1,478 research outputs found
variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability
No full textAbstract not available.Lucy C. Fox, Michelle Tan, Anna L. Brown, Peer Arts, Ella Thompson, Georgina L. Ryland, Jennifer Lickiss, Hamish S. Scott, Nicola K. Poplawski, Kerry Phillips, Neil A. Came, Paul James, Stephen B. Ting, David S. Ritchie, Jeff Szer, Christopher N. Hahn, Anthony Schwarer, Piers Blomber
Partisan Representation in Congress and the Geographic Distribution of Federal Funds
No full textIn a two-party legislature, districts represented by the majority may receive greater funds if majority-party legislators have greater proposal power or disproportionately form coalitions with each other. Funding types received by districts may depend on their legislators’ party-identity when party preferences differ. Estimates from the United States – using fixed-effect and regression-discontinuity designs – indicate that states represented by members of Congress in the majority receive greater federal grants, especially in transportation, and defense spending. States represented by Republicans receive more for defense and transportation than those represented by Democrats; the latter receive more spending for education and urban development.
corpus B AUPELF-UREF
No full textCinq répétitions à cinq styles différents : normal, lent, rapide, hypo et hyperarticulé
du texte "La bise et le soleil".Les sujets ont été enregistrés dans la chambre sourde de L'ILPGA avec un magnétophone DAT
Sony DTC 690 réglé sur une fréquence d'échantillonnage de 48 KHz. Le micro (audio / Technica ATM
33A) était placé à environ 25 cm de la bouche du locuteur. Le locuteur était assis en face de
l'expérimentateur dans une situation de communication normale
Microbial pathogen-induced necrosis mediated by NLRP3 and ASC
No full textNLRP3 and ASC are important components of the inflammasome, a multi-protein complex required for caspase-1 activation and IL-1[beta] production. NLRP3 mutations underlie autoinflammation characterized by excessive IL-1[beta] secretion. Disease-associated NLRP3 also causes a program of necrosis-like cell death in macrophages, the mechanistic details of which are unknown. We find that patient monocytes carrying disease-associated NLRP3 mutations exhibit excessive necrosis-like cell death by a process dependent on ASC and cathepsin B, resulting in spillage of the proinflammatory mediator HMGB1. Shigella flexneri and Klebsiella pneumoniae infection also cause NLRP3-dependent macrophage necrosis with features similar to the death caused by mutant NLRP3. This necrotic death is independent of caspase-1 and IL-1[beta], and thus independent of the inflammasome. While similar proteins mediate pathogen-induced cell death in plants, this report identifies NLRP3 as an important host regulator of pathogen-induced necrosis in animals, a process we term pyronecrosis
Graphical representation of allelic ratio (A) Subject 34 and (B) Subject 12
No full text<p><b>Copyright information:</b></p><p>Taken from "Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array"</p><p></p><p>Biological Procedures Online 2007;9():27-42.</p><p>Published online Jan 2007</p><p>PMCID:PMC2211573.</p><p>Article © by the author(s). This paper is Open Access and is published in Biological Procedures Online under license from the author(s). Copying, printing, redistribution and storage permitted. Journal © 1997-2007 Biological Procedures Online.</p
Confidence intervals for functions of variance components
No full textA variety of methods for constructing approximate confidence intervals for particular functions of variance components in balanced data random effects models have been proposed by various authors. These range from the popular Satterthwaite (1946) method to the latest modified large-sample (MLS) method suggested by Gui, Graybill, Burdick, and Ting (1995). The monograph of Burdick and Graybill (1992) gives recommendations on the best existing methods. Some examples are the MLS methods of Graybill and Wang (1979, 1980), Wang and Graybill (1981), Arteaga, Jeyaratnam, and Graybill (1982), Leiva and Graybill (1986), Ting, Burdick, Graybill, Jeyaratnam, and Lu (1990), and Ting, Burdick, and Graybill (1991). The methods in these provide intervals for particular functions of variance components in selected models, and usually involve complicated formulas;We propose a simple general method for constructing confidence intervals for arbitrary functions of variance components in balanced data normal theory random effects models. The concept of "surrogate variables" is introduced as part of the description of the proposed method. The proposed