543 research outputs found
Clinical outcome and olanzapine plasma levels in acute schizophrenia
No full textPURPOSE: This open label study was performed to evaluate the relationship between the plasma concentration of olanzapine and the response in acute schizophrenic inpatients.
MATERIAL AND METHODS: A total of 54 inpatients, 38 males and 16 females, age ranging from 18 to 75 years, affected by Schizophrenia (DSM IV criteria) during an exacerbation phase were included in the study. Olanzapine (OLZ) was started at a dose of 5-20 mg/day and was increased to a mean dose of 15.27 mg +/-5.53 S.D. Patients were evaluated at baseline, and after 2 weeks, by using BPRS, PANNS, HRS-D, EPSE, and ACS.
RESULTS: BPRS and total PANSS showed a statistically significant improvement at the end of the study. Olanzapine plasma levels (PL) ranged from 5 to 120 ng/ml (mean 33.15 ng/ml +/- 28.28 S.D.) and showed a positive correlation with OLZ dosage. A significant curvilinear correlation between OLZ PL and clinical improvement (BPRS, PANSS and HRS-D percent of amelioration) was observed.
CONCLUSION: Olanzapine plasma level determination seems to be a useful tool in optimizing acute treatment particularly for more problematic cases
Clinical outcome and olanzapine plasma levels in acute schizophrenia
No full textPurpose: This open label study was performed to evaluate the reletionship between the plasma concentration of olanzapine and the response in acute schizophrenic inpatients.
Material and methods. A total of 54 inpatients, 38 males and 16 females, age ranging from 18 to 75 years, affected by schizophrenia during an exacerbation phase were included in the study. Olanzapine (OLZ) was started at a dose of 5-20 mg/day and was increased to a mean dose of 15.27 mg +/- 5.53 sd. Patients were evaluated at baseline, and after 2 weeks, by using BPRS, PANNS, HRS-D, EPSE and ACS.
Results.BPRS and total PANSS showed a statistically significant improvement at the end of the study. Olanzapine plasma levels (PL)ranged from 5 to 120 ng/ml (mean 33.15 ng/ml; sd 28.28) and showed a positive correlation with OLZ dosage. A significant curvilinear correlation between OLZ PL and clinical improvement (BPRS, PANSS and HRS-D percent of amelioration) was observed.
Conclusion. Olanzapine plasma level determination seems to be a useful tool in optimizing acute treatment particularly for more problematic cases
CPC: a control section synthesizer
No full textDeals with CPC, the SYCO control section synthesizer. CPC receives a hierarchical high level description of the circuit to be designed. The control section generated by CPC is made up of a stack of control slices. Each one is implemented by a single PLA. For each control slice, CPC performs three steps: (1) state table generation, (2) logic optimization and the completion of implicit jumps, (3) PLA generation. The author shows how the synthesis scheme can depend on the synthesizer intermediate form and the target architecture of the controller generated. The advantage of the CPC, compared to other control section synthesizers, is that the intermediate form is kept in a high level language. And it is well adapted to the target architecture
Webis Crowd Paraphrase Corpus 2011 (Webis-CPC-11)
No full text<p>The Webis Crowd Paraphrase Corpus 2011 (Webis-CPC-11) contains 7,859 candidate paraphrases obtained from Mechanical Turk crowdsourcing. The corpus is made up of 4,067 accepted paraphrases, 3,792 rejected non-paraphrases, and the original texts. These samples have formed part of <a href="https://doi.org/10.5281/zenodo.3250123">PAN 2010</a> international plagiarism detection competition, but were not previously available separate to rest of the competition data.</p>
<p>We provide the dataset as a single folder in a Zip archive. Each paraphrase is represented by three files, containing the original text (e.g.: "1-original.txt"), the paraphrase text (e.g.: "1-paraphrase.txt"), and a file containing metadata (e.g.: "1-metadata.txt"), with information about the task identifier, task author identifier, time taken, and whether the paraphrase was accepted or rejected.</p>
CPC and affordable private rental housing: An explorative study of collaboration between parties
No full textThe middle-income households in the Netherlands are currently disadvantaged in finding affordable housing, as they are pushed towards the private rental market in which affordable private rental housing is scarce. Together with participation trends, this gives opportunities for collective private commissioning (CPC) to add to the supply and make it more inclusive and stable, as different interests could come together and the housing is expected to stay affordable. Therefore, this study entails an explorative research into the possibilities of CPC and affordable private rental housing, focussing on the type of collaboration, the enablers and barriers in the collaborative process and the role division within the collaboration. A single case study of CPC for middle-segment owner-occupied housing was conducted, supplemented with a cross-sectional study, with interviewees currently involved in CPC for affordable private rental housing. The main findings show that the type of collaboration can be considered hybrid, as it can act in a commercial market while maintaining its social goal and it has a collaborative and innovative approach. Important enablers and barriers towards collaboration are in the initial phases of such a project, where expertise and political influence are crucial. During collaboration, a board providing connecting leadership, acknowledging power differences, trust and striving for a win-win situation by serving both social and commercial interests encourage collaboration. However, difficulties in the complex financial situation of such a development can cause barriers. Important roles for this type of development are defined as process responsible and executive, in order to guide the process. An enabler within the role division is making clear agreements at the beginning. Besides the previous implications, the role of the residents seems moderated compared to other forms of CPC, as they will only be in charge after the housing is realised. Implications for practice can be found and this type of development is considered to be an option, as the findings show that with the right conditions, this type of development can contribute to the supply of affordable private rental housing in the long-term.Architecture, Urbanism and Building Sciences | Management in the Built Environmen
Selecting cadres: former members of the CCYL in the 19th Central Committee of CPC
No full textThis chapter examines the role of Chinese Communist Youth League (CCYL) as
breeding ground for crucial political leaders in China. Author shows the share of former
affiliates of Central Committees CCYL in the 19th Central Committee of Communist
Party of China (CC CPC) and compares with data from previous CCs. Analysis
