633 research outputs found

    Long terminal repeats act as androgen-responsive enhancers for the PSA-Kallikrein locus

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    The androgen receptor (AR) signaling pathway is a common therapeutic target for prostate cancer, because it is critical for the survival of both hormone-responsive and castrate-resistant tumor cells. Most of the detailed understanding that we have of AR transcriptional activation has been gained by studying classical target genes. For more than two decades, Kallikrein 3 (KLK3) (prostate-specific antigen) has been used as a prototypical AR target gene, because it is highly androgen responsive in prostate cancer cells. Three regions upstream of the KLK3 gene, including the distal enhancer, are known to contain consensus androgen-responsive elements required for AR-mediated transcriptional activation. Here, we show that KLK3 is one of a specific cluster of androgen-regulated genes at the centromeric end of the kallikrein locus with enhancers that evolved from the long terminal repeat (LTR) (LTR40a) of an endogenous retrovirus. Ligand-dependent recruitment of the AR to individual LTR-derived enhancers results in concurrent up-regulation of endogenous KLK2, KLK3, and KLKP1 expression in LNCaP prostate cancer cells. At the molecular level, a kallikrein-specific duplication within the LTR is required for maximal androgen responsiveness. Therefore, KLK3 represents a subset of target genes regulated by repetitive elements but is not typical of the whole spectrum of androgen-responsive transcripts. These data provide a novel and more detailed understanding of AR transcriptional activation and emphasize the importance of repetitive elements as functional regulatory units.Mitchell G. Lawrence, Carson R. Stephens, Eleanor F. Need, John Lai, Grant Buchanan, and Judith A. Clement

    Data and code for "Runoff variability in the Truckee-Carson River basin from tree rings and a water balance model"

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    Data, supplemental material and R computer code for the paper "Runoff variability in the Truckee-Carson River basin from tree rings and a water balance model." The paper, submitted to Earth Interactions, illustrates reconstruction of point runoff in a mountain watershed from a combination of tree-ring chronologies of total-width, sub-annual-width and delta blue intensity chronologies. The reference for the paper is as follows:Meko, D. M., Biondi, F., Taylor, A. H., Panyushkina, I. P., Thaxton, R. D., Prusevich, A. A., Shiklomanov, A. I., Lammers, R. B. and Glidden, S. (submitted, 2024). Runoff variability in the Truckee-Carson River basin from tree rings and a water balance model. Earth Interactions.For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to [email protected]</p

    The evolution of population III stars: a study of selected models with regard to the early enrichment of the interstellar medium

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    Modelling of the evolution of 15M[sub]sun, 10M[sub]sun, 5M[sub]sun arid 2M[sub]sun stars has been carried out at three different initial compositions that could be thought of as 'population III' - Z=10⁻¹⁰, 10⁻¹⁰ and zero. The effects of mass loss due to a stellar wind have been included in the modelling, the mass loss rates taken from an empirical formula by Nieuwenhuijzen and de Jager (1990). An original and amended form of a FORTRAN 77 quasi-hydrostatic evolutionary code, written by Dr. T. R. Carson and modified by the author of this work, were used to create and evolve the models. The aims of the evolutionary modelling were to confirm that the sensitivity of stellar parameters to the initial metallicity of a star continues to a lower level of Z than has previously been thought, and to provide some evidence that nucleosynthesis and subsequent mass loss in a population III is a plausible mechanism for the prompt enrichment of the early interstellar medium. We find that there is sensitivity of stellar parameters to the initial metallicity Z in the range 0≤Z≤10⁻¹⁰ but this is less apparent in models of intermediate or low masses. During the evolution of the models, no significant loss of enriched material occurs, due to low rates of mass loss and the absence of any 'dredge-up' of enriched material. The results of the modelling were connected with bare-core studies of helium stars to determine the amount and composition of the material that would be returned to the interstellar medium during the endstates of the models. Functions for the rates of enrichment due to a population III and the distribution of mass in a population III were determined and their implications examined. From our results, we find that the enrichment of the interstellar medium due to population III stars must have come about entirely due to rapid mass loss during endstates, such as supernovae, as opposed to a slower rate of mass loss during the lifetime of the stars. We also find that our results indicate that the level of helium enrichment from a population III would be negligible compared to that due to cosmological mechanisms. Our distribution functions for a population III indicate that massive stars are very much fewer by number that would be expected for stars in our epoch. Overall, we can consider that a primordial population III can be considered a plausible mechanism for a prompt enrichment of metals in the early universe, but not for the prompt enrichment of helium

