9,312 research outputs found
Chemotherapy dose intensity in non-Hodgkin's lymphoma: is dose intensity an emerging paradigm for better outcomes?
No full textBackground: Higher chemotherapy dose intensity has been studied as a way of improving the clinical outcomes in various malignancies, including non-Hodgkin's lymphoma (NHL). Methods: We reviewed clinical trials that have studied the relation between dose and response in cancer chemotherapy, the theory behind dose-intense chemotherapy, and the clinical results with dose-escalated and dose-dense therapy in aggressive NHL. Results: Myeloablative high-dose chemotherapy with stem cell transplantation produces higher 5-year survival rates than standard salvage chemotherapy in relapsed aggressive lymphoma, but its role as initial therapy is not yet clear. Nonmyeloablative dose-escalated chemotherapy is feasible with granulocyte colony-stimulating factor (G-CSF) support, but this approach does not improve outcomes. Dose-dense (14-day) CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with G-CSF support produces better results than 21-day CHOP in patients with previously untreated aggressive lymphoma, without additional toxicity. The addition of etoposide to dose-dense CHOP may provide further benefits in younger patients. The addition of rituximab to G-CSF-supported dose-dense CHOP is feasible. Preliminary data suggest the feasibility of dose-dense chemotherapy for NHL with the once-per-cycle G-CSF, pegfilgrastim. Conclusion: Dose-dense chemotherapy with G-CSF support produced better clinical outcomes in both younger and older patients. Phase 3 trials of dose-dense CHOP plus rituximab with CSF support are warranted
Lipids and atrial fibrillation: New insights into a paradox
No full textIn this Perspective, Dimitrios Sagris, Stephanie Harrison, and Gregory Lip discuss new evidence concerning the paradoxical relationship between circulating lipids and atrial fibrillation
The Rhetoric of Landscape in Gregory of Nyssa’s Homilies on the Song of Songs
No full textThis is the author accepted manuscript. The final version is available from Brill via the ISBN in this recordAnalytical and Supporting Studies. Proceedings of the 13th International Colloquium on Gregory of Nyssa (Rome, 17-20 September 2014)Series:
Vigiliae Christianae, Supplements, Volume: 150In this paper I want to take you on a walk through a garden. It is, to be sure, an imaginary garden; nevertheless, it bears a significance which extends beyond itself. Some of this significance concerns words and texts: for as we shall see, the garden is, amongst other things, a ‘garden of rhetoric’. The garden in question appears in the Gregory of Nyssa’s Homilies on the Song of Songs.[...
An Evening with Richard Claxton “Dick” Gregory, Civil Rights Activist, Nutritionist, Comedian, and Author
No full textGregory, Richard Claxton “Dick” (Born, October 12, 1932, St. Louis, Mo.), African American comedian and civil rights activist whose social satire changed the way white Americans perceived African American comedians since he first performed in public. Gregory’s autobiography, Nigger, was published in 1963 prior to The assassination of President Kennedy, and became the number one best-selling book in America. Over the decades it has sold in excess of seven million copies. His choice for the title was explained in the forward, where Dick Gregory wrote a note to his mother. “Whenever you hear the word ‘Nigger’,” he said, “you’ll know their advertising my book.” In 1984 he founded Health Enterprises, Inc., a company that distributed weight loss products. In 1987 Gregory introduced the Slim-Safe Bahamian Diet, a powdered diet mix, which was immensely profitable. Economic losses caused in part by conflicts with his business partners led to his eviction from his home in 1992. Gregory remained active, however, and in 1996 returned to the stage in his critically acclaimed one-man show, Dick Gregory Live! The reviews of Gregory’s show compared him to the greatest stand-ups in the history of Broadway
“Judge Me Gently”: Reflections on the Religious Life of John Milton Gregory, 1822–1898
No full text John Milton Gregory is familiar to many Christian educators through his 19th-century publication, The Seven Laws of Teaching. For most readers of this important book, little is known about the author himself. This article explores the religious life and theological foundations of John Milton Gregory, who was both author of The Seven Laws of Teaching and founding president of the University of Illinois. Utilizing his spiritual diaries preserved in his daughter's biography of her father and archival sources from the University of Illinois, this essay offers a theological and spiritual understanding of this important historical figure. </jats:p
Book Review: Sun Tzu in Space: What International Relations, History, and Science Fiction Teach Us About Our Future
No full textAuthor: Gregory D. Miller
Reviewed by: Lieutenant Colonel Timothy S. Martin, director, Defense Strategy Course, US Army War College, and Captain Stephanie St. Louis, strategic planner, Office of the Chief of Army Reserve, Fort Belvoir
Sun Tzu in Space combines an examination of history and science fiction to assess what humanity’s future in space could look like through an international relations lens. The reviewer sees it as “a pulse check on the potential for violent future conflicts” and recommends it for policymakers and science fiction enthusiasts alike.
