10,415 research outputs found
Epigenetic therapy in lung cancer and mesothelioma
No full textThoracic malignancies present a considerable global health burden with the incidence and mortality of\ud
both lung cancer and malignant pleural mesothelioma (MPM) increasing year on year. Survival rates\ud
are poor and treatment options are limited in these cancers. Several epigenetic modifications have been\ud
associated with the development of both of these diseases with alterations discriminating between\ud
MPM and adenocarcinoma (AC) of the lung. In addition, studies have suggested that epigenetic agents\ud
are effective in altering the cellular characteristics of lung and MPM cells in terms of proliferation and\ud
migration. Furthermore, it has been demonstrated that epigenetic therapy can alter a pathologically\ud
relevant gene expression profile, with one that is more associated with comparative normal tissue.\ud
Therefore agents, which target the epi-genomes of lung cancer and MPM, may provide a substantial\ud
therapeutic improvement when used in combination with current therapy or indeed benefit when used\ud
as a single treatment modality
Steven Gray portraits - shots 1 and 2, 1961
No full textSteven Gray casual portraitsKendall Webb Collectio
Steven Gray portraits - shots 3 and 4, 1961
No full textSteven Gray casual portraitsKendall Webb Collectio
Steven Gray portraits - shots 1 and 2, 1962
No full textSteven Gray in Scout uniform portraitsKendall Webb Collectio
Steven Gray portraits - shots 3 and 4, 1962
No full textSteven Gray in Scout uniform portraitsKendall Webb Collectio
Ambulatory assisted living fallers at greatest risk for head injury
No full textOBJECTIVES: To determine the relationship between head injuries sustained during each fall with various known high risk health and demographic factors predictive of falls.
DESIGN: Prospective cohort study conducted over 1 year
SETTING: Assisted living and skilled nursing units of a Continuing Care Retirement Community located in the northeastern United States.
PARTICIPANTS: Sixty nine OAs who fell.
MEASUREMENTS: Age, gender, diagnosis, high risk medication, functional, cognitive, ambulation/elimination status, mode of locomotion, fall related symptoms and the position of the fall, were analyzed using General Estimating Equations among elderly fallers with and without head injury.
RESULTS: A total of 173 falls (average of 2.9 times) were observed for 62 patients who had complete injury data. Injuries were recorded in 40.5% of falls, with 41.4% being head injuries. Head injuries were more likely to be hematomas than lacerations (66.7% vs. 14.7%) and among assisted living residents (p=0.04). Head injured patients were more likely to be walking at the time of the fall (69% vs. 36.1%) and less likely to have bowel incontinence (3.5% vs. 28.5%; p=0.04). None of the high risk diagnosis or medications associated with falls risk increased risk for head injury.
CONCLUSION: Those at greatest risk for head injury were ambulatory assisted living residents. None of the known clinical conditions predictive of risk to fall were predictive of head injury. For head injury prevention to be successful we need a closer examination of resident’s mobility, shoe-wear, health behavior with respect to ability to use assistive devices, and floor surface landing area. Future health policy implications include measures to ensure standard of care practices for head injured patients are in place.This is the peer reviewed version of the following article: Gray-Miceli, D. L., Ratcliffe, S. J. and Thomasson, A. (2013), Ambulatory Assisted Living Fallers at Greatest Risk for Head Injury. Journal of the American Geriatrics Society, 61: 1817–1819, which has been published in final form at https://dx.doi.org/10.1111/jgs.12467. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Peer reviewe
Teaching Strategies for Atypical Presentation of Illness in Older Adults
No full textAtypical presentation of illness is one of those phenomena where “seeing is believing”. Expert geriatric nurses and clinicians know all to well the early signs and symptoms of this frequent masquerader of bacterial infections, pain, acute myocardial infarction, heart failure or other serious medical ailments in older adults. Students however, as novices to clinical practice, require interactive learning approaches to reflect on the client’s illness presentations, help with developing the necessary skills to analyze and synthesize clinically relevant data, and to witness resolution of an atypical presentation when found and treated. We discuss various learner-centered, interactive approaches to teach students how to recognize an atypical presentation of illness using a real-life clinical case. Outlined are teaching strategies for faculty, drawn on visual, auditory, reading and kinesthetic modes of student learning. Use of the senses to teach nurses about care of patient’s is not entirely new or innovative, as reflected on by Florence Nightingale’s (1846) earliest writings of the "rules of nursing".Peer reviewe
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