7,527 research outputs found
Efficacy of NPI in the Rescue of γ-Secretase Activity Following Knockdown with RNAi Treatment
No full text1 broadside : ill.Alzheimer’s disease is the leading cause of dementia and memory loss among the
elderly. One in ten people over age 65 suffers from Alzheimer’s, and more than half of all
people over 85 have the disease. Care for the disease is expensive – in America, it is the
third most expensive disease, following heart disease and cancer, with an average lifetime
cost of care per patient of $174,000. For the above reasons, the search for effective
treatments and preventative measures for this disease is a high priority.
At the cellular level, Alzheimer’s disease is linked to the enzymatic cleavage of a
particular transmembrane protein, the amyloid precursor protein (APP), which results in
the release of an ectodomain known as Aβ. Gamma-secretase, which is responsible for the
transmembrane proteolysis of APP (Figure 1), is a complex of several proteins.
Recently, the St. George-Hyslop lab has identified a novel protein (NP1) that may be
required for regulation of this cleavage event, as suppression of NP1 production in vitro
leads to elevated levels of secreted Aβ (Figure 2, Hasegawa, Unpublished). NP1 is a type I,
transmembrane, trafficking-related protein that belongs to a family of proteins studied
previously in the context of vesicular transport. Due to the observed elevation in secreted
Aβ and the observation that NP1 co-precipitates with all known components of the γ-
secretase complex, it is therefore possible that this protein has a role in the function of the
γ-secretase complex, and, subsequently, in APP processing.Centre for Research in Neurodegenerative Diseases. University of Toronto. Toronto, Canada.Kalamazoo College. Department of Biology. Diebold Symposium, 2006Introduction -- Methods and materials -- Results -- Discussion -- Literature cited -- Acknowledgment
"Fifty key Christian thinkers" by Peter McEnhill & George Newlands
No full textReview of Peter McEnhill & George Newlands, Fifty Key Christian Thinkers (London: Routledge, 2004)Publisher PD
Zechariah 9-14 as the substructure of 1 Peter’s eschatological program
No full textThe principal aim of this study is to discern what has shaped the author of 1 Peter to regard Christian suffering as a necessary (1.6) and to-be-expected (4.12) component of faithful allegiance to Jesus Christ. Most research regarding suffering in 1 Peter has limited the scope of inquiry to two particular aspects—its cause and nature, and the strategies that the author of 1 Peter employs in order to enable his addressees to respond in faithfulness. There remains, however, the need for a comprehensive explanation for the source that has generated 1 Peter’s theology of Christian suffering. If Jesus truly is the Christ, God’s chosen redemptive agent who has come to restore God’s people, then how can it be that Christian suffering is a necessary part of discipleship after his coming, death and resurrection? What led the author of 1 Peter to such a startling conclusion, which seems to runs against the grain of the eschatological hopes and expectations of Jewish restoration ideology?
This thesis analyzes the appropriation of shepherd and fiery trials imagery,
and argues that the author of 1 Peter is dependent upon Zechariah 9-14 for his
theology of Christian suffering. Said in another way, the eschatological program of
Zechariah 9-14, read through the lens of the Gospel, functions as the substructure
for 1 Peter’s eschatology and thus its theology of Christian suffering.
In support of this hypothesis, this study highlights the fact that Zechariah 9-
14 was available and appropriated in early Christianity, in particular in the Passion
Narrative tradition; that the shepherd imagery of 1 Pet 2.25 is best understood
within the milieu of the Passion Narrative tradition, and that it alludes to the
eschatological program of Zechariah 9-14; that the fiery trials imagery found in 1
Peter 1.6-7 and 1 Pet 4.12 is distinct from that which we find in Greco-Roman and OT
wisdom sources, and that it shares exclusive parallels with some unique features of
the eschatological program of Zechariah 9-14; that Zechariah 9-14 offers a more
satisfying explanation for the modification of Isa 11.2 in 1 Pet 4.14, the transition
from 4.12-19 to 5.1-4, why Peter has oriented his letter with the term διασπορά,
and why he has described his addresses as οἶκος τοῦ θεοῦ; and finally that 1 Peter
contains an implicit foundational narrative that shares distinct parallels with the
eschatological program of Zechariah 9-14.
