606 research outputs found
The light of the eye : doctrine, piety and reform in the works of Thomas Sherlock, Hannah More and Jane Austen
No full textBibliography: leaves 376-401.This thesis investigates the ways in which three eighteenth-century writers, Bishop Thomas Sherlock, Hannah More and Jane Austen embody orthodox Anglican doctrine according to their individual perceptions of the enlightening properties of Protestant Christianity. After situating them in their respective gender, literary and ecclesiastical contexts, I examine some of their key doctrines and analyse excerpts from their works. My selection of passages from Sherlock's works is fairly comprehensive, but in the case of More and Austen, where there is already a formidable body of literary criticism, it is more selective. Thus, I focus on doctrine in More's tracts, Strictures on the System of Female Education, An Essay on St Paul and most especially Coelebs in Search of a Wife and in the case of Austen, on her prayers and select passages from Sense and Sensibility and Mansfield Park. I conclude that, although diverse in their particular kind of Anglicanism (High, Evangelical and Median) and in their choice of genre, transparency or obscurity (anonymity and pseudonymity) and the various narratological strategies some of them invoke to circumvent certain taboos, Sherlock, More and Austen champion the same central orthodox doctrines, defend them against current alternatives to orthodoxy such as Latitudinarianism, Deism and various forms of Freethinking, and promote similar moral and ecclesiastical reforms. However, indirectly (through female characters who resist male representation or control) the women writers subject their ostensibly authorially-endorsed male narrators/characters to scrutiny and sometimes (when the males objectify the women) subversion
"In this moment of alarm and peril": Female Education, Religion and Politics In the Late Eighteenth Century, With special reference to Catharine Macaulay and Hannah More
No full textPhDCatharine Macaulay and Hannah More are conventionally represented as
ideological opposites. Through an analysis which centres on their writings, this
thesis critically examines that representation, and more broadly explores
contemporary perceptions of the roles of women of the middling sort in the late
eighteenth century. It argues that revolution, particularly the French Revolution,
created a climate wherein the duties of women became the subject of increasing
debate. The discussion challenges and builds upon recent work on women's
writing and history, by examining how and why the role of women changed at this
time. This work is concerned with contemporary representations of women, and
concentrates on analysis of primary texts and archival material over a wide range
of genres, including educational treatises, plays, popular tracts, political pamphlets,
historical writing and newspapers - the latter proving a major resource.
Following a critical introduction, the thesis falls into four chapters. Chapter one
discusses the reputation, critical reception and public fame of Macaulay and More,
thereby providing insights into contemporary sexual and social politics. Women
were considered arbiters of morals and manners - believed to play a vital role in
ensuring social stability - and the second chapter examines how the threat of
revolution led to increasing anxiety and debate about the nature of female
education. The third and fourth chapters discuss religion and politics respectively,
and argue that beliefs about the interdependency of Church and State, together with
the feminization of religion, legitimized women's involvement in politics and
enlarged their sphere of influence.
