1,057 research outputs found
Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
No full textCong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng, Wang, Junfeng (2023): Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production. Phytochemistry (113593) 208: 1-8, DOI: 10.1016/j.phytochem.2023.113593, URL: http://dx.doi.org/10.1016/j.phytochem.2023.11359
Fig. 5 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
No full textFig. 5. Chiral HPLC analyses of ochrathinol A (±)-1.Published as part of Cong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng & Wang, Junfeng, 2023, Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production, pp. 1-8 in Phytochemistry (113593) 208 on page 4, DOI: 10.1016/j.phytochem.2023.113593, http://zenodo.org/record/823033
Fig. 6 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
No full textFig. 6. Chiral HPLC analyses of ochrathinol B (±)-2.Published as part of Cong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng & Wang, Junfeng, 2023, Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production, pp. 1-8 in Phytochemistry (113593) 208 on page 4, DOI: 10.1016/j.phytochem.2023.113593, http://zenodo.org/record/823033
sj-docx-1-tct-10.1177_15330338231184995 - Supplemental material for Plasma Thioredoxin Reductase as a Potential Biomarker for Gynecologic Cancer
No full textSupplemental material, sj-docx-1-tct-10.1177_15330338231184995 for Plasma Thioredoxin Reductase as a Potential Biomarker for Gynecologic Cancer by Yinxing Zhu, MS, Yixuan Hu, MS, Junfeng Shi, MD, Xiaowei Wei, MD, Yaqi Song, MD, Cuiju Tang, MD, PhD, and Wenwen Zhang, MD, PhD in Technology in Cancer Research & Treatment</p
Time-lens-based optical phased array LiDAR for ranging and accuracy enhancement
No full textLight Detection and Ranging (LiDAR) has been widely applied to a variety of fields. Among various approaches, the time-of-flight (ToF) ranging cooperated with silicon optical phased array (OPA) has gained intense interest because of simple operation, all solid-state structure, and precise beam control. However, the long-range ToF LiDAR usually requires high optical power that is unsustainable for human eyes safety and even for the chip-scale devices. Besides, the nanosecond-width optical pulse used in the ToF LiDAR limits the ranging accuracy and requires complex processing for time discrimination. Hence, the millimeter-order accuracy is still challenging for the ToF LiDAR. Here, we propose a novel design of a time-lens-based OPA system that can improve the detection range and accuracy of a ToF LiDAR simultaneously. By virtue of a time-lens system, the target echo signal can be translated into a train of compressed pulses with boosted peak power prior to the light detection. In a proof-of-concept demonstration, a 10-ns width echo signal has been compressed into a series of 22-ps subpulses with 2.74 dB SNR improvement at a repetition rate of 4.8 GHz. In addition, the time-lens system enables the ToF LiDAR to detect the noise-overwhelming echo signals through coherent amplification. The ultra-narrow pulse width of the subpulses can improve the accuracy of time discrimination. Consequently, the ranging precision and accuracy can be improved to 6 mm and 1.5 cm, respectively. Last but not least, the minimum location shift that the system can distinguish is 5.6 mm.
Fig. 8. Ochrathinols A in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
No full textFig. 8. Ochrathinols A (±)-1 compensated the NAD+/NADH ratio induced by LPS. Cells were exposed to 0.1 μg/mL LPS and co-treated with compounds of (±)-1 (10 μM) for 24 h. Intracellular NAD+/NADH ratios were determined by NAD+/NADH assay kit. Data are shown as mean ± SD (n = 3). *P <0.05, ****P <0.001 vs. LPS group, n = 3. P value was assessed by two-tailed Student's t-test.Published as part of Cong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng & Wang, Junfeng, 2023, Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production, pp. 1-8 in Phytochemistry (113593) 208 on page 5, DOI: 10.1016/j.phytochem.2023.113593, http://zenodo.org/record/823033
High resolution millimeter wave imaging for self-driving cars
No full textRecent years have witnessed much interest in expanding the use of networking signals beyond communication to sensing, localization, robotics, and autonomous systems. This thesis explores how we can leverage recent advances in 5G millimeter wave (mmWave) technology for imaging in self-driving cars. Specifically, the use of mmWave in 5G has led to the creation of compact phased arrays with hundreds of antenna elements that can be electronically steered. Such phased arrays can expand the use of mmWave beyond vehicular communications and simple ranging sensors to a full-fledged imaging system that enables self-driving cars to see through fog, smog, snow, etc.
