1,719 research outputs found

    The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response

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    Sensory perception requires accurate encoding of stimulus information by sensory receptor cells. We identified NCKX4, a potassium-dependent Na(+)/Ca(2+) exchanger, as being necessary for rapid response termination and proper adaptation of vertebrate olfactory sensory neurons (OSNs). Nckx4(-/-) (also known as Slc24a4) mouse OSNs displayed substantially prolonged responses and stronger adaptation. Single-cell electrophysiological analyses revealed that the majority of Na(+)-dependent Ca(2+) exchange in OSNs relevant to sensory transduction is a result of NCKX4 and that Nckx4(-/-) mouse OSNs are deficient in encoding action potentials on repeated stimulation. Olfactory-specific Nckx4(-/-) mice had lower body weights and a reduced ability to locate an odorous source. These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception

    Alice and Cliff Donahue

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    Photograph - Friends of Alice B. and William Clifford Donahue, Athabasca, Alberta. Seated, left to right: Cliff Donahue, Joe Mikkelsen, Beryl Mikkelsen, and Marge Logan. Standing, left to right: Don Logan, Alice B. Donahue, Aaron Jones, Lorene Jones, and Beatrice Par

    Synthesis and heteroatom-hydrogen activation studies of the anionic zirconocene trihydride [Cp*(2)ZrH(3)](-).

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    Synthetic routes to an anionic zirconocene trihydride complex [Cp*2ZrH3]- 67 have been investigated. The original synthetic strategy involved the addition of KH or LiH to the zirconocene dihydride [Cp*2ZrH2] 10. Though this method proved to be reliable, generating the dihydride staring material was plagued by poor yields. An alternative synthetic route involved oxidative addition of dihydrogen to Zr(II) species generated in situ via the Negishi method. Again this allowed for the isolation of [Cp*2ZrH3]- 67 but it was contaminated with LiCl. A two-step process was eventually developed allowing for the facile high yielding synthesis of the first zirconocene trihydride anion 67. Initial reactivity studies of 67 were directed at exploring the nature of the hydride ligand. Analogies were drawn between the reactivity of 67 and the parent complex [Cp*2ZrH2] 10. Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1838. Adviser: D. W. Stephan. Thesis (Ph.D.)--University of Windsor (Canada), 2001

    The costs associated with prosecuting crime in Oregon

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    prepared by: Master of Public Administration capstone team: Heidi Blaine, Megan Entwistle, Mark Nystrom, B. Aaron Weaver ; prepared for: Oregon Criminal Justice Commission.Title from PDF cover (viewed on February 10, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (page 15).Mode of access: Internet from the Oregon Government Publications Collection.Text in English

    Aaron Burr as his contemporaries saw him : senior honors thesis [(HONRS 499)]

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    It is the author's purpose in this presentation to discuss Aaron Burr as he was seen by his own period of history and his own world. This objective shall be accomplished by examining sources contemporary to Burr and relevant to the three major areas of his life: the man, the politician, and the conspirator. This division of discussion has been chosen because the author feels that almost every part of Aaron Burr's life can be adapted to one of these three areas. The author has also found that any matter which cannot be suited to one of these three areas is but incidental commentary and has little importance for the subject at hand.Thesis (B.?.)Honors Colleg

    Men who missed it; great Americans who missed the White House,

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    Aaron Burr.--Henry Clay.--John C. Calhoun.--Daniel Webster.--William H. Seward.--Salmon P. Chase.--Stephan A. Douglas.--General George B. McClellan.--Horace Greeley.--Samuel J. Tilden.--James G. Blaine.--Robert M. La Follette.--William Jennings Bryan.--Charles Evans Hughes.Mode of access: Internet

    Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome

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    Background: Several imprinted genes have been implicated in the process of placentation. The distal region of mouse chromosome 7 (Chr 7) contains at least ten imprinted genes, several of which are expressed from the maternal homologue in the placenta. The corresponding paternal alleles of these genes are silenced in cis by an incompletely understood mechanism involving the formation of a repressive nuclear compartment mediated by the long non-coding RNA Kcnq1ot1 initiated from imprinting centre 2 (IC2). However, it is unknown whether some maternally expressed genes are silenced on the paternal homologue via a Kcnq1ot1-independent mechanism. We have previously reported that maternal inheritance of a large truncation of Chr7 encompassing the entire IC2-regulated domain (DelTel7 allele) leads to embryonic lethality at mid-gestation accompanied by severe placental abnormalities. Kcnq1ot1 expression can be abolished on the paternal chromosome by deleting IC2 (IC2KO allele). When the IC2KO mutation is paternally inherited, epigenetic silencing is lost in the region and the DelTel7 lethality is rescued in compound heterozygotes, leading to viable DelTel7/IC2KO mice. Results: Considering the important functions of several IC2-regulated genes in placentation, we set out to determine whether these DelTel7/IC2KO rescued conceptuses develop normal placentae. We report no abnormalities with respect to the architecture and vasculature of the DelTel7/IC2KO rescued placentae. Imprinted expression of several of the IC2-regulated genes critical to placentation is also faithfully recapitulated in DelTel7/IC2KO placentae. Conclusion: Taken together, our results demonstrate that all the distal chromosome 7 imprinted genes implicated in placental function are silenced by IC2 and Kcnq1ot1 on the paternal allele. Furthermore, our results demonstrate that the methylated maternal IC2 is not required for the regulation of nearby genes. The results show the potential for fully rescuing trans placental abnormalities that are caused by imprinting defects.Medical Genetics, Department ofMedicine, Faculty ofOther UBCNon UBCReviewedFacult

    Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

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    Correction to: Nature Genetics https://doi.org/10.1038/ng.3668, published online 26 September 2016. In the version of the article published, the surname of author Aaron Isaacs is misspelled as Issacs

    The 5E model as a framework for facilitating multiple teacher education outcomes : a secondary science methods course in Australia

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    Australia is a large country geographically with a relatively small population of approximately twenty four million people. Like many countries, the health of the economy fluctuates over time, but Australia has enjoyed a mostly healthy and stable trajectory of economic output over the last forty years. There is now a strong push to develop STEM education throughout the country, not only due to the need for more students to enter into STEM professions, but also due to concerns about science and mathematics literacy (Australian Council of Learned Academies, 2013). This chapter describes preparing grade 7–10 science teachers at Western Sydney University in Australia using an approach based on the 5E learning cycle (Bybee et al., 2006). The author focuses on teacher discourse practices as his signature lesson, and has students develop their own 5E lesson plan as a summative assessment in the course

    Hypogena cryptica Grey & Smith 2020, sp. nov.

