348,137 research outputs found
Differing effects of N\u3csup\u3eG\u3c/sup\u3e-monomethyl L-arginine and 7-nitroindazole on detrusor activity
No full textAims: Previous studies reported that nitric oxide (NO) synthase (NOS) inhibition decreases micturition volume threshold (MVT), the volume required to produce a centrally mediated micturition contraction, and that NO can be released from urothelium by means of certain stimuli. With elucidation of multiple isoforms of NOS, studies were performed to determine whether inhibition of specific isoforms of NOS altered MVT in different ways. Methods: In naive, anesthetized cats, the urinary bladder was exposed by means of a midline abdominal incision and cannulated through a slit in the internal urethra approximately 4-5 cm distal to the neck of the bladder. The left renal artery and left radial vein were cannulated for the intra-arterial and intravenous administration of drugs, respectively. All nerves were left intact. A control MVT was determined by slowly infusing saline into the bladder at a rate of 0.018 mL/kg per minute. Varying doses of L-NMMA (NG-monomethyl-L-arginine) or 7-NI (7-nitro indazole) were administered and the MVT was again determined. Results: Inhibition of endothelial NOS (eNOS), by L-NMMA, or neuronal NOS (nNOS), by 7-NI, produces varying effects on certain detrusor activities and that inhibition of different isoforms of NOS produces qualitatively different effects. L-NMMA significantly decreases MVT (up to 60% decrease), whereas 7-NI significantly increases MVT (over 300% increase). L-NMMA increases frequency and onset of small bladder contractions, whereas 7-NI produces opposite effects. Conclusions: The results suggest that detrusor relaxation and contractility may be modulated by NO levels and that NO released from the urothelium may be a mediator of detrusor relaxation during the storage phase of micturition. © 2003 Wiley-Liss, Inc
Mandibular micrognathia and vertical maxillary excess correction with combination LeFort I and inverted L osteotomies
No full textA 34-year-old woman with mandibular micrognathia, vertical maxillary excess, and an open bite characterized by a “bird-face” deformity was treated with orthodontics combined with LeFort I and bilateral inverted L osteotomies. The total treatment time was 16 months. Her occlusion and facial appearance were significantly improved by a surgical-orthodontic plan. This case report presents the discussion of a unique and complex orthognathic surgical case and the myriad of orthodontic and surgical considerations that it involved
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No full textinstallation view, one-man exhibition, California Palace of the Legion of Honor, San Francisco, July 1947; left to right: 1946-H-No 1, 1946-L, Untitled (PH-197
Can probiotics stop oral cancer progression?
No full textData sources Four electronic databases (PubMed, Web of Science, Scopus and PLOS) were queried to identify studies that investigated the effects of probiotics against oral cancer, published in the English language between January 2015 and February 2020. Study selection Randomised controlled trials (RCT) including in vivo and in vitro studies that evaluated the effects of probiotics against oral cancer were included. Data extraction and synthesis The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-P) 2015 guidelines were followed to conduct this systematic review. Screening of titles, abstracts and full texts was done independently by four authors with disagreements resolved by mutual discussion. Individual studies\u27 year, author, country, as well as strain of probiotics, type of sample, mechanisms of probiotics and outcomes, were analysed by two authors. The methodological quality of the included studies was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Tools (Checklist for Randomised Controlled Trial) by three authors. Meta-analysis was performed with Review Manager software, Version 5.3 and results were reported in odds ratio. Inconsistency test (I2) was used to examine the heterogeneity between studies. Results From an initial 774 articles, only five met the study eligibility criteria to be included in this review. Two studies used in vivo animal models and three studies conducted in vitro experiments using cancer and normal cell lines. There were no studies on humans. Four probiotics were reported to inhibit oral carcinogenesis; namely, Acetobacter syzygii (A. syzygii), Lactobacillus plantarum (L. plantarum), Lactobacillus salivarius (L. salivarius) Ren and AJ2 (combination of Streptococcus thermophiles, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus bulgaricus). Two studies that used L. salivarius Ren were combined quantitatively in a meta-analysis which showed 95% reduction of risk in oral cancer development (OR = 0.05, 95% CI 0.01-0.23; p \u3c0.05). Conclusions Within the limitations of in vivo (animal) and in vitro (cell lines) studies, the authors concluded that the probiotics analysed in this review, especially L. salivarius Ren, seem to play a role in oral cancer inhibition
Correlation between Sway Balance and the Modified Balance Error Scoring System