method produces the commonly known exact (Chi Square and F distribution based) confidence intervals for expected mean squares and ratios of them. Moreover, it is extremely easy to implement and delivers both "equal-tail" and "shortest-length" confidence intervals for any parametric function of interest. (In contrast, only a small number of MLS methods have prescriptions for computing a sort of "shortest-length" interval.);We demonstrate the effectiveness of the proposed method for estimating several commonly studied functions of variance components in various standard models, including the two-way random effects model (with and without interaction), the two-fold nested random effects model and the three-factor cross-classification random effects model. We show that the proposed intervals easily maintain the nominal confidence level and have average interval lengths that are comparable to or better than those of the best existing methods. Moreover, we show that in a particular application, the standard MLS method of Gui et al. (1995) can be extremely liberal, while the proposed method easily maintains the nominal confidence level.</p
Squatina formosa Shen & Ting 1972
No full textSquatina formosa (Shen & Ting, 1972) Squatina formosa, Shen & Ting 1972: 23, Figure 4, valid, holotype: NTT 7213130. Figure 2. Common name. Taiwan angelshark. Diagnosis. A squatinid with the following distinctive characters: upper lip arch semi-circular, height greater than other WNP squatinids (3.8–5.1 % in width, 1.4–2.1 % TL in height); pectoral fins broadly rounded, especially posterior free tip; pelvic girdle moderately broad, pelvic anterior margin slightly curved, angle of lateral apex considerably more obtuse than 120 °, pelvic fin tips reaching first dorsal origin; dorsal fins lobe-like with slightly rounded anterior margin, first dorsal fin base slightly larger than second dorsal base; caudal fin lobed, especially dorsally, with a curvilinear caudal posterior ventral margin. Description. Dorsal surface, except for posterior portion of caudal fin, covered with denticles of moderate roughness. Ventral surface smooth except for narrow bands of denticles on the pectoral and pelvic fins anterior margins. Head rounded, length about 0.2 times total length, maximum width occurring just anterior of gill openings. Moderately rough tubercles interspersed above mouth and eye crests. Eyes almond-shaped, widely set, interorbital space 8.2 (7.7–8.9). Eye-spiracle space short. Spiracles are crescent shaped without large papillae. Interspiracle space (7.8–8.2) slightly less than interorbital space. Center of upper lip exposed at midpoint of upper jaw, exposure semi-circular in shape, extending dorsally approximately 0.6–0.7 of upper jaw space, upper lip height (1.2–2.1), upper lip arch width (3.8–5.1). Labial furrows conspicuous, roughly equal in length, extending from corners of mouth medially, with upper labial furrow partially covered with dermal folds. Distinct nasal flaps protruding from dermal folds above mouth, two barbels protruding from each flap. Inner nasal barbel rod-like with a spatulate tip, inner basal portion contains little if any fringe. Outer nasal barbel narrow. Nostrils large, slightly protruding. Dermal folds along exterior of head, one small lobe present at corners of mouth extending ventrally. Mouth length about 0.3 times as long as mouth width. Dentition consisting of small, dagger-like teeth, conical without cusplets on a broad base, in 3 orderly longitudinal rows, no 9 − 10 − 9 − 10 teeth at symphysis, teeth by row 10 − 10. Pectoral fins large, broadly rounded, originating just behind gills. Anterior margin of pectoral fin slightly convex and about three quarters as long as pectoral length, extending to a lateral apex. Angle of lateral apex slightly more obtuse than 120 °. Margin from lateral apex to most posterior lobe slightly concave. Posterior lobe broadly convex. Pectoral inner margin convex, about one half of pectoral length. Overall pelvic fin shape somewhat triangular with rounded fintips. Pelvics originating anterior to pectoral fin free rear tips. Pelvic fin length approximately two thirds as long as pectoral fin length. Pelvic fin base approximately 1.2 times broader than pectoral base. Anterior margin slightly curvilinear, extending at roughly a 45 ° angle from trunk to rounded apex lateral of body, anterior margin 0.5 times as long as pelvic fin length. Pelvic girdle width (26.3–29.8) between pelvic fin apexes moderately broad, about 1.4 times head length. Posterior margin of pelvic fin, approximately 0.8 times pelvic fin length, straight to posterior free tip. Pelvic inner margin concave