Unfortunately, using mmWave signals for imaging in self-driving cars is challenging due to the very low resolution, the presence of fake artifacts resulting from multipath reflections and the absence of portions of the car due to specularity. This thesis presents HawkEye, a system that can enable high resolution mmWave imaging in self-driving cars. HawkEye addresses the above challenges by leveraging recent advances in deep learning known as Generative Adversarial Networks (GANs). HawkEye introduces a GAN architecture that is customized to mmWave imaging and builds a system that can significantly enhance the quality of mmWave images for self-driving cars.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-12-01The student, Junfeng Guan, accepted the attached license on 2019-12-09 at 12:07.The student, Junfeng Guan, submitted this Thesis for approval on 2019-12-09 at 12:16.This Thesis was approved for publication on 2019-12-09 at 15:49.DSpace SAF Submission Ingestion Package generated from Vireo submission #14758 on 2020-02-28 at 17:23:56Made available in DSpace on 2020-03-02T22:15:15Z (GMT). No. of bitstreams: 2
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China's Wind-Power Generation Policy and Market Development
No full textThe Chinese government set its wind power generation capacity target at 5 million kW for 2010 and 30 million kW for 2020 in its Medium to Long-term Renewable Energy Development Plan released in September 2007. The 11th Five-Year Renewable Energy Development Plan, announced in March 2008, doubled the 2010 target to 10 million kW, attracting much attention from relevant parties. This report considers the challenges and future course of the Chinese wind power development policies and other background factoes behind the government's upward revision to the wind power genration capacity in the 11th Five-Year Renewable Energy Development Plan.China, wind-power, Energy, market developments
Single-chain nanoparticle based catalysts
No full textEnzymes achieve their excellent catalytic properties by surrounding the catalytic sites with a polypeptide scaffold. The three-dimensional structure of the peptide chains creates a local environment that supramolecularly binds substrates to facilitate the catalysis. In this dissertation, synthetic polymers are used to serve a similar role, binding substrates and creating an optimal environment for performing efficient catalysis. Several single-chain nanoparticle (SCNP) catalysts have been developed to perform copper(I)-mediated alkyne–azide cycloaddition (CuAAC), “click” reactions, or the photoreduction of azido groups to amines. The nanoparticles are shown to have significantly higher activity when compared to analogous small molecule catalysts. Structure-activity relationships and reaction mechanisms are studied with SCNPs of different structures. The polymeric scaffolds are found to bind substrates in an enzyme-like manner. The catalysts operate in two modes: an “uptake mode” where small molecule substrates bind inside the polymer pockets and an “attach mode” that involves surface binding of protein substrates. The versatility and high efficiency of the nanoparticles lead to applications in protein and cell surface modification. In addition, another SCNP was shown to co-deliver an exogenous enzyme inside cells. The enzyme and SCNP reside and stay active in the endosomes, in essence engineering the endosome into an artificial organelle. The SCNP-enzyme complex can perform both concurrent and tandem reactions performing organic synthesis intracellularly. The combination of SCNP and enzymatic catalysts provides a versatile tool for intracellular organic synthesis with applications in chemical biology.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2022-05-01The student, Junfeng Chen, accepted the attached license on 2020-04-21 at 15:27.The student, Junfeng Chen, submitted this Dissertation for approval on 2020-04-21 at 15:53.This Dissertation was approved for publication on 2020-04-23 at 10:51.DSpace SAF Submission Ingestion Package generated from Vireo submission #15024 on 2020-08-25 at 17:27:49Made available in DSpace on 2020-08-26T23:54:35Z (GMT). No. of bitstreams: 2
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Fig. 7 in Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production
No full textFig. 7. Anti-inflammation activity of ochrathinols A and B ((±)-1, (±)-2). Cells were exposed to 0.1 μg/mL LPS and co-treated with compounds of (+)-1, ()-1, (±)-1, (+)-2, ()-2, (±)-2 (10 μM) for 24 h, respectively. (A) (±)-1 reduced the release of LPS-induced IL-6, TNF-α, and MCP-1 in culture medium, n = 3. (B) qPCR analysis of pro-inflammatory cytokines genes (IL-1β, IL-6, TNF-α, and MCP-1) normalized by β-actin, n = 3. All data are presented as the mean ± SD of three independent experiments. ns, P> 0.05, *P <0.05, **P <0.01, ***P <0.005, ****P <0.001 vs. LPS group; #P <0.05, ##P <0.01, ###P <0.005, ####P <0.001 vs. control group, n = 3. P value was assessed by two-tailed Student's t-test.Published as part of Cong, Mengjing, Ren, Xue, Song, Yue, Pang, Xiaoyan, Tian, Xinpeng, Liu, Yonghong, Guo, Peng & Wang, Junfeng, 2023, Ochrathinols A and B, two pairs of sulfur-containing racemates from an Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702 inhibit LPS-induced pro-inflammatory cytokines and NO production, pp. 1-8 in Phytochemistry (113593) 208 on page 5, DOI: 10.1016/j.phytochem.2023.113593, http://zenodo.org/record/823033
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