We can conclude that 1 Peter offers a unique vista into the way in which at
least one early Christian witness came to understand and to communicate the fact
that Christian suffering was a necessary feature of faithful allegiance to Jesus Christ
Education in post-Reformation Scotland : Andrew Melville and the University of St Andrews, 1560-1606
No full textAndrew Melville (1545-1622) was the leader of the Presbyterian wing of the Scottish
Kirk between 1574 and 1607, and he and his colleagues were a perpetual irritant to
James VI and I in his attempts to establish a royal and Episcopal dominance over the
Kirk. Yet much of Melville’s reputation has been based on the seventeenth-century
Presbyterian historical narratives written by the likes of James Melville (Andrew’s
nephew) and David Calderwood. These partisan accounts formed the basis of modern
historiography in Thomas M’Crie’s monumentally influential Life of Andrew Melville.
Modern historians broadly agree that Melville’s portrayal as a powerful and decisive
church leader in these narratives is greatly exaggerated, and that he was at best an
influential voice in the Kirk who was quickly marginalised by the adult James VI.
However, only James Kirk has commented at any length on Melville’s other role in
Jacobean Scotland—that of developing and reforming the Scottish universities.
Melville revitalised the near-defunct Glasgow University between 1574 and 1580, and
from 1580 to 1607 was principal of St Mary’s College, St Andrews, Scotland’s only
divinity college. He was also rector of the University of St Andrews between 1590
and 1597. This thesis provides a detailed account of Melville’s personal role in the
reform and expansion of the Scottish universities. This includes an analysis of his
direct work at Glasgow, but focuses primarily on St Andrews, using the untapped
archival sources held there and at the Scottish National Library and Archives to create
a detailed picture of the development of the University after the Reformation. This
thesis also evaluates the intellectual content of Melville’s reform programme, both as
it developed during his time in Paris, Poitiers and Geneva, and as we see it in action in
St Andrews
"This word is the gospel preached to you" : ecclesiology and the Isaianic narrative in 1 Peter
No full textThe appropriation of Isaiah in 1 Peter occurs through explicit quotations, but also by means of subtle allusions and echoes. I propose that the ecclesiology of 1 Peter draws upon the narrative of the restoration of divine presence among the people of God despite present suffering, which is informed largely by the themes and images of Isaiah, so that the church is identified as participants in a scriptural narrative through its participation in Christ, who is
understood to be the Messiah of the scriptures.
This study explores the relationship between 1 Peter and the scriptures it employs along
several lines. First, comparison is made with available textual evidence to determine differences between the texts in 1 Peter and their Vorlagen. This helps determine the extent to which texts have been modified, the cause of modification, and any interpretive uses such modifications may
have occurred. Second, individual texts used in 1 Peter are correlated with the larger narrative of scripture. It is argued that the terms suffering and glory express this narrative in the language of the epistle as a present conflict and future resolution. Third, Isaiah informs the ecclesiology of
the letter, in harmony with other scriptural texts, so that the church is viewed as participating in the scriptural narrative of the restoration of divine presence. Finally, the narrative drawn from scripture provides comfort and consolation to Christians suffering in Asia Minor by showing
how present suffering is consistent with the experiences of God’s people in ages past and with the experience of Christ. Furthermore, the hope of future glory entails the vindication of present calamities and the reward of honorable conduct.
I conclude by showing how the Isaianic narrative has been formative for Peter’s
understanding of the church. In his address to the churches of Asia Minor, he builds an
argument from his reading of the Isaianic narrative that 1) indicates how the scriptures of Israel are the basis of gospel proclamation and community formation, 2) proposes a high ethical standard in the midst of suffering based on the pattern of Christ, and 3) depicts the vindication
of the suffering church at the revelation of Christ
The Reformation in the burgh of St Andrews : property, piety and power
No full textThis thesis examines the impact of the Reformation on the estates of ecclesiastical
institutions and officials based in St Andrews. It argues that land and wealth were
redistributed and power structures torn apart, as St Andrews changed from Scotland’s
Catholic ecclesiastical capital to a conspicuously Protestant burgh. The rapid dispersal
of the pre-Reformation church’s considerable ecclesiastical lands and revenues had
long-term ramifications for the lives of local householders, for relations between
religious and secular authorities, and for St Andrews’ viability as an urban community.
