63 research outputs found
Synthesis and coordination chemistry of scorpionate ligands and their applications in 11C-positron emission tomography
No full textThis thesis is concerned with the synthesis and coordination chemistry of· a range of poly(pyrazolyl)borate 'scorpionate' ligands and examines their suitability in facilitating rapid [llC]carbonylation reactions to form radiotracers for application in positron emission tomography (PET). Author (full names): Steven Kealey Title of thesis: Synthesis and Coordination Chemistry of Scorpionate Ligands and their Applications in He-Positron Emission Tomography The second part of this thesis concerns the use of a copper(I)-Tp system for selectively solubilising llCO from nitrogen-rich gas streams for subsequent use in palladium-catalysed carbonylation reactions between amines and aryl-halides to form amides. These reactions were performed on a microfluidic device and in Schlenk apparatus using unlabelled carbon monoxide. These reactions ~were transferred to the radiochemical laboratory whereby efficient llCO trapping was observed prior to the formation of llC-radiolabelled amides. The third part of this thesis explores the coordination chemistry of palladium(II) towards a novel hybrid ligand consisting of pyrazolyl and triphenylphosphine moieties. The potential hemilabile behaviour of this ligand and its derivatives towards palladium was investigated and the use of these complexes as catalysts for carbonylation reactions is described. The final part of this thesis examines the coordination chemistry of poly(pyrazolyl)borates bearing additional coordinating groups appended to the 3- or 5~position ofthe pyrazolyl rings. Reactions ofthe 3-substituted derivatives were carried out with a range of metals and found to display varied coordination behaviour depending on the specific coordination requirements ofthe metal.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Volume 52, Number 3 - April 1973
No full textVolume 52, Number 3 - April 1973. 19 pages including covers and advertisements. Cabrera, Ana Margarita Poem: on being the only Cuban woman among you Gouise, Gene The Moon and the Steeple O\u27Neill, Terrence Goose Rocks O\u27Neill, Terrence To The Man Who Called At Midnight Langlois, Donald A Song Selley, April Emily Kealey, Suzanne Rain Bortolot, Gary Breakwater Ruzzo, Steven A Picture Ruzzo, Steven The Old Heater Osborne, Joseph Grandfather Osborne, Joseph Fathers Slonina, Patricia Games Slonina, Patricia Choir Boy
Pictures Pietros, Steven Plummer, Jo
Volume 52, Number 3 - April 1973
No full textVolume 52, Number 3 - April 1973. 19 pages including covers and advertisements. Cabrera, Ana Margarita Poem: on being the only Cuban woman among you Gouise, Gene The Moon and the Steeple O\u27Neill, Terrence Goose Rocks O\u27Neill, Terrence To The Man Who Called At Midnight Langlois, Donald A Song Selley, April Emily Kealey, Suzanne Rain Bortolot, Gary Breakwater Ruzzo, Steven A Picture Ruzzo, Steven The Old Heater Osborne, Joseph Grandfather Osborne, Joseph Fathers Slonina, Patricia Games Slonina, Patricia Choir Boy
Pictures Pietros, Steven Plummer, Jo
Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds
No full textThe presence of positron emission tomography (PET) centers at most major hospitals worldwide, along with the improvement of PET scanner sensitivity and the introduction of total body PET systems, has increased the interest in the PET tracer development using the short-lived radionuclides carbon-11. In the last few decades, methodological improvements and fully automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 by substituting one of the backbone carbons with the radionuclide has provided important information on the biochemistry of the authentic compounds and increased the understanding of their in vivo behavior in healthy and diseased states. The number of endogenous and natural compounds essential for human life is staggering, ranging from simple alcohols to vitamins and peptides. This review collates all the carbon-11 radiolabeled endogenous and natural exogenous compounds synthesised to date, including essential information on their radiochemistry methodologies and preclinical and clinical studies in healthy subjects.</p
Synthesis and coordination chemistry of scorpionate ligands and their applications in 11C-positron emission tomography
No full textOpen Acces
Sex Spying::The RCMP Framing of English- Canadian Women’s Liberation Groups During the Cold War
No full textAn overview of surveillance against women's liberation groups by the Royal Canadian Mounted Police from the late 1960s until the 1980s
Knowledge movement in response to coastal British Columbia oil and gas development: Past, present, and future
No full textThe Mythology of the Small Community in Eight American and Canadian Short Story Cycles
No full textScholarship has firmly established that the short story cycle is well-suited to representations of community. This study considers eight North American examples of the genre: four by Canadian authors Stephen Leacock, Duncan Campbell Scott, George Elliott, and Alice Munro; and four by American authors Sarah Orne Jewett, Sherwood Anderson, John Cheever, and Joyce Carol Oates. My original idea was to discover whether there were significant differences between the Canadian and American cycles, but ultimately I became far more interested in the way that all of the cycles address community formation and disintegration. The focus of each cycle is a small community, whether a small town, a village, or a suburb. In all of the examples, the authors address the small community as the focus of anxiety, concern, criticism, and praise, with special attention to the way in which, despite its manifold failings, the small community continues to inspire longings for the ideal home and source of identity.
