1,605 research outputs found
Miss Jennie Small of Developmental Psychology
No full textDepartment of Psychology - Research Studies & site - Dr. Mark Dickerson, Mr. Jon Fabre, Irene Bermingham, Don Byrne, Miss Jennie Small, Vic Kennedy, Anna Maria Sabbione, Laura Bregu & other
Jennie C. Lee papers, W.0113
No full textAbstract: Contains photographs, letters, programs, and other materials created and collected by Lee, who was director of the Tuskegee Choir for twenty-five years (1903-1928).Scope and Content Note: The Jennie C. Lee papers contain photographs; letters; telegrams; newspaper clippings; programs for assorted musical performances and dedications; pamphlets; publications; and circulars. Many appear to have been removed from scrapbooks; a large number of the photographs are still affixed to black scrapbook paper.Volume one, 1891-1934, contains numerous photographs, loose and attached to scrapbook pages. There are several photographs of persons who are clearly Tuskegee Institute faculty members. Many have brief descriptions or names written on them. For example, one very small photograph has the inscription "choir & visitors - Roosevelt's visit '06."Correspondence of significance includes a telegram from Booker T. Washington in 1903 inviting her to Tuskegee; a letter Booker T. Washington wrote to her in 1906; a letter Julius T. Rosenwald wrote to her in 1915 regarding a gift of $100 he gave her; and a letter from Tuskegee Institute principal Robert Moton at the time of her retirement in 1928.Volume two, 1905-1938, is smaller than volume one, and it contains the same types of material. Correspondence of significance includes two letters from Roscoe C. Bruce.Biographical/Historical Note: Jennie Cheatham Lee was born in Tennessee on November 16, 1866, to Anderson and Elizabeth Cheatham. She attended Fisk University. In 1903, Booker T. Washington asked her to take the position of choir director at Tuskegee Institute. She held the position until 1928 when she retired.She passed away in Nashville,Tennessee, in 1956. According to her death certificate, she was divorced
MDOCS Publication-2015-11-08, TV Journalist Stone Philips
No full textTV journalist Stone Phillips to serve as honorary chair at gala
The Saratogian
November 8, 2015
Author: Jennie Gre
Orr, Jennie Miller (SC 2624)
No full textFinding aid only for Manuscripts Small Collection 2624. Paper by Jennie Miller Orr titled Captain Ed Porter Thompson. Also include a 1987 letter from Frances J. Fletcher, Orr\u27s niece, explaining the paper
Green, Jennie Scott, 1879-1965 (SC 962)
No full textFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 962. Will, 1959, of Jennie Scott Green of Grayson County, Kentucky
054 - Jennie Bukowski
No full textAirborne mineral dust has dilatant influences on the atmosphere and local environment: dust aerosols function as cloud condensation and ice nuclei, interact with radiation, fertilize maritime ecosystems, and are harmful to the human respiratory system. In arid regions, dust storms can loft an enormous amount of dust particles into the atmosphere and reduce visibility to near zero. In particular, the Arabian Peninsula reports frequent severe dust outbreaks as a result of strong surface winds, forced either by synoptic dynamics or mesoscale downdrafts, known as haboobs. Current forecast and climate models are run at high enough resolution to simulate synoptic events but still employ convective parameterizations, which are incapable of resolving many mesoscale processes. As such, the prediction of dust storms, specifically the location and timing of haboobs, remains a significant forecasting challenge. To understand the uncertainty introduced in the location and concentration of mineral dust via the use of convective parameterizations, the ratio of convective to non-convective dust events must first be established.
