884 research outputs found
Screening for hepatocellular carcinoma: patient selection and perspectives
No full textWaleed Fateen, Stephen D Ryder NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospitals NHS Trust, The University of Nottingham, Nottingham, UK Abstract: Hepatocellular carcinoma (HCC) develops on the background of liver cirrhosis often from multiple, simultaneous factors. The diagnosis of a single small HCC comes with good prognosis and provides a potential for cure. In contrast, the diagnosis of multifocal, large HCC has high mortality and poor prognosis. Unfortunately, the majority of HCC is diagnosed at such late stages. A surveillance program endorsed by regional liver societies involves six-monthly ultrasound surveillance of at-risk patients. This had been in action for the last two decades. It has led to marked increase in the proportion of patients presenting with small unifocal nodules found on surveillance. The development of tools to enhance our ability in optimizing available surveillance is likely to improve the prognosis of patients with HCC. In this review, we discuss the difficulties in utilizing HCC surveillance and possible means of improvement. Keywords: hepatocellular carcinoma, surveillance, screening, risk stratification 
World Style File: Design Research and Education on a Global Scale
No full text'Style File' is a unique educational project that proposes to unite design students from around the world in an international collaborative design project, using the Internet and other electronic means of communication. It is an example of how the Internet can be used to provide students with a valuable learning experience on a global scale. The concept for “Style File” was initiated early in 2006 by Ted Polhemus – well-known “Style Commentator”, anthropologist, author, journalist and photographer. Polhemus is a widely-used consultant on youth marketing and style trends and is the author of several books on the anthropology of personal style and image. Many of these books are standard texts for design students and students of cultural studies. The author of this paper has been asked by Polhemus to monitor the progress of the students involved in the project at Liverpool John Moores University, UK, a founding participant in the project, and to provide illustrations for the book and web site that arise from the project. These illustrations will also form part of the International touring exhibition that is planned to coincide with the publication of the book in each participating country
The 2010 Mw 8.8 Maule, Chile earthquake: Nucleation and rupture propagation controlled by a subducted topographic high
No full textKnowledge of seismic properties in an earthquake rupture zone is essential for understanding the factors controlling rupture dynamics. We use data from aftershocks following the Maule earthquake to derive a three-dimensional seismic velocity model of the central Chile forearc. At 36°S, we find a highvp (>7.0 km/s) and high vp/vs(?1.89) anomaly lying along the megathrust at 25 km depth, which coincides with a strong forearc Bouguer gravity signal. We interpret this as a subducted topographic high, possibly a former seamount on the Nazca slab. The Maule earthquake nucleated at the anomaly's updip boundary; yet high co-seismic slip occurred where the megathrust is overlain by lower seismic velocities. Sparse aftershock seismicity occurs within this structure, suggesting that it disrupts normal interface seismogenesis. These findings imply that subducted structures can be conducive to the nucleation of large megathrust earthquakes, even if they subsequently hinder co-seismic slip and aftershock activity
Postfeminist authorial corpography Winona Ryder and the 1990s Woman Author Cycle
No full textThis article explores the gendering of the authorial body in Little Women (Gillian Armstrong, 1994), How to Make an American Quilt (Jocelyn Moorhouse, 1995), and Girl, Interrupted (James Mangold, 1999). As I will show, Ryder’s 1990s woman author cycle mobilises female authorship’s unruly connotations of female self-determination and autonomy, so that the Ryder figure emerges as an ideal vehicle for the enactment of feminist-inflected agency. Crucially, however, these feminist signifiers exist alongside conservative narrative trajectories which attempt to contain, contextualise, or frame the oppositional potential of this figure. Through these contradictory discursive movements, I argue, Ryder’s woman author films engage a set of sophisticated recuperative manoeuvres associated with postfeminism. In this way, this article sheds light on the hitherto overlooked ways in which the female author figure has come to function as a signifier of the contradictions and ambiguities constitutive of postfeminism, the role of Ryder’s star persona in this signification, as well as the implications of this film cycle for the broader conceptualisation of « The Author »
Stephen McCausland, state police spokesman, yesterday said that Vincent Fougere,
No full textStephen McCausland, state police spokesman, yesterday said that Vincent Fougere, 68, of Aulds Cove, Nova Scotia, fell asleep at the wheel of the Ryder rental truck he was driving before triggering Wednesday\u27s chain-reaction crash on the Maine Turnpike. Fougere\u27s passenger and two others involved in the multiple-vehicle accident remained hospitalized yesterday with serious injuries. The accident was another in a series of recent mishaps involving fatigued truck drivers. Details
Proving Relative Lower Bounds for Incremental Algorithms
