2,876 research outputs found
Pride of Bilbao FerryBox 2005 - an overview of the data obtained and improvements in procedures
No full textThe collection of high quality, long term data from diverse environments is required if the interplay of the complex factors affecting phytoplankton bloom development is to be investigated. With this in mind the English Channel and Bay of Biscay between Portsmouth and Bilbao has been intensively monitored starting in 2002. In 2005 the ‘FerryBox’ suite of sensors measured temperature, salinity, fluorescence, oxygen and turbidity. The data are merged with position and can be viewed in real time at http://www.noc.soton.ac.uk/ops. The ferry travels between Portsmouth and Bilbao completing a round trip every 3 days; measurements in water pumped in from 5 metres depth provide data which are collected every second. In 2005 the ‘FerryBox’ methods were improved to reduce the affects of bio fouling on the sensors; the sensors were systematically cleaned weekly and sensor calibrations madefrom samples collected during monthly ferry crossings. These showed that the fluorescence and oxygen sensors were stable and a high quality dataset was produced. Calibration of the fluorescence sensor was monitored using extracted chlorophyll suspended in solid Perspex blocks. The ‘FerryBox’ dataset has been mapped against time and latitude to show the occurrence of phytoplankton blooms, using fluorescence, along with calculations of oxygen anomaly. Such continuous monitoring allows us to pinpoint the timings of phytoplankton bloom initiation and duration. The detailed data from the FerryBox allows the occurrence of these blooms to be correlated with other changes in the oceanic system, such as tidal energy, light and fresh water run off.The methods used to process the data from the initial raw 1Hz ASCII files through to the quality controlled 5 minute set are documented together with the post processing resolution of system faults that caused errors in the measured salinity. The quality controlled data are archived as 5 minuteaverages and are held by the British Oceanographic Data Centre (BODC)
Rapporteur’s report – innovative geotechnologies for energy transition
No full textThe 9th Society for Underwater Technology (SUT) International Conference on Offshore Site Investigation and Geotechnics (OSIG) closed with a Rapporteur’s report given by the author. This paper provides a record of that report, transcribed from a video recording. The presentation slides are shown as Figures.</p
DEFRApH - Sample collection and handling procedures
No full textAll chemical and biogeochemical process in the sea are affected by the acidity of the water. Acidity is therefore fundamental property of seawater. The growing concern that the acidity of the oceans might be increasing has revealed weaknesses in our knowledge of this fundamental property and its variation in space and time. In 2008 the DEFRApH project (DEFRA contract ME4133) was initiated to provide this missing information in UK related waters. It required sampling for and analysis of the total inorganic carbon and total alkalinity content of samples. This reports documents the procedures sued for sampling. A companion document Hartman Dumousseaud and Roberts (NOC Internal Document No. 01) describes in detail the analytical procedures used and the calculation of the results
Author Correction:Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention (Nature Communications, (2019), 10, 1, (5280), 10.1038/s41467-019-13244-9)
No full textThe original version of this Article contained an error in the spelling of the author Wilma D.J. van de Berg, which was incorrectly given as Wilma D.J. van den Berg. This has now been corrected in both the PDF and HTML versions of the Article.</p
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
A report on the Red Funnel FerryBox 2004 - an overview of the data obtained, improvements and calibration procedures
No full textThis report aims to provide a complete record of the work done as part of the ‘FerryBox’ activities on the Red Funnel Ltd ‘Red Falcon’ ferry in Southampton Water and the Solent in 2004. The procedures, hardware and software used are described and listed in detail. The results are summarised. Details are provided of the content and location of all of the data files produced, both observational data and data collected to calibrate the instruments. The collection of high quality, long term data in as many environments as possible is required to investigate the interplay of different factors affecting phytoplankton bloom development. With this in mind the Southampton Water and Solent estuarine system has been intensively monitored over the last 6 years using the FerryBox system. The ferry travels the length of the estuary up to 16 times a day. The ‘FerryBox’ suite of sensors measurestemperature, salinity, fluorescence and turbidity. These data are collected with at a frequency of 1Hz and are merged with position data, collected using a GPS system.In 2004 the FerryBox methods were improved to reduce the affects of bio fouling on the sensors. The sensors were systematically cleaned and the sensors calibrated during weekly ferry crossings. Calibrations of the turbidity and fluorescence sensors were monitored using materials suspended in solid Perspex blocks. The sensors were found to be stable and a high quality dataset was produced. Variations were seen in the ratio of fluorescence to chlorophyll throughout the estuary and with the time of year. Using the ‘FerryBox’ dataset the occurrence of phytoplankton blooms has been related to environmental factors such as light and to the tides. Such continuous monitoring allows us to pinpoint the timings of phytoplankton bloom initiation and duration. In 2004 a series of regular peaks influorescence occurred throughout the summer months. The detailed data from the FerryBox allows the occurrence of these blooms to be correlated with changes in the tidal energy of the system, light and fresh water run off
Reply to the discussion by McCarron on “Modelling spatial variability in as-laid embedment for high pressure and high temperature (HPHT) pipeline design”
No full textN/AThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
Wavelength tunable 10-GHz 3-ps pulse source using a dispersion decreasing fiber-based nonlinear optical loop mirror
No full textWe experimentally demonstrate the use of a dispersion decreasing fiber (DDF)-based nonlinear optical loop mirror (NOLM) for the generation of wavelength tunable soliton-like pulses at a repetition rate of 10 GHz. We compress ~12 ps Gaussian pulses from an electro-absorption modulator (EAM) (followed by 125 m of DCF for preliminary linear dispersion compensation) into 3 ps pedestal-free pulses using both high-order soliton compression and nonlinear switching effects within an 8.5 km DDF-based loop mirror. The output pulses from the DDF-based NOLM show considerable pedestal reduction compared to those obtained by directly compressing the EAM seed pulses via a single passage through the DDF. Wavelength tuning of the compressed pulses over a ~15 nm bandwidth (from 1541 to 1556 nm) is demonstrated without a significant increase in pulse duration or degradation in pulse quality
An introduction to management science: quantitative approaches to decision making
No full textRetaining the accessible application-driven approach for which An Introduction to Management Science is highly regarded, adapting author Mik Wisniewski has carefully reworked the existing US textbook to benefit students across the UK, Europe, Middle East and Africa. Packed with diverse realistic examples from Scotland to Saudi Arabia, the landmark text from the ASW team is now available in a truly internationalised version for students studying Management Science and Operations Research at postgraduate and undergraduate level
Verslag van de vierde Benelux-havenstudiedagen
No full textVerslag met een welkomstwoord van D.J. Wansink en R. Burgert, een inleiding door prof. Kuiler, en presentaties over de samenwerking tussen havens en de scheepsbouw, de sleutels van het deltagebied, de problematiek van de mechanisatie van de overslag van goederen, de ontwikkelingen in de scheepsbouw en de economische consequenties van de ontwikkeling in de scheepsbouw voor de havens
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