and short, only about 0.4 times as long as pectoral fin length. Pelvic insertion furrows on ventral extend in a narrow ellipse to anterior apogee of vent in most specimens, vent is within ellipse. Pelvic fin tips reach origin of first dorsal. Dorsal fins lobed and nearly equal in size, with denticles covering the whole of fins. Interdorsal space about 0.8 times as long as dorsal caudal finspace. Anterior margin of dorsals slightly convex, nearly equidistant. First dorsal base slightly shorter than second, first dorsal base 15.2 (10.0– 11.8), second dorsal base 17.4 (13.0–15.0). Apex of dorsals lobed. Posterior margins slightly convex, about 0.7 times as long as anterior margins. Inner margins of dorsals slightly convex, approximately 0.7 times as long as anterior margins. Caudal peduncle compressed dorso-ventrally with lateral longitudinal ridges, tapering posteriorly. Caudal fin lobe-like, markedly at dorsal apex. Caudal dorsal margin broadly rounded, about 0.8 times as long as preventral caudal fin margin. Subterminal caudal fin margin approximately half as long as caudal upper post ventral margin. Caudal lower postventral margin convex, approximately 0.8 times as long as caudal upper post ventral margin. Total vertebrae 137–139; total precaudal vertebrae 107-110; monospondylous vertebrae 48–52; diplospondylous vertebrae 58–59; caudal vertebrae 29-30. Coloration. Dorsal surface of specimens prior to preservation are light to dark brown throughout with numerous black and white spots of varying sizes. Black blotches laterally at origin of dorsals. Ventral surface pale white with some black mottling on abdomen, pectoral and pelvic fin ventral margins with denticles colored similar to dorsal. Color after preservation tends to fade to a lighter brown or pale yellow with spots becoming indistinct. Distribution. Endemic to western North Pacific including the East China Sea (Compagno et al, 2005 a), waters surrounding northern Taiwan, and East Taiwan Strait (Shuyuan 1994). Etymology. Named in allusion to the known geographic range (Formosa Strait, Taiwan) where the holotype was collected. Remarks. Examination of the holotype (labeled NTT 7213130 in Shen & Ting 1972, now labeled NTUM 01329) and non-type comparison material revealed that S. formosa is distinct from other WNP squatinids through four characters (Fig 2). First, S. formosa possesses a lobed caudal fin, especially in the dorsal lobe, and has a more curved postventral caudal margin. Second, S. formosa has lobed dorsal fins with a curvilinear anterior margin. Third, the pelvic girdle distance in S. formosa is more narrow than other WNP squatinids, at 1.4 or less the head length (where both measurements are standardized by total length). Fourth, S. formosa has an upper lip arch which is semicircular in shape, where the upper lip arch height is greater than 1.5 % of the total length. Comparison of the three S. formosa paratypes (originally labeled as NTU 7041631, NTU 7041632, NTU 7222433 in Shen and Ting 1972; now labeled as NTUM 01327(x 2) and NTUM 01328) with the holotype reveals differences among these four characters (Table 2). The paratypes possess angular caudal fins without curved postventral caudal margins, angular dorsal fins with straight anterior margins, a wider pelvic girdle distance, and upper lip arches which are more semi-oval in shape (Fig 3 A-C). Therefore, our contention is that these paratypes of S. formosa are, in fact, a different species. Furthermore, these characters are most consistent with the S. nebulosa comparison material we examined. TABLE 2: Distinguishing characters between S. formosa and S. nebulosa. S. formosa S. nebulosa 1. Caudal fin lobed, especially dorsally; curvilinear caudal 1. Caudal fin angular; straight caudal postventral margin. postventral margin. 2. Dorsal fins lobed; curvilinear dorsal anterior margins. 2. Dorsal fins angular; straight dorsal anterior margins. 3. Pelvic Gridle Width / Head Length 1.4 4. Upper Arch Height> 1.5 % TL 4. Upper Arch Height <1.5 % TL An apparent change in designation of one of the paratypes for unknown reasons has also added to the confusion in the type series. At present, one of the paratypes (NTUM 01328) has been designated as the holotype, and the true holotype (NTUM 01329) now has a question mark on its catalogue card next to its holotype designation, as documented by the junior author (DAE) who examined the type material of S. formosa in May 1988 and again in May 2005. However, comparison of the type material with photos of the holotype within the original species description (Shen & Ting, 1972) confirms that the NTUM 0 1329 specimen is the actual holotype. A squatinid