©2025 Timothy G. Martin and Stephanie St. Louishttps://press.armywarcollege.edu/parameters_bookshelf/1108/thumbnail.jp
Predicting UK Domestic Electricity and Gas Consumption between Differing Demographic Household Compositions
No full textThis paper examines the influence of building characteristics, occupant demographics and behaviour on gas and electricity consumption, differentiating between family groups; homes with children; homes with elderly; and homes without either. Both regression and Lasso regression analyses are used to analyse data from a 2019 UK-based survey of 4358homes (n = 1576 with children, n = 436 with elderly, n = 2330 without either). Three models (building, occupants, behaviour) were tested against electricity and gas consumption for each group. Results indicated that homes without children or elderly consumed the least energy. Property Type emerged as the strongest predictor in the Building Model (except for homes with elderly), while Current Energy Efficiency was less significant, particularly for homes with elderly occupants. Homeownership and number of occupants were the most influential factors in the Occupants Model, though this pattern did not hold for homes with elderly. Many occupant and behaviour variables are often considered ‘unregulated energy’ in calculations such as SAP and are thus typically disregarded. However, this study found these variables to be significant, especially as national standards improve. The findings suggest that incorporating occupant behaviour into energy modelling could help reduce the energy performance gap
Harnessing the Energy: Development of Radioimmunotherapy for Patients with Non-Hodgkin’s Lymphoma
No full textRadioimmunotherapy (RIT) combines the use of targeted monoclonal antibodies with radionuclides for the treatment of non-Hodgkin's lymphoma (NHL), taking advantage of its inherent radiosensitivity. A number of trials have shown significantly higher response rates and longer progression-free survival times in patients treated with the CD20-targeted radioimmunoconjugate yttrium-90-ibritumomab tiuxetan compared with the standard of care. Furthermore, these benefits have also been shown in heavily pretreated patients who relapsed or were resistant to rituximab. Currently, a number of different treatment regimens and strategies are available for the treatment of NHL patients. Therefore, in an attempt to minimize toxicity, maximize efficacy, and improve survival, it is crucial to appropriately select patients who are good candidates for individual treatment approaches. A strategy for patient selection has been developed, including the use of existing patient assessment tools, such as the Follicular Lymphoma International Prognostic Index, to determine the optimal regimen for patients with follicular lymphoma according to their disease characteristics and physical condition. Patients who are fit make ideal candidates for potentially curative regimens, which include induction chemotherapy with or without immunotherapy followed by RIT consolidation and, potentially, maintenance therapy. Patients who are considered "compromised" would also benefit from induction treatment and RIT consolidation, with a view to reducing the lymphoma burden and decreasing the risk for disease progression. "Frail" patients would be better suited to supportive therapy to control symptoms. This paper explores factors that should be considered when assessing whether a patient is a good candidate for treatment with RIT, and aids physicians in the selection of the most appropriate therapy for each patient group. The Oncologist 2009; 14(suppl 2): 4-1
Heterocycles from wine: synthesis and biological evaluation of salidrosides
No full textWine is composed of a variety of tannins, of which a sub-class includes salidrosides, which are largely uninvestigated compounds. The first syntheses of galloylated salidrosides are reported in 7 steps from commercially available starting materials through a platform approach. The antimicrobial activity of the salidrosides against Escherichia coli strains is described.This is a manuscript of an article published as Guney, Tezcan, Stephanie A. Kohles, Victoria L. Thompson, Gregory J. Phillips, and George A. Kraus. "Heterocycles from wine: synthesis and biological evaluation of salidrosides." Tetrahedron 71, no. 20 (2015): 3115-3119. DOI: 10.1016/j.tet.2014.08.065. Posted with permission.</p
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Homeric Echoes in Posidippus
No full textLabored in Papyrus Leaves: Perspectives on an Epigram Collection Attributed to Posidippus (P.Mil.Vogl. VIII 309) is a Center for Hellenic Studies publication, specifically Hellenic Studies Series 2. Since Gregory Nagy is both article author and Director of the Center for Hellenic Studies, no special permission needed for online submission.The ClassicsAuthor's Origina
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