147 research outputs found
Here be stories: exploring maps in children’s books with medieval cultural treasures and The Stone Feather lighting the way
No full textThrough my creative practice in writing the children’s novel The Stone Feather,inspired by Domesday Book; the creation of my own artworks, including maps of thefictional world I have created; and my research into medieval ‘cultural treasures’ – inparticular manuscripts and mappae mundi – I have discovered a fresh lens throughwhich to explore and illuminate the presence and purpose of maps in children’s books. Ifocus on interlace as a ‘perceptual mode’1 and ideas around the ‘meditativeengagement’2 that interlace design encourages, in relation to the roles that literary mapsplay, as well as its impact on my own process as a writer.My thesis is presented within the context of contemporary publishing and theneed for children to develop a high level of visual literacy in a world dominated byvisual images. My critical commentary includes a review of children’s books thatfeature maps and ‘cultural treasures’ as an integral part of imaginative world buildingand explores the notion of the ‘author as curator’.As an adventure story for 8-12 year olds with an ethical heart, The Stone Featheroffers children the opportunity to reflect on different models of masculinity, compassionand strength – aspects of this original work that are valuable and timely
Co-existing pseudo-planar and saddle conformers of tetramethyl tetraaza[14]annulene platinum complexes: X-ray crystallographic studies on [PtII(tmtaa)] and trans-[PtIVCl(2)(tmtaa)]
No full textOrange platelets of [Pt(tmtaa)], where H₂tmtaa = 6,8,15,17-tetramethyl-5,6,9,14,15,18-hexahydrodibenzo[b,i ][l,4,8,11]tetraazacyclotetradecine, show the expected ‘pseudo-planar’ centrosymmetric macrocyclic conformation but red needles of another [Pt(tmtaa)] modification and purple trans-[PtCl2(tmtaa)] both show saddle-form co-ordination with the metal ion only 0.046(1) Å (Pt²⁺) or 0.024(5) Å (Pt⁴⁺) above the N4 plane; X-ray powder diffraction reveals similar dimorphism for [Pd(tmtaa)] but not for [Ni(tmtaa)].Rowena L. Paul, Stephen F. Gheller, Graham A. Heath, David C. R. Hockless, Louis M. Rendina and Meta Stern
Characterisation of two members of a macroschizont gene family, Tashat1 and Tashat3, from Theileria annulata
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
"Gäller att passa in i bilden eller så är man fel på det..." En kvalitativ studie i mäns upplevelse av att bli ofrivilligt far
No full textABSTRACT Author: Rowena E. Nystrand Title: “It’s a case of fitting into the picture, otherwise you’ve failed …” A qualitative study of men's experience of becoming an involuntary father (translated title) Supervisor: Anders Östnäs Assessor: Håkan Jönson The background to this paper lies in a media interest in the problems of unwilling fathers but with very little research having been done in the area. During the 1990’s, interest in male research increased but the focus on the maternal role still dominates in 2010.The aim of the paper is to describe and analyse men’s experiences of becoming unwilling fathers. More specifically, by means of interviews, the paper endeavours to capture the experience of involuntary fatherhood: how it affects the individual in his different roles, society’s views of unwilling fathers, what sort of support society can offer and how the relationship to the child’s mother is affected. The study is based on a qualitative approach with four semi-structured interviews. Two of these are with unwilling fathers and two are with researchers in the area of male parenting/involuntary fatherhood. The result showed that all men can become unwilling fathers, that the reasons for unwillingness may be several and that the experience can vary. Common factors are powerlessness and a crisis process. The relationship to the child’s mother is generally affected and the relationship is seldom maintained. Support from society may vary, depending on how willing the man is to accept help, depending on the resources of the local municipality and also the amount of commitment there is to the issue. More research in the area is desirable, which can result in the level of knowledge among professional people being raised. This can ultimately lead to unwilling fathers being able to get help in their roles both as men and in their roles as fathers. Key words: Qualitative Study, Involuntary Fatherhood, Parenting, Responsibility, Crisis Process, Powerlessness
Correction for Millership et al., Increased lipolysis and altered lipid homeostasis protect -synuclein-null mutant mice from diet-induced obesity
No full textCorrection for “Increased lipolysis and altered lipid homeostasis protect γ-synuclein–null mutant mice from diet-induced obesity,” by Steven Millership, Natalia Ninkina, Irina A. Guschina, Jessica Norton, Ricardo Brambilla, Pieter J. Oort, Sean H. Adams, Rowena J. Dennis, Peter J. Voshol, Justin J. Rochford, and Vladimir L. Buchman, which appeared in issue 51, December 18, 2012, of Proc Natl Acad Sci USA (109:20943–20948; first published December 3, 2012; 10.1073/pnas.1210022110). The authors note that the author name Ricardo Brambilla should instead appear as Riccardo Brambilla. The corrected author line appears below. The online version has been corrected
Impacts of climate change on the planktonic food web in the European Arctic
No full textAcross the globe, planktonic consumer resource interactions are being altered by changing environmental conditions. Climate change is altering the distributions of both phytoplankton and zooplankton, thus modifying the base of the food web, which has consequences for the feeding environment of consumers and predators with knock on effects for population viability. In the Arctic, inflows of Atlantic waters are strengthening, which is increasing sea surface temperatures, weakening stratification and transporting temperate and sub-Arctic plankton species deeper into the Arctic interior. In other regions, increased sea ice melt is freshening and stratifying the water column, causing phenological shifts to phytoplankton blooms. These heterogenous alterations have direct effects to zooplankton feeding and the wider food web. Our knowledge of the responses of zooplankton feeding within the planktonic Arctic food web is limited due to the highly seasonal nature of the Arctic environment that adds to food web complexity. Untangling this complexity remains a challenge if we are to accurately predict and understand the functioning of marine food webs in the Arctic. In this thesis I aim to resolve the spatial and interannual feeding ecology the calanoid copepods Calanus in the Arctic. I use multivariate statistical techniques on an abundance Continuous Plankton Recorder dataset to define the feeding environment for Calanus and a dual biomarker approach of isotope analysis and DNA gut content analysis to estimate the