reported from the Philippines as S. formosa (Compagno et al., 2005 b) is also not likely this species. Examination of photographs of the Philippines specimen, provided by L.J.V. Compagno, revealed several characters inconsistent with S. formosa. These characters include pelvic fins which do not reach the first dorsal base, a wider pelvic girdle, a more shallow upper lip arch and distinctly different coloration than observed in S. formosa. Therefore, the Philippines specimen most likely represents a different, possibly undescribed, squatinid species from true S. formosa. Material Examined. Type material: Holotype S. formosa: NTT 7213130 (now labeled as NTUM 01329), immature female, Tung-Kang, Pingtung, Taiwan, 31 Jan 1972, identified by S.C. Shen. Paratypes S. formosa: NTU 7222433 (now labeled as NTUM 01327), and NTU 7041632 (now labeled as NTUM 1327), caught 3 km off the coast of Tahsi, Taiwan (24 ° 56.5 ’N, 121 °53.0’E) in single trawling net at 100-120 fathoms, 16 Apr 1970, collected by W.H. Ting, identified by S.C. Shen; NTU 7041632 (now labeled as NTUM 01328), immature female, Tahsi, Taiwan, 24 Feb 1972, collected by W.H. Ting, identified by S.C. Shen. Comparative material: DAE 881805, immature male, Tahsi, Taiwan, May 1988, collected by David A. Ebert; DAE 0 52105, immature male, Tahsi, Taiwan, May 2005, collected by David A. Ebert; DAE 052305 - 2, immature female, Tahsi, Taiwan, May 2005, collected by David A. Ebert.Published as part of Walsh, Jonathan H. & Ebert, David A., 2007, A review of the systematics of western North Pacific angel sharks, genus Squatina, with redescriptions of Squatina formosa, S. japonica, and S. nebulosa (Chondrichthyes: Squatiniformes, Squatinidae), pp. 31-47 in Zootaxa 1551 on pages 35-38, DOI: 10.5281/zenodo.17813
On rights and demands : how theorists of rights can benefit from taking demands seriously
No full textThis thesis explores the normative significance of making a rights-backed, authorized demand as a right holder. Rights, I argue, enable their holders to make a special kind of demand which comes with a special force. It is, in other words, one of rights’ functions that they are demands-enabling. I single out what sort of demands I am interested in exploring. I also look at how these special demands are normatively significant. I call them rights-backed, authorized demands. They are normatively significant, first, because of the interesting role they play in other agents’ practical-reasoning, and , second, because the very making of these demands, as a matter of rights, is empowering in an abstract way. I go on to contrast my view with other ‘demand theories’ in existence and conclude that my view is substantively different. In particular, existing demand theories of rights all fail to sufficiently highlight the importance of actual demands, and instead focus on the ‘status’ of ‘being in a position’ to make demands. I argue that this focus is a fundamental mistake. I also consider how my view can contribute to some related literature on rights. First, I argue that my view highlights a new function which rights have: it has interesting implications on the shape of the long-standing debate between the will and interest theory of rights. Second, I argue that my view provides us with a new way to counter one of the most discussed criticisms of the existence of welfare human rights, which is the argument that rights must correlate with some specific duties as a necessary existence condition, and that human welfare rights fail on this mark. I conclude that if human rights indeed have a demand-related function as I argue, it weakens the intuitive appeal of this criticism
Theory of flux motion with backflow current in high- superconductors
No full textBased upon the well-known normal-core model for flux line in high- superconductors and by correctly taking into account the backflow current due to both pinning forces and other vortices, we developed a theory for flux motion in the framework of the Bardeen-Stephen and Nozières-Vinen approaches. We derived analytically the longitudinal resistivity xx and the Hall resistivity xy as functions of the magnetic field in the region of flux flow. Our results explain qualitatively all the essential features of recent experiments on xy, including, in particular, the observed negative Hall resistivity at low magnetic field in certain high-Tc superconductors. Furthermore, a long-standing problem concerning the expressions for the viscous-drag force and the applied force on a vortex is discussed and clarified. © 1992 The American Physical Society.link_to_subscribed_fulltex
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