No full textA general powerful method that permits simple proofs of relative lower bounds for incremental update algorithms is presented. This method is applied to derive a hierarchy of relative incremental complexity. Which classifies functions by relative lower bounds. We demonstrate our technique by bounding a number of incremental algorithms drawn from various domains. The method described expands upon work by Paull, Berman, and Cheng ~71 and generalizes a result of Even and Gazit 2. Our results have interesting implications with respect to the optimality of an incremental algorithm previously developed by Ryder in [9, 101. We also show that for certain graphs, Frederickson's update algorithm for minimum spanning tree is nearly optimal. Perhaps most importantly, the proof method and hierarchy suggest which types of problems are likely to yield good incremental algorithms (i.e., of lower complexity) and which cannot be improved by an incremental approach.Technical report DCS-TR-15
Somatization vs. Psychologization of Emotional Distress: A Paradigmatic Example for Cultural Psychopathology
No full textThis paper describes the developing area of cultural psychopathology, an interdisciplinary field of study focusing on the ways in which cultural factors contribute to the experience and expression of psychological distress. We begin by outlining two approaches, often competing, in order to provide a background to some of the issues that complicate the field. The main section of the paper is devoted to a discussion of depression in Chinese culture as an example of the types of questions that can be studied. Here, we start with a review of the epidemiological literature, suggesting low rates of depression in China, and move to the most commonly cited explanation, namely that Chinese individuals with depression present this distress in a physical way. Different explanations of this phenomenon, known as somatization, are explored and reconceptualized according to an increasingly important model for cross-cultural psychologists: the cultural constitution of the self. We close by discussing some of the contributions, both theoretical and methodological, that can be made by cross-cultural psychologists to researchers in cultural psychopathology
Anatomy of a megathrust: The 2010 M8.8 Maule, Chile earthquake rupture zone imaged using seismic tomography
No full textKnowledge of seismic velocities in the seismogenic part of subduction zones can reveal how material properties may influence large ruptures. Observations of aftershocks that followed the 2010 MwMw 8.8 Maule, Chile earthquake provide an exceptional dataset to examine the physical properties of a megathrust rupture zone. We manually analysed aftershocks from onshore seismic stations and ocean bottom seismometers to derive a 3-D velocity model of the rupture zone using local earthquake tomography. From the trench to the magmatic arc, our velocity model illuminates the main features within the subduction zone. We interpret an east-dipping high P-wave velocity anomaly (>6.9 km/s) as the subducting oceanic crust and a low P-wave velocity (<6.25 km/s) in the marine forearc as the accretionary complex. We find two large P-wave velocity anomalies (?7.8 km/s) beneath the coastline. These velocities indicate an ultramafic composition, possibly related to extension and a mantle upwelling during the Triassic.We assess the role played by physical heterogeneity in governing megathrust behaviour. Greatest slip during the Maule earthquake occurred in areas of moderate P-wave velocity (6.5–7.5 km/s), where the interface is structurally more uniform. At shallow depths, high fluid pressure likely influenced the up-dip limit of seismic activity. The high velocity bodies lie above portions of the plate interface where there was reduced coseismic slip and minimal postseismic activity. The northern velocity anomaly may have acted as a structural discontinuity within the forearc, influencing the pronounced crustal seismicity in the Pichilemu region. Our work provides evidence for how the ancient geological structure of the forearc may influence the seismic behaviour of subduction megathrusts
Static Infinite Wait Anomaly Detection in Polynomial Time
No full textInnite wait anomalies associated with a barrier rendezvous model (e.g., Ada) can be divided into two classes: stal ls and dead locks. Although precise static deadlock detection is NP-hard, we present two polynomial time algorithms which operate on a statically derivable program representation, the sync graph, to certify a useful class of programs free of deadlocks. We identify three conditions local to any deadlocked tasks, and a fourth global condition on all tasks, which must occur in the sync graph of any program which can deadlock. Again, exact checking of the local conditions is NP-hard; the algorithms check them using conservative approximations. Certifying stall freedom is intractable for programs with conditional branching, including loops. We give program transforms which may help alleviate this diculty.Technical report lcsr-TR-14
Supplemental Material - Application and Extension of the Alcohol Recovery Narratives Conceptual Framework
No full textSupplemental Material for Application and Extension of the Alcohol Recovery Narratives Conceptual Framework by Mohsan Subhani, Usman Talat, Holly Knight, Joanne R. Morling, Katy A. Jones, Guruprasad P. Aithal, Stephen D. Ryder and Stefan Rennick-Egglestone in Qualitative Health Research</p
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