165 research outputs found
Cross-Layer Design for Combining Adaptive Modulation and Coding with Hybrid ARQ to Enhance Spectral Efficiency
No full textNumerical Studies on the Thermal Performances of Electroosmotic Flow in Y-Shaped Microchannel Heat Sink
No full textThis paper numerically studies the thermal performances of electroosmotic flow (EOF) in a symmetric Y-shaped microchannel heat sink (MCHS) having a constant total channel surface area, that is, constant convective heat transfer area. It is found that the average convective heat transfer coefficient of EOF increases with the increasing driven voltage, which is attributed to the increase of EOF flowrate with the increasing driven voltage. However, the maximum MCHS temperature shows an increasing after decreasing trend with the driven voltage owing to the dramatically increasing Joule heating when the voltage is large enough. Further, both the maximum MCHS temperature and average convective heat transfer coefficient are sensitive to the cross-sectional dimensions of the Y-shaped microchannels. The thermal performances of EOF in the Y-shaped MCHS show a strengthening to weakening trend with the increasing daughter-to-parent channel diameter ratio of the Y-shaped microchannel with circular cross-sectional shape, and show a similar strengthening to weakening trend with the increasing daughter-to-parent channel width ratio and the increasing microchannel height of the Y-shaped microchannel with rectangular cross-sectional shape. These cross-sectional dimension dependences of thermal performances are related to the increasing to decreasing trend of EOF flowrate changing with the microchannel cross-sectional dimensions
Cross-layer combination of hybrid ARQ and adaptive modulation and coding for QoS provisioning in wireless data networks
No full text
A Theoretical Framework for Quality-Aware Cross-Layer Optimized Wireless Multimedia Communications
No full textAlthough cross-layer has been thought as one of the most effective and efficient ways for multimedia communications over wireless networks and a plethora of research has been done in this area, there is still lacking of a rigorous mathematical model to gain in-depth understanding of cross-layer design tradeoffs, spanning from application layer to physical layer. As a result, many existing cross-layer designs enhance the performance of certain layers at the price of either introducing side effects to the overall system performance or violating the syntax and semantics of the layered network architecture. Therefore, lacking of a rigorous theoretical study makes existing cross-layer designs rely on heuristic approaches which are unable to guarantee sound results efficiently and consistently. In this paper, we attempt to fill this gap and develop a new methodological foundation for cross-layer design in wireless multimedia communications. We first introduce a delay-distortion-driven cross-layer optimization framework which can be solved as a large-scale dynamic programming problem. Then, we present new approximate dynamic programming based on significance measure and sensitivity analysis for high-dimensional nonlinear cross-layer optimization in support of real-time multimedia applications. The major contribution of this paper is to present the first rigorous theoretical modeling for integrated cross-layer control and optimization in wireless multimedia communications, providing design insights into multimedia communications over current wireless networks and throwing light on design optimization of the next-generation wireless multimedia systems and networks
Author response
No full textThe neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene regulation. Here we examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. Through expanded architectural comparisons between these complexes and HIF-1α-ARNT, HIF-2α-ARNT and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of transcription factors for direct targeting by small-molecule drugs.sponsorship: [
"National Institutes of Health NIGMS 1R01GM117013 Fraydoon Rastinejad",
"Army Research Office W81XWH-16-1-0322 Fraydoon Rastinejad"
] (National Institutes of Health|NIGMS 1R01GM117013, Army Research Office|W81XWH-16-1-0322)status: Publishe
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