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The conclusion argues that the political and religious climate provided
opportunities for women to reassess and redefine their roles; while often remaining
within parameters defined by commonly held perceptions of femininity, they
politicized the domestic, extended female agency, and elevated the status of
women
Hannah Arendt's political ontology
No full textSeeking a more global as well as historical and philosophically situated understanding of the thought of the German philosopher and political theorist Hannah Arendt, this thesis investigates the paths through which the author undertakes in her work, in a consistent movement of critical appropriation of the central theses that shape the contemporary philosophical traditions that helped in making of her a thinker, a philosophical turn of great ontological consequences. We have, therefore, as a general objective, to make explicit how Arendt, starting from the contemporary intersection between the phenomenological, existentialist and hermeneutic traditions, conceives a fundamentally political ontology, inserting the category of plurality, central to her thought, within philosophical thinking, so as to implode its traditional foundations. More than a regional ontology of the political dimension of human existence, what Hannah Arendt puts forward is a philosophy based on a notion of Being always constituted from plurality as a fundamental ontological condition of human existence. In this sense, we will try, from the outset, to find the ontological and methodological core of Arendt's thought in its relationship with the thought of authors such as Edmund Husserl, Martin Heidegger, Karl Jaspers and Maurice Merleau-Ponty, among others. Starting, then, from such a radical theoretical contextualization, we will seek, centrally, first, to conceive the properly Arendtian way of phenomenologically describing the world that, in its daily actualization, human existence, so to speak, opens up for itself. From there, taking as a touchstone the important Arendtian distinction between truth and meaning, we will propose a systematizing interpretation of the core of Arendtian ontology around the understanding of the structural articulations of the phenomenal world and the human dynamics of meaning donation. Finally, an effort will be made to understand and bring to light, in an indicative way, the deep relationships between this radically philosophical-ontological scenario and the more well-known and widely studied, although with often divergent results, thema of Arendtian political thought. In this process, will emerge the contours of a philosophical normativity, present in Arendt's thought will, that points to an understanding of democracy as an ontologically grounded imperative of human existence.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Tendo em vista a busca por uma compreensão mais global e histórico-filosoficamente situada do pensamento da filósofa e teórica política alemã Hannah Arendt, esta tese investiga os caminhos pelos quais a autora empreende em sua obra, numa dinâmica consistente de apropriação crítica das teses centrais que conformam as tradições filosóficas contemporâneas que diretamente a formaram enquanto pensadora, uma virada filosófica de amplas implicações ontológicas. Temos, assim, como objetivo geral, tornar explícito como Arendt, partindo do entrecruzamento contemporâneo entre as tradições fenomenológica, existencialista e hermenêutica, concebe uma ontologia fundamentalmente política, inserindo a categoria da pluralidade, central ao seu pensamento, no seio do pensar filosófico, de modo a implodir seus alicerces tradicionais. Mais do que uma ontologia regional da dimensão política da existência humana, Hannah Arendt nos propõe uma filosofia fundada numa noção de ser constituída sempre desde a pluralidade enquanto condição ontológica fundamental da existência humana. Nesse sentido, trataremos, desde um primeiro momento, de encontrar o cerne ontológico e metodológico do pensamento de Arendt em sua relação para com o pensamento de autores como Edmund Husserl, Martin Heidegger, Karl Jaspers e Maurice Merleau-Ponty, dentre outros. Partindo, então, de um tal enraizamento, buscaremos, centralmente, primeiro, conceber o modo propriamente arendtiano de descrever fenomenologicamente o mundo que, em sua atualização cotidiana, a existência
humana, por assim dizer, abre para si. E, em seguida, tendo como pedra de toque a importante distinção arendtiana entre verdade e sentido, proporemos uma interpretação sistematizadora do núcleo da ontologia arendtiana em torno da compreensão das articulações estruturais do mundo fenomênico e da dinâmica humana de significação do mesmo. Por fim, se fará o esforço por compreender e trazer à tona, de modo indicativo, as relações profundas entre esse cenário radicalmente filosófico-ontológico e o panorama mais bem conhecido e vastamente estudado, ainda que com resultados muitas vezes divergentes, do pensamento político arendtiano. Se farão notar, nesse processo, os contornos de uma normatividade filosófica presente no pensamento de Arendt que aponta para um entendimento da democracia como imperativo ontologicamente fundamentado da existência humana
