613 research outputs found
JCB903697 Supplemental Material - Supplemental material for Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status
No full textSupplemental material, JCB903697 Supplemental Material for Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status by Di Wu, Jian Chen, Mohammed Hussain, Longfei Wu, Jingfei Shi, Chuanjie Wu, Yanhui Ma, Mo Zhang, Qi Yang, Yongjuan Fu, Yunxia Duan, Cui Ma, Feng Yan, Zixin Zhu, Xiaoduo He, Tianqi Yao, Ming Song, Xinglong Zhi, Chunxiu Wang, Lipeng Cai, Chuanhui Li, Shengli Li, Yongbiao Zhang, Yuchuan Ding and Xunming Ji in Journal of Cerebral Blood Flow & Metabolism</p
Genome-wide association study of adolescent idiopathic scoliosis in Southern Chinese and significant improvement in detection of missing heritability and genetic risk prediction in genome-wide association studies by 1000 genomes-based imputation
No full textAdolescent idiopathic scoliosis (AIS) is a lateral curvature of the spine affect school age children. Although many studies have been conducted to investigate the candidate loci and genes for AIS, the underlying mechanisms of the pathogenesis is still poorly understood. In this study, a genome-wide association study on a cohort consisting of 189 AIS patients and 313 controls was performed to investigate the genetic variants associated with AIS in the southern Chinese population. The most promising association region is 12p13.32, in which a significant linkage signal was found in previous study. The three most significant SNPs (rs10849195, P = 6.84 × 10-7, OR = 0.51, 95% CI 0.39-0.67; rs11063476, P = 9.82 × 10-6, OR = 0.55, 95% CI 0.42-0.72; rs2109185, P = 3.83 × 10-5, OR = 0.57, 95% CI 0.44-0.75) in this region were in the same linkage disequilibrium (LD) block of about 2 kb. The most significant SNPs rs10849195 on chromosome 12 was successfully replicated in two independent replication studies. One replication study with 1271 individuals consist of 568 cases and 703 controls (P = 0.037, OR = 0.84, 95% CI 0.72-0.99), and the other replication study with 536 individuals consist of 286 cases and 250 controls (P = 0.026, OR = 0.76, 95% CI 0.60-0.97). The combined two stage P-value is 9.1 × 10-7, OR = 0.74.
SNP rs11190870 near LBX1 (ladybird homeobox 1), which was associated with Japanese adolescent idiopathic scoliosis patients by a genome-wide association study, was also validated in an independent southern Chinese population. The results suggested that SNP rs11190870 is statistically significant associated with adolescent idiopathic scoliosis in southern Chinese (P = 9.1 10-10; odds ratio = 1.85; 95% confidence interval = 1.52 - 2.25).
Quality control (QC) by removing individuals or markers with low genotyping quality is of utmost importance to minimize potential false positive associations. IPGWAS was developed to facilitate the identification of the rational thresholds in QC of GWAS datasets, association analysis, Manhattan plot, quantile-quantile (QQ) plot, and format conversion for genetic analyses, such as meta-analysis, genotype phasing, and imputation. IPGWAS is freely available at http://sourceforge.net/projects/ipgwas/.
Missing heritability is a common problem in genome-wide association study. The Wellcome Trust Case Control Consortium Phase I genotype data were imputed using 1000 genomes as reference. Then phenotypic variance explained by SNPs passed certain p-value thresholds was estimated. The results suggested that the proportions of phenotypic variance explained by genetic variants increased significantly when the new association variants identified through 1000 genome based imputation were included for most complex diseases. The obtained results were consistent with the larger number of variants that are yet to be identified as potential sources of missing heritability.