No full textMcKinney G, Alexander J, Bordenave E. Correlation between Sway Balance and the Modified Balance Error Scoring System. JEPonline 2022;25(5):27-38. Falls are the leading cause of injury and death among older Americans. Approximately 3 million older adults will visit the emergency department annually for fall-related injuries. Health care professionals depend on reliable assessment tools to rule out balance dysfunction caused by several associated and comorbid conditions. Methods: This quantitative descriptive study evaluated and compared postural balance results using the mBESS and Sway Balance. A convenience sample of 36 participants from A.T. Still University Still Standing Falls Prevention Outreach Program engaged in a series of five stances used to assess balance. Results: The demographic ratio of females to males was 80% and 20%, respectively, ages 55 and older (M = 79.5, SD = 8 years). The average score for Sway Balance was M= 59.66, and for the mBESS, M=15.26. The Spearman correlation coefficient was negative (rs = -.131), an indication of the tendency for mBESS scores to decrease as Total Sway increased. The P-value was not statistically significant (P = 0.454); the two assessments were not correlated. Conclusions: Our study examined and compared comprehensive balance measures using validated instruments, providing a unique opportunity to deliver alternative options for objective assessments of postural instability. While study results found no correlation between Sway Balance and the mBESS scores; research does support Sway Balance as a viable solution for objective assessments for primary care providers to diagnose and treat balance problems. Further research is recommended to determine the maximum achievable enhancement of accelerometer technology like Sway Balance in the clinical setting
Perceived influence of community oral health curriculum on graduates\u27 dental practice choice and volunteerism
No full textThe purpose of this study was to determine if A.T. Still University Arizona School of Dentistry and Oral Health (ASDOH) curricular content regarding community oral health has influenced graduates\u27 dental practice choice and volunteering activities in their communities. At ASDOH, the community oral health curriculum consists of three components: 1) coursework in public health resulting in a certificate or master\u27s degree in public health; 2) service-learning activities in the Dentistry in the Community series of course modules, wherein students plan and implement community projects; and 3) community-based clini-cal rotations of approximately ninety-five days during the fourth year. To accomplish the purposes of the study, a survey was sent to ASDOH alumni who graduated between 2007 and 2010. Of the 208 graduates contacted, ninety-four responded (45.2 percent). Of those who responded, 85 percent reported that the community oral health curriculum influenced their practice choice, and 76 percent reported that they volunteer. Additionally, 58 percent of the respondents reported that the amount of dental school debt they had incurred affected their career plans and professional decision making
A “Fishy” Situation, Rare Pathogen and Presentation in Prosthetic Valve Infective Endocarditis
No full textLactococcus garviae (L. garviae) is a gram-positive coccus belonging to the Streptococcaceae family. While primarily a pathogen in fish farms causing hemorrhagic sepsis, it can act as a rare opportunistic pathogen in humans. A 2021 case report by Bravo et al. documented less than 30 cases of infective endocarditis caused by L. garviae worldwide at that time. This case report describes the 27th documented case globally and 7th documented case in the USA of L. garviae causing infective endocarditis of a prosthetic valve. L. garviae is found in unpasteurized dairy products, raw fish, and meat (pork, beef, and poultry), but the route of human transmission remains unclear. It seems to have a predilection for individuals with prosthetic valves, immunocompromised states, prior gastrointestinal surgery, gastrointestinal disorders (colon polyps and diverticulosis), and the use of acid-reducing medications. Infective endocarditis is the most common systemic disease caused by L. garviae This report details the case of a 75-year-old male, with multiple comorbidities and risk factors for L. garviae infection who was admitted for “symptomatic anemia”. High clinical suspicion, coupled with an inadequate hemoglobin response to transfusion, a normal anemia workup, and blood cultures positive for L. garviae, promoted a transesophageal echocardiogram (TEE). However, the results were negative. Consequently, an 18F-fluorodeoxyglucose positron emission tomography/computed tomography scan (18 FDG PET/CT) was performed. The scan revealed increased uptake in the aortic valve replacement consistent with prosthetic valve endocarditis in the setting of Lactococcus garviae bacteremia
The Hills Remember: The Complete Short Stories of James Still
No full textJames Still remains one of the most beloved and important writers in Appalachian literature. Best known for his acclaimed novel River of Earth (1940), the Alabama native and adopted Kentuckian left an enduring legacy of novels, stories, and poems during his nearly seventy year career.
