791 research outputs found

    sj-docx-1-mpp-10.1177_23814683221083839 – Supplemental material for Sample Size and Model Prediction Accuracy in EQ-5D-5L Valuations Studies: Expected Out-of-Sample Accuracy Based on Resampling with Different Sample Sizes and Alternative Model Specifications

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    Supplemental material, sj-docx-1-mpp-10.1177_23814683221083839 for Sample Size and Model Prediction Accuracy in EQ-5D-5L Valuations Studies: Expected Out-of-Sample Accuracy Based on Resampling with Different Sample Sizes and Alternative Model Specifications by Tonya Moen Hansen, Knut Stavem and Kim Rand in MDM Policy & Practice</p

    Switching from one reference biological to another in stable patients for non-medical reasons: a literature search and brief review

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    Background: The practice of non-medical switch (NMS) from a reference biological (originator) to a biosimilar is widely accepted in some countries. However, there is little documentation on the impact of NMS from one originator to another originator. Objectives: To assess the consequences for patients of NMS from one biological originator to another, based on existing literature. The focus was on efficacy and cost of treatment with TNF-α-inhibitors in three disease areas. Methods: A literature search was conducted in Ovid (PubMed, EMBASE) and abstracts from meetings in key therapeutic areas, to identify studies reporting efficacy, safety or costs by switching between originator biologics. Results: 167 references were identified and abstracts screened; 36 papers reviewed in full text, and 6 fulfilled the inclusion criteria. Three clinical studies of NMS had very small sample sizes, but suggested that NMS is beneficial. The remaining three studies used administrative data with little clinical information, indicating that NMS was disadvantageous and associated with increased health care utilization and costs. Conclusions: There is very limited documentation on NMS from one originator biological to another, and the literature suffers from methodological limitations. The results are mixed and preclude drawing an overriding conclusion. Future studies, are warranted

    Front Matter, Table of Contents, Preface, List of Authors

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    Front Matter, Table of Contents, Preface, List of Author

    Post-lobotomy epilepsy illustrated by the story of Ellinor Hamsun, the daughter of the famous Norwegian author Knut Hamsun

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    In Scandinavia, at least 11.500 people were lobotomized in the period 1939–1983. Beside grave personality changes, the surgery caused epilepsy in 10–35% of the patients. Moreover, many died due to perioperative bleedings, convulsive status epilepticus or SUDEP. Most of the stories of these people are anonymous and their post-lobotomy lives are scarcely documented. If it was not for the fact that Ellinor Hamsun (1916–1987) was the daughter of the famous Nobel Prize winning Norwegian author Knut Hamsun, her lobotomy story and the subsequent iatrogenic epilepsy would probably have remained unknown

    Tax systems in the reforming socialist economies of Europe

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    As socialist countries move toward market systems, fiscal policy is an important part of their reform agenda. First, they need to reorient public spending to focus more on the provision of"public"goods. Second, they need to adopt more selective, predictable, and nondiscretionary means to finance such spending. The goal of this paper is to lay out some of the broad trends and issues now emerging as socialist economies attempt to reform their systems of taxation. The primary focus is on Eastern Europe, although many of the same trends and issues arise in the reforming socialized countries of Asia and Africa. Particular attention is paid to Hungary and Poland, which are most advanced in the tax reform process. The experiences they have had and the problems they are facing provide valuable lessons for those countries just starting on the reform process.Public Sector Economics&Finance,Environmental Economics&Policies,Economic Theory&Research,Banks&Banking Reform,Municipal Financial Management

    Beundring og opposisjon. Forholdet mellom Knut Hamsun og Johannes V. Jensen

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    AbstractIn this article, I will discuss Knut Hamsun’s connection to the Danish capital Copenhagen, and his lifelong acquaintance with the famous Danish author, Johannes V. Jensen. By the end of the 19th century, Copenhagen was the cultural capital of the Nordic countries. Together with many other eminent Nordic artists, Knut Hamsun spent considerable time in Copenhagen and experienced personal and professional growth during his stays there. Johannes V. Jensen and Hamsun knew each other for years and held each other in high esteem, yet their acquaintance was marked by both fascination and critique. Johannes V. Jensen, in particular, had mixed feelings and opinions about Hamsun. This article focusses on the similarities and differences between Knut Hamsun and Johannes V. Jensen, and discusses how an initially shared value system could lead them in two opposite political directions.</jats:p

    Knut Hamsun en Hispanoamérica: hacia una revaloración

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    Although the work of Norwegian writer Knut Hamsun, the author of the masterpieces Hunger, Mysteries and Pan is at present not so familiar to the Spanish American readers, it is surprising to find that his titles were well received and widely published in the continent during the first years of the XXth century, particularly after he was awarded the Nobel prize in literature in 1920. Based on samples from library catalogues in Argentina, Colombia, Chile, México and Uruguay, this article intends to follow Spanish and Spanish American translations of Hamsun's works from 1919 to 2009.Aunque la obra del escritor noruego Knut Hamsun, autor de grandes novelas como Hambre, Misterios y Pan es actualmente poco conocida entre los lectores hispanoamericanos, sorprende la difusión y recepción que tuvo en el continente en los primeros años del siglo XX, especialmente a raíz de que obtuviera el premio Nobel de literatura en 1920. Con base en un muestreo de catálogos de bibliotecas en Argentina, Colombia, Chile, México y Uruguay, el presente artículo traza el camino recorrido por las traducciones españolas e hispanoamericanas de la obra de Hamsun desde 1919 hasta 2009
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