1,374 research outputs found
JANA MARION BORCHARDT Trumpet SENIOR RECITAL Saturday, February 9, 1991 4:00 p.m. in the Shepherd School Recital Hall
No full textProgram: Konzert für trompete und kammerorchester nach Domenico Scarlatti, Dieter Schönbach (1931-2012) -- Sonata for trumpet and piano, Halsey Stevens (1908-1989) -- Aria and rondo, Joseph Hector Fiocco (1703-1741) -- Three bagatelles, Fisher Tull -- Canzona Bergamasca for brass quintet, Samuel Scheidt (1587-1654).This recital is given in partial fulfillment of the requirements for the degree Bachelor of Music
Fig. 2 Cae o in Caenorhabditis monodelphis sp. n.: defining CrossMark the stem morphology and genomics of the genus Caenorhabditis
No full textFig. 2 Cae o abolts mo ode ph s sp. n., matu e spe matozoa fema e post- ıte e sac, TEM A ovvs=spe m ce sPublished as part of Dieter Slos, Walter Sudhaus, Lewis Stevens, Wim Bert & Mark Blaxter, 2017, Caenorhabditis monodelphis sp. n.: defining CrossMark the stem morphology and genomics of the genus Caenorhabditis, pp. 1-15 in BMC Zoology 2 (4) on page 5, DOI: 10.1186/S40850-017-0013-2, http://zenodo.org/record/32231
Searching for a New Role in East Asian Regionlization: Japanese Production Networks in the Electronics Industry
No full textThis paper will be published in Peter and J. Katzenstein and Takashi Shiraishi, eds. Remaking East Asia: Beyond Americanization and Japanization, Cornell University Press. Part 1 introduces a few conceptual building-blocks that we need to capture the interactions between international business organization and regionalization. Part 2 describes the growing dependence of Japan's electronics industry on Asia, and explores how Japanese electronics firms are searching for ways to expand and upgrade their regional production networks, with China as the main prize. Part 3 examines constraints to change. I highlight peculiar features of the Japanese network management model in East Asia that once may have reflected strength. But now these very same features have turned into systemic weaknesses, as they constrain the capacity of Japanese firms to cope with and shape East Asia's increasingly complex processes of regionalization. The chapter concludes with an illustrative example of how some Japanese electronics firms are seeking to turn around gradually their EAPNs, by developing strategic alliances with emerging new industry leaders in Asia, primarily from Greater China. Forthcoming as: "Searching for a New Role in East Asian Regionalization - Japanese Production Networks in the Electronics Industry", chapter 7, in: Peter and J. Katzenstein and Takashi Shiraishi, eds., Remaking East Asia: Beyond Americanization and Japanization, Cornell University Press.
Randomized comparison between a low and a new high impedance true bipolar defibrillation lead
No full textRandomized comparison between a low and a new high impedance true bipolar defibrillation lead
No full text1-Year performance of a defibrillation lead with a small electrode surface for high impedance pacing: A randomized, controlled study
No full textA small electrode surface reduces pacing current drain and can extend generator longevity. The study evaluated the performance of a tined, quadripolar defibrillation lead (model 6944) that has a small-surfaced, steroid-eluting electrode tip for high impedance pacing. In a prospective, controlled study, 34 patients with conventional ICD indications were randomized one to one to receive the high impedance model 6944 or a tined defibrillation lead with a conventional sized, steroid-eluting electrode tip model 6942. Lead Performance was evaluated at implant, prior to hospital discharge, and 1, 3, 6, and 12 months thereafter. Baseline characteristics did not differ significantly between patients implanted with lead model 6942 (n = 16) or model 6944 (n = 17). One patient randomized to receive the model 6942 was excluded from the study and was implanted with an active-fixation lead after stable lead positioning was neither possible with the 6942 nor with the 6944 electrode. No other lead related adverse events were observed. At implant, there were no significant differences between pacing thresholds, sensing performance, defibrillation impedances, and defibrillation thresholds in both groups, but pacing impedance of the model 6944 (988.6 +/- 217.7 Omega) was approximately twice as high as in the model 6942 (431.7 +/- 83.7 Omega; P < 0.0001). This difference remained highly significant throughout the observation period of 12 months, while R wave amplitudes and pacing thresholds remained equal in both lead models. The use of a tined defibrillation lead with a small, steroid-eluting electrode tip appears safe and results in a high pacing impedance without compromising system performance
