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Comparative BAC-based mapping in the white-throated sparrow, a novel behavioral genomics model, using interspecies overgo hybridization
No full textBACKGROUND
The genomics era has produced an arsenal of resources from sequenced organisms allowing researchers to target species that do not have comparable mapping and sequence information. These new "non-model" organisms offer unique opportunities to examine environmental effects on genomic patterns and processes. Here we use comparative mapping as a first step in characterizing the genome organization of a novel animal model, the white-throated sparrow (Zonotrichia albicollis), which occurs as white or tan morphs that exhibit alternative behaviors and physiology. Morph is determined by the presence or absence of a complex chromosomal rearrangement. This species is an ideal model for behavioral genomics because the association between genotype and phenotype is absolute, making it possible to identify the genomic bases of phenotypic variation.
FINDINGS
We initiated a genomic study in this species by characterizing the white-throated sparrow BAC library via filter hybridization with overgo probes designed for the chicken, turkey, and zebra finch. Cross-species hybridization resulted in 640 positive sparrow BACs assigned to 77 chicken loci across almost all macro-and microchromosomes, with a focus on the chromosomes associated with morph. Out of 216 overgos, 36% of the probes hybridized successfully, with an average number of 3.0 positive sparrow BACs per overgo.
CONCLUSIONS
These data will be utilized for determining chromosomal architecture and for fine-scale mapping of candidate genes associated with phenotypic differences. Our research confirms the utility of interspecies hybridization for developing comparative maps in other non-model organisms
Sparrow&Spaniol(2018)_experiment2
No full textexploring age differences in altruism (online experiment) CFC-14 included as potential moderato
Sparrow&Spaniol(2018)_Experiment1
No full textlaboratory study exploring age differences in altruism, CFC-14 included as potential moderator. Country of origin include
Sparrow&Spaniol(2018)_experiment2
No full textexploring age differences in altruism (online experiment) CFC-14 included as potential moderato
Sparrow&Spaniol(2018)_Experiment1
No full textlaboratory study exploring age differences in altruism, CFC-14 included as potential moderator. Country of origin include
Sparrow, Armstrong, Fiocco & Spaniol (2019)
No full textstudy exploring acute stress and altruism in younger and older adults. CFC-14 included
Oral history of Margaret Sparrow
No full textMargaret Sparrow was born in Baltimore, Maryland. She earned her undergraduate degree from Goucher College in 1950 and her graduate degree in political science from Johns Hopkins University. Sparrow served as the executive director of the Baltimore Council of Fire Girls from 1955 until 1965. After moving to White Plains, New York, Sparrow took a position as the executive director pf the Southwest Connecticut Girl Scout Council for 5 years. She spent the remainder of her career as an executive director of the Constituent Leagues for the National League for Nursing in New York. Sparrow was also active in Republican politics and ran for a spot on the Baltimore City Council in 1950. In this history, Sparrow talks about her life, growing up in Baltimore, and Girl Scouts. This oral history is part of the Mame Warren oral histories series
Sparrow, Armstrong, Fiocco & Spaniol (2019)
No full textstudy exploring acute stress and altruism in younger and older adults. CFC-14 included
Letter to Mary Sibley from W. Sparrow, May 5, 1873
No full textTranscript of Letter to Mary Sibley from W. Sparrow, May 5, 1873. Sparrow mentions receiving Mary\u27s letter meant for Isaac Yokoyama
coleygroup/sparrow: v1.0.0
No full text<p>SPARROW (Synthesis Planning And Rewards-based Route Optimization Workflow) v1. SPARROW performs an automatic downselection of compounds for synthesis by balancing reward and synthetic cost. This version solves a linear problem that optimizes a scalarized objective function.</p>
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