    Review of "Rachel Carson: A Witness for Nature"

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    Not peer reviewedBook Revie

    Prostate Cancer-Associated Kallikrein-Related Peptidase 4 Activates Matrix Metalloproteinase-1 and Thrombospondin-1

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    National Health and Medical Research Council of Australia (#1010144) and the Cancer Council Queensland (#614273, #1064484−Morris Ronald Huggett Research Project). J.C. is a National Health and Medical Research Council Principal Research Fellow (#1005717). R.F.-L. was a recipient of a Queensland Government Smart Futures Ph.D. scholarship, Australian Postgraduate Award, and scholarships from Queensland University of Technology (QUT) and the Institute of Health and Biomedical Innovation (QUT)

    Land lease between Dominguez Estate Company and Ng. Soon Jip, July 1937-June 1938

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    Lease describes agreement terms beginning July 1, 1937 ending June 30, 1938 for 30 3/4 acres of the M. R. Dominguez allotment of Rancho San Pedro with a yearly rent of $615. Land is described as connecting the south line of the Carson allotment and the east line of the Los Angeles River Flood Control. Lease is signed by the company and lessee. A portion of the lease relating to subletting is stricken. Additional typescript is added to the lease referring subletting and to alien land laws and the company's policy to maintain record of birth certificates or naturalization documents as a part of the agreement

