697 research outputs found

    Platelet activity and atherothrombosis: Clinical studies in postmenopausal women and renal disease patients

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    Stehouwer, C.D.A. [Promotor]Huijgens, P.C. [Promotor

    In-training assessment in an undergraduate clerkship : feasibility, reliability, effect on learning environment

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    Stehouwer, C.D.A. [Promotor]Vleuten, C.P.M. van der [Promotor]Donker, A.J.M. [Copromotor]Scherpbier, A.J.J.A. [Copromotor

    Hyperhomocysteinemia, diabetes and cardiovascular disease. The Hoorn study

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    Bouter, L.M. [Promotor]Heine, R.J. [Promotor]Kostense, P.J. [Copromotor]Stehouwer, C.D.A. [Copromotor

    Vascular Insulin Resistance Through Fat: Intracellular Signaling, Genetic Interferences and Hemodynamics

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    Hinsbergh, V.W.M. van [Promotor]Stehouwer, C.D.A. [Promotor]Eringa, E.C. [Copromotor]Sipkema, P. [Copromotor

    On diagnostic tools in coeliac disease and its complicated forms

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    Mulder, C.J.J. [Promotor]Peña, A.S. [Promotor]Stehouwer, C.D.A. [Promotor

    Homocysteine as a Risk Factor for the Development of Cardiovascular Disease; the Role of NOX Proteins

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    Niessen, J.W.M. [Promotor]Hinsbergh, V.W.M. van [Promotor]Stehouwer, C.D.A. [Copromotor]Rauwerda, J.A. [Copromotor

    Pathogenesis and prevention of cardiovascular disease in patients with chronic kidney disease

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    Wee, P.M. ter [Promotor]Stehouwer, C.D.A. [Promotor]Smulders, Y.M. [Copromotor]Guldener, C. van [Copromotor

    Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease?

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    Can mild-to-moderate hyperhomocysteinaemia impair endothelial function in the absence of other risk factors for cardiovascular disease? Honing ML, Stehouwer CD. Department of Internal Medicine, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands. The majority of clinical studies demonstrate that patients with hyperhomocysteinaemia have an increased risk of atherothrombotic events. However, there is a striking and poorly understood heterogeneity in the severity of clinical features in individuals with hyperhomocysteinaemia. This observation suggests that other factors must exist that modulate the relationship between hyperhomocysteinaemia and clinical disease. Therefore identifying factors that inhibit or enhance the vasculotoxic effects of homocysteine is important, as is elucidation of how homocysteine damages blood vessels. This comment discusses the study of Woodman and colleagues in this issue of Clinical Science in which they investigate the effects of hyperhomocysteinaemia on endothelial functio

    Microvascular Dysfunction: Metabolic and Cardiovascular Causes and Consequences

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    Stehouwer, C.D.A. [Promotor]IJzerman, R.G. [Copromotor]Serne, E.H. [Copromotor
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