1,783 research outputs found
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells
No full textAnna C Cunningham-Edmondson1,2, Steven K Hanks11Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, USAAbstract: Elevated Src tyrosine kinase activity is commonly observed in breast cancer and likely contributes to neoplasia and malignancy. p130Cas (“Crk-associated substrate”) is a major Src substrate found at the sites where integrins mediate cell adhesion to the extracellular matrix. Src phosphorylates multiple tyrosines in the p130Cas “substrate domain” (SD) and this signaling event has been implicated in the promotion of cell motility, primarily from studies on fibroblasts. In breast cancer, studies on p130Cas have focused on its role in conferring antiestrogen resistance to cells that express the estrogen receptor (ER+). However, little is known regarding the role of p130Cas in the more aggressive estrogen receptor negative (ER-) breast cancers for which there is a need for development of effective targeted therapies. We found high levels of p130Cas SD tyrosine phosphorylation to be a common characteristic of ER- breast cancer cell lines, with particularly high levels observed for the BT-549 cell line. Using RNA interference to knock down p130Cas expression in BT-549 cells, combined with rescue by WT p130Cas versus a signaling-deficient control, we provide evidence that p130Cas SD tyrosine phosphorylation is an important signaling event in the migration, invasion, proliferation, and survival of this ER- breast cancer cell line.Keywords: adhesion, BCAR1, integrins, Src, FAK, tyrosine phosphorylatio
Sectoral allocation by gender of Latin American workers over the liberalization period of the 1990s
No full textThe recent restructuring of Latin American economies has renewed interest in the effects of trade liberalization, on labor markets, and on the gender division of labor. The author does not attempt to establish casuality between economic reforms, and the types of jobs that men and women hold. Instead, she provides a detailed description of the trends in male, and female formal, and informal sector participation during the economic reform period in Argentina, Brazil, and Costa Rica. The author first compares the gender composition of the formal, informal wage, and self-employment sectors in a year before reforms (1988 for Argentina, 1989 for Brazil, and Costa Rica), and a year after reforms implementation (1997 for Argentina, 1995 for Brazil and Costa Rica). Although women continued to be more likely than men to work in the informal wage sector, there is no trend of"masculinization"or"feminization"of the informal sector, or any other. Instead, in Argentina men have overtaken women as the most prevalent workers in the informal wage sector, while in Brazil, the opposite has occurred (as men move into self-employment). In Costa Rica there have been no statistical, observable changes. The author then considers the distribution across sectors within each gender group, to identify whether men, and women are more likely to select different sectors in the post-reform period relative to the pre-reform period. Among both men, and women in all three countries (except Brazilian men), workers have become more likely to hold informal wage jobs, and less likely to hold formal sector jobs. Trends in human capital accumulation explain these changes for both men, and women, while changes in gender roles, primarily in homecare and marriage, do not seem to have an effect.Health Monitoring&Evaluation,Labor Policies,Population&Development,Public Health Promotion,Environmental Economics&Policies,Health Monitoring&Evaluation,Environmental Economics&Policies,Population&Development,Banks&Banking Reform,Work&Working Conditions
Redistribution of garbage codes to underlying causes of death: a systematic analysis on Italy and a comparison with most populous Western European countries based on the Global Burden of Disease Study 2019 (Jan, 10.1093/eurpub/ckab194, 2022)
No full textIn the originally published version of this manuscript, an author was erroneously omitted from the list of authors. The list should read:
“Lorenzo Monasta, Gianfranco Alicandro, Maja Pasovic, Matthew Cunningham, Benedetta Armocida, Christopher J L Murray, Luca
Ronfani, Mohsen Naghavi, GBD 2019 Italy Causes of Death Collaborators” instead of “Lorenzo Monasta, Gianfranco Alicandro, Maja
Pasovic, Matthew Cunningham, Benedetta Armocida, Luca Ronfani, Mohsen Naghavi, GBD 2019 Italy Causes of Death Collaborators”. This
error has been corrected online
Breadwinner or caregiver? - how household role affectslabor choices in Mexico
No full textRecent volatility in the Mexican economy, has required households to alter patterns of participation in the labor force, voluntarily or not. The author uses panel data to examine patterns of labor force entry among adult men, and women with different household responsibilities, asking whether gender is a primary determinant, shaping these patterns. She finds that labor supply patterns are driven more by household role, than by gender. Heads of households, regardless of sex, behave similarly. Women who have neither spouses, nor children behave more like men, than like married women. They are also more likely than any other group to have inflexible, higher-paying jobs in the formal sector - which raises the question: Do employers discriminate, based on gender, or on household structure? She also detects a strong added-worker effect among secondary workers, a result not detected in the labor markets of developed countries that have social insurance programs. Finally she finds that wives'choice of sector during downturns, is subject to the households'earning needs, that husbands use informal wage, or contract employment as an employer of last resort, only in response to negative income shocks to the household, and that single mothers do not select the informal sector over the formal sector in response to either expected, or realized negative income shocks. The policy implications? Interventions that target women aren't necessarily appropriate, because women are heterogeneous. And programs that aid household heads - male or female - should be directed toward employment that will last beyond the economic shock.Environmental Economics&Policies,Labor Markets,Educational Policy and Planning,Labor Policies,Health Economics&Finance,Environmental Economics&Policies,Health Economics&Finance,Labor Markets,Educational Policy and Planning,Health Monitoring&Evaluation
Multi-view clustering for mining heterogeneous social network data
