117,648 research outputs found
LINEE GUIDA PER LA SORVEGLIANZA SANITARIA.
No full textIn: Apostoli P., Imbriani M., Soleo L., Abbritti G., Ambrosi L. (Eds) Linee guida per la formazione continua e l'accreditamento del medico del lavoro
WORK OF THE PARLIAMENTARY RESEARCH COMMISSION ON THE PHENOMENON OF OCCUPATIONAL INJURIES PARTICULARLY REGARDING THE SO-CALLED "WHITE DEATH"
No full textSi riferisce sull'attività della Commissione e sugli obiettivi proposti. Emerge la necessità di adottare una normativa aggiornata "testo unico". Viene ribadita l'importanza dell'attività di formazione ed informazione, del ruolo della sorveglianza sanitaria affidata al medico competente
Biological monitoring in occupational exposure to low levels of 1,3-butadiene
No full textExposure to 1,3-butadiene (BD), a probable carcinogen to humans, was investigated in two groups of subjects working in a petrochemical plant where BD is produced and used to prepare polymers: 42 occupationally exposed workers and 43 internal non-occupationally exposed controls. BD personal exposure was very low but significantly different in the two groups (median airborne BD 1.5 and 0.4 microg/m(3) in exposed and controls, respectively). Similarly, BD in blood and urine, but not in exhaled air, was higher in the exposed workers than in controls (blood BD 3.7 ng/l versus <1.8 ng/l, urinary BD 2.4 ng/l versus <1.0 ng/l). These three biomarkers correlated significantly with personal exposure ( 0.283 < or = Pearson's r < or = 0.383) and between them (0.780 < or = r < or = 0.896). Excretion of urinary mercapturic acids N-acetyl-S-(3,4-hydroxybutyl)-l-cysteine (MI), N-acetyl-S-(1-hydroxymethyl-2-propenyl)-l-cysteine and N-acetyl-S-(2-hydroxy-3-butenyl)-l-cysteine (MII), chromosomal aberrations (CA), and sister chromatid exchanges (SCE) in peripheral blood lymphocytes were not influenced by occupational exposure. Our results show that unmetabolised BD in biological fluids, and particularly urinary BD, represents the biomarker of choice for assessing occupational exposure to low airborne concentrations of BD
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