163,145 research outputs found
La riforma keynesiana - Analisi della teoria generale di J. M. Keynes
No full textLa presente monografia analizza in maniera scrupolosa e con linguaggio accessibile la Teoria generale di J. M. Keynes avvalendosi dei contributi di altri autori usciti subito dopo la sua pubblicazione. La Teoria generale ha riformato la macroeconomica ma, come si può desumere dalla lettura di questo libro, ci sono autori precedenti che hanno introdotto, seppur in maniera non sistematica, concetti considerati tipicamente keynesiani. Ragion per cui preferiamo parlare di “riforma keynesiana” piuttosto che di “rivoluzione keynesiana”. Nel testo figura anche una breve analisi della Grande Depressione degli anni ’30 poiché è stata proprio questa congiuntura sfavorevole a ispirare l’opera maggiore di J. M. Keynes
ECONOMIA INTERNAZIONALE MONETARIA UN'INDAGINE TEORICA DEI MECCANISMI E DELLE POLITICHE DI AGGIUSTAMENTO DELLA BILANCIA DEI PAGAMENTI CAPITOLO 6 (BOZZA FINALE)
No full textQuesto sesto capitolo del saggio affronta la rilevante tematica delle politiche di stabilizzazione interna ed esterna. Si prendono in esame, sia modelli di natura statica che di natura dinamica. Si considerano, per completezza, i due regimi valutari alternativi: cambi fissi e cambi flessibili. Particolare enfasi è dedicata al modello di Krugman e Obstfeld (2003b), caratterizzato da perfetta mobilità dei capitali con aspettative sul cambio legate alla teoria della parità dei poteri d'acquisto, secondo quanto delineato nel capitolo 5. Spazio è dedicato anche al problema dei lags temporali e all'effetto J
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Optimal Dislocation of Branch Offices From View of Transport Availability
No full textThe district authorities were canceled and substituted by self-governments branch offices after the public administration reform in the Czech Republic. So-called municipalities with extended sphere of authority were proposed for placing of branch offices. These branch offices were chosen regardless of their transport availability. The article deals with the problem of determination of optimal number of branch offices and of their attract areas, from view of their transport availability. The problem is solved with the methods of mathematical programming. The problem was by the help of Lagrange multiplicator converted to incapacitated location problem with criterion function sum(fyi)+sum sum (cij xij) where xij is arbitrary variable expressing whether the municipality j is allocated to the branch office i, cij is a coefficient representing distance from branch office i, weighted with population of the municipality j, yi is bivalent variable expressing whether in the municipality will be established the branch office and f is constant presenting branch office establishment costs. Model is solved with Erlenkotter method realized by the help of BB dual algorithm.
SYNAPTIC AVAILABILITY OF GLUN2A SUBUNIT OF NMDA RECEPTORS FROM PHYSIOLOGICAL MECHANISMS TO 
PATHOLOGY: THE ROLE OF RABPHILIN 3A
No full textBackground and Purpose - NMDA receptor subunit composition strictly commands receptor function and pharmacological responses. The identity of the GluN2 subunit regulates biophysical and pharmacological properties of the receptor and influences receptor assembly, signaling and trafficking to the postsynaptic membrane. The number or subunit composition of NMDA receptors vary during activity dependent plasticity and CNS disorders like Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) where you can find an enhanced extrasynaptic localization of GluN2B-containing NMDA receptors and an increase of the GluN2A/GluN2B ratio at striatal synapses. Recently, a two-hybrid screening to find potential proteins interacting with the C-terminal tail of the GluN2A subunit of the NMDA receptor has highlighted Rabphilin 3A (Rph3A) as a potential partner. Rph3A is a synaptic vesicle-associated protein that was first identified as a binding partner of the GTP-bound Rab3A, a member of the Rab family of GTPases implicated in vesicle docking/fusion reactions. Moreover, different studies have indicated that Rph3A can regulate exo- and endocytosis processes at synaptic sites. Our goal was to characterize Rph3A interaction with GluN2A at postynaptic sites and to assess its relevance in PD and LID.