Yet this major redistribution of wealth has had limited attention from scholars.
The first part of this study considers the role played by the Catholic Church in St
Andrews before the Reformation, and the means by which it was financed, examining
the funding of the city’s pre-Reformation ecclesiastical foundations and officials, and
arguing that (contrary to some traditional assumptions) the Catholic Church in St
Andrews was on a reasonably sound financial footing until the Reformation. The second
section considers the immediate disruption to St Andrews’ religious lands and revenues
caused by the burgh’s public conversion to Protestantism, and then explores the more
planned reorganisation of the 1560s. The disputes and difficulties triggered by the
redistribution of ecclesiastical wealth are examined, as well as the longer term impact
on St Andrews of the treatment of church revenues at the Reformation. Evidence for this
study is chiefly drawn from the extensive body of manuscripts concerning St Andrews
held by the National Library of Scotland, the National Records of Scotland, and the
University of St Andrews Special Collections
George McDowall Oral History
No full textBiographical Information:
George McDowall was born on August 11, 1922 in Chicago, Illinois, to William and Grace McDowall. George grew up in Joliet, Illinois. In the summer of 1942, he enlisted in the Army Air Corps and served as a B-24 Bomber pilot during the World War II. George deployed to the Pacific Theater in 1944 and flew 44 combat missions. He was discharged from service on November 11, 1945 and remained in the reserves after the war. In 1948, George and his father, Bill, purchased a roofing company which George operated the company until he retired. McDowall was married to Mary Elizabeth Leonard on February 28, 1951 and they had eight children –Patrick, John, David, Peter, Lawrence, Paul, Mary, and Steven. George died on December 15, 2007 and buried in Assumption Cemetery in St. Cloud, Minnesota.
Transcript Summary:
In an interview conducted on October 18, 1989, George McDowall described his experience as a pilot in the Army Air Corps during World War II. In October 1942, McDowall enlisted with the Army Air Corps His initial training was at Miami Beach and then to the San Antonio Aviation Cadet Center. Here it was to be determined whether he would be a pilot, navigator, or bombardier. McDowall was shipped to Illinois for primary flight school and then Winfield, Kansas for basic flight school. He soon was sent to Waco, Texas to train twin engine planes and, upon completion, McDowall went to Naval Air Station Joint Reserve Base Fort Worth for B-24 training. After the completion of all his training, McDowall made his way to Nadzab, New Guinea. While discussing his training, he explained what training was like, cadets washing out of the program and fatal airplane accidents.
McDowall told about the first training mission from Nadzab as well as describing he should have received and the kind of pilots that were sent back to train. After Nadzab, McDowall was stationed at Morotai and remembered the conditions there compared to Nadzab. McDowall recounted different events while stationed at Morotai including the Japanese bombing the airfield and different airstrips in the Philippines. He also detailed the bomb run on the Japanese Navy at Brunei Bay in Borneo as well as the aftermath for the different bomber groups. Another event recounted the Battle of Leyte Gulf and his bomb run on the town of Ormac. McDowall detailed the intricacies of a bomb run and the use of the Norden bombsight. McDowall compared the strengths and weaknesses of the different bombers. He ended the interview regarding his positive and negative feelings from World War II and men dodging the draft during the Vietnam War.
Interview by David Over
Interview with Peter Hetzel
No full textDon Dunstan Oral History Project interview transcripts. No conditions are imposed on the reuse of this transcript by the interviewee.Interview with Dr Peter Hetzel by George Lewkowicz. Peter was a school friend of
Don at St Peter’s College, knew Don at university and later was one of his doctors. The interview was held on the 4th July 2008
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