.45; all P<0.001). This confirms the results of our original analysis (Biopool AB) using 2 commercial D-dimer assays, demonstrating the potential usefulness of D-dimer in providing early prognostic information after ischemic stroke in different clinical settings. We also provide information on the performance of the 3 assays in predicting progressing stroke at a variety of cutoff values.</p>
<p><b>Conclusions:</b> Ischemic stroke patients at high risk of early progression can be identified using commercial D-dimer measurements. This could allow selection of high-risk patients for inclusion in randomized trials of early antithrombotic treatments.</p>
A specimen chamber for soft X-ray spectromicroscopy on aqueous and liquid samples
No full textA specimen chamber is described for soft X-ray spectromicroscopy of hydrated specimens and solutions. Applications include imaging and carbon edge spectroscopy of hydrated clay/polymer suspensions
Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression
No full text<p><b>Background and Purpose:</b> Early clinical progression of ischemic stroke is common and is associated with increased risk of death and dependency. We hypothesized that activation of the coagulation system is an important contributor in some cases of deterioration. We aimed to characterize alterations in circulating hemostatic markers in patients with progressing stroke.</p>
<p><b>Methods:</b> Consecutive acute ischemic stroke admissions were recruited. Progressing stroke was defined by deterioration in components of the Scandinavian Stroke Scale. Hemostatic markers (coagulation factors VIIc, VIIIc, and IXc, prothrombin fragments 1+2 [F1+2], thrombin-antithrombin complexes [TAT], D- dimer, fibrinogen, von Willebrand factor [vWF] and tissue plasminogen activator) were measured within 24 hours of symptom recognition.</p>
<p><b>Results:</b> Fifty-four (25%) of the 219 patients met criteria for progressing stroke. F1+2 (median 1.28 versus 1.06 nmol/L, P=0.01), TAT (5.28 versus 4.07 mug/L, P lt 0.01), D-dimer ( 443 versus 194 ng/mL, P lt 0.001) and vWF (216 versus 198 IU/dL, P lt 0.05) levels were higher in these patients than in stable/improving patients. In logistic regression analysis, with all important clinical and laboratory variables included, only natural log D-dimer (odds ratio [OR]: 1.87; 95% confidence interval [CI]: 1.38 to 2.54; P=0.0001) and mean arterial blood pressure (OR: 1.26 per 10 mm Hg change; 95% CI: 1.05 to 1.51; P=0.01) remained independent predictors of progressing stroke.</p>
<p><b>Conclusions:</b> There is evidence of excess thrombin generation and fibrin turnover in patients with progressing ischemic stroke. Measurement of D-dimer levels can identify patients at high risk for stroke progression. Further research is required to determine whether such patients benefit from acute interventions aimed at modifying hemostatic function.</p>
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
RG 9015-024-000 Clarence D. Sypherd Collection
No full textMetropolitan Life Insurance Company branch office, Robert Stott, assistant superintendant
RG 9015-024-000 Clarence D. Sypherd Collection
No full textMetropolitan Life Insurance Company branch office, Robert Stott, assistant superintendant
RG 9015-024-000 Clarence D. Sypherd Collection
No full textMetropolitan Life Insurance Company branch office, Robert Stott, assistant superintendent
RG 9015-024-000 Clarence D. Sypherd Collection
No full textMetropolitan Life Insurance Company branch office, Robert Stott, assistant superintendant
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