5,798 research outputs found
New insights in naevogenesis: Number, distribution and dermoscopic patterns of naevi in the elderly
No full textBackground/Objectives: It is well recognized that the number and patterns of acquired melanocytic naevi vary with age, but little is known about naevus patterns in the elderly. This is a cross-sectional study assessing the prevalence, dermoscopic pattern and anatomical distribution of naevus subtypes in a stratified cohort aged between 60 and 89 years
Atypical (Dysplastic) Nevus
No full textAtypical or dysplastic nevus is our preferred term for a group of melanocytic skin tumors which cause endless debate and controversy. Synonyms include atypical mole, BK mole, Clark nevus, and nevus with architectural disorder. In 1978 Wallace H. Clark, Jr. first drew attention to this particular type of nevus by studying numerous melanocytic nevi in patients with concomitant melanomas
Intraepidermal Dendritic Melanocytes in Spitzoid Neoplasms
No full textMelanocytes with prominent bipolar dendritic processes are a well-recognized component of some dermal melanocytic lesions, the so-called “dermal dendritic melanocytic proliferations,”1 the most frequent of them being “common” blue nevus. Moreover, “compound” blue (Kamino) nevus,2 lentigo labialis,3 pigmented actinic keratosis,4 and melanoma 5 are characterized by the presence of dendritic melanocytes within the epidermis. Massi and LeBoit 6 also stated that “early” Reed nevus and spitzoid melanoma on sun-damaged areas are composed of junctional nests of melanocytes with delicate intraepidermal dendritic processes. We examined the histologic specimens of 45 consecutively excised nevi belonging to the morphologic spectrum of pigmented spindle cell Spitz/Reed nevus (lumped together as previously assessed 7). Moreover, seven cases of spitzoid melanoma metastatic to the sentinel lymph node were retrieved and also examined. All the selected cases were from the Department of Dermatology of the Second University of Naples. No case of “atypical Spitz tumor” as defined earlier 8 was selected. Each case had undergone dermoscopic examination and documentation before the surgical procedure. The individuals with Spitz/Reed nevus were mainly females (male-to-female ratio = 0.7:1), with a mean age of 22 years (age range: 1 to 58 years); most lesions were located on the limbs (29 cases, 64.4%). On dermoscopy, the most common pattern was described as “starburst” pattern 7 (17 cases, 37.8%). Histopathologically, 19 out of these 45 nevi showed clearly visible single intraepidermal dendritic melanocytes outside the junctional nests. These dendritic processes were thin and regular, mainly oriented perpendicular to the skin surface (Fig. 1). No significant difference was found between the 2 groups of nevi with and without single dendritic cells in terms of sex and age of the patients and of location and dermoscopic features of the lesions
NRAS and BRAF mutations in cutaneous melanoma and the association with MC1R genotype: findings from Spanish and Austrian populations
No full textThere is increasing epidemiologic and molecular evidence that cutaneous melanomas arise through multiple causal pathways. To further define the pathways to melanoma, we explored the relationship between germline and somatic mutations in a series of melanomas collected from 134 Spanish and 241 Austrian patients. Tumor samples were analyzed for melanocortin-1 receptor (MC1R) variants and mutations in the BRAF and NRAS genes. Detailed clinical data were systematically collected from patients. We found that NRAS-mutant melanomas were significantly more likely from older patients and BRAF-mutant melanomas were more frequent in melanomas from the trunk. We observed a nonsignificant association between germline MC1R status and somatic BRAF mutations in melanomas from trunk sites (odds ratio (OR) 1.8 (0.8-4.1), P=0.1), whereas we observed a significant inverse association between MC1R and BRAF for melanomas of the head and neck (OR 0.3 (0.1-0.8), P=0.02). This trend was observed in both the Spanish and Austrian populations.Elke Hacker, Eduardo Nagore, Lorenzo Cerroni, Susan L. Woods, Nicholas K. Hayward, Brett Chapman, Grant W. Montgomery, H Peter Soyer, David C. Whitema
Author\u27s Response to Children and Nature: Psychological, Sociocultural, and Evolutionary Investigations: Children and Nature – and Technology by Peter H. Kahn, Jr.
No full textAuthor\u27s Response to Children and Nature: Psychological, Sociocultural, and Evolutionary Investigations: Children and Nature – and Technology by Peter H. Kahn, Jr
Dermoscopic features of melanoma on the scalp
No full textThere is a need to improve the early detection of melanoma of the scalp because it is characterized by a poorer prognosis compared with melanoma on other body sites. Dermoscopy is a useful tool for the early detection of melanoma but no previous reports on dermoscopic features of scalp melanoma have been published. We describe the first case of melanoma of the scalp seen by dermoscopy exhibiting a multicomponent global pattern with atypical pigment network, irregular streaks, and regression structures. in contrast to the dermoscopic features usually seen in melanoma occurring on the face, the same morphologic type of pigment network usually seen in melanoma of the trunk was observed in our case of scalp melanoma
Dermoscopy: The Essentials
No full textDermoscopy: The Essentials presents the practical guidance you need to master this highly effective, more economical, and less invasive alternative to biopsy. Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 30% new clinical and dermoscopic images, valuable pearls and checklists, and online access to the fully searchable and downloadable text, you’ll have everything you need to diagnose earlier and more accurately
Dermoscopy of pigmented skin lesions - a valuable tool for early diagnosis of melanoma
No full textThe clinical use of dermoscopy has uncovered a new and fascinating morphological dimension of pigmented skin lesions. Dermoscopy is a non-invasive diagnostic technique that links clinical dermatology and dermatopathology by enabling the visualisation of morphological features not seen by the naked eye. Close examination of pigmented skin lesions in this way increases the effectiveness of clinical diagnostic tools by providing new morphological criteria for distinguishing melanoma from other melanocytic and non-melanocytic pigmented skin lesions.In the past, dermoscopy has been known by various names, including skin surface microscopy, epiluminescence microscopy, incident light microscopy, dermatoscopy, and videodermatoscopy. However, the term 'dermoscopy', first used by Friedman and colleagues in 1991 , is the most widely used
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