1,721,022 research outputs found
Angiogenesi tumorale: il ruolo prognostico dell’espressione di CD105 nei carcinomi squamosi della laringe.
No full textStudio vincitore del Primo Premio presso Premio Unico nazionale della Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-facciale. Bologna, 31 maggio-3 giugno 2006
Carcinosarcoma de novo of the parotid gland.
No full textOnly 29 cases of salivary gland carcinosarcoma de novo have been described in the English-language literature. We present a new case of parotid gland carcinosarcoma de novo and discuss diagnostic and treatment modalities of this pathologic entity. Our patient underwent total parotidectomy with facial nerve preservation, chemotherapy, and radiotherapy. At 26-month follow-up, the patient presented no evidence of recurrence. One-third of the cases of salivary carcinosarcoma de novo died of the disease after a median period of 10 months. Although the number of cases is limited, the combination of radical surgical excision and radiotherapy seems currently the treatment of choice
Simposio: L’impiego dei moderni biomarkers può rivoluzionare la diagnostica ed il trattamento dei carcinomi della testa e del collo?
No full textSyringocystoadenoma papilliferum of the external ear canal: an immunohistochemical study.
No full textAbstract Not available
...Syringocystoadenoma papilliferum (SCAP) is an uncommon
benign hamartomatous tumour of the skin
characterized by extensive papillary growth of epithelial
elements down into the dermis. Fewer than 200
cases have been reported in the literature (1) and
approximately one-third were associated with a preexisting
nevus sebaceous (2). The lesions have been
noted at birth in:/50% of cases, and during infancy
and childhood in another 15%. The site of occurrence
of SCAP has been the head and neck in:/75% of
cases (3). SCAP of the external ear canal is exceedingly
rare. In a review of the literature by Muller and
Theissig (1), only 11 cases of SCAP of the external ear
canal were disclosed. Since that review, another case of
congenital syringocystoadenoma of the tragus, concha
and lobule extending to the outer ear canal has been
described by Jordan et al. (3) in a 21⁄2-week-old infant..
Il significato prognostico delle espressioni di angiogenina e CD105 nel carcinoma della laringe.
No full textStudio vincitore del Primo Premio presso Premio Unico della Societa' Italiana di Otorinolaringologia e Chirurgia Cervico- Facciale: Caliceti-Citelli-Pietrantoni. Riccione 19-22 maggio 2010
Successful palliative chemotherapy for peristomal recurrence of laryngeal metastasis from colon adenocarcinoma.
No full textabstract not available
...Rare cases of metastasis of colon adenocarcinoma
to the larynx usually present with disseminated
disease. In view of the poor chances of long-term
survival only palliative laryngeal treatment aimed to
improve the patients’ quality of life is advised. In
palliative approaches to laryngeal metastases from
colon carcinoma, laser endoscopic resection of the
laryngeal lesion has been described as an ideal tool
for relieving airway obstruction without significant
morbidity [2]. Associated chemotherapeutic approaches
in patients with head and neck metastatic
colorectal cancer should also be considered. Considering
the therapy for metastatic colorectal cancer,
a recent review by Goldberg [3] showed that the
chemotherapeutic regimens FOLFOX (oxaliplatin/
5-fluorouracil/leucovorin) and FOLFIRI (irinotecan/
5-fluorouracil/leucovorin) consistently lead to
median overall survivals in the range of 1520
months. Combinations seemed to confer a 56
month advantage in median overall survival when
compared with single-agent chemotherapy. The
patients aged over 70 seemed to tolerate FOLFOX
regimen as well as younger patients. There are few
published data on the tolerability of first-line irinotecan-
based regimens in elderly patients [3]. Our
patient did not respond significantly to the FOLFOX
regimen; on the other hand, the FOLFIRI
regimen determined a good partial response of
peristomal recurrence and lung metastases
Leiomyosarcoma of the larynx: critical analysis of the diagnostic role played by immunohistochemistry.
No full textLaryngeal leiomyosarcoma (LMS) is definitely considered a rare occurrence: our exhaustive literature review disclosed to date only 45 cases (including the new case we have reported). The morphological diagnosis of laryngeal LMS may be problematic on conventional light microscopy especially in small laryngeal specimens. In the past, LMSs of the larynx were frequently confused with other spindle-cell malignant tumors. Nowadays, immunohistochemical investigations are considered necessary to distinguishing LMS from other spindle-cell tumors. On immunostaining, LMS is usually positive for muscle-specific actin and negative for cytokeratins and epithelial membrane antigen. In most cases, immunohistochemical study allows reliable diagnosis of LMS, but it can produce ambiguous or inconclusive results when the tumor cells lack specific immunohistochemical reactivity. In these controversial cases, LMS diagnosis has to be substantiated by electron microscopy. Distinguishing laryngeal LMS from other spindle-cell malignancies plays a role not only in academic interest. Confusion in the diagnosis of a spindle-cell laryngeal malignancy could result in inappropriate clinical management and inadequate treatment
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