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    <i>Hypogena cryptica</i> sp. nov. <p>(Figs 1, 21, 22)</p> <p>urn:lsid:zoobank.org:act: 73FFCE8E-60F7-48E9-ADF8-8A89CEA814BA</p> <p> <i>Type Material</i>: HOLOTYPE (male) labeled: (a) “ MEX: Baja Norte / 9 mi NNW Rosarito / X-5-1983 / D. Faulkner & / F. Andrews ”; (b) “Under leaves on / stalk of dead / <i>Agave shawii</i> ”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21889”; (d) “ HOLOTYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). Designated here. PARA- TYPES (5 males, 8 female) labeled: (a) “ MEX: Baja Sur, Santa Inez Dam/ 8 mi. NE Todos Santos / X-10-83/ F. G. Andrews k”; (b) “Under bark of dead <i>Bursura microphylla</i> ”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (d) Tenebrionid Base numbers: 21594-21603, 21782, 21798, 21803. (CSCA). PARATYPES (6 males, 1 female) labeled: (a) “ Todos Santos,/ L. Cal. VII-15-38”; (b) ”Michelbacher&/Ross Collectors”; (c) “tricornis/ Determined by/ FEBlaisdell”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (e) Tenebrionid Base numbers: 20772-20774, 20782-20785 (CSCA). PARATYPES (4 males) labeled: (a) “ Todos Santos,/ L. Cal. VII-15-38”; (b) ”Michelbacher&/Ross Collectors”; (c) “tricornis/ Determined by/ FEBlaisdell”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (e) Tenebrionid Base numbers: 21793-21796. (CASC). PARATYPE (male) labeled: (a) “Santiago,/ L. Cal. VII-8-38”; (b) “Michelbacher&,/ Ross Collectors”; (c) “tricornis/ Determined by/ FEBlaisdell”; (d) “Tenebrionid Base / Aaron D. Smith / Catalog # 20786”; (e) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020” (CSCA). PARATYPES (4 males, 4 females) labeled: (a) “ MEX: Baja Calif. Sur. 3.6 mi NE Cabo San Lucas./ IX-29-1981 / F. Andrews & D.Faulkner ”; (b) “Collected under bark of standing dead “Torote” <i>Bursera microphylla</i> ”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (c) Tenebrionid Base numbers: 21783- 21789, 21891. (CSCA). PARATYPE (female) labeled: (a) “ MEX: Baja Calif. Sur. 3.6 mi NE Cabo San Lucas./ IX-29-1981 / F. Andrews & D.Faulkner ”; (b) “Collected under bark of standing dead “Torote” <i>Bursera microphylla</i> ”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (d) Tenebrionid Base number: 21797;. (RLAC). PARATYPE (female) labeled: (a) “AZ: Pima Co. / Tucson / July 25, 2007 / Eric Eaton coll.”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21810”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (DMNS). PARATYPES (3 male) labeled: (a) “AZ: Pima Co. / Tucson / July 27, 2007 / Eric Eaton coll.”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (b) Tenebrionid Base numbers: 21790-21792. (DMNS). PARATYPES (4 males, 1 female) labeled: (a) “ MEX: Baja Norte / 7.7 mi NNW Rosarito / X-4-1983 / D. Faulkner & / F. An- drews”; (b) “Under leaves on / stalk of dead / <i>Agave shawii</i> ”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”; (d) Tenebrionid Base numbers: 21799-21802, 21890. (CSCA). PARATYPE (female) labeled: (a) “ MEX: Baja Norte / 9 mi NNW Rosarito / X-5-1983 / D. Faulkner & / F. Andrews ”; (b) “Under leaves on / stalk of dead / <i>Agave shawii</i> ”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21809”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). PARATYPE (male) labeled: (a) “Mex.:Baja Calif. Sur/ 1.5 mi. east of San / Jorge. 24.VII.1971 / H.G Real & R.E.Main / In decaying Cardón”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21804”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (female) labeled: (a) “ Mexico: Baja California / Sur. Ramal naranjos rd./ 2.9 mi W Highway 1,650’/ IX-1-1990 F. Andrews / T. Eichlin & A. Gilbert ”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21805”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). PARATYPE (male) labeled: (a) “ 5 mi S./ Miraflores,/ L Cal. VII-10-38”; (b) “Michelbacher &/ Ross Collectors”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21806”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (male) labeled: (a) “ 5 mi. W San Bartolo / L. Cal. VII-13-1938 ”; (b) “Michelbacher & Ross Coll.”