Knowledge cluster formation as a science policy: lessons learned
No full textRegional science policy aims at the creation of productive knowledge clusters, which are central places within an epistemic landscape of knowledge production and dissemination, K-clusters are said to have the organisational capability to drive innovations and create new industries. The following paper will look at Malaysia, Indonesia and Vietnam and their path towards a Knowledge-based economy. All governments have used cluster formation as one of their development strategies. Some evidence on the current state of knowledge cluster formation is provided. If the formation of a knowledge cluster has been the government policy, what has been the result? Is there an epistemic landscape of knowledge clusters? Has the main knowledge cluster really materialised? Data collected from websites, directories, government publications and expert interviews have enabled us to construct the epistemic landscape of Peninsular Malaysia and the Mekong Delta of Vietnam. Several knowledge clusters of a high density of knowledge producing institutions and their knowledge workers have been identified and described. An analysis of the knowledge output, measured in terms of scientific publications, patents and trademarks show that knowledge clusters have, indeed, been productive as predicted by cluster theory, though the internal working of clusters require further explanation.Science policy; knowledge and development; knowledge-based economy; knowledge clusters; knowledge corridors; Malaysia; Vietnam
Caenorhabditis monodelphis Dieter Slos & Walter Sudhaus & Lewis Stevens & Wim Bert & Mark Blaxter 2017
No full text<p> <i>Caenorhabditis monodelphis</i> 1 sp. n. Slos & Sudhaus</p> = <i>Caenorhabditis</i> sp. SB341 [7] <p>= <i>Caenorhabditis</i> sp. SB341 and <i>Caenorhabditis</i> sp. n.</p> <p>SB341 [36]</p> <p>= <i>Caenorhabditis</i> sp. n. 1 (SB341) and (lapse)</p> <p> <i>Caenorhabditis</i> sp. n. 4 (SB341) [10]</p> <p>= <i>Caenorhabditis</i> sp. 1 SB3 41 [6, 8, 37]</p> <p>= <i>Caenorhabditis</i> sp. 4 SB3 41 [38]</p> (Figs. 1, 2, 3 and 4; Table 1) Adult <p>Small species (female 0.7 2 - 1.0 4 mm, male 0.6 5 <i>–</i> 0.7 7 mm); cuticle thin, ca. 1 μm wide and finely annulated, 0.8 μm wide at midbody. Lateral field inconspicuous, about 9% of body width, consisting one ridge that can be traced anteriorly to the level of the median bulb and posteriorly at level of rectum in females and about 1½ spicules length anterior of the cloacal aperture in males. Six lips slightly protruding, each with one apical papilliform labial sensillum and a second circle of four sublateral cephalic sensilla in both sexes; amphids opening on the lateral lips, hardly discernible. Buccal tube long and slender, more than twice the width in lip region, pharyngeal sleeve envelopes nearly half of the stoma, the anterior as well as the posterior end of the tube appear slightly thickened, cheilostom inconspicuous, arcade cells forming the gymnostom sometimes visible; glottoid apparatus completely absent. Pharynx with a prominent median bulb, diameter more than 90% of diameter of terminal bulb; terminal bulb pyriform, with double chambered haustrulum, the anterior chamber smallish; cardia conspicuous, opens funnel-like in intestine. Nerve ring encircles isthmus in its anterior part in living specimens, more to the middle of the isthmus in heat relaxed or preserved specimens; deirids usually conspicuous in the lateral field at level of beginning of terminal bulb, sometimes not visible in heat relaxed animals; pore of excretory-secretory system hard to discern posterior of deirid level. Two gland cells ventral and slightly posterior of terminal bulb conspicuous in live specimens. Lateral canals visible in live specimens extending anteriorly to two stoma length from the anterior end and ending at rectum level in the female. Postdeirids usually very conspicuous dorsally of the lateral field at about 7 5% of body length in both sexes and about half the length between vulva and beginning of rectum (or at level of posterior end of uterus remnant) in females, sometimes not visible in heat relaxed specimens.