The narrative feature that ultimately provided the critical framework for the study is the recurring presence of the metropolis in all of the eight cycles. The city, set on the horizons of these small communities, consistently provides a backdrop against which author and characters seem to measure and understand their lives. Always an influence (whether for good or bad), the city’s presence is constructed as the other against which the small community’s identity is formulated and understood. The relationship between small community and city led me to an investigation into the mythology of the small community, a mythology that sets the small community in opposition to the city, portraying the former as the keeper of virtue and the latter as the disseminator of vice. The cycles themselves, as I increasingly discovered, challenge the mythology by identifying how the small community depends, in large part, on the city for self-understanding. The small community, however, as an idea, and a mythic ideal, is never dismissed as obsolete or irrelevant
Determination of the Neuromuscular Mechanisms Responsible for Stair Climb Negotiation
No full textThe stair climb task is not only an activity of daily living, but an essential task in the fire service. Firefighters often have to negotiate stairs following an emergency, and potentially while fatigued. Understanding the mechanisms responsible for the stair climb as well as how stair negotiation differs following exercise-induced fatigue may provide insights into the safety of the stair climb task. The primary aim of this project was to investigate the influence of exercise-induced fatigue on peak vertical ground reaction force during the ascent and descent of a stair climb bout. A secondary aim was to quantify the potential mechanisms that explain peak vertical ground reaction force during a stair climb. Fifteen career firefighters (mean SD: age: 34 5 years, body mass: 86.4 13.8 kg, height: 69.3 3.0 in) volunteered for this study. Participants completed three visits to the laboratory, all separated by at least two days. The initial visit consisted of completing the informed consent, health history questionnaire, body composition, and ultrasound assessments. In addition, participants completed familiarization of the stair climb and neuromuscular assessments. The following two visits were in a randomized and counterbalanced order and included pre-assessment, fatiguing task, and post-assessment. The pre- and post-assessment consisted of either neuromuscular or stair climb tests. An a priori alpha level of 0.05 was used to determine statistical significance. To determine the effect of fatigue a dependent samples t-test was performed, and Cohen’s d was calculated to measure effect size. Pearson’s product-moment correlation coefficient was calculated to determine which variables may be independently associated with peak vertical ground reaction force (pVGRF). Variables found to have a relationship were then input into a stepwise multiple linear regression model to determine which variables may explain the greatest variance in pVGRF. The results suggest a significant difference between pre- and post-pVGRF for stair climb descent (t = 2.60, p = 0.03, d = 0.51, CI = 12.50 – 162.55), but not ascent (t = 0.73, p = 0.06, d = 0.06, CI = -11.93 – 45.52). There were no significant differences between pre- and post-time for stair climb descent (t = -0.23, p = 0.80, d = 0.28, CI = -0.12 – 0.10) or ascent (t = 0.83, p = 0.42, d = 0.23, CI = -0.08 – 0.18). The only significant predictor of stair climb ascent pVGRF was vastus lateralis cross-sectional area (p < 0.001, R2 = 0.76). Predictors of stair climb ascent pVGRF fatigue were vastus lateralis cross-sectional area, extensor peak torque, extensor rapid torque at 100 ms, and flexor rapid torque at 100 ms normalized to body mass (p < 0.01, R2 = 0.88). Significant predictors of stair climb descent pVGRF were vastus lateralis cross-sectional area, biceps femoris cross-sectional area, extensor peak torque, and extensor rapid torque at 100 ms (p < 0.05, R2 = 0.88). The only significant predictors of stair climb descent pVGRF fatigue were biceps femoris cross-sectional area and extensor rapid torque at 100 ms (p = 0.05, R2 = 0.54). These findings suggest stair climb descent is impacted by exercise-induced fatigue within career firefighters. In addition, quadricep and hamstring muscle size and strength are contributors to stair climb pVGRF.Embargo status: Restricted until 06/2025. To request the author grant access, click on the PDF link to the left
The Mythology of the Small Community in Eight American and Canadian Short Story Cycles
No full textScholarship has firmly established that the short story cycle is well-suited to representations of community. This study considers eight North American examples of the genre: four by Canadian authors Stephen Leacock, Duncan Campbell Scott, George Elliott, and Alice Munro; and four by American authors Sarah Orne Jewett, Sherwood Anderson, John Cheever, and Joyce Carol Oates. My original idea was to discover whether there were significant differences between the Canadian and American cycles, but ultimately I became far more interested in the way that all of the cycles address community formation and disintegration. The focus of each cycle is a small community, whether a small town, a village, or a suburb. In all of the examples, the authors address the small community as the focus of anxiety, concern, criticism, and praise, with special attention to the way in which, despite its manifold failings, the small community continues to inspire longings for the ideal home and source of identity.
The narrative feature that ultimately provided the critical framework for the study is the recurring presence of the metropolis in all of the eight cycles. The city, set on the horizons of these small communities, consistently provides a backdrop against which author and characters seem to measure and understand their lives. Always an influence (whether for good or bad), the city’s presence is constructed as the other against which the small community’s identity is formulated and understood. The relationship between small community and city led me to an investigation into the mythology of the small community, a mythology that sets the small community in opposition to the city, portraying the former as the keeper of virtue and the latter as the disseminator of vice. The cycles themselves, as I increasingly discovered, challenge the mythology by identifying how the small community depends, in large part, on the city for self-understanding. The small community, however, as an idea, and a mythic ideal, is never dismissed as obsolete or irrelevant
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