    W. R. Myers High School 2021

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    The annual publication of the students of W. R. Myers High School Taber, Alberta. (Volume 2020-2021)pdfHers High school - move from being a victim to being a "survivor" and even to becoming a "thriver" - be "stress hardy" adapting to whatever life sends, and for some, even evidencing "post-traumatic growth" RESILIENCE reflects the ability to - bounce back - beat the odds -transform one's emotional and physical pain into something "positive" - evidence of a relatively stable trajectory of healthy functioning across time RESILIENCE is the process ■ and outcome of successfully ' adapting to difficult or challenging life circumstances. RESILIENCE is the capacity of people to effectively cope with, adjust, or recover from stress or adversity. RESILIENCE reflects the ■ ability to maintain a stable W equilibrium and relatively stable healthy level of psychological and physical functioning, even in the face of highly disruptive stressful and traumatic events. all information on this page is cited from Donald Meichenbaum, Ph.D. (melissainstitute.org) Hughes, Adam llczynski. Corrie Jensen, Arica Kallen. Amber Kehler, Noel Astalos, Lisa Bennett, Sam Bodnar, Kristin Bowes, Greg Braun, Reanne Brugger, Caitlyn Dupuis, Sean Ellingson, Jessie Enns, Lorena Friesen, Dale Gedny, Trina alladay, Quintina Hansen, Lana Harding, Mark Haslam, Janae McClelland, Stacy Moriyama, Hyrum Morrow, Adara Nguyen, Chris Pickerell, Lori Lavoie. Rene Leavitt, Douglas Luchanski, Tim Machacek, Tanis Makarchuk, Andrea Planger, Melissa Pon, Ken Ressler, Jessica Schnoor, Maxine Skov, Jocelle (Missing Photos: Chris Archer (TMS), Heather Brantner, Laurie Chomany, Shane Hawke, Cristine Lumley) L Sowinski, Lisa Vanmeetelen, Linda Wasylowich, Kimberley Whipple, Dalziel Hello Rebels Family! It's easy to believe that the rich and famous are born well...rich and famous. Not so! On the way to being famous...Gwen Stefani worked at Dairy Queen, Madonna was fired from Dunkin' Donuts, Brad Pitt handed out flyers wearing a chicken suit for El Polio Loco, Rachel McAdams was a server at McDonald's and Beyonce was swept up hair in her mother's salon. There are jobs you will have before you 'make it' too. Some you will enjoy. And some - not so much. On my way to becoming a teacher I was a waiter, a landscaper, a tree planter, and a bartender. Some of these jobs I liked and some I hated. But ALL of these jobs brought me to the profession I love and shaped who I have become. At W.R. Myers High School we are proud of being a school where every student can find an avenue for success and in being part of a community where everyone in the Rebel family strives to find the best in themselves and others. As Christian Larson said, "Believe in yourself and all that you are. Know that there is something inside you that is greater than any obstacle." Remember that you are the star of your own life and that, with hard work, your dreams will become reality! Take care, Ken Pon Principal Wow! What a year! I chose "REBEL RESILIENCE" as the yearbook theme this year as I thought it was rather fitting given our current 'COVID-1 9' situation. Some of you are already VERY RESILIENT, while others may feel like you are not. One thing is for sure - you can always WORK on becoming MORE resilient. Here are 10 ways you can work on becoming more resilient: Have the courage to be imperfect Take time for yourself Sign up for that course, join that club Be active every day in as many ways as you can Spend time with people who make you feel good Laugh out loud each day Invite your neighbor (friend) over for a cup of tea (chat) Do one thing now that you've been putting off Focus more on things you can control Remember, this too shall pass (~https://wayahead.org.au/get-the-facts/building-resilience/) Thank you to all those who gave me a big smile (or at least didn't run away) when I put the camera in front of your face! I apologize to those teams I missed getting photos of (that actually had the opportunity to play). Because this year is unlike any other, I also decided to change up the color scheme from the traditional red/black/yellow! I would love some feedback on this decision (love it/dislike it etc). A huge shout-out to a stellar group of grade 9's who helped me with the yearbook in June (Madisen and Bryden O'Connor, Kiernan Gyepesi, Will Evanson, Madison Reid, Heston Bevans and Allen Clements). Thank you specifically to Bryden O'Connor for creating the color graphic used throughout the yearbook. Some of the quotes found through out the yearbook were from the survey you filled out in the spring, which in, most cases, does not have the author information and therefore simply states the grade level the quote came from. All other quotes with Author Unknown" were found online and in most cases didn't have any author information either. In any case, my hope is that they will either put a smile on your face, make you go 'hmm' or possibly even take time to pause and reflect on the message being shared. Enjoy! 