434 research outputs found
Construction of Hong-dae cultural district : cultural place, cultural policy and cultural politics
No full textCho M. Construction of Hong-dae cultural district : cultural place, cultural policy and cultural politics. Bielefeld (Germany): Bielefeld University; 2007.This dissertation examines how the process of creating the "Hong-dae cultural district" in Seoul has involved the mobilisation of various social groups and triggered the (re)institutionalisation of the meaning of "the cultural". It seeks to explicate how a cultural policy project can stimulate the emergence of social groups, which challenge existing policy provisions and laws and lead to the (re)institutionalisation of "Hong-dae culture". In so doing, the author will be able to simultaneously take account of the issues of agency, structure and culture by explicating the relationship between cultural policy and social change
A flexible endoscopic surgery robot K-FLEX and its feasibility validation in in-vivo animal trial
No full textsj-docx-1-wso-10.1177_17474930231158211 – Supplemental material for Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis
No full textSupplemental material, sj-docx-1-wso-10.1177_17474930231158211 for Optimal use of antithrombotic agents in ischemic stroke with atrial fibrillation and large artery atherosclerosis by Tae Jung Kim, Ji Sung Lee, Jae Sun Yoon, Mi Sun Oh, Ji-Woo Kim, Soo-Hyun Park, Keun-Hwa Jung, Hyun Young Kim, Jee-Hyun Kwon, Hye-Yeon Choi, Hahn Young Kim, Kyung Yoon Eah, Sang Won Han, Hyung-Geun Oh, Young-Jae Kim, Byoung-Soo Shin, Chang Hun Kim, Chi Kyung Kim, Jong-Moo Park, Kyung Bok Lee, Tai Hwan Park, Jun Lee, Man-Seok Park, Jay Chol Choi, Chulho Kim, Dong-Ick Shin, Soo Joo Lee, Dong-Eog Kim, Jae-Kwan Cha, Eung-Gyu Kim, Kyung-Ho Yu, Keun-Sik Hong, Young-Seok Lee, Ju-Hun Lee, Sung Il Sohn, Hee-Joon Bae, Young-Bae Lee, Jun Hong Lee, Joung-Ho Rha, Byung-Chul Lee, Dae-Il Chang, Sang-Bae Ko and Byung-Woo Yoon in International Journal of Stroke</p
Abstract 2232: Dietary flavonoids, CYP1A1 genetic variants, and the risk of colorectal cancer
No full textAbstract
The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater habitual dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether CYP1A1 genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavonones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped. A logistic regression was used to investigate dietary flavonoid intake, CYP1A1 genetic variants, and their interaction in relation to colorectal cancer risk. Among the subclasses of flavonoids, flavonols (OR [95% CI] = 0.10 [0.06, 0.16], highest vs. lowest quartile) and flavan-3-ols (OR [95% CI] = 0.54 [0.41, 0.71], highest vs. lowest quartile) were significantly associated with colorectal cancer risk after adjusting for confounders. Homozygous variants of CYP1A1 rs4646903 showed a protective effect on the risk of rectal cancer (OR [95% CI] = 0.60 [0.37, 0.96], CC vs. TT/TC). Carriers of the CC homozygous variant with high flavonol intake showed a greater decrease in colorectal cancer risk compared with T allele carriers with low flavonol intake (P for interaction = 0.02), particularly regarding rectal cancer (P for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs by flavonoid subclasses and CYP1A1 genetic variants.
Citation Format: Jeongseon Kim, Young Ae Cho, Jeonghee Lee, Jae Hwan Oh, Dae Kyung Sohn, Hee Jin Chang. Dietary flavonoids, CYP1A1 genetic variants, and the risk of colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2232. doi:10.1158/1538-7445.AM2017-2232</jats:p
Targeted deletion of Crif1 in mouse epidermis impairs skin homeostasis and hair morphogenesis
No full textAbstractThe epidermis, which consists mainly of keratinocytes, acts as a physical barrier to infections by regulating keratinocyte proliferation and differentiation. Hair follicles undergo continuous cycling to produce new one. Therefore, optimum supply of energy from the mitochondria is essential for maintaining skin homeostasis and hair growth. CRIF1 is a mitochondrial protein that regulates mitoribosome-mediated synthesis and insertion of mitochondrial oxidative phosphorylation polypeptides into the mitochondrial membrane in mammals. Recent studies reveal that conditional knockout (cKO) of Crif1 in specific tissues of mice induced mitochondrial dysfunction. To determine whether the mitochondrial function of keratinocytes affects skin homeostasis and hair morphogenesis, we generated epidermis-specific Crif1 cKO mice. Deletion of Crif1 in epidermis resulted in impaired mitochondrial function and Crif1 cKO mice died within a week. Keratinocyte proliferation and differentiation were markedly inhibited in Crif1 cKO mice. Furthermore, hair follicle morphogenesis of Crif1 cKO mice was disrupted by down-regulation of Wnt/β-catenin signaling. These results demonstrate that mitochondrial function in keratinocytes is essential for maintaining epidermal homeostasis and hair follicle morphogenesis.</jats:p
Glucose Deprivation Regulates K(ATP) Channel Trafficking via, AMP-Activated Protein Kinase in Pancreatic beta-Cells