points out an insignificant correlation between engagement in CCYL and promotion
into the CPC structures which shows the importance of the official youth organization
of the CPC in the process of selecting the most powerful cadres of the party is
overrated
Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity
No full textAuthor Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Current Biology 19 (2009): 1210-1215, doi:10.1016/j.cub.2009.05.061.During animal cell division, a gradient of GTP-bound Ran is generated
around mitotic chromatin. It is generally accepted that this RanGTP
gradient is essential for organizing the spindle since it locally activates
critical spindle assembly factors. Here, we show in Xenopus egg
extract, where the gradient is best characterized, that spindles can
assemble in the absence of a RanGTP gradient. Gradient-free spindle
assembly occurred around sperm nuclei but not around chromatin-coated
beads and required the chromosomal passenger complex (CPC). Artificial
enrichment of CPC activity within hybrid bead arrays containing both
immobilized chromatin and the CPC supported local microtubule assembly
even in the absence of a RanGTP gradient. We conclude that RanGTP and
the CPC constitute the two major molecular signals that spatially promote
microtubule polymerization around chromatin. Furthermore, we
hypothesize that the two signals mainly originate from discreet physical
sites on the chromosomes to localize microtubule assembly around
chromatin: a RanGTP signal from any chromatin, and a CPC-dependent
signal predominantly generated from centromeric chromatin.This work was supported by the American
Cancer Society (grant PF0711401 to T.J. Maresca), the National Cancer Institute
(grant CA078048-09 to T.J. Mitchison) and the National Institutes of Health (grant
F32GM080049 to J.C. Gatlin and grant GM24364 to E.D. Salmon)
Collective private commissioning initiatives by elderly facilitated by the municipality: A research on how urban municipalities can better facilitate CPC projects in order to meet the increasing demand by elderly.
No full textDue to the limited quantitative and qualitative supply of elderly housing and an increasing demand for alternative housing forms, more and more resident initiatives arise in the Netherlands. However, it is evident from these resident initiatives that municipal processes lack focus, cooperation and experience with resident initiatives such as collective private commissioning projects. Therefore, this research aimed to explore how municipalities can better facilitate collective private commissioning (CPC) to respond to the increasing demand for elderly housing in urban areas. Literature review and desk research were conducted to create a theoretical framework; and to gain more insights into the concept, demand and useful instruments to facilitate CPC projects. CPC can be defined as a social project development method in which a group of future residents jointly have decision making authority and full responsibility for the use of the land and/or the building, the design and (re)development of their own private and public spaces, and sometimes even facilities, in a transformation, renovation, or newly-built housing project. Based on the theoretical framework, a qualitative study was conducted to discover the motives and experiences of municipalities when facilitating CPC. Seven municipalities were interviewed to create an overview of barriers and opportunities. These barriers and opportunities were made clear based on the theoretical framework.The results are presented in the form of a list of barriers and opportunities in relation to an instrument quadrant. The findings support the philosophy behind the quadrant: that more than one quadrant results in effective steering. Therefore, the general conclusion on how to better facilitate CPC projects is: to make use of multiple governance and maximize the soft steering aspects. The opportunities that are identified can help (radical, or soft) to better facilitate CPC projects. Architecture, Urbanism and Building Sciences | Management in the Built Environmen
CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine
No full textRecent transcriptome studies have revealed that a large number of transcripts in mammals and other organisms do not encode proteins but function as noncoding RNAs (ncRNAs) instead. As millions of transcripts are generated by large-scale cDNA and EST sequencing projects every year, there is a need for automatic methods to distinguish protein-coding RNAs from noncoding RNAs accurately and quickly. We developed a support vector machine-based classifier, named Coding Potential Calculator (CPC), to assess the protein-coding potential of a transcript based on six biologically meaningful sequence features. Tenfold cross-validation on the training dataset and further testing on several large datasets showed that CPC can discriminate coding from noncoding transcripts with high accuracy. Furthermore, CPC also runs an order-of-magnitude faster than a previous state-of-the-art tool and has higher accuracy. We developed a user-friendly web-based interface of CPC at http://cpc.cbi.pku.edu.cn. In addition to predicting the coding potential of the input transcripts, the CPC web server also graphically displays detailed sequence features and additional annotations of the transcript that may facilitate users' further investigation.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000255311500065&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Biochemistry & Molecular BiologySCI(E)PubMed293ARTICLEWeb Server issueW345-W3493
Temperature and pressure effects on the performance of the portable TSI 3007 condensation particle counter: Implications on ground and aerial observations
No full textOne of the most commonly employed instruments in the category of handheld condensation particle counters (CPCs) is the TSI 3007, which employs a simplified system for achieving a temperature difference between its saturator and its condenser in view of increasing portability, energy efficiency and autonomy. As a result, particle growth and consequently the detection efficiency of the instrument can be affected by the measurement conditions. In this work we measure the detection efficiency of the TSI 3007 CPC under temperatures and pressures that differ from standard conditions. Our results show that the performance of the CPC has a strong temperature dependence in the range of 5–30 °C, whereas it is not affected by ambient pressure when this varies between 0.7 and 1.0 atm. The temperature dependent detection efficiency of the instrument becomes significant at sizes below 20 nm. Recording the temperature at which this CPC is operated is therefore strongly advised, especially when required to determine the number concentration of sub-20 nm aerosol particles.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Atmospheric Remote Sensin
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