5 Abela, Abby Acosta, Aielle Baker, Jaryn Bevans, Heston Boyd-Foster, Ryu Brown, Keira Brown, Mackenzie Buchta, Jayce Camiros, Christian Camiros, Christian Clarkson, Lliam Clements, Allen Collier, Olivia Coon, Kason Damberger, Hunter De Haan, William Dearing, Tristen Dueck, Vickie Duell, Kade Ellingson, Liam Estremos, Gene Eusebio, Gracia Evanson, Will Farwell, Aiden Froese, Alan Geeraert, Maggie Guimond. Katie Gyepesi, Kiernan Hansen, Tayla Higa, Brock Holst, Bentley Hull, Xavier Jennison, Evan Jensen, Carter Johnson, Austin Kast, Donovan Klassen, Cody Koizumi, Evan Kramer, Vance Kuypers, Logan Liptak, Kayce Livingstone, Maren Loewen, Devan McClenaghan, Bronwyn Nelson, Emma Neustaeter, Abraham Nilsson, Mackenzie O'connor, Bryden O'connor, Madisen 6 Gr 9 - Favorite Shoes 2% Guess 28% Vans 4% Under Amour 8% Adidas Near 52% Nike 4% Payne, Riley Rabaca, Joshua Reid, Madison Schnarr, Tessa Stronski, Denim Van Beers, Kinlee West, Megan (Photo missing for: Seirge Cabilan) Williams, Leland Wise, Parker Wright, Kahil Young, Declan Gr 9 - Favorite Jeans 6% Gr 9 - Favorite Athletic Clothing 2% 9% Puma Rdidos 20% Under Amour 11% Champion 46% Nike 48% American Cagle Gr 9 - Time Spent Online (Daily) True Religion 12% Guess Silvers 24% Levi's 6% Wranglers 2% 7 for All Mankind 6% Lululemon Gr 9 - Most Used App 40% TikTok 7 Abela, Brennan Bailey, Jenna Becker, Izzy Bennett, Addyson Blasetti, Matteo Bolig, Hudson Buchta, Shaylee Bullock, Brooklyn Burns, Robert Camps, Lisa Charlton, Dru Colby. Avery Couch, Kayli Coutts, Jett Daisley, Kyron De Haan, Simon Debona, Vinnie Denhollander, Alexis Dongworth, Carson Duncan, Chloe Duncan, Tatum Edlund, Olivia Embro, Daniel Erick, Alyssa Feininger, Kali Friesen, Evan Gedny, Lexi Giesbrecht-Bael, Zackery Gillespie, Justice Gulay, Wilford Hackywicz, Robyn Hall, Shawney Harris, Teya Heger, Johnathon Hirney, Alexis Hofer, Paige Holcek, Emma Hughes, Thatcher Hutzul, Taylor llczynski, Sydney Johansen, Joshua Kane, Hailey Klassen, Danae Klemen, Kayleigh Klimchuk, Ashton Knight, Hudson Kroeker, Linda Leismeister, Zach Lucas, Emily 8 Puma Under Amour Pierson, Brigam Porter, Logan Postma, Zaedyn Rabusic, Evan Rasmussen, Lily Rios, Belinda Robbins, Seth Schnoor, Owen Schortinghuis, Kara Skiba, Walker Slade, Austin Smith, Amy Mouland, Noah Munshaw, Michael Neustaeter, Sarah Nilsson, Josie Peters, Geoffery Peters, Kimberly 35% Nike Maillet, Kaitlyn Makarchuk, Alex Marko, Keith Martinson, Colten Marty, Aidan Mehlhaff, Ryden Merkl, Reese 37% Lululemon Champion 6% Adidas EV ^ ^J^E^K Speer, Mackenzie Stanley, Brooklyn _ stobert. Jack Gr 10 - Favorite Shoes Torrie, Brooklyn 6% Sketchers Torrie, Colby Van Den Elzen, Mira Warkentin, Mathias Werewka, Morgan West, Emma Wiebe, Amanda Worme, Colin Wright. Kaden (Photo missing for: Tristyn Chief, Viktoria Feist, Cody Guimond, Tyler Gurney, Vanessa Horvath) 9 Gr 10 - Favorite Athletic Clothing Acosta, Ajelle Anderson, Avery Anderson, Tyler Astalos. Keira Banga, Chris Banman, Frank Benedicto, Julie Bennett, John Bentson, Shae Binondo, Malcolm Blindback, Kwynn Bos. Olivia Broadbent, Cohen Brown, Brylin Campbell, Alyssa Campbell, Kira Camps, Kevin Cannady, Dylan Carlsen, Talaina Carver, Emily Cetinski, Rylan Coney, Camryn Crowson, Cadence Cruz, Alisson David, Elizabeth Davis, Logan Eckert, Wyatt Ellingson, Christian Fehr, Ulanda Fisher, Cody Froese, Andrew Gamache, Cheyenne Garner, Shea Gonzales, Cassandra Hamm, Reuben Hammond, Daimen Hansen, Blaze Hansen, Colby Harker, Alysha Heezen, Andrea llczynski. Ally James, Kyler Jensen, Chase Jensen, Sydni Jensen, Taia Jensen, Tyler Johnson, Zachary Jones, Bryanne Kabatoff, Josie 10 CD Keeping, Nathan Kientopp, Noah Klassen, Brandan Klassen, Brendan (Photo missing for: Jay Jay Buitenhuis, Zack Calestagne, Alvino Froese. Mitchell Malinsky, Owen Parks, Jayden Prosper) Gr 10 - Most Used App Gr 10 - Favorite Jeans Snapchat 100% 32% Instagram 43% American Cagle Gr 10 - Favorite Movie App 36% TikTok Amazon Prime Thrasher Pink 10% Other Vintage 100% Billabong 4% Volcom 35% American Cagle 20% Carhartt Gr 11 - Daily Time Online 7% 1 -2 hours 6+ hours 40% 2-3 hours 14% 3-4 hours 4-5 hours 28% Gr 11 - Favorite Casual Clothing Disney* 100% 75% Netflix Guess Silvers 100% 36' Levi': Gr 11 - Favorite Athletic Clothing Other 2.5% Puma Zyia Gr 11 - Favorite Shoes 24% Under Amour >% Sketchers Other Under Amour New Balance Nike 43% 27% Vans 27% Lululemon Gr 11 - Most Used App 10% Adidas 33% Snapchat Other 100% 12 TikTok Uri campus Educ Our Off-Campus programing is "second to none" here at WR Myers! With Mrs. Heather Brantner at the helm, you can be sure you will have every opportunity to learn outside of school, through Work Experience, apprenticeship placements (RAP), Green Certificate (farm-related) specializations. Mrs. Brantner would like to send a special shout-out to all of the employers, community members, and trainers we partner with! Their willingness to work with our students ensures we get real-life learning and training while in school. 13 "Never take your life too seriously. You'll never get out of it alive." ~ Elbert Hubbard (Grade 9 Student) esses ?sb! "If you are not first, you're last." (Grade 10 Student) 14 5 5 it's a COVID Sometimes it's fun to do the impossible! ~ Wa/t Disney (Grade 10 Student) "Life is short, stunt it!" (Grade 11 Student) 15 Jenna Bailey Brooklyn Bullock Lisa Camps Alyssa Erick Gracia Eusebio Kali Feninger Vanessa Horvath Reese Merkl Mackenzie Nilsson Belinda Rios Kinlee Van Beers Megan West John Bennett Heston Bevans Ethan Chapple Andrew Froese Justice Gillespie Chase Jensen Scoreboard Covid 19-1, JV/SV Boys-C A Message ■ from ou„r awth^lOtiC DiPOCtO It was a sad reality that we all had to face this year with little to no athletic competitions across the Province for High School Sport. But very thankfully, and in true Rebel Spirit, we made the most of