73 research outputs found
Characterization of IGF-1 expessing RG3.6 cells for transplantation following traumatic brain injury
No full textTraumatic brain injury is one of the leading cause of neuronal damage which affects the cognitive function of the brain. Traumatic brain injury (TBI) also causes damage to the neuronal stem cells pool. IGF-1 is an important trophic factor that increases cell survival by inducing neuroprotection and anti-apoptotic activity. Therapeutic strategy to protect the neurons/neuronal stem cell pool and restoration of damage neuron and induce their ability to produce multipotent, proliferative cell that can adopt the neuronal phenotype could have beneficial effect on functional recovery of the brain after TBI. Here, we characterized and used genetically engineered rat neural stem cells, RG3.6/IGF-1+ cells, which conditionally express the insulin growth factor-1 (IGF-1). Our results demonstrate that IGF-1 induces neurogenesis in a culture system and in damaged area of the rat brain after transplantation and could have important implication in amelioration of brain damage after TBI.M.S.Includes bibliographical referencesby Sweta Sing
Optimized Fuzzy Rule-Based System to Measure Uncertainty in Human Decision Making System
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