1,722,125 research outputs found
High technology local economies: geographical mobility of the highly skilled
No full textBook synopsis: A map which shows where innovation is clustered worldwide is also a map of the location of the highly skilled and talented labour. New technologies, their creative applications or synergy across different areas of scientific research or technology development always create opportunities for the employment of particularly creative labour. This book explores the kinds of institutions and structures which need to exist to make sure that such skills are both offered and employed in particular ‘islands of innovation’.
Networking Regionalised Innovative Labour Markets illustrates the theme of how existing concentrations of skills in scientific, technological and managerial elites are reinforced through inter-regional mobility using exemplars from a range of countries and regions. These include the US, UK, Italy, Germany, and Central and Eastern Europe.
The book’s originality lies in its in-depth assessments of the factors associated with the extent to which some regions hold their positions in networked islands of innovation. It is shown that those islands of innovation that attract highly skilled workers from abroad, particularly those from foreign islands of innovation, perform better for example in the US, Italy and the UK. In contrast, even the most innovative Czech regions tend to lose the highly skilled workers vis-à-vis the most innovative regions of the world, mainly to regions in the USA
Selected places for attracted labour: islands of innovation as carriers of knowledge for science-based development
No full textBook synopsis: A map which shows where innovation is clustered worldwide is also a map of the location of the highly skilled and talented labour. New technologies, their creative applications or synergy across different areas of scientific research or technology development always create opportunities for the employment of particularly creative labour. This book explores the kinds of institutions and structures which need to exist to make sure that such skills are both offered and employed in particular ‘islands of innovation’.
Networking Regionalised Innovative Labour Markets illustrates the theme of how existing concentrations of skills in scientific, technological and managerial elites are reinforced through inter-regional mobility using exemplars from a range of countries and regions. These include the US, UK, Italy, Germany, and Central and Eastern Europe.
The book’s originality lies in its in-depth assessments of the factors associated with the extent to which some regions hold their positions in networked islands of innovation. It is shown that those islands of innovation that attract highly skilled workers from abroad, particularly those from foreign islands of innovation, perform better for example in the US, Italy and the UK. In contrast, even the most innovative Czech regions tend to lose the highly skilled workers vis-à-vis the most innovative regions of the world, mainly to regions in the USA
Local Literacies in Early Childhood: Inequalities in place, policy and pedagogy
No full textThis book contributes to current debates about the importance of early literacy and the different ways that literacy resources offer support to parents with young children. It sheds light on the impact of policy discourse and austerity measures on community resources designed to support children’s early literacy learning.Based on an ethnographic study carried out in a small town in the East Midlands, UK, the book shows how government policy is enacted in four local resources – Sure Start children’s centres, pre-schools, a public library and privately run parent and child early education classes. It reveals how inequalities and contradictions exist in different forms of community literacy provision which can explain some of the educational differences evident when children start school. With a particular focus on mothers, the book reveals how parents are supported differently depending on where they go and how they are viewed by the professionals they encounter. The book contributes to the current literature around literacy in early childhood and combines a unique case study with theoretical concepts to offer a new way of thinking about early intervention, parental engagement and school readiness.Local Literacies in Early Childhood will be highly relevant reading for researchers, academics and post-graduate students in the field of early childhood education and literacy education. It will also be of interest to policymakers, early childhood professionals, literacy advisors and librarians from different local, national and international contexts wishing to support parents and children more equitably so that learning opportunities can be maximised and educational inequalities tackled
Inequitable interventions and paradoxical pedagogies: how mothers are ‘taught’ to support their children's literacy development in early childhood
Full text linkAt a time when neo-liberal policy agenda are resulting in many public services being taken away from families with young children, this paper draws on Basil Bernstein’s concepts of visible and invisible pedagogies to reveal how mothers receive ‘support’ for their young (under five years old) children’s literacy development in a small town in the East Midlands (England). It draws on findings from an ethnographic study which show that mothers are 'taught' to support their young children differently depending on the way English education policy is interpreted and enacted in the places they visit. It is argued that dominant policy discourses around ‘good’ parenting can lead to inequitable interventions, paradoxical pedagogies and the disempowerment of some parents. The paper therefore contributes to the wider debate about more equitable ways of working with families that will be applicable across other contexts
Combinatorial chemistry and polyamines in the battle against Typanosomes and Leishmanias
No full textThe Trypanosoma and Leishmania parasites are responsible for the infection of several million people and animals worldwide, causing widespread disease and fatalities. These parasites are highly susceptible to oxidative stress, yet maintenance of a reducing cellular environment is not carried out in these organisms by the usually ubiquitous glutathione/glutathione reductase (GR) system. This rôle is assumed by the unique metabolite trypanothione (N1, N8, -bis(glutathionyl)spermidine) and its enzyme trypanothione reductase (TR). The high substrate specificity of both these enzymes makes TR a potential target for antitrypanosomal drug design.This thesis describes the development of novel polyamine templates for attachment to the solid phase based on the spermidine backbone of trypanothione. The solid phase synthesis of trypanothione has been followed by the preparation of several thousand polyamine-peptide conjugates for screening against trypanothione reductase, via the technique of combinatorial chemistry. These libraries of compounds have been screened using several different methodologies, either in solution or whilst tethered to the solid support. Several potent inhibitors of TR have been discovered and resynthesised from screening a 576-member solution library. Ki values have been determined with values as low as 100 nM.The same library has been prepared and secreened using three different techniques giving a direct comparison of each method. The results corresponded completely, from similar structural characteristics to identical compounds. Strong binding motifs have become apparent which are in accordance with the majority of TR inhibitors reported to date. Polyamines displaying high affinities to TR are conjugated to a positively charged moiety (at physiological pH i.e. arginine) followed by a small aromatic or hydrophobic group (i.e. tryptophan, tyrosine or phenylalanine).The success of these screens gives a wider scope for the discovery of even more potent inhibitors of TR and potentially novel chemotherapeutic agents against trypanosomal disease.</p
FIGURES 1–7 in Synonymy of Homalopoltys (Araneae: Araneidae) with the genus Dolichognatha (Araneae: Tetragnathidae) and descriptions of two new species
No full textFIGURES 1–7. Dolichognatha incanescens female (RBIN). 1–4, spinnerets. 1, spinneret field, left side. 2, ALS. 3. PMS. 4, PLS (right side, image reversed). 5–7, legs. 5, dorsal tarsus, left leg IV. 6, tarsal organ, left leg 1. 7, tarsal claws, left leg I.Published as part of Smith, Helen M., 2008, Synonymy of Homalopoltys (Araneae: Araneidae) with the genus Dolichognatha (Araneae: Tetragnathidae) and descriptions of two new species, pp. 1-24 in Zootaxa 1775 on page 7, DOI: 10.5281/zenodo.18220
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