Nutraceutical and pharmaceutical cocktails did not improve muscle function or reduce histological damage in D2-mdx mice
No full textProgressive muscle injury and weakness are hallmarks of Duchenne muscular dystrophy. We showed previously that quercetin (Q) partially protected dystrophic limb muscles from disease-related injury. As quercetin activates PGC-1α through Sirtuin-1, an NAD+-dependent deacetylase, the depleted NAD+ in dystrophic skeletal muscle may limit quercetin efficacy, hence, supplementation with the NAD+ donor, nicotinamide riboside (NR), may facilitate quercetin efficacy. Lisinopril (Lis) protects skeletal muscle and improves cardiac function in dystrophin-deficient mice, therefore it was included in this study to evaluate the effects of lisinopril used with quercetin and NR. Our purpose was to determine the extent to which Q, NR, and Lis decreased dystrophic injury. We hypothesized that Q, NR or Lis alone would improve muscle function and decrease histological injury and when used in combination would have additive effects. Muscle function of 11-month-old DBA (healthy), D2-mdx (dystrophin-deficient), and D2-mdx mice was assessed following treatment with Q, NR, and/or Lis for 7-months. To mimic typical pharmacology of DMD patients a group was treated with prednisolone (Pred) in combination with Q, NR and Lis. At 11-months of age, dystrophin deficiency decreased specific tension and tetanic force in the soleus and extensor digitorum longus muscles and was not corrected by any treatment. Dystrophic muscle was more sensitive to contraction-induced injury, which was partially offset in the QNRLisPred group, while fatigue was similar between all groups. Treatments did not decrease histological damage. These data suggest treatment with Q, NR, Lis and Pred failed to adequately maintain dystrophic limb muscle function or decrease histological 46 damage.This is a manuscript of an article published as Spaulding, Hannah R., Tiffany Quindry, Kayleen Hammer, John C. Quindry, and Joshua T. Selsby. "Nutraceutical and pharmaceutical cocktails did not improve muscle function or reduce histological damage in D2-mdx mice." Journal of Applied Physiology 127, no. 4 (2019): 1058-1066. doi: 10.1152/japplphysiol.00162.2019. Posted with permission.</p
PGC-1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin-deficient skeletal muscle
No full textDuchenne muscular dystrophy (DMD) is caused by the absence of functional dystrophin protein and results in progressive muscle wasting. Dystrophin deficiency leads to a host of dysfunctional cellular processes including impaired autophagy. Autophagic dysfunction appears to be due, at least in part, to decreased lysosomal abundance mediated by decreased nuclear localization of transcription factor EB (TFEB), a transcription factor responsible for lysosomal biogenesis. PGC‐1α overexpression decreased disease severity in dystrophin‐deficient skeletal muscle and increased PGC‐1α has been linked to TFEB activation in healthy muscle. The purpose of this study was to determine the extent to which PGC‐1α overexpression increased nuclear TFEB localization, increased lysosome abundance, and increased autophagosome degradation. We hypothesized that overexpression of PGC‐1α would drive TFEB nuclear translocation, increase lysosome biogenesis, and improve autophagosome degradation. To address this hypothesis, we delivered PGC‐1α via adeno‐associated virus (AAV) vector injected into the right limb of 3‐week‐old mdx mice and the contralateral limbs received a sham injection. At 6 weeks of age, this approach increased PGC‐1α transcript by 60‐fold and increased TFEB nuclear localization in gastrocnemii from PGC‐1α treated limbs by twofold compared to contralateral controls. Furthermore, lamp2, a marker of lysosome abundance, was significantly elevated in muscles from limbs overexpressing PGC‐1α. Lastly, increased LC3II and similar p62 in PGC‐1α overexpressing‐limbs compared to contralateral limbs are supportive of increased degradation of autophagosomes. These data provide mechanistic insight into PGC‐1α‐mediated benefits to dystrophin‐deficient muscle, such that increased TFEB nuclear localization in dystrophin‐deficient muscle leads to increased lysosome biogenesis and autophagy.This article is published as Spaulding, Hannah R., Amanda K. Ludwig, Katrin Hollinger, Matthew B. Hudson, and Joshua T. Selsby. "PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle." Physiological reports 8, no. 4 (2020): e14383. doi: 10.14814/phy2.14383.</p
Arendt and Dante
