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Bromotyrosine-derived natural products: synthetic and biological studies
No full textBromotyrosine-derived natural products are a fascinating class of compounds that are
produced by marine sponges of the order Verongida. Furthermore, they exhibit a rich
variety of chemical structures and display a diverse range of bioactivities which
makes them of great interest to both the chemical and biological research
communities.
This thesis is divided into four Chapters and describes the total syntheses of five
bromotyrosine-derived natural products and analogues thereof. The anticancer activity
of these compounds was also investigated. In addition, studies towards the total
syntheses of the ceratamines are reported.
The first Chapter gives a general introduction into the history, biosynthesis, structures
and biological activities of bromotyrosine-derived natural products. A background
into the anticancer properties of ceratamines A and B is also provided.
The research in Chapter two is concerned with bromotyrosine-derived oximes and is
divided into two parts. The syntheses of the natural products (5)-bromoverongamine,
ianthelline and JBIR-44 are described in Part one and the structure-activity
relationship studies into these products is described in Part two.
The total syntheses of subereamollines A and B are discussed in Chapter three.
Furthermore, both enantiomers of the natural products were accessed and their
absolute stereochemistry was unambiguously assigned.
The first section of Chapter four provides an in-depth review of the research carried
out by the Andersen and Coleman groups into the ceratamines. This is followed by an
account of the Ley group approach towards the syntheses of these natural products
Necker y Jovellanos: un «área neckeriana» en el Informe de Ley Agraria
No full textEditada en la Fundación Empresa PúblicaEl trabajo analiza la presencia de las ideas de Necker en el Informe de Ley Agraria de Jovellanos. Dejamos constancia de la importante huella que en esta obra existe de la metodología y el pensamiento económicos de Necker. Ello indica que este autor ha influido en España más de lo que habitualmente se reconoce y propicia una reflexión acerca del influjo de su pensamiento relativista e intervencionista en este texto fundamental del liberalismo ilustrado español.This essay analyzes the influence of Necker's ideas as contained in Informe de Ley Agrarian of Jovellanos. We have demonstrated that the methodology and economic thought of Necker play an important role in this work. This proves that this author has had a stronger influence in Spain than has been previously admitted and leads us to reflect on the presence of his relativist and interventionist thought in this fundamental text of Spanish enlightenment liberalism.Publicad
Pd-EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl- and Alkenyl- Substituted Acetylenes via Microwave-Assisted Sonogashira Type Reactions
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Professor Steven V Ley CBE FRS FMedSci
No full textProfessor Steven Ley is currently Professor of Chemistry and Director of Research at at the University of Cambridge. He is also a Fellow of Trinity College and was BP 1702 Professor of Chemistry for 21 years. Steve obtained his PhD from Loughborough University with Professor Harry Heaney and afterwards carried out postdoctoral research with Professor Leo Paquette (Ohio State University) and then Professor Derek Barton (Imperial College). He was appointed as a lecturer at Imperial College in 1975, promoted to Professor in 1983, and became Head of Department there in 1989. In 1990 he was elected to the Royal Society (London) and was President of The Royal Society of Chemistry from 2000-2002. Steve’s research interests are varied and span many disciplines including new synthetic methodologies, the total synthesis of natural products and the development of enabling technologies for chemical synthesis - especially in the area of flow chemistry technologies. Four spin-out companies have emerged from these research interests. Steve has published over 860 papers and has been honoured with 50 major awards including recently (since 2009): the Tetrahedron Prize for Creativity in Organic Chemistry (Elsevier); Heinrich Wieland Prize (Boehringer Ingelheim, Germany); The Paracelsus Prize (Swiss Chemical Society); The Royal Medal (The Royal Society, London); The Longstaff Prize (The Royal Society of Chemistry); the Franco-Britannique Prize (Société Chimique de France); and the IUPAC-Thales Nano Prize in Flow Chemistry. Professor Ley is also recipient of the 2018 Arthur C. Cope Award
The Changing Face of Organic Synthesis
No full textThe article describes the content of the Paul Karrer Lecture given at the University of Zürich on the 20th of June 2007 by Professor Steven V. Ley. The lecture illustrates the work underway within the Chemistry Department at Cambridge to develop microreactors for flow chemistry
applications. These modular, small footprint devices are capable of preparing a wide range of compounds including natural products in up to seven synthesis steps. Products can generally be obtained in high yield and purity without conventional work-up methods using a variety of reaction mixer
chips and pre-packed flow tubes of immobilised reagents and scavengers
The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors
No full textHerein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification
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