</p> Female <p>Maximum body diameter clearly anterior of the vulva, vulva position 65% body length, a transverse slit, bordered in both ends by cuticular longitudinal flaps, vulva lips moderately protruding, four diagonal vulval muscles conspicuous; one pseudocoelomocyte exists anterior of gonad flexure ventrally. Genital tracts asymmetrical; posterior branch rudimentary, sac like, on the left hand side of intestine, without flexure, almost as long as body diameter at the level of the vulva, containing spermatozoa (Fig. 2); anterior branch right of intestine, reflexed dorsally close to the pharynx, flexure more than half the length of the gonad (measured from vulva to flexure); at the flexure oocytes in several rows, downstream in one row, oocytes predominantly growing in the last position, where granules are stored inside; sphincter between oviduct and uterus, only a few sperm cells in oviduct, most of them in uterus and blind sac; oviparous, one egg at a time in uterus (rarely two), segmentation starts in the uterus. Rectum a little S-shaped, rectal gland cells very small, posterior anal lip slightly protuberant. Tail short, panagrolaimid, dorsally convex, with offset tip tapering, smooth to somewhat telescope-like by cuticle forming a sleeve-like structure; tail tip with tiny hooks, mostly one dorsal, but also subventral (compare with <i>Poikilolaimus</i>); opening of phasmids located at 60 <i>–</i> 65% of tail length, shortly anterior of tip, phasmid glands not reaching anus level.</p> Male <p>Testis right of intestine, ventrally reflexed in a certain distance posterior of pharynx; flexure relatively short. One pseudocoelomocyte between pharynx and flexure ventrally. Bursa well developed, peloderan, anteriorly open, with smooth margin and sometimes terminally indented, posterior part of velum transversely striated.</p> <p>Nine pairs of genital papillae (GP) present, two of them anterior of the cloaca, genital papilla 1 (GP1) and GP2 spaced, GP3 to GP6 and GP7 to GP9 clustered, GP5 and GP7 point to the dorsal side of the velum, GP6 slightly bottle shaped, GP8 and GP9 fused at base, GP2 and GP8 not reaching the margin of velum. Phasmids forming small tubercles to the ventral side posterior of the last GP; formula of GPs: v1,v2/(v3,v4,ad,v5) (pd,v6,v7)ph. Precloacal sensillum small, precloacal lip simple (according to type A of W Sudhaus and K Kiontke [39]), postcloacal sensilla long filamentous. Spicules short and stout, tawny, separate, slightly curved, with prominent head; shaft with a transverse seam, with a prominent longitudinal ridge, a dorsal lamella, and an oval <i>“</i> window <i>”</i>, the tip notched. Gubernaculum dorsally projecting, flexible, in the distal part following the contour of the spicules, spoon shaped in ventral view.</p> Dauer larva <p>Unsheathed, mouth closed; stoma long, slender. Pharyngeal sleeve covering about half of the stoma; pharynx with welldeveloped median and terminal bulbs; corpus length ca. 52% of pharynx length. Nerve ring somewhat in the middle between the middle and terminal bulb. Genital primordium at about 60% of body length, elongated oval in shape. Tail conical. Amphids, lateral lines, position excretory pore, deirids and phasmids not observed.</p> <i>Aberration</i> <p>In one female a second set of <i>“</i> sensilla <i>”</i> were observed a short distance posterior to postdeirids, possibly a duplication of the postdeirids.