113,518 research outputs found
Pioneer personal history, Mr Charles T. Stevenson
No full textTypescript of a brief biography of Charles T. Stevenson, from an interview. Stevenson was a miner at Bingham County and Park City. Typed by Harry Taylor, August 22, 193
It looks like a lamplit vicious fairy land behind me: Robert Louis Stevenson and Scotland
No full textThis thesis concerns a man and his home country, exploring the physical, the emotional and the imaginative bonding of the two. The man is Robert Louis Stevenson. A frail, consumptive novelist, poet and Scot, who transcended his infirmities to create romantic heroes of magnificent adventures, and transcended his self-imposed exile by setting them amidst the heather. The country is Scotland, a country which nurtured and debilitated, inspired and repelled Stevenson. It was also one in which he was ultimately unable to survive. Stevenson was not solely a Scottish writer, just as he is not solely a children's writer. His work does reflect his peripatetic life, but the purpose of this thesis is to focus upon his Scottish fiction. It will argue that it was in these works that his imagination and his artistic skills fused best. Scotland’s influence upon Stevenson will be seen as twofold. Firstly, the geographical and historical impressions which were made upon him, and secondly, the traditions of superstion which so characterised its people. A study of Stevenson's non-fictional portrait of Edinburgh will be made to elucidate his continued impulse to write about Scotland and what it meant to be Scottish. Stevenson’s Scottish fiction will be shown as far more than the laments of a homesick ex-pat. In recognising the viciousness of his fairyland, perceiving the skull beneath the skin, Stevenson gave to his fiction and his Scotland a richness and vitality which might not have been possible had he been a comfortable resident of a comfortable Edinburgh house
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
[Letter from Coke R. Stevenson to T. N. Carswell - July 8, 1942]
No full textA letter written to Mr. T. N. Carswell, Abilene, Texas, from Coke R. Stevenson, Austin, Texas, dated July 8, 1942. Stevenson expresses his appreciation for the support pledged by Carswell for his run for Governor of Texas
[Letter from Coke R. Stevenson to T. N. Carswell - July 29, 1948]
No full textA letter written to Mr. T. N. Carswell, Carswell Agency, Abilene, Texas, from Coke R. Stevenson, 256-8 Driskill Hotel, Austin, Texas, dated July 29, 1948. Stevenson expresses his appreciation for the fine support Carswell gave to him before the First Primary and that he feels certain their victory is assured in the Second Primary
Food additives and children's behaviour: evidence based policy at the margins of certainty
No full textThe possible effects of food additives (specifically artificial colours) have been debated for over 30 years. The evidence accumulated suggests that for some children with attention deficit hyperactivity disorder (ADHD) food colours exacerbate their condition. Two studies
undertaken by a research group at the University of Southampton have extended these findings to the effects on hyperactivity in children from the general population who do not show ADHD. This article reviews the response from policy-makers to these findings and concludes that the failure to impose a mandatory ban on the six food colours in the Southampton study is inadequate and that such a ban would be an appropriate application of the precautionary principle when the evidence is considered to be at the margins of certaint
[Letter and Certificate: From Governor Coke Stevenson to T. N. Carswell - October 17, 1942]
No full textA letter addressed to Mr. T. N. Carswell, Abilene, Texas, from Coke Stevenson, Governor, Austin, Texas, dated October 17, 1942. The letter serves as a confirmation by Stevenson of the appointment of Carswell as a Member of the Taylor County Parole Board and advisement of enclosed commission and card. The certificate is issued by The State of Texas and signed by Coke R. Stevenson, Governor of Texas, W. J. Lawson, Secretary of State dated October 17, 1942
[Letter from Coke R. Stevenson to T. N. Carswell - January 14, 1948]
No full textA letter written to Mr. T. N. Carswell, Carswell Agency, from Coke R. Stevenson, Stevenson Ranch, Junction, Texas, dated January 14, 1948. Stevenson expresses his appreciation for the letter from Carswell dated January 2 and for his assurance of friendship and assistance. "No man can succeed politically without a host of good friends who are willing to aid the efforts he puts forth to become acquainted with the voters." Stevenson expresses his appreciation for the knowledge that "so many people are willing to lend a helping hand" and advises Carswell of his hope of seeing him while in his community, that he will be glad to have "the benefit of his suggestions and advice"
481. Nightcap owned by Mrs. E. T. (Rhoda Richards) Stevenson of Salt Lake City, Utah
No full textPhotographs of and document for a nightcap owned by Mrs. E. T. (Rhoda Richards) Stevenson of Salt Lake City, Utah. History unknow
[Letter from Coke R. Stevenson to T. N. Carswell - May 20, 1948]
No full textA letter written to Mr. T. N. Carswell, Carswell Agency, Abilene, Texas, from Coke R. Stevenson, Austin, Texas, dated May 20, 1948. Confirmation from Stevenson that the suggestions contained in the recent letter from Carswell have been very helpful and the advisement of how those suggestions have been implemented. He requests that Carswell keep him informed as to his "situation" in that section of the State
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