1,721,276 research outputs found
The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine
No full textThe purpose of this article is to review the basis of arrhythmogenesis, the functional and clinical role of the late Na current, and its therapeutic inhibition. Under pathological conditions such as ischemia and heart failure this current is abnormally enhanced and influences cellular electrophysiology as a proarrhythmic substrate in myocardial pathology. Ranolazine the only approved late Na current blocker has been demonstrated to produce antiarrhythmic effects in the atria and the ventricle. We summarize recent experimental and clinical studies of ranolazine and other experimental late Na current blockers and discuss the significance of the available data
The late Na current as a therapeutic target: Where are we?
No full textAbstractIn this article we review the late Na current which functionally can be measured using patch-clamp electrophysiology (INa,late). This current is largely enhanced under pathological myocardial conditions such as ischemia and heart failure. In addition, INa,late can cause systolic and diastolic contractile dysfunction via a Na-dependent Ca-overload of the myocyte. Moreover, INa,late plays a crucial role as ventricular and atrial proarrhythmic substrate in myocardial pathology by changing cellular electrophysiology. We summarize recent experimental and clinical studies that investigate therapeutic inhibition of this current and discuss the significance of the available data and try to answer not only the question, where we currently are but also where we may go in the near future. This article is part of a Special Issue entitled “Na+ Regulation in Cardiac Myocytes”
Scientific teamwork--a particular approach.
No full textThe purpose of this article is to discuss the significance of academic collaboration within cardiovascular medicine and surgery, in both clinical and research settings, at a major academic institution in Europe
Scientific teamwork--a particular approach.
No full textThe purpose of this article is to discuss the significance of academic collaboration within cardiovascular medicine and surgery, in both clinical and research settings, at a major academic institution in Europe
Young ambitious cardiologists and scientific research - reasons to get involved.
No full textAs far as we are concerned as clinicians and scientists, we regard as our most important task to combine two very opposite spheres: empathizing with the anxious patient who suffers from serious heart complaints and to do sheer natural scientific research with dead tools in order to help living beings
Young ambitious cardiologists and scientific research - reasons to get involved.
No full textAs far as we are concerned as clinicians and scientists, we regard as our most important task to combine two very opposite spheres: empathizing with the anxious patient who suffers from serious heart complaints and to do sheer natural scientific research with dead tools in order to help living beings
Arzneimittelinteraktionen, die man kennen muss!
No full textDrug-drug interactions (DDI) represent a significant problem in modern medicine. The number of patients with multi-morbidity, who take multiple drugs, is constantly increasing (polypharmacy). The related exponential increase in potential DDI is almost incomprehensible. In this article, we review pharmacodynamic DDI and provide clinically relevant examples. In addition, we extensively review pharmakokinetic DDI (e.g. through the cytochrome P450-system or p-glycoproteins) that can modify the plasma concentration of many compounds, thereby also increasing the likelihood of unwanted side effects. Finally we provide tools, which may help clinicians in their daily practice to identify and avoid potential DDI. In the context of an ageing society receiving polypharmacy, a better awareness of DDI and of strategies to prevent them is expected to reduce mortality and morbidity. Arzneimittelinteraktionen (AMI) sind ein haufig unterschatztes Problem der modernen Medizin. Die Zahl alterer, multimorbider Patienten, die mehrere Wirkstoffe gleichzeitig einnehmen, nimmt stetig zu - der damit verbundene exponentielle Anstieg moglicher AMI ist fast unuberschaubar. Diese ubersicht stellt haufige, relevante AMI anhand von Beispielen dar und zeigt Strategien auf, wie sie in der Praxis fruhzeitig erkannt und vermieden werden konnen
- …