the situation and were able to organize and provide our student-athletes with a few opportunities to participate in sport. The Rebels made teams and practiced as much as they possibly could in football, volleyball, cross-country, golf, basketball, and curling. Unfortunately, a few of our traditional sports were not able to get off the ground in the Spring, but hopefully that will only fuel the fire of the up and coming athletes for next season! We want to give a big thanks to all those student-athletes and coaches who committed to one or more of our teams during these tough, unprecedented circumstances, and a special shout out to all the Grade 1 2 student-athletes for all of their years of dedication to High School Sport! Gr 12 - Favorite Jeans Gr 12 - Time Spent Online (Daily) 39% America Cagle 2% Rock n' Roll 17% UUronglers 10% Guess Rriat 24% Levi's 19% 0-1 hour 39 5+ hours Gr 12 - Favorite Casual Clothing 16% 3-4 hours 7%, 1-2 hours Gr 12 - Most Used App Gr 12 - Favorite Movie App Crave 19% 4-5 hours 22% Carhartt Snapchat 35% 2% Volcom 2% Silvers 24% Vintage Billabong Instagram Disney* 100% 43% American Cagle 2.5%. Amazon Prime 62% Netflix 26% TikTok 100% 19 academic Awards The WR Myers Academic Awards Night would not be possible without the many and generous contributions from our local Taber businesses and families. Our community has donated 16 885 this year! Unfortunately, we could not celebrate the academic successes of our students with our annual evening event. But we still took the time acknowledge these amazing and talented students on their academic accomplishments! We hope to return to our evening event next year! Thank you to our sponsors - Alberta Teachers Association Local #4, Mrs. Alyson Archibald and Mr. Gary Lyckman, Mr. Brian and Mrs. Valerie Anderson, Avail CPA, Baldry Sugden Law Office .Canadian Natural Resources Ltd. Chin Ridge Farms Ltd., Mr. Jerry and Mrs. Joyce Fawns, 1st Choice Savings and Credit Union, Future Focus, Glacier Communications, Horizon School Division No. 67, Institute of Chartered Accountants of Alberta, Inter Pipe Fund, Mr. Jae Hun Shim (Shim Law), Dr. and Mrs. Tyler Johnson, K-40 Club, Kinsmen Club, Kiwanis Club, Lamb Weston, McDonald Chevrolet Ltd., Merit Contractors Association, Moonlite Graphics, PixelBoom Media Ltd., 20 Royal Bank, Rogers Sugar/Lantic Inc., Royal Canadian Legion Branch #20, Royal Canadian Legion Ladies Auxiliary, Ryan Holcek Memorial Society, Saunders Farm, Saunders Insurance, Southland Funeral Chapel, Taber Clinic, Taber Co-Op, Taber IGA, Taber Japanese Canadian Club, Taber Oilmen's Association, Taber Times, Taivin Oil Field Supply, Mr. Larry and Mrs. Marion Valgardson, Western Financial Group, W & G Tschritter Farms, W. R. Myers Band Parents Association 21 BN MS 9 IC? ® "Nothing fades as fast as the future, nothing clings like the past." (Grade 10 Student) 22 ^Ot tyaslt Rebel spi "The past is in your head and the future is in your hands." (Grade 10 Student) "The moment you give up is the moment you let someone else win." (Grade 11 Student) "To the well organized mind, death is only just the next great adventure." ~A/bus Dumb/edore (Grade 9 Student) 1 23 Olivia Edlund Andrea Heezen Bryanne Jones Madison Layton Beth Nelson Shylynn Rice Belinda Rios Elisa Rios Kassidy Virostek Abby Wood Jenna Bailey 27 "He that stands for nothing, will fall for anything." (Grade 10 Student) 28 "Some things break your heart but fix your vision." (Grade 11 Student) "Courage isn't having the strength to go on, it is going on when you don't have the strength." ~ Napoleon Bonaparte (Grade 11 Student) "The most beautiful things in the world cannot be seen or even touched, they must be felt with the heart." ~ Helen Keller (Grade 11 Student) "You miss 100% of the shots you don't take." ~ Wayne Gretsky (Graded, 10 and 11 Students) "You do not find a happy life, you make it." (Grade 12 Student) M "Confidence is not B 'They will like me.' Confidence is TH be fine if they don't'." (Grade 12 Student) ■ "Appear weak when you are strong, and r strong when you are Weak." (Grade 11 Student) "If you can park your truck and not look back at it as you walk away, you bought the wrong truck." (Grade 11 Student) "Money doesn't ■ buy happiness W but it'll buy a diesel. I've never seen a sad person rollin' coal." (Grade 11 Student) ma "People say nothing is impossible, but I do nothing every day." F> range from fitness model to hungry child in a chocolate factory. It's balance!" ~ Author Unknown 9 ' IIIHIIIII eating habits 36 37 The W.R. Myers Concert and Stage Bands were unable to perform this year due to COVID, but we were lucky enough to still be able to play our instruments. Vince Gassi, a composer from Toronto, was commissioned by the W.R. Myers Band Parent Association to write a piece for the Concert Band. The band students met with Mr. Gassi via Zoom in October to talk to him about the piece and the writing process. He completed the piece for us in January and we began working on it. Again the band students met with Mr. Gassi on Zoom for him to listen to us play and give feedback. But unfortunately due to the COVID restrictions, we were unable to premier the piece. Hopefully, next year we will be able to play Tomorrow Shines Soon. Andrea Makarchuk "Biology 20, Biology 30 and Wilderness is where it is at, if you can hardly wait to get your hands on these dissecting tools!" 