No full textThe Action chapter of Hannah Arendt’s 'The Human Condition' opens with a quotation from Dante’s 'Monarchia'. Why does Arendt choose this exergue? Why does she open the discussion of the “political activity par excellence” and fulcrum of her reactivation of active life with a reference to an author who asserts the primacy of the speculative over the practical? The paper delves into Arendt’s reflection and articulates its discourse in three parts: 1. the marginal position of Dante in Arendt’s work and the enigma of Dante’s quotation; 2. Dante as the philosopher of active life; 3. the intensification of the agent’s being and its revelatory function
Dante in the margins of Hannah Arendt
No full textThe Action chapter of Hannah Arendt’s The Human Condition opens with a quotation from Dante’s Monarchia. Why does Arendt choose this exergue? Why does she open the discussion of the “political activity par excellence” and fulcrum of her reactivation of active life with a reference to an author who asserts the primacy of the speculative over the practical? Through a complex exegetical and critical-hermeneutical work, this article delves into Arendt’s reflection and articulates its discourse in three parts: 1. Margins and the Robber Quotation, which talks about the marginal position of Dante in Arendt’s work and the enigma of Dante’s quotation; 2. Dante as Philosopher of Active Life, where, with the help of Étienne Gilson, Arendt presents Dante as the philosopher who, while reaffirming the primacy of contemplative life over the active one, gave it an unusual dignity in medieval thought; 3. The Joy of Acting, which shows that, by referring to the passage from the Monarchia, Arendt derives some fundamental characteristics of action, namely, the intensification of the agent’s being and its revelatory function
Flower Morphology Influences Pollinator Community with Implications for Cross-Pollination: Observations in Rabbiteye Blueberry (Vaccinium ashei Reade)
No full textThe narrow, long corolla of rabbiteye blueberries (Vaccinium ashei) presents a challenge to foraging pollinators, particularly honey bees (Apis mellifera), and variations in this floral morphology appear to alter the species composition of the visiting bee community. In particular, the rabbiteye var. ‘Premier’ exhibits abnormal flower morphology, with shortened and split corollas that appeared to affect the community of bee pollinators visiting flowers. We conducted observations to compare bee visitation rates at ‘Premier’ flowers to other common rabbiteye varieties (‘Powderblue’ and ‘Brightwell’) that have more typical flowers. Timed observations were conducted during 2009 and 2010, and significantly more A. mellifera and significantly fewer wild bees visited ‘Premier’ flowers when compared to other rabbiteye cultivars. This apparent resource partitioning may reduce cross-pollination, which is important for successful rabbiteye blueberry production but may also increase A. mellifera visitation. A similar visitation rate increase by A. mellifera in blueberries has been suggested to occur following nectar robbing by carpenter bees (Xylocopa spp.).Paper presented at NABREW Conference, Paper Session I:Blueberry Pollinators, on June 24, 2014, Atlantic City, N.J
Nine years of video landers at the Oregon Department of Fish & Wildlife's Marine Resources Program
No full textLeif K. Rasmuson, Kelly A. Lawrence, Gregory K. Krutzikowsky, Jessica L. Watson, Lindsay Aylesworth, Robert W. Hannah, Brett T. Rodomsky, Brittany Huntington, Keith Matteson, Ryan R. Easton.Title from PDF title page (viewed on April 1, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 40-46).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
A Retrospective Examination of a Successful Developmental Reviewing Process
No full textIn this essay, we describe a retrospective examination of a review process for a manuscript that was published in the Journal of Management Studies (JMS) in 2015 (Hannah &Robertson, 2015). The two authors of the essay are (a) the first author of the JMS manuscript, David Hannah, and (2)the JMS editor of that manuscript, Dries Faems. We originally engaged in this examination to prepare for a presentation at the Strategy Process Interest Group workshop on“The Process of Publishing Process Research” during the 2015 Strategic Management Society meeting in Denver, Colorado. We have written this essay with a goal of sharing our observations about this review process. Although we share some of the content of the original manuscript herein, we focus most of our attention on describing each step in the review process from the perspective of the author as well as the editor. We conclude by offering what we hope are usefuland generalizable lessons about the challenges that authors and editors face in the review process, how to navigate them, and how to systematically improve the overall review process.We begin in July 2013, with JMS submission P0431, titled, “Why do Employees put Confidential Information at Risk? CI Protection and Confidentiality Tension in High-Tech Employees.” The paper reported the findings of a qualitative, theory-elaborating study involving 55 semistructured interviews with the employees of two high-tech companies
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