Methods and Results - Firstly, we verified its interaction with GluN2A by immunoprecipitation and GST pull-down experiments. Subcellular fractionation assays revealed that Rph3A is present in Triton Insoluble Postsynaptic compartment and post-synaptic density (PSD) fractions. Immunofluorescence studies performed in neuronal hippocampal cultures, confirmed biochemical experiments revealing Rph3A colocalization with PSD-95 (marker of the postsynaptic compartment) and GluN2A. Moreover, we found Rph3A to be interacting with a 40AA domain on C-terminal tail of GluN2A between AA 1349 and 1389. Therefore, we designed a cell permeable peptide containing this sequence called TAT-2A-40. This peptide is capable of disrupting the interaction between Rph3A and GluN2A. By doing this, it can reduce the expression of GluN2A in dendritic spines and its surface expression as we show by immunocytochemistry and electrophysiology. Moreover, we have observed an increase of GluN2A/Rph3A interaction in a rat PD model as well as a rat LID model. We have that the TAT-2A-40 was capable of significantly reducing the dyskinetic behavior in these animals.
Conclusions - These results strongly indicate the presence of Rph3A in the PSD compartment and suggest a function of Rph3A in the modulation of NR2A localization. Rph3A could play a crucial role in the stabilization of GluN2A subunits at the plasma membrane in dendritic spines. Therefore, this interaction could be a potential therapeutic target for diseases where NMDAR composition is significantly altered such as Parkinson's Disease and L-DOPA-induced dyskinesia
From star‐forming spirals to passive spheroids: integral field spectroscopy of E+A galaxies
No full textWe present three‐dimensional spectroscopy of 11 E+A galaxies at z = 0.06–0.12. These galaxies were selected for their strong Hδ absorption but weak (or non‐existent) [O ii ] λ3727 and Hα emission. This selection suggests that a recent burst of star formation was triggered but subsequently abruptly ended. We probe the spatial and spectral properties of both the young (≲1 Gyr) and old (≳few Gyr) stellar populations. Using the Hδ equivalent widths we estimate that the burst masses must have been at least 10 per cent by mass ( M burst ≳ 10 10 M ⊙ ), which is also consistent with the star formation history inferred from the broad‐band spectral energy distributions. On average the A stars cover ∼33 per cent of the galaxy image, extending over 2–15 kpc 2 , indicating that the characteristic E+A signature is a property of the galaxy as a whole and not due to a heterogeneous mixture of populations. In approximately half of the sample, we find that the A stars, nebular emission and continuum emission are not co‐located, suggesting that the newest stars are forming in a different place than those that formed ≲1 Gyr ago, and that recent star formation has occurred in regions distinct from the oldest stellar populations. At least 10 of the galaxies (91 per cent) have dynamics that class them as ‘fast rotators’ with magnitudes, v /σ, λ R and bulge‐to‐total (B/T) ratio comparable to local, representative ellipticals and S0s. We also find a correlation between the spatial extent of the A stars and the dynamical state of the galaxy such that the fastest rotators tend to have the most compact A star populations, providing new constraints on models that aim to explain the transformation of later type galaxies into early types. Finally, we show that there are no obvious differences between the line extents and kinematics of E+A galaxies detected in the radio (active galactic nucleus, AGN) compared to non‐radio sources, suggesting that AGN feedback does not play a dramatic role in defining their properties, and/or that its effects are short.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90164/1/j.1365-2966.2011.20082.x.pd
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
A Tripartite Post-Recession Rebalancing
No full textIn this latest Advance & Rutgers Report, entitled “A Tripartite Post-Recession Rebalancing,” Dean James W. Hughes and Professor Joseph J. Seneca deliver an incisive assessment of the current market conditions and obstacles in the path of our economic recovery. They offer a statistical cautionary tale that the private and public sector need to hear and acknowledge in order for the economy to make continued progress.This report was published as Issue Paper Number 7, November 2011, in Advance & Rutgers Report
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