</p> <i>Type carrier and locality</i> <p>Holotype and paratypes of <i>Caenorhabditis monodelphis</i> sp. n. were isolated from the tunnels of <i>Cis castaneus</i> (Herbst, 1793) (Ciidae, Coleoptera) in the bracket fungus <i>Ganoderma applanatum</i> (Polyporales) on a stump of the common beech (<i>Fagus sylvatica</i>) a few centimetres above the ground in Berlin-Grunewald in April 2 0 0 1. The same sample included individuals of <i>Diploscapter</i> sp., <i>Plectus</i> sp., <i>Oscheius dolichura</i> and one individual dorylaimid and mononchid.</p> <i>Type material</i> <p>Holotype male (collection number WT 3684) and five female and four male paratypes (WT 3685, WT 3686) are deposited in the National Plant Protection Organization Wageningen, The Netherlands. In addition, four female and four male paratypes, are deposited in the collection of Museum Voor Dierkunde at Ghent University, Ghent, Belgium, five female and three male paratypes in Museum für Naturkunde an der Humboldt-Universität zu Berlin, Berlin, Germany. Additional paratypes are available in the UGent Nematode Collection (slides UGnem158, 159 & 160) of the Nematology Research Unit, Department of Biology, Ghent University, Ghent, Belgium.</p> <i>Diagnosis and relationship</i> <p> <i>Caenorhabditis monodelphis</i> sp. n. can be recognised as a <i>Caenorhabditis</i> based on the thickened GP6 and the clearly visible postdeirids. <i>Caenorhabditis monodelphis</i> sp. n. is distinguished from all other described <i>Caenorhabditis</i> species by the presence of a monodelphic genital tract in the female with a blind sac posterior the vulva, a panagrolaimid female tail shape, adults with only one ridge on the lateral field, a very long and slender stoma without visible glottoid apparatus and male with short, stout spicule with bifurcate tip.</p> <i>Ecology and biology</i> <p> <i>Caenorhabditis monodelphis</i> sp. n. is a gonochoristic species with both males and females. Females are oviparous and carry only one egg (rarely two eggs). Development from egg to adult took about 5 <i>–</i> 6 days in juice prepared from brown algae at room temperature. Development from dauer larva to adults was completed in less than 3 days at 20 ̊C on NA seeded with OP50. The lifespan of adults is at minimum 1 4 days for males and 1 7 days for females. One pair of adults produced 1 6 7 offspring in 8 days and the daily production of fertile eggs was 6 <i>–</i> 3 1 (mean 1 8; <i>n</i> = 1 4). After the reproductive phase, females lived 9 <i>–</i> 1 4 days (<i>n</i> = 3) with males present.</p> <p> <i>Caenorhabditis monodelphis</i> sp. n. has until now only been found in <i>Ganoderma</i> and <i>Fomes</i> in Germany and Belgium in relation with the ciid beetle <i>Cis castaneus</i>. The <i>Ganoderma</i> carrying <i>C. monodelphis</i> sp. n. from Oslo was not investigated for the presence of <i>C. castaneus</i>. In fungal fruiting bodies lacking the beetle <i>C. monodelphis</i> sp. n. was not found. Dauers of <i>C. monodelphis</i> sp. n. were found under the elytra of the beetle, but were not found internally when the beetle was further dissected. These findings indicate a phoretic association with the beetle. As only dauer larvae were isolated from beetles, while adults and larvae were present in the fruiting bodies, we infer that <i>C. monodelphis</i> sp. n. exit from dauer within the mushroom, develop to adulthood and start to reproduce. The food source of the species in natural conditions is not known, but they survive and reproduce easily on <i>E. coli</i> OP50 in culture.</p> <p> <i>Genome sequence of an inbred strain of Caenorhabditis</i> <i>monodelphis sp. n.</i></p> <p>We sequenced the genome of an inbred strain (JU1677) of <i>C. monodelphis</i> sp. n. using Illumina sequencing technology to ~110x coverage. The genome was assembled into 6,864 scaffolds, spanning 115.1 Mb with a scaffold N50 of 49.4 kb (Table 2). CEGMA (Core Eukaryotic Gene Mapping Approach) [40] scores suggested the assembly is of high completeness. We predicted 17,180 protein coding gene models using RNA-Seq evidence. These statistics, and the overall gene content and structure of the assembly were largely in keeping with those determined for other <i>Caenorhabditis</i> species. The genome was larger than that of <i>C. elegans</i> and <i>C. briggsae</i>, which are hermaphroditic species, but smaller than that of <i>C. remanei</i>, a gonochoristic species.