No full textPaper presented at the Workshop on Information Retrieval over Social Networks, 31st European Conference on Information Retrieval (ECIR'09), Toulouse, France, April 6-9, 2009Uncovering community structure is a core challenge in social network analysis. This is a significant challenge for large networks where there is a single type of relation in the network (e.g. friend or knows). In practice there may be other types of relation, for instance demographic or geographic information, that also reveal network structure. Uncovering structure in such multi-relational networks presents a greater challenge due to the difficulty of integrating information from different, often discordant views. In this paper we describe a system for performing cluster analysis on heterogeneous multi-view data, and present an analysis of the research themes in a bibliographic literature network, based on the integration of both co-citation links and text similarity relationships between papers in the network.Science Foundation IrelandConference detailshttp://ecir09.irit.fr/access.ph
Defining indigenous plants: some problematic species from Norfolk Island
No full textDefining indigenous species may at first appear straight forward; most botanical texts provide similar definitions. The consistent requirement of such definitions is the lack of human intervention in the occurrence of the species within the area under consideration. Islands around the world have been invaded by plant species brought to their shores by humans. They are also places where self-introduced species can be continually arriving, as they have done for millennia. Scrutiny of the situation on Norfolk Island (1200 km east of Australia) finds that the distinction between indigenous and introduced taxa is sometimes unclear. There is also inconsistency regarding the acceptance of self-introduced species as indigenous. This paper explores these issues and notes that they are more important than idle botanical curiosity, because control of introduced (weed) species is a major area of activity in managing protected natural areas
RRS James Cook Cruise JC064, 10 Sep - 09 Oct 2011. RAPID moorings cruise report
No full textThis cruise report covers scientific operations conducted during RRS James Cook Cruise JC064. Cruise JC064, departed from Falmouth on Thursday 1st September 2011 arriving Santa Cruz de Tenerife Saturday 10th September to pick up extra members of the scientific party and arriving again in Santa Cruz on the 9th October. The purpose of the cruise was the refurbishment of an array of moorings on the mid-Atlantic Ridge and off the Moroccan Coast at a nominal latitude of 26.5°N. The moorings are part of a purposeful Atlantic wide mooring array for monitoring the Atlantic Meridional Overturning Circulation and Heat Flux. The array is a joint UK/US programme and is known as the RAPID-WATCH/MOCHA array. Information and data from the project can be found on the web site hosted by the National Oceanography Centre Southampton http://www.noc.soton.ac.uk/rapidmoc and also from the British Oceanographic Data Centre http://www.bodc.ac.uk.
The array as deployed in 2011-2012 consists of a total of 17 moorings, 16 landers and a single inverted echo sounder. The moorings are primarily instrumented with self logging instruments measuring conductivity, temperature and pressure. Direct measurements of currents are made in the shallow and deep western boundary currents. The bottom landers are instrumented with bottom pressure recorders (also known as tide gauges), measuring the weight of water above the instrument.
The RAPID naming convention for moorings is Western Boundary (WB), Eastern Boundary (EB) and Mid‐Atlantic Ridge (MAR) indicating the general sub‐regions of the array. Numbering increments from west to east. An L in the name indicates a bottom lander, M indicates a mini‐mooring with only one instrument, H indicates a mooring on the continental slope. During JC064 we recovered: MAR0, MAR1L4, MAR1, MAR2, MAR3, MAR3L4, EB1, EB1L7, EBHi, EBH1, EBH1L7, EBH2, EBH3, EBH4, EBP2, EBH5, EBM5. We did not recover EBM1, EBM4, EBM6, EBH1 and MAR3. We deployed: MAR0, MAR1L7, MAR1, MAR2, MAR3, MAR3L6, EB1, EB1L7, EBHi, EBH1, EBH1L8, EBH2, EBH3, EBH4, EBP2, EBH5. A sediment trap mooring NOGST was also recovered and redeployed for the Ocean Biogeochemistry and Ecosystems Group at the NOCS.
CTD stations were conducted at convenient times throughout the cruise for purposes of providing pre and post deployment calibrations for mooring instrumentation and for testing mooring releases prior to deployment.
Shipboard underway measurements were systematically logged, processed and calibrated, including: waves (spectra of energy and significant wave height), surface meteorology (air pressure, temperature, wind speed and direction and radiation (total incident and photosynthetically active), 6m‐depth sea temperatures and salinities, water depth, navigation (differential GPS measurements feeding two independent and different receivers, heading, pitch and roll, gyro heading and ships speed relative to the water using an electromagnetic log). Water velocity profiles from 15m to approximately 800m/300m depth were obtained using a ship mounted 75/150 kHz acoustic Doppler current profiler. Seawater samples from CTD stations and of the sea-surface were obtained for calibration and analysed on a salinometer referencing these samples against standard sea water. For velocity data (wind and currents) measured relative to the ship considerable effort was made to obtain the best possible earth referenced velocities.
Seven APEX argo floats supplied by the Met Office were deployed at preassigned locations, filling gaps in the network
A comparison of factors in school adjustment of transfer and resident students in Lompoc Senior High School, Lompoc, California, 1966
No full textThe poetical works of the Ettrick shepherd : including the Queen's wake, Pilgrims of the sun, Mador of the moor, Mountain bard, &c. &c. /
No full text"With a life of the author by Professor Wilson ...": t.-p. (v. 1-4). "Wilson's Life never appeared." Batho, E. C. The Ettrick shepherd. p. 219."Reminiscences of some of his contemporaries [Sir Walter Scott, Wordsworth, Allan Cunningham, Galt, Southey, Lockhart, Sym] by the Ettrick shepherd": v. 5, p. [xcvi]-cxxvi.Each volume has added t.-p., engraved.Mode of access: Internet
Molecular phylogeny of the mud lobsters and mud shrimps (Crustacea: Decapoda: Thalassinidea) using nuclear 18S rDNA and mitochondrial16S rDNA
No full textArticle published in: Invertebrate Systematics, 2002, 16, pp. 839- 847
- …