The Hills Remember: The Complete Short Stories of James Still honors the late writer by collecting all of Still’s short stories, including his stories from On Troublesome Creek (1941), Pattern of a Man and Other Stories (1976), and The Run for the Elbertas (1980), as well as twelve prose pieces originally published as short stories and later incorporated into River of Earth. Also included are several lesser-known stories and ten never-before-published stories. Recognized as a significant writer of short fiction in his day—many of his stories initially appeared in The Atlantic and The Saturday Evening Post and were included in The O. Henry Memorial Award Stories and The Best American Short Stories collections—Still’s short stories, while often overshadowed in recent years by his novels and poetry, are among his most enduring literary works. Editor Ted Olson offers a reassessment of Still’s short fiction within the contexts of the author’s body of work and within Appalachian and American literature. Compiling all of James Still’s compelling and varied short stories into one volume, The Hills Remember is a testament to a master writer.
James Still (1906–2001) was the author of numerous works of fiction and poetry, including River of Earth; From the Mountain, From the Valley: New and Collected Poems; and Chinaberry.
Ted Olson is professor of Appalachian Studies and English at East Tennessee State University. He is the editor of From the Mountain, From the Valley, the editor of two scholarly books exploring James Still’s work, the coeditor of The Bristol Sessions: Writings about the Big Bang of Country Music, and the author of Blue Ridge Folklife and Breathing in Darkness: Poems.
James Still is better known as a novelist and poet, but as this volume confirms, he was an excellent short story writer as well. Bravo to Ted Olson and University Press of Kentucky for this valuable addition to James Still\u27s legacy. —Ron Rash, author of Serena
This collection of all the short stories of James Still, in chronological order, reveal the development of his craft during Still\u27s years of keen observation of the character, values, and sly humor of his eastern Kentucky neighbors, as well as his accurate ear for their dialect, not presenting it exactly, but weaving it into a rare art form, and with his insight to render a vivid portrait and intonation of the people of this particular place, mainly during the years of the Great Depression. These stories affirm Still’s art as a master story teller. -- Loyal Jones, former director of the Appalachian Center at Berea College and author of Appalachian Values
James Still chopped a path through the literary landscape that Appalachian writers continue to follow. He gave the land and culture a vivid life on the page, using language of such quality that it set a standard for all the writers from the hills. Mr. Still is more than the master. He is our grandfather, our great-grandfather, our godfather—the revered elder of the tribe of Appalachian writers. Here is a sentence he wrote: \u27We went on, not stopping or speaking until we saw our hill standing apart from all the others.\u27 These words readily describe James Still’s work. If each published book is viewed as a hill in the geography of literature, his stories will forever stand apart from all the others. -- Chris Offutt -- Author of Kentucky Straight
In his stories drawn from local life and speech in the Kentucky mountains, James Still finds timeless beauty and universal meaning. -- Gurney Norman -- former Kentucky poet laureate and author of Kinfolks: The Wilgus Stories
In a long-ago conversation James Still said to me, \u27You must read Daudet—he can pierce your heart in a single line.\u27 I nodded, thinking I could name another writer who had such skill, remembering the haunting lilt and ache of his poems and how each chapter of River of Earth left me breathless, struck by the power of simple lines that went straight to the heart without a trace of sentimentality. Later, when Still read \u27The Nest\u27 to one of my writing classes at Carson-Newman College, I had the profound pleasure of watching the mesmerizing effect of his words transform that class into a community of listeners united by a shared, unforgettable experience. And that’s what this collection of James Still’s stories can do for a new generation of readers—lead them into an awareness of the range and depth of human experience through an artistry of language. This collection reaffirms what so many of us have known for years—James Still is a master of the short story, his work a national treasure. -- Jeff Daniel Marion, author of The Hills Remember
See a Glossary of Terms used in Still\u27s work and explore more about James Still at www.thehillsremember.wordpress.com
While the reason behind creating a complete anthology of James Still\u27s short stories might be to forever cement his reputation as the grand old man of Appalachian literature, I hope The Hills Remember reaches farther . . .hopefully people will discover that James Still is a great Appalachian writer, a great Southern writer, and most importantly, a great American writer. -- BiblioBuffet
Bravo to Ted Olson and the University Press of Kentucky for this valuable addition to James Still\u27s legacy. -- Ron Rash -- author of One Foot in Eden: A Novel
This collection of all the short stories of James Still reveals the development of Still\u27s craft during his years of keen observation of the character, values, and sly humor of his eastern Kentucky neighbors...to render a vivid portrait and intonation of the people of this place. -- Loyal Jones -- former director of the Appalachian Center at Berea College and author of Appalachian Values