</p> <p>We carried out preliminary comparisons of the structure and content of the <i>C. monodelphis</i> sp. n. genome with those of other sequenced <i>Caenorhabditis</i> species. The number of genes identified was lower than estimates for most other <i>Caenorhabditis</i> species. To compare the gene structures of <i>C. monodelphis</i> sp. n. to that of <i>C. elegans</i>, we identified 6,174 orthologous gene pairs and calculated gene structure statistics (Table 3, Fig. 5.). To minimize bias from erroneous gene predictions (such as merged or split genes), orthologous gene pairs which differed in CDS length by 20% were considered outliers. <i>C. monodelphis</i> sp. n. genes were typically longer than their orthologues in <i>C. elegans.</i> We also found a clear trend toward more coding exons per gene in <i>C. monodelphis</i> sp. n. than in <i>C. elegans</i> (Fig. 5a). A few examples of <i>C. monodelphis</i> sp. n. gene models compared to those of orthologues in <i>C. elegans</i> are shown (Fig. 5b). Although introns are, on average, shorter in <i>C. monodelphis</i> sp. n. than in <i>C. elegans,</i> <i>C. monodelphis</i> genes typically have a longer total span of introns than <i>C. elegans</i> transcripts (Table 3, Fig. 5.).</p> <p>a from anus to flexure in the female; from cloaca to flexure in the male b <i>n</i> = 7</p> <p>a Scaffolds shorter than 500 bp were not considered</p> <p> <i>C. monodelphis sp. n. is sister to other known</i> <i>Caenorhabditis</i></p> <p>We clustered a total of 634,56 4 protein sequences from <i>C. monodelphis</i> sp. n., twenty-two other <i>Caenorhabditis</i> species, and two rhabditomorph outgroup species (<i>Oscheius tipulae</i>; data courtesy of M. A. Félix, and <i>Heterorhabditis bacteriophora</i>) to define putative orthologues. We identified 34,425 putatively orthologous groups containing at least two members, 303 of which were either single copy or absent across all 25 species. These single copy orthologues were aligned, and the alignments concatenated and used to perform maximum-likelihood and Bayesian inference analysis using RAxML and PhyloBayes, respectively. Both analysis methods resulted in an identical topology, with the placement of <i>C. monodelphis</i> sp. n. arising basally to all other <i>Caenorhabditis</i> species (Fig. 6). All branches had maximal support except for three nodes within the <i>Elegans</i> super-group. Our analysis included data from several new and currently undescribed putative species of <i>Caenorhabditis</i>, including <i>C.</i> sp. 21 which is the sister taxon to the <i>Drosophilae</i> plus <i>Elegans</i> super-groups and <i>C.</i> sp. 31 which forms the first branch in the <i>Elegans</i> super-group. <i>C.</i> sp. 38 is placed within the <i>Drosophilae</i> super-group, while <i>C.</i> sp.</p> <p>26, <i>C.</i> sp. 32 (sister to <i>C. afra</i>) and <i>C.</i> sp. 40 (sister to <i>C. sinica</i>) are all members of the <i>Elegans</i> super-group. From these analyses we conclude that <i>C. monodelphis</i> sp. n. is sister to all other known <i>Caenorhabditis</i>.</p> <i>Stemspecies pattern reconstruction</i> <p>Our phylogenetic analyses were based on species with whole genome data available, and thus did not include the full known diversity of the genus. The stemspecies pattern was reconstructed based on ingroup and outgroup comparison. Previous molecular phylogenetic analyses of <i>Caenorhabditis</i> species using a small number of marker genes [1 0] placed <i>C. monodelphis</i> sp. n. and <i>C. sonorae</i> [4 1] as sister species, again arising at the base of the genus.</p> <p>The following morphological synapomorphies can be hypothesised to support a <i>C. monodelphis</i> sp. n. <i>– C. sonorae</i> clade: mouth opening triangular (Fig. 4b), spicule having a complicated tip (notched or dentated) and a longish thin walled <i>“</i> window <i>”</i> in the blade (Figs. 1i, 4l), postcloacal sensilla being filiform (Fig. 4k), and the female tail shortened to less than three times anal body width. Other similarities between both these species are plesiomorphic.