316 research outputs found
Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation
No full textROLE OF COMORBIDITIES IN OPTIMIZING DECISION-MAKING FOR ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION
No full text<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><span lang="EN-US">Allogeneic conventional hematopoietic cell transplantation (HCT) following high-dose, myeloablative conditioning regimens has been used since the 1970’s as potentially curative treatment for </span><span style="line-height: 200%; mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;" lang="EN-US">patients with malignant, hematological disorders</span><span lang="EN-US">. </span><span style="line-height: 200%; mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;" lang="EN-US">The toxicities of conditioning regimens have limited conventional HCT to relatively young patients in otherwise good medical condition.</span><span lang="EN-US"> </span><span style="line-height: 200%; mso-bidi-font-size: 11.0pt; mso-bidi-font-family: Arial;" lang="EN-US">With the development of less toxic nonmyeloablative regimens and improvements in supportive care, increasing numbers of older and medically infirm patients have been treated by allogeneic HCT. </span><span lang="EN-US">Until recently, there has been almost no effort to evaluate the prevalence of comorbidities among HCT recipients and their impact on outcomes. We first evaluated the Charlson Comorbidity Index (CCI) developed for patients with solid malignancies, for this purpose. While useful, it lacked sensitivity and specificity for the HCT setting. We next introduced the HCT-specific comorbidity index (HCT-CI) which was based on objective laboratory data to better define comorbidities. Here, we describe this development and illustrate the usefulness of the HCT-CI in predicting HCT outcomes in patients with myeloid and lymphoid malignancies undergoing allogeneic transplantation</span></span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%;"><span lang="EN-US"><span style="font-size: small; font-family: Times New Roman;"> </span></span></p>
Restriction fragment length polymorphism of the major histocompatibility complex of the dog
No full text
Poetics of the same: a philosophical poetic recourse into sameness
No full textPhDThis study endeavours to investigate the philosophical and poetological
dimensions, the philological origins, and significant philosophical-literary
representations of the Same. It also assesses sameness as a philosophical and
poetological modus operandi; that is to say, it analyzes the ways in which the
Same operates in different types of discourses both as an object of investigation
and as an agent of (poetic) thought. The concept of the Same or the operation of
sameness as the philosophical question par excellence will be considered in the
development of Continental philosophy and philosophical poetics from classical
antiquity to Postmodernism, and its transposition into poetry.
The elaboration of the issue of sameness encompasses any philosophical
inquiry which seeks to establish the essence of Being and make it susceptible to a
general, unifying principle: as a search for an underlying element; for a
metaphysical unity or universal, preceding division or difference and amounting
to the harmony in the Universe; or for a transcendental absolute totality.
Postulations of the pure conceptual difference are likewise examined as part of the
elaboration of sameness, and will be viewed as indispensable for revealing the
genuine plenitude of sameness.
Part One traces the inception of sameness as a concept of pure identity,
amounting to the harmony of the Universe by virtue of the operations of
belonging (Presocratics), participation (Plato), and emanation (Plotinus), anchored
in the relationships between the One and the many, between the Whole and its
parts, between the Original and the copy. Part Two inquires into the limits of
postulating sameness in terms of pure identity and points to two possible solutions
to this problem: a philosophical-aesthetic digression from sameness (Kant and
related aesthetic theories of the seventeenth and eighteenth centuries) and the
return to sameness as an absolute totality in Part Three (Schelling and Hegel).
Part Four investigates the re-postulation of sameness as pure Difference
(Nietzsche, Heidegger, Derrida), hence the entire re-organization of thought in
terms of the other. Part Five analyzes the transposition of sameness from
3
philosophy into the poetic language of repetition, using Rilke’s Sonnets to
Orpheus as its prime poetic example.