38 "Happiness can be found in even the darkest of times, if only one remembers to turn on the light." (Grade 17 Student) a memory. (Grade J2 Student) 4 ^^ "Do the best you can until you know better, then when you know better, do better." (Grade 12 Student) "We weren't made to be perfect, we were made to be real." (Grade 11 Student) 39 "Sometimes you will never know the value of a moment until it becomes "During the day I don't believe in ghosts. At night I become a bit more open-minded!" ~Author Unknown "I walk around like everything is fine, but deep down, inside my shoe, my sock is sliding off!" ~Author Unknown "I don't mean to brag, but I put together a puzzle in 1 day and the box said 2-4 years." ~Author Unknown Photograph by: Jalyn Sprin WR Myers Photography "I've learned so much from my mistakes, I'm thinking of making a few more!" ~Author Unknown "I used to think I was indecisive... ....but now I am not too sure." ~Author Unknown 4 STAGES OF LIFE " 1. You believe in Santa Claus. 2. You don't believe in Santa Claus. 3. You are Santa Claus. 4. You look like Santa Claus!" ~Author Unknown 46 "I think the worst time to have a heart attack is during a game of charades!" ~Demetri Martin "Sunglasses: Allow you to stare at people without getting caught. It's like Instagram in real time!" ~Author Unknown 47 "The happiest people don't have everything, they just make the best of everything they have!" ~Author Unknown The end of the school year can't come ^3. y^ "I love asking kids what they want to be when they grow up because I'm still looking for ideas!!" ~Author Unknown "I don't like to think before I speak. I like to be just as surprised as everyone else about what comes out of my mouth!" ~ Author Unknown 48 we what we "A relationship is like a house. When a light bulb burns out you do not go and buy a new house, you fix the light bulb!" ~Author Unknown. "Single doesn't mean you don't know anything about love, it just means you know enough to wait for it." ~Author Unknown 49 hove to do! Filters courtesy of PhotoLab. 1 uuho took o 1 chance a mapped Faces! ■ -**'«- E'W ..had the opportunity to be a part of the "Minister's Youth Council." The Minister's Youth Council consists of 40 junior and senior high school students (in Alberta) all of which have many diverse interests, perspectives, and backgrounds. Students get the opportunity to share their perspectives on many different topics in education. Over the last couple of years students on this council have worked with the Alberta Government Education Department, MLA's, industry professionals, teachers and school boards to help better education in out province. Specifically, these students helped inform a vaping policy from Edmonton Public Schools, assisted in the creation of Bill 1 9 which aims to reduce vaping use in Alberta and helped shape the Ministerial Order on Student Learning. ^ef Keira1' created all of these masterpieces during 'Round 1' of Covid shutdown. These photos show true dedication to her module completion as well as a exceptional eye for "Food Presentation." Who n°Ws maybe Keira will choose a career as a "Food Stylist!" 57 fcW :-»<—•■ W»W*MRm"WRP«WRW<l| em- ^.^wr.5 Sayge Turcato was in the Alberta High School Rodeo Provincials Finals at the beginning of June she went into the finals as the season leader in the Barrel Racing and she was 8th in District 1 for the Breakaway Roping with a few go round wins she ended up winning the Alberta Finals in the Barrel Racing and placing 4th in the Breakaway. That qualified Sayge to go to the National High School Rodeo Finals 2021 in Lincoln, Nebraska. Way to go Sayge!! Kayce Liptak has also had a great showing this year so far. She placed 2nd at Provincials, just behind Sayce Turcato. This meant that she also qualified to go to the National High School Rodeo Finals 2021 in Lincoln, Nebraska. 5ft Looks like Blaze Hansen could give us all a few lessons in surf technique!! Abby and Brennan Abela - both experienced Taekwondoin's. Colby Garner - playing Junior A hockey with the Sherwood Park Crusaders. The Taber Thrashers get a season after all! With vaccinate numbers up and COVID cases dropping substantially after a short shutdown the Lacrosse league got the green light to play. And play they did! If you enjoy watching playing a high-intensity, high-contact sport, then this is a game for you! With the Lacrosse league in its infancy in ^ber (this is just the second season of play) the team did a stellar job working on basic skills, learning plays, and Alling as a team unit. They definitely had their ups and downs where the scoreboard was concerned. But considering ^ey were up against teams with many more years experience, the Thrashers had a phenomenal season! a 61 i ■ B V CHS / / /T) ■ ___^1^ were discovered in a burial site at the grounds of the Kamloops Indian penetrating technology. Students in several classes began creating a Ksented in this discovery. The legacy of Residential Schools struck a chord rn to decorate stylized feathers created by Michelle Stoney (@mstoneyart) ‘ as a visual representation of the individual beauty of each individual child On 28 May, the bodies of 21 5 childre Residential School using new, grounJ memorial wall honouring the lives rel with many students which moved t™ Gitxsan artist. The display was put ua and as a way to visualize the staggering reality of the number of bodies discovered. This is the kind of response, the compassion and commitment to diversity that our student body has developed. 62 time. Details answer a question