</p> <p> <i>Caenorhabditis</i> and its sister group constitute the monophylum Anarhabditis within the Rhabditina. For convenience, we will call the sister clade of <i>Caenorhabditis</i> Protoscapter (Fig. 7): it comprises <i>“ Protorhabditis ”</i>, <i>Prodontorhabditis</i>, <i>Diploscapter</i> and <i>Sclerorhabditis</i> [4 2]. To reconstruct the characters of the stemspecies of <i>Caenorhabditis</i> it is necessary to consider the morphologies of all these taxa, and not only the taxa for which we have molecular data. <i>“ Protorhabditis ”</i> is paraphyletic. The <i>Oxyuroides</i> group is sister taxon of <i>Prodontorhabditis</i> [4 3, 4 4], and the <i>Xylocola</i> group may be sister taxon of <i>Diploscapter</i> / <i>Sclerorhabditis</i>. However, the two species <i>Protorhabditis elaphri</i> (Hirschmann in Osche, 1952) and <i>P. tristis</i> [4 5] appear to represent basal branches in Protoscapter (compare [43]). These last two species, despite the paucity of information available for them, are crucial for comparisons that will illuminate the stemspecies patterns of Anarhabditis, Protoscapter and <i>Caenorhabditis</i>.</p> <i>C. monodelphis</i> sp. n. C. elegans <p>All values are medians</p> <p>a orthologous gene pairs which differed in CDS length by 20% were not included</p> <p>By ingroup comparison we reconstruct the following characters of the stemspecies of Anarhabditis without differentiating them into apo- or plesiomorphies (on apomorphies see the legend of Fig. 7):</p> <p> <i>–</i> adults of small size (less than 1 mm); − lips not offset from anterior end; − four cephalic sensilla present in male and female; − stoma with pharyngeal sleeve (stegostom length nearly that of gymnostom); − median bulb of pharynx strongly developed, corpus intima with transverse ridging, terminal bulb with double haustrulum; − gonochoristic; − female tail elongate conoid; − gonads amphidelphic, the anterior branch right and the posterior left of intestine; − vulva at midbody, a transverse slit; − oviparous, usually only one egg at a time in the uteri; − male gonad on the right side, reflexed to the ventral; − bursa peloderan and anteriorly open, oval-shaped in ventral view, with smooth margin, terminally not notched; − 9 pairs of even genital papillae, two precloacal largely spaced, GP3 <i>–</i> 6 evenly spaced, the last three GPs forming a tight cluster; GP1, GP5 and GP7 terminate on the dorsal surface of the bursa velum; − phasmids open behind GP9, inconspicuous; − bursa formula thus v1,v2/v3,v4,ad,v5 (pd,v6,v7)ph; − male tail tip present; − 1 + 2 circumcloacal sensilla inconspicuous, precloacal lip simple; − spicules separate, stout, head not rounded, behind the shaft a slight ventral projection, dorsal part of blade weakly cuticularised (velum), its tip possibly not even (argued below); − gubernaculum simple spatulate; − dauerlarvae with double cuticle (ensheathed), not waving.</p>Published as part of <i>Dieter Slos, Walter Sudhaus, Lewis Stevens, Wim Bert & Mark Blaxter, 2017, Caenorhabditis monodelphis sp. n.: defining the stem morphology and genomics of the genus Caenorhabditis, pp. 1-15 in BMC Zoology 2 (4)</i> on pages 3-10, DOI: 10.1186/s40850-017-0013-2, <a href="http://zenodo.org/record/1156816">http://zenodo.org/record/1156816</a>
Evolution Physics
No full textThis work is a revised edition of the former article "Evolution and Mutation Physics” by the same author. Some unclear formulations have been eliminated.
New ideas and new calculations have been included, especially the important connection between successive entropy - changes and increasing DNA –length at slowly decreasing temperature-decrease of surroundings
Die Kalkulation irreparabler Mutationen
No full textThis work is a revision of the article "Die Kalkulation kalkulierbarer Mutationen” by the same author. In some chapters errors have been corrected in the mathematical representation. Chapters 6 and 7 have been re-edited. In this work, corrected excerpts from "Tumour Physics" and from "Evolution and mutation Physics" are used. To the agencies concerned should be noted
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