It will be argued that the philosophical displacement of the Same from a
concept of identity into that of difference does not amount to an abandonment of
its plenitude, but rather points to the need for a precarious balance between
sameness and difference, the simultaneous quest for unity and the absolute
singularity of the other. This balance, it will be argued, must be sought for in
every genuine creation
Design and Validation of an Augmented Hematopoietic Cell Transplantation-Comorbidity Index Comprising Pretransplant Ferritin, Albumin, and Platelet Count for Prediction of Outcomes after Allogeneic Transplantation
No full textAbstractPretransplant values of serum ferritin, albumin, and peripheral blood counts were previously suggested to provide prognostic information about hematopoietic cell transplantation (HCT) outcomes. Whether these “biomarkers” have prognostic value independent of each other and the HCT-comorbidity index (HCT-CI) is unknown. We analyzed data from 3917 allogeneic HCT recipients at multiple sites in the United States and Italy using multivariate models including each biomarker and the HCT-CI. Data from all sites were then randomly divided into a training set (n = 2352) to develop weights for the relevant biomarkers to be added to the HCT-CI scores and a validation set (n = 1407) to validate an augmented HCT-CI compared with the original index. Multivariate analysis with data from one site showed that ferritin, albumin, and platelets—not neutrophils or hemoglobin—were independently associated with increased nonrelapse mortality (NRM) and decreased overall survival. Findings were validated in data from the other sites. Subsequently, in a training set from all sites, ferritin >2500 mg/dL (hazard ratio [HR], 1.69); albumin 3 to 3.5 g/dL (HR, 1.61) and <3.0 g/dL (HR, 2.27); and platelets 50 to <100,000 (HR, 1.28), 20 to <50,000 (HR, 1.29), and <20,000 (HR, 1.55) were statistically significantly associated with NRM. Weights were assigned to these laboratory values following the same equation used to design the original index. In the validation set, the addition of the biomarkers to the original index to develop an augmented HCT-CI resulted in a statistically significant increase in a higher c-statistic estimate for prediction of NRM (P = .0007). Ferritin, albumin, and platelet counts are important prognostic markers that further refine the discriminative power of the HCT-CI for transplant outcomes
Simultaneous Ultrasound Imaging Velocimetry (UIV) and Flow Visualization in Taylor-Couette flows: Validation of UIV in single-phase flows
No full textUltrasound Imaging Velocimetry (UIV) is applied to a Taylor-Couette flow, for the case of pure inner cylinder rotation. By imaging a radial-azimuthal plane, two velocity components are obtained simultaneously in a two-dimensional plane. For the single-phase flow studies, Iriodin flakes (commonly used for visualizing flow structures) are used as “flow tracers” for the backscatter of ultrasound. This allows for a simultaneous mapping of the flow regime, via flow visualization, as well as extracting quantitative velocity information in the radial gap. After validating UIV against the analytically well-defined laminar Circular Couette flow as well as turbulent Taylor-Couette flow, other regimes are probed as well, in particular, the Wavy Vortex flow. Finally, the application of UIV to a particle-laden Taylor-Couette flow (particle volume fraction, f_0:01) is considered, under the conditions of oscillatory pure inner cylinder rotation. The results presented here serve as a proof-of-concept for the application of UIV to the Taylor-Couette flow and will be applied to denser particle-laden flows (f _ 0:05) in the future.Multi Phase SystemsFluid Mechanic
CCR5 Expression on Cells from HLA-Matched Unrelated Marrow Donors and Graft-versus-Host Disease
No full textMEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES www.mjhid.org ISSN 2035-3006 Original Article Role of Comorbidities in Optimizing Decision-Making for Allogeneic
No full textwhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Allogeneic conventional hematopoietic cell transplantation (HCT) following high-dose, myeloablative conditioning regimens has been used since the 1970’s as potentially curative treatment for patients with malignant, hematological disorders. The toxicities of conditioning regimens have limited conventional HCT to relatively young patients in otherwise good medical condition. With the development of less toxic nonmyeloablative regimens and improvements in supportive care, increasing numbers of older and medically infirm patients have been treated by allogeneic HCT. Until recently, there has been almost no effort to evaluate the prevalence of comorbidities among HCT recipients and their impact on outcomes. We first evaluated the Charlson Comorbidity Index (CCI) developed for patients with solid malignancies, for this purpose. While useful, it lacked sensitivity and specificity for the HCT setting. We next introduced the HCT-specific comorbidity index (HCT-CI) which was based on objective laboratory data to better define comorbidities. Here, we describe this development and illustrate the usefulness of the HCT-CI in predicting HCT outcomes i
Validation of the Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) in Single and Multiple Institutions: Limitations and Inferences
No full text- …