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21807”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (female) labeled: (a) “ MEXICO: S. L. P.,/ 12 mi S Cu. Mante / VI-21-1975 ”; (b) “under bark/ DS Chandler”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21808”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (UCDC). PARATYPE (male) labeled: (a) “ Colossal Cave / Park. Arizona/ 8.4.1970 ”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21811”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (NMNH). PARATYPE (male) labeled: (a) “Needles Cal./ XI-27-21/ J.A Kusche / Collector”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21812”; (c) “PARA- TYPE/ <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (NHMB). PARATYPE (male) labeled: (a) “ GUATEMALA:/ Nueva Concepcion/ 50’. VIII-17-63/ D.Q. Cavagnaro / & M.E. Irwin / collectors”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21813”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (male) labeled: (a) “ARIZ: Pima Co. / Avra Valley #1/ Mar. 29, 1972 JCS”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21814”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (male) labeled: (a) “FtGrant/ 14.7 Ar”; (b) “CollHubbard/ &Schwarz” (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21815”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (NMNH). PARATYPE (male) labeled: (a) “FtYuma/ 9.4 Ar”; (b) “CollHubbard/ &Schwarz”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21816”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (NMNH). PARATYPE (female) labeled: (a) “ San Bernardino Co. / Needles Cal./ X-14-61”; (b) “ A. Hardy Coll. ”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21817”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). PARATYPE (male) labeled: (a) “ MEX: B.Calif. / 4.5 mi.NE.of/ Los Planes / 21-XII-1958 ”; (b) “ H.B.Leech / Collector”; (c) “Ex dead/ <i>Bursera sp</i>.”; (d) “Tenebrionid Base / Aaron D. Smith / Catalog # 21818”; (e) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (female) labeled: (a) “ Venedio / Sinaloa Mex./ VI-10-1918 ”; (b) “Van Dyke/ Collection; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21819”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARATYPE (female) labeled: (a) “CALIF: Imperial CO. / Algodones Dunes, 7miSE/ Glamis 32°,55’,20”N/ 114°, 59’, 14”W Site 4/ V-1to15-1979” (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21820”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). PARATYPE (female) labeled: (a) “El Zapotal, 2 mi. S./ Tux.Gutierrez, Chias/ MEX. VII-12-57”; (b) “ J.A Chemsak / B.J Rannells / Collectors”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21821”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (EMEC). PARATYPE (female) labeled: (a) “ 8 mi E Concordia / Sin. Mex./ VIII-23-69/ J.Doyen ”; (b) “ Tenebrionid Base / Aaron D. Smith / Catalog # 21822”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CASC). PARA- TYPE (male) labeled: (a) “ Indio / Riverside Co. / Cal VIII-6-1963 ”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21823”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). PARATYPE (female) labeled: (a) MEX: S. L. Potosi / Tamazunchale, 18/ mi. SW. VIII-2-53”; (b) “ J. Doyen / Collector”; (c) “Tenebrionid Base / Aaron D. Smith / Catalog # 21824”; (d) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (EMEC). PARA- TYPE (male) labeled: (a) ” Mexico: Baja/ California Sur/ 16 km N. Tropic of / Cancer, Near/ Santiago/ 9 November 1981 / W. E. Steiner ”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21825”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (NMNH). PARATYPE (male) labeled: (a) “ Lago Catemaco Vera / Cruz MEXICO / VIII-20-1965 / A.R.Gillogly ”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21826”; (c) “ PARATYPE / <i>Hypo- gena/ cryptica /</i> Grey & Smith, 2020”. (RLAC). PARATYPE (female) labeled: (a) “Blythe Cal./ X-8-1945 ”; (b) “InQuar from/ Providence RI”; (c) “Collected from/ soil”; (d) “Cal.Dept.Agr./ No. BL45J19”; (e) “Tenebrionid Base / Aaron D. Smith / Catalog # 21827”; (f) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). PARATYPE (male) labeled: (a) “ Arizona, St. Catalina / Mts., Molino Basin / Oct. 13 1974 / K. Stephan leg.”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21828”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (FSCA). PARATYPE (male) labeled: (a) “ MEX. San Felipe / Baja Calif / III-26-1963 / G.I. Stage ”; (b) “Tenebrionid Base / Aaron D. Smith / Catalog # 21892”; (c) “ PARATYPE / <i>Hypogena / cryptica /</i> Grey & Smith, 2020”. (CSCA). (See Fig. 21).