feeding strategies of Calanus. These dietary descriptors are contextualised by environmental parameters derived from CTD casts, remote sensing databases and models. Changes to the food environment for Calanus were variable on both spatial and interannual scales, these include differences in net primary production, and in the phytoplankton assemblage. The drivers of these changes were factors that altered the strength of stratification, which impact nutrient delivery and primary production in the surface. Despite these changes, Calanus were consistently omnivorous, occupying the trophic level 2.5. In some regions, the smaller C. finmarchicus/glacialis had a slightly higher TP than the larger C. hyperboreus, likely due to the earlier termination of feeding by the latter. In water masses with low productivity and strong stratification, the niches of these two Calanus groups were separated, indicating different resource utilization. Whereas in highly productive regions, there was high niche overlap, suggesting the sharing of resources. The high plasticity of Calanus indicates that, providing the nutritional quality of dietary items is maintained, they should continue to transfer essential lipids to the rest of the food web despite the regionally specific changes in stratification and net primary production rates
Challenges in the business models of creative professional service firms
No full textRecent studies have shown that professionals in the built environment need new or improved business strategies to survive in increasingly dynamic and competitive environments. To gain insight into how professional businesses can be successfully reshaped, a profound understanding of their business models is necessary. So far, business model research in project-based organisations has focused on large companies that are primarily profit-oriented. Work that addresses the business challenges of small, creative service firms is extremely limited. This study aims to develop knowledge around the business models of architectural firms by focusing on their value propositions, value creation and value capture. Iterating between business model literature and empirical data from 41 semi-structured interviews with Dutch architects and clients, architectural firms’ business models were systematically examined regarding theirconfigurations and outcomes. This resulted in an overview of key business model components, their interrelationships and accompanying challenges for architectural firms. The study contributes to theory and practice by the development of a strategic decision making framework that specifically addresses the business model challenges of small creative service firms. The framework helps practitioners to enhance their business strategies and to develop new or improved business models with increased benefits.Design & Construction ManagementManagement in the Built Environmen
The history and development of the Georgia Chapter of the American Association of Social Workers, 1944
No full textCharacterisation of two members of a macroschizont gene family, Tashat1 and Tashat2, from Theileria annulata
No full textTheileria annulata is a protozoan parasite of cattle, that causes the disease tropical theileriosis throughout sub-tropical regions of the Old World. Theileria parasites have the ability to immortalise the host leukocyte they infect causing clonal expansion and dissemination of infected leukocytes throughout the host. This property has allowed the development of an in vitro system for the culture of bovine cells infected by the macroschizont stage of the parasite. In addition, differentiation of the parasite towards the next life cycle stage, the merozoite, can be induced in culture. The signals that cause the macroschizont to differentiate into merozoites are not fully understood, although it is known that this event is associated with a major elevation in merozoite gene expression (Shiels et al., 1994). Recently a small family of parasite genes that are negatively regulated early during differentiation to the merozoite were identified. One member, known as TashAT2 contained predicted AT hook DNA binding motifs and was shown to be localised to the host cell nucleus. It has been postulated that the TashAT2 polypeptide may play a role in the regulation of macroschizont or modulation of host cell gene expression (Swan et al., 1999). The focus of this project was to characterise TashAT1, a second member of the TashAT gene family. To this end, the TashAT1 gene was sub-cloned and sequenced and mapped to a region of the genome containing TashAT2 and a third Task AT gene, TashAT3. The 1.4kb open reading frame of TashAT1 was virtually identical to the five prime end of TashAT3, indicating that TashAT1 or TashAT3 (TashAT1/3) were derived from a recent duplication event. The predicted amino acid sequence of TashAT1/3 contained four AT hook motifs, a nuclear localisation signal and a signal sequence. Northern blot analysis revealed that TashAT1, TashAT2 and TashAT3 mRNA were down regulated early, during differentiation to the merozoite in vitro. However, no down regulation was observed for any of the TashAT transcripts in a cell line that was severely attenuated with respect to parasite differentiation. Sequence analysis of the upstream regions of TashAT1/3 identified a motif element (TashUM) located 43bp upstream of the putative transcription start site of TashAT1/3 that was highly related to a sequence upstream of TashAT1 and another, unrelated macroschizont gene, Tash1. Preliminary electromobility band shift analysis of TashUM revealed that it bound to a factor found in host and parasite enriched nuclear extract, which appeared to decrease in abundance as the parasite differentiated towards merogony. Antisera generated against a region of TashAT1 failed to recognise a TashAT1 polypeptide by Western blot analysis. However, a 180kDa polypeptide that was down regulated with respect to merogony and co-localised to the host nucleus was specifically recognised. The detected polypeptide was identified as TashAT3 on the basis of size, sequence identity and predicted expression profile. Immunofluorescence analysis showed that the anti-TashAT1 antisera reacted against both the host nucleus and parasite. This reactivity was lost as the parasite differentiated to the merozoite. The host reactivity was probably due to recognition of TashAT3, while it could not be concluded that the parasite reactivity was directed against TashAT1. Taken together, the results indicated that TashAT3 and possibly TashAT1 are additional candidates for parasite encoded factors that are translocated to the host nucleus, bind to DNA and alter host cell gene expression. This modulation of gene expression could directly or indirectly alter the phenotype of the host cell and be involved in parasite dependent regulation of leukocyte cell division
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