101 research outputs found

    Sur la convergence des tests de Schlee et de Yatchew

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    L'auteur adapte l'approche de Schlee (1980) et de Yatchew (1992) à la construction de deux tests de convexité pour une fonction de régression dans un modèle non paramétrique. Il établit de nouveaux résultats de convergence pour ces tests et étudie leur comportement dans de petits échantillons à l'aide de simulations. /// The author adapts the approach of Schlee (1980) and Yatchew (1992) to the construction of two tests of convexity of a regression function in a nonparametric model. He gives some new asymptotic results of convergence of these tests and studies their small-sample behaviour through simulations

    The stable value

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    Game Theory

    Study of Systematic and Statistical Uncertainty in Offset, Noise, and Gain Determination of the DSSC Detector for the European XFEL

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    The DSSC (DEPFET Sensor with Signal Compression) is a new instrument with non-linear response and parallel signal processing (filtering, linear amplification, and 8-bit digitization) for all pixels. The DSSC will serve as ultra-fast megapixel imaging detector at the European XFEL (X-ray Free Electron Laser) in Schenefeld, Germany, which began science operation in September this year. The DSSC detector needs to be calibrated for each of a set of twelve predefined operation modes before being employed in scientific experiments. A crucial step in the calibration of the response of each individual detector pixel is the calibration of offset and gain. We present a study of both systematic and statistical uncertainty in the determination of offset, noise, and gain. The best possible calibration of offset and gain requires that these two quantities can be determined with an uncertainty that is less than half the finite resolution of the respective read-out ASIC calibration settings. The study is based on simulated calibration data, which were then analyzed using our calibration tools. Systematic and statistical uncertainty in offset, noise, and gain determination was quantified by comparing analysis results with the actual values employed in the simulations. A review of all results identified the most suitable calibration approaches. Their ability for providing the best possible offset and gain calibration is discussed

    Evolution of Smart-n Players

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    A memória como efeito estético nos contos de Aldyr Garcia Schlee

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    A presente tese, desenvolvida no âmbito do Programa de Pós-Graduação em Letras (Doutorado em História da Literatura), analisa nove contos escritos pelo escritor Aldyr Garcia Schlee sob o eixo temático da memória. Os livros trabalhados são Memórias de o que já não será (2014), Contos da vida difícil (2013) e Os limites do impossível (2009). Trabalha-se com a hipótese de que nestas narrativas curtas, a memória é a principal interface para a produção de sentido. Entende-se que este elemento, enquanto objeto imaginário, forma a estrutura nocional responsável pelo eixo comunicativo do referido autor. As questões que envolvem as estruturas do leitor e do texto serão desenvolvidas pelas teorias de Wolfgang Iser (O ato da leitura, Uma teoria do efeito estético). Para a compreensão dos estudos mnemônicos será elencado Paul Ricoeur: A memória, a história, o esquecimento. Segundo as teorias apresentadas, procura-se investigar o uso da "memória" como estética formadora das lembranças e das recordações.This thesis developed by the postgraduate program in History of Literature (Doctorate), analyzes nine short stories written by writer Aldyr Garcia Schlee under the thematic axis of memory. The books worked are Memories of what will no longer be (2014), Tales from the difficult life (2013) and The limits of the impossible (2009). It is hypothesized that in these short narratives, memory is the main interface for meaning making. It is understood that this element, as an imaginary object, forms the notional structure responsible for the communicative axis of that author. The questions surrounding the structures of the reader and the text will be developed by the theories of Wolfgang Iser (The Act of Reading, A Theory of Aesthetic Effect). For the understanding of mnemonic studies Paul Ricoeur will be listed: Memory, history, forgetfulness. According to the theories presented, we seek to investigate the use of "memory" as the formative aesthetic of memories and memories

    Der Einfluss von Entzündungsreaktionen auf die Reifung von Engrailed-2 überexprimierenden, zerebellären Purkinjezellen in Gewebekulturen

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    Autismus-Spektrum-Störung (ASD) wird durch genetische und extrinsische Faktoren beeinflusst, wobei die zugrunde liegenden Mechanismen weiterhin unklar sind. In dieser Arbeit wird untersucht, wie die Überexpression des Transkriptionsfaktors Engrailed-2 (EN2), ein Höomobox-Gen, das mit ASD assoziiert ist, und entzündliche Reize die Differenzierung von zerebellären Purkinjezellen beeinflussen. Mittels Schnittkulturen aus En-2 überexprimierenden Mäusen wird gezeigt, dass sowohl genetische Prädisposition als auch durch Lipopolysaccharid und Interferon-gamma induzierte Entzündung die dendritische Entwicklung der Purkinjezellen unabhängig und additiv beeinträchtigen. Die entzündungsbedingten Effekte werden durch Hemmung der Mikroglia-Aktivität und Blockade des TNFα-Rezeptors signifikant gemindert werden. Die Arbeit liefert wichtige Erkenntnisse über die multifaktorielle Genese von ASD
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