    The influences of lateral ground-tilting on channel morphology and alluvial architecture

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    This thesis characterises and quantifies the influence of lateral ground-tilting on rivers in terms of: i) channel planform changes and migration style, ii) temporal and spatial patterns of channel movement, and, iii) the preserved alluvial architecture formed by aggrading fluvial systems. A dual field and physical modelling approach is used to examine the impact of tilting on river channels at a range of temporal and spatial scales. Fieldwork was undertaken on the Carson River, Nevada, USA which has been proposed as an example of avulsive downdip channel movement towards an active basin-bounding fault (Leeder, 1993). Froude scale models of both meandering and braided rivers were established in a stream table which could simulate aggradation and be tilted laterally. Quantification of the Holocene history of the Carson River, combined with independent dating of movements on the basin-bounding fault, allows the alluvial-tectonic relationships to be analysed. In addition to local tectonics, factors which may also affect channel movement such as climate change, regional periods of channel incision and intrinsic channel avulsion are investigated. The Carson River is shown to possess a more complex spatial relationship with fault movement and lateral tilting than that envisaged by Leeder (1993). Phases of channel onlap towards the locus of subsidence after fault events are separated by channel offlap during periods of tectonic quiescence. In addition, lag times between faulting and channel movement appear to be short. The preserved alluvial architecture modelled in flume experiments on aggrading braided streams is subdivided into a number of key depositional niches and their geometries quantified. A number of cross-stream and vertical variations in niche geometries can be attributed to the timing, magnitude and frequency of imposed lateral tilting, and confirm Leeder and Alexander's (1987) conceptual model of progressive downdip channel movement in response to lateral tilting. No unambiguous relationship between channel bend parameters and imposed lateral ground-tilting could be defined in the meandering river experiments because the rate and type of bend development masks the impact of tilting. However, the rate of channel movement towards the downtilted margin appears to increase after tilting and be directly related to tilt magnitude. A new model of progressive downdip channel migration in response to lateral tilting is presented which resolves the incompatibility of previous models. In addition, a criterion based on the rate of tilting is proposed in order to distinguish between channels that respond to tectonic tilting either by avulsion or by gradual downdip migratio