</p> <p> <i>Diagnosis</i>: This species is similar in size and shape to <i>H. brasilica</i>. The horns are also similar to <i>H. brasilica</i> by having a short clypeal horn and long supraorbital horns that point inward toward each other. The hypomeron and prosternum not having long, gold/yellow setae distinguish this species from <i>H. brasilica</i>. The mesepisternum is also not scalloped as in <i>H. brasilica</i>. Finally, in this species the coarse punctures are not primarily concentrated on the lateral portions of the pronotum, rather they are spread out across the pronotum (Fig. 21).</p> <p> <i>Description</i>: Male. Size: 8—11 mm; 3—4 mm.</p> <p>Head. Distance between cardo and eye less than width of cardo (34:1). Clypeal horn short, conical (4:1; 5:0); twice as wide, at base, as one supraorbital horn (7:2); produced forward (8:0); finely punctate (9:1). Supraorbital horns long, thin and slightly bent inwards (11:1; 12:1); produced perpendicular to head (13:1); not bent anteriorly (14:0); finely punctate (15:1). Antennae not forming club (17:0). Antennae with stellate sensoria (22:0). Third antennomere equal in size to fourth and more than 1.5 times size of second (18:0; 19:2). Vertex and frons with punctures smaller than eye facets (26:1; 28:1). Gena not extending laterally past eye (36:0). Clypeus is pointed in middle (29:2). Mentum trapezoidal and densely setose (40:0; 41:1). Groove on mandible present and continuing to connection point on cranium (44:1). Labrum fully setose (39:1).</p> <p>Thorax. Pronotum punctures biordinal in size (54:1). Coarse punctures numerous and spread evenly across pronotum (57:2). From lateral view, pronotum not arched (58:0); disc flat (60:1). Anterior edge of pronotum reaching middle of eye, but not past eye (63:1). Lateral margins of pronotum subparallel (61:1). Margins of pronotum expanded wider than diameter of one coarse puncture (62:2). Hypomeron laterally rugulose (75:2). Mesepisternum punctate; punctures smaller than eye facets and separated by one or less than one diameter (71:1). Mesepisternum not pubescent (73:0). Prosternum punctate and not pubescent (66:0); punctures smaller than eye facets (67:1), puncturing separated by less than one diameter (68:1). Prosternal process not continuing past posterior edge of pronotum (69:0). Elytra striae present and punctate (46:1); punctures shallow (47:1); separated by less than one diameter (48:0). Elytral interstices convex (49:1); punctures equal to or smaller than one fourth size of strial punctures (50:1); punctures separated by more than one diameter (51:1).</p> <p>Abdomen. All abdominal segments densely punctate; first three visible abdominal segments coarsely punctate (89:0; 90:0; 91:0); fourth and fifth visible abdominal segments finely punctate; punctures separated by less than one diameter. Abdominal sternites not setose (94:0). Legs. Tarsi pubescent. Cuticular outgrowths present on proximal two tarsomeres (86:1). Tibiae with two apical spurs (85:1). On lateral edge of protibia, seven or more socketed spines present on distal third (81:1; 82:0). All tibiae and femurs setose along entire length.</p> <p>Female. Similar to male, except as follows: Cuticle on intraocular space narrowly raised near eye (23:1). Intraocular space impinging on eye (24:1). Puncturing on vertex as large as or larger than eye facets (25:2). Clypeus with punctures smaller than eye facets and spread evenly across clypeus (31:1; 32:2). Anterior edge of clypeus flat but corners are rounded (30:1). Clypeus tumid (33:1).</p> <p> <i>Distribution</i> (Fig. 22): Mexico (Baja California, San Luis Potosi, Veracruz, Tamaulipas, Baja California Sur), USA (Arizona, California), Guatemala.</p> <p> <i>Etymology</i>: The specific epithet <i>cryptica</i> is a reference to the similarity that this species bears to <i>H. brasilica</i>. It is feminine.</p>Published as part of <i>Grey, Luna & Smith, Aaron D., 2020, A matrix-based revision of the genus Hypogena Dejean, 1834 (Coleoptera Tenebrionidae), pp. 201-258 in Zootaxa 4780 (2)</i> on pages 230-233, DOI: 10.11646/zootaxa.4780.2.1, <a href="http://zenodo.org/record/3842368">http://zenodo.org/record/3842368</a&gt
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