Most GWAS results cannot achieve a reliable genetic risk prediction performance. After genotype imputation, both prediction sensitivity and specificity were increased to a relative reliable level (>0.7). It is promising to transfer the results from basic genetic research to clinical utility.published_or_final_versionBiochemistryDoctoralDoctor of Philosoph
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No full textEffect of coordination number of particle contact force on rutting resistance of asphalt mixture
No full textOptimizing asphalt mix design at the indoor stage is of significant importance for enhancing the rutting resistance of asphalt mixture, which is affected by its structural characteristics. In this work, the coordination number of particle contact force (CNpcf) was proposed as an indicator to represent contact characteristics of skeleton structure aggregates in asphalt mixture. Nine asphalt mixtures with different gradations were designed, and the relationship of CNpcf with the number of aggregate contact zones (CZ) was established by combining rutting tests and digital image processing technique (DIP). The Mann-Whitney U test was implemented to analyze the distribution properties of inter-particle contacts before and after the rutting test. In addition, the resistance to the further expansion of rutting was analyzed. The results revealed a significant positive correlation (PCCs = 0.843, R2 = 0.711) between CNpcf and CZ. The content of coarse aggregates in the dominant structure did not exhibit monotonic related to anti-rutting performance of the asphalt mixture. Therefore, an optimum aggregate content of 57% was utilized. The Mann-Whitney U test revealed that the mesoscale skeleton structure of the asphalt mixes before and after rutting exhibited excellent stability. This study further indicated the applicability of combining CNpcf to adjust the mix design to enhance the rutting resistance of asphalt mixture and to prevent rutting expansion in flexible pavement.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Pavement Engineerin
Study on electromagnetic propagation characteristics of two-layer media with CST software
No full textNational Blood Pressure Reference for Chinese Han Children and Adolescents Aged 7 to 17 Years
No full textWe sought to develop and validate a national blood pressure (BP) reference based on age, sex, and height for Chinese children. Data were obtained on 197 430 children aged 7 to 17 who participated in the Chinese National Survey on Students' Constitution and Health in 2010. BP percentiles were estimated and fitted using the lambda, mu, and sigma method and then compared with a US reference and China existing reference. In an external independent validation sample of 59 653 children aged 7 to 18 from 7 Chinese provinces in 2013, the prevalence of elevated BP was compared applying the 3 references. BP values were similar for boys and girls at the younger ages (7-13 years) and lower height percentiles, whereas higher at the older ages (14-17 years) for boys than girls. At medial height in boys and girls aged 7 to 13, the 50th, 90th, 95th, and 99th percentiles of BP for the new national reference were consistent with US reference and lower than current Chinese reference. In the independent sample, elevated BP prevalence, based on the new national reference, ranged from 7.8% to 18.5% among children aged 7 to 17, which was higher than the US reference values (4.3%-14.5%) and lower than the current Chinese reference (12.9%-25.5%) in each age group. The new national BP reference for Chinese children based on age, sex, and height from large-scale and nationally representative data seems to improve the ability for identifying Chinese hypertensive children and for stratifying them with regard to cardiovascular risk.National Natural Science Foundation [81673192]; Research Special Fund for Public Welfare Industry of Health [201202010]; China Scholarship Council [201606015038]; National Heart, Lung and Blood Institute [R01HL117736]SCI(E)ARTICLE5897-+7
The change in temporal trend and spatial distribution of CO<sub>2</sub> emissions of China's public and commercial buildings
No full textThe CO2 emission mitigation of the commercial and public building sector (P&C) is critical for achieving China's carbon peak and carbon neutrality. Analyzing changes in CO2 emissions and their driving factors from temporal and spatial perspective provides insights for developing equitable and effective decarbonization strategies. This study investigated the change in temporal trend and spatial distribution of CO2 emissions of China's P&C during period of 2005–2018 according to the Kaya identify and Gravity Center model. Meanwhile, combined with the Logarithmic Mean Divisia Index, this study proposed a decomposed method to identify the driving factor of the movement of the gravity center. The results showed that: 1) in the temporal dimension, China's P&C has still not achieved its CO2 emissions peak, arriving 820.68 MtCO2. The most positive and negative driving factors were per capita add value of tertiary industry and energy efficiency, respectively; 2) in the spatial dimension, during the 13th Five Year Plan period, the gravity center moved southwestward, and the most positive and negative driving factors were energy consumption unit area and energy efficiency, respectively; Besides, to accelerate the decarbonization of China's P&C, this study reviewed the main decarbonization strategies, divided them into six categories and provided policy implications. In summary, this study provides a completed assessment on CO2 emission changes of China's P&C, facilitating policy-makers to develop more reasonable implementation plans for emission mitigation.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Design & Construction Managemen
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