    EphB4 localises to the nucleus of prostate cancer cells

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    The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of prostate cancer cell lines. We used in silico methods to identify a bipartite nuclear localisation signal (NLS) in the extracellular domain and a monopartite NLS sequence in the intracellular kinase domain of EphB4. To determine whether both putative NLS sequences were functional, fragments of the EphB4 sequence containing each NLS were cloned to create EphB4NLS-GFP fusion proteins. Localisation of both NLS-GFP proteins to the nuclei of transfected cells was observed, demonstrating that EphB4 contains two functional NLS sequences. Mutation of the key amino residues in both NLS sequences resulted in diminished nuclear accumulation. As nuclear translocation is often dependent on importins we confirmed that EphB4 and importin-α can interact. To assess if nuclear EphB4 could be implicated in gene regulatory functions potential EphB4-binding genomic loci were identified using chromatin immunoprecipitation and Lef1 was confirmed as a potential target of EphB4-mediated gene regulation. These novel findings add further complexity to the biology of this important cancer-associated receptor

    Health Hazard Evaluation Report: HETA-85-329-1708: R. T. French Company; Springfield, Missouri

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    The United Food and Commercial Workers at the R. T. French Company (SIC-2099), Springfield, Missouri requested an evaluation of worker exposure to ethylene-oxide (75218) and methyl-bromide (74839). The facility employs 375 workers and was established exclusively for spice handling and manufacturing. Thirteen personal air samples for ethylene-oxide ranged in concentration from .01 to 1.07 parts per million (ppm). The three samples which exceeded the OSHA standard of 1ppm were from workers unloading sacks of sterilized spices from inside trucks. Twelve environmental air samples for ethylene-oxide ranged from less than .01 to 15ppm, with the highest being obtained from inside the trucks during unloading operations. No methyl- bromide was detected in personal samples on the packaging line and the two area samples on top of the tote bins in the fumigation room showed 12.5 and 45ppm. The author concludes that uncontrolled conditions which exist may result in exposure to the compounds; during this survey, the levels to which workers were exposed would not represent a health hazard. It is recommended that a means be devised to ventilate the trucks carrying spices during the trip from the contract sterilizer. Trucks should be monitored during unloading to be certain that levels of ethylene-oxide are not rising. The ventilation system in the fumigation room should be reviewed. The manner in which totes are treated with methyl-bromide should also be reconsidered
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