A must read for anyone who is \u27from here\u27 or that has embraced the Appalachian mountain region as their own. We will learn more about ourselves than we knew and will be the better for having done so. -- Smoky Mountain News
Still\u27s stories are among the best written by an American author. They are powerful, compact, and enriched by striking resonant language. -- Ashland Daily Independent
In his distinctive style--simple, compact and powerful--Still relays the rich textures of the fabric of Appalachian life. -- Chevy Chaser
Still has a gift for choosing the right word or phrase to convey the isolation and alienation of generations of eastern Kentucky folk. -- Bowling Green Daily News
The Hills Remember honors the late writer with the first comprehensive collection of his short fiction. -- Floyd County Times
Indeed, Olson\u27s collection of Still\u27s work is complete, but it is so much more than that--it is a tribute to one of Kentucky\u27s finest writing minds, and in particular a showcase for how the Dean of Appalachian Literature arrived at a level to which so many aspire. -- Becky L. Meadows -- H-Net Kentucky -- St. Catharine College
In this landmark book, Ted Olson favorably compares Still\u27s short fiction to the work of Poe, Hawthorne, Hemingway, Welty, and Cheever. Presenting all of Still\u27s compelling and varied short stories in one volume, The Hills Remember is a testament to a master writer. This book is required reading for anyone who is \u27from here\u27 or who has embraced the Appalachian mountain regions. -- Thomas Crowe -- Now & Then
With The Hills Remember, his voice will continue to resonate as clea and as pure as a dipperful of cold mountain water on a hot day. -- Tina LoTufo -- The Knoxville News-Sentinel
The hills do remember James Still, and so should readers everywhere. -- Appalachian Journal
[. . .] Still’s style and narrative quality should warrant him a place among the great Southern storytellers. -- Georgia Library Quarterlyhttps://uknowledge.uky.edu/upk_american_literature/1016/thumbnail.jp
A combination of generated hydrogen sulfide and nitric oxide activity has a potentiated protectant effect against cisplatin induced nephrotoxicity
No full textAbstract
Aim: Hydrogen sulfide and nitricoxide role= presentation style= box-sizing: inherit; display: inline-block; line-height: 0; font-size: 19.04px; font-size-adjust: none; overflow-wrap: normal; word-spacing: normal; text-wrap-mode: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative; \u3enitricoxidenitricoxide possess cytoprotective activity and in vivo, they are generated from exogenous sodium hydrosulfide and L-arginine respectively. Cisplatin is a major chemotherapeutic agent used to treat cancer and has a high incidence of nephrotoxicity as a side effect. The study aim was to explore the effects of NaHS and L-arginine or their combination on cisplatin induced nephrotoxicity in rats.
Methods: Wistar Kyoto rats were given a single intraperitoneal dose of cisplatin (5 mg/kg) followed either by NaHS (56 μmol/kg, i. p.), L-arginine (1.25 g/L in drinking water) or their combination daily for 28-days. Post-mortem plasma, urine and kidney samples were collected for biochemical assays and histopathological analysis.
Results: Cisplatin decreased body weights and increased urinary output, while plasma creatinine and urea levels were elevated, but sodium and potassium concentrations were diminished. The renal function parameters, blood urea nitrogen and creatinine clearance, were raised and decreased respectively. Regarding markers of reactive oxygen species, plasma total superoxide dismutase was reduced, whereas malondiadehyde was augmented.Cisplatin also diminished plasma and urinary H2S as well as plasma NO, while NaHS and L-arginine counteracted this activity on both redox-active molecules. Cisplatin cotreatment with NaHS, and/or L-arginine exhibited a reversal of all other measured parameters.
Conclusion: In current study, NaHS and L-arginine as monotherapy protected the rats from cisplatin-induced nephrotoxicity but the combination of both worked more effectively suggesting the augmented anti-inflammatory and antioxidative potential of test treatments when administered together
Critical incidents, successes, and challenges of community-based dental education
No full textIn 2006, the Arizona School of Dentistry & Oral Health at A.T. Still University (ATSU ASDOH) implemented an intensive community-based education program for its inaugural fourth-year students called the Integrated Community Service Partnerships (ICSP) program. As part of the ICSP program, students spend half of their clinical experience (approximately ninety-five days) in rotations at four or five community-based clinics. More than sixty clinics in Arizona and throughout the country serve as rotation sites. ATSU ASDOH conducts focus groups with all fourth-year students prior to graduation for program improvement and research. The purpose of this study was to characterize critical incidents students identified as instrumental to learning, as well as successes and challenges of the program. Qualitative data from the 2009 and 2010 focus groups were analyzed, including a total of 104 students. The types of critical incidents students chose to describe in the focus groups involved patient factors, contextual factors, and interpersonal factors. While students believed their ICSP program external rotation experiences were fundamental in their clinical and professional development, they also noted challenges associated with this intense communitybased education program
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