No full textOBJECTIVE-AMP-activated protein kinase (AMPK) and the ATP-sensitive K(+) (K(ATP)) channel are metabolic sensors that become activated during metabolic stress. AMPK is an important regulator of metabolism, whereas the K(ATP) channel is a regulator of cellular excitability. Cross talk between these systems is poorly understood. RESEARCH DESIGN AND METHODS-Rat pancreatic beta-cells or INS-1 cells were pretreated for 2 h at various concentrations of glucose. Maximum K(ATP) conductance (G(max)) was monitored by whole-cell measurements after intracellular ATP washout using ATP-free internal solutions. K(ATP) channel activity (NPo) was monitored by inside-out patch recordings in the presence of diazoxide. Distributions of K(ATP) channel proteins (Kir6.2 and SUR1) were examined using immunofluorescence imaging and surface biotinylation studies. Insulin secretion from rat pancreatic islets was measured using an enzyme immunoassay. RESULTS-G(max) and NPo in cells pretreated with glucose-free or 3 mmol/l glucose solutions were significantly higher than in cells pretreated in 11.1 mmol/l glucose solutions. Immunofluorescence imaging and biotinylation studies revealed that glucose deprivation induced an increase in the surface level of Kir6.2 without affecting the total cellular amount. Increases in G(max) and the surface level of Kir6.2 were inhibited by compound C, an AMPK inhibitor, and siAMPK transfection. The effects of glucose deprivation on K(ATP) channels were mimicked by an AMPK activator. Glucose deprivation reduced insulin secretion, but this response was attenuated by compound C. CONCLUSIONS-K(ATP) channel trafficking is regulated by energy status via AMPK, and this mechanism may play a key role in inhibiting insulin secretion under low energy status. Diabetes 58:281.3-2819, 2009Xavier GD, 2003, BIOCHEM J, V371, P761Thurmond DC, 2003, MOL ENDOCRINOL, V17, P732, DOI 10.1210/me.2002-0333Zhou GC, 2001, J CLIN INVEST, V108, P1167Partridge CJ, 2001, J BIOL CHEM, V276, P35947Cartier EA, 2001, P NATL ACAD SCI USA, V98, P2882Hallows KR, 2000, J CLIN INVEST, V105, P1711Shyng SL, 2000, P NATL ACAD SCI USA, V97, P937Russell RR, 1999, AM J PHYSIOL-HEART C, V277, pH643Kurth-Kraczek EJ, 1999, DIABETES, V48, P1667Shyng SL, 1998, SCIENCE, V282, P1138Salt IP, 1998, BIOCHEM J, V335, P533Gribble FM, 1998, J BIOL CHEM, V273, P26383Tucker SJ, 1997, NATURE, V387, P179Gribble FM, 1997, EMBO J, V16, P1145Nichols CG, 1996, SCIENCE, V272, P1785CORTON JM, 1995, EUR J BIOCHEM, V229, P558LARSSON O, 1993, J PHYSIOL-LONDON, V463, P349Walker J, 2003, AM J PHYSIOL-GASTR L, V285, pG850, DOI 10.1152/ajpgi.00077.2003Tsuboi T, 2003, J BIOL CHEM, V278, P52042, DOI 10.1074/jbc.M307800200Luiken JJFP, 2004, PFLUG ARCH EUR J PHY, V448, P1, DOI 10.1007/s00424-003-1199-4Bezzerides VJ, 2004, NAT CELL BIOL, V6, P709, DOI 10.1038/ncb1150Carattino MD, 2005, J BIOL CHEM, V280, P17608, DOI 10.1074/jbc.M501770200Hallows KR, 2005, CURR OPIN NEPHROL HY, V14, P464Dugani CB, 2005, EMBO REP, V6, P1137, DOI 10.1038/sj.embor.7400584Kennedy MJ, 2006, ANNU REV NEUROSCI, V29, P325, DOI 10.1146/annurev.neuro.29.051605.112808Tarasov AI, 2006, DIABETES, V55, P2446, DOI 10.2337/db06-0360Mankouri J, 2006, EMBO J, V25, P4142, DOI 10.1038/sj.emboj.7601275Smith AJ, 2006, BIOCHEM BIOPH RES CO, V348, P1123, DOI 10.1016/j.bbrc.2006.07.170Towler MC, 2007, CIRC RES, V100, P328, DOI 10.1161/01.RES.0000256090.42690.05Yang SN, 2007, CELL METAB, V6, P217, DOI 10.1016/j.cmet.2007.08.002Jewell JL, 2008, J BIOL CHEM, V283, P10716, DOI 10.1074/jbc.M709876200Lamontagne J, 2009, ENDOCRINOLOGY, V150, P3465, DOI 10.1210/en.2008-1557Hu KL, 2003, NEURON, V38, P417Hardie DG, 2003, FEBS LETT, V546, P113, DOI 10.1016/S0014-5793(03)00560-XKOZLOWSKI RZ, 1990, P ROY SOC LOND B BIO, V240, P397ASHCROFT FM, 1989, PROG BIOPHYS MOL BIO, V54, P87KAKEI M, 1986, FEBS LETT, V208, P631
Current status of endoscopy training for surgeons in Korea: a narrative review
No full textFlexible gastrointestinal (GI) endoscopy is a fundamental skill in surgical practice, offering both diagnostic and therapeutic capabilities for a wide range of GI diseases. In Korea, the incidence estimates for gastric and colorectal cancers rank among the highest worldwide, underscoring the critical need for well-trained endoscopists. Surgeons play a pivotal role in managing GI diseases, reinforcing the necessity of systematic and comprehensive endoscopic education. This paper reviews the status of surgical endoscopy education in Korea, focusing on its historical evolution, structured training programs for residents and fellows, certification processes, and continuing medical education initiatives. Despite significant advancements led by organizations such as the Korean Surgical Society, challenges persist, including disparities in training opportunities across institutions and limited access to advanced therapeutic endoscopy. To address these issues, strategic recommendations include standardizing educational curricula, optimizing residency workloads for dedicated endoscopy training, enhancing simulation-based education through high-fidelity simulators and artificial intelligence, and fostering international collaboration to encourage global best practices. Implementing these strategies will strengthen Korea’s GI endoscopy education system, ensuring that future surgeons are well-prepared to meet the evolving demands of patient care
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