This study seeks to identify the origins of regional dust events across the Arabian Peninsula and quantify the relative contributions of synoptic versus mesoscale dust lofting. Here, the Weather Research and Forecasting Model coupled with Chemistry (WRF-Chem) is used to simulate a 2016 summertime dust outbreak over the Arabian Peninsula. Several coarse grid simulations with various convective parameterizations are compared against the same runs with the convective parameterizations turned off, leaving only synoptic sources of dust lofting. These results are then contrasted against a fine grid simulation with resolved convection. For simulations including convection, the inception of individual dust plumes is separated into convective and non-convective source categories. Dust concentrations based on origin are then analyzed with respect to total domain dust abundance as well as horizontal and vertical extent. Results suggest that convective dust lofting over the Arabian Peninsula is a substantial source of dust to the atmosphere, and concentrations differ between simulations with convective parameterizations and those explicitly resolving convection
Ketcham, Jennie B. (Brown) (SC 987)
No full textFinding aid only for Manuscripts Small Collection 987. Autograph album of Jennie B. (Brown) Ketcham, probably of New London, Ohio. There are also entries of friends and family from Bridgeport, Connecticut, and New York City
Green, Jennie Scott, 1879-1965 (SC 637)
No full textFinding aid and scan (Click on additional files below) for Manuscripts Small Collection 637. Photocopies of letters to Ellis Ford Hartford, Lexington, Kentucky, from Miss Jennie Scott Green, Falls of Rough, Kentucky, relative to her aiding Dr. Hartford with his historical research. She mentions the problems of invasion of privacy which she encounters and some incidents about the Sebastian family
Interview with Jennie Williams - OH 496
No full textIN PROCESSING
Interviews with extension members and agents throughout the country documenting the history and development of the extension movement in the U.S. The interviews describe homemaking, child bearing and family management in the small towns and rural areas where they live. They also discuss the role of extension homemakers groups in their lives
Investigating lipid-responsive T cells in tuberculosis; paving the way for new lipid-based vaccines
No full textMycobacterium tuberculosis (M.tb), which causes Tuberculosis (TB), remains one of the leading causes of death worldwide. The lack of an effective vaccine and the persistence of multi-drug resistant strains highlights the urgent need for improved therapeutic interventions for TB. Unconventional T cells, including CD1-restricted T cells, represent potential targets for future therapeutics due to the non-polymorphic nature of CD1 and the ability to respond to lipid antigens such as those found in the lipid-rich cell wall of M.tb. Although subsets of CD1c-restricted T cells specifically recognise mycobacterial lipids, the majority of T cells restricted by CD1c exhibit autoreactivity as they recognise CD1c bound to self-lipids. Importantly, these autoreactive T cells exhibit dual recognition of both foreign, pathogen derived lipid antigens and self-derived lipids when bound to CD1c. This may indicate a role for CD1c-restricted T cells in TB infection, but their exact function remains unknown. To investigate the hypothesis that “CD1c autoreactive T cells modulate the host-pathogen interaction in human TB infection”, I first investigate molecular mechanisms that underpin CD1c recognition by a cognate TCR. I employed methods such as site directed mutagenesis and lipid pulsing to investigate TCR binding footprint and lipid antigen reactivity, respectively. I demonstrate that binding of a CD1c autoreactive αβTCR is likely focused away from the F’ roof of CD1c, but further molecular studies are required to unravel exact binding footprint. Furthermore, I identified that this TCR also exhibits promiscuous recognition of various self-derived lipid cargo when bound to CD1c, but recognition is augmented by adjustments in the lipid alkyl chains suggesting a novel mechanism of recognition driven by a degree of fine specificity for lipid alkyl chains. Using CD1c tetramer guided cell sorting, I demonstrate the isolation and cloning of bona fide CD1c autoreactive γδTCRs. New TCRs can be employed in future studies to unravel the molecular mechanisms underpinning their binding to CD1c. Next, I optimised a short-term culture assay to investigate CD1c autoreactive T cells in a small cohort of healthy donors. My results showed that these responses are present in the circulation and they readily expand in vitro in response to CD1c+ APC with the majority of expanded cells exhibiting a CD4-CD8- phenotype. I then go on to investigate CD1c immunity in the context of M.tb infection. I show for the first time using immunohistochemistry that both γδ T cells and CD1c+ cells are present in the lungs of TB patients, but are largely found away from areas of caseous necrosis and reside in inflammatory tissue distal to the infection focus. Moreover, in a cohort of South African TB patients, I demonstrate an increased frequency of CD1c autoreactive αβ T cells in the peripheral blood and CD1c autoreactive Vδ1+ T cells in the lungs when compared to healthy controls. My results also reveal that lung resident Vδ1+ T cells of TB patients express elevated levels of PD1 compared to uninfected controls, suggesting that these cells had become activated and then exhausted in response to antigen. Taken together, my results suggest that M.tb drives CD1c mediated responses in vivo, indicating an important role for CD1c mediated immune responses in the host pathogen interaction in TB. I also investigated the hypothesis that “CD1d-restricted iNKTs are associated with disease severity” in the macaque model of infection. I carried out longitudinal studies in the peripheral blood of a small cohort of macaques, pre- and post-M.tb challenge, to monitor iNKT numerical and functional changes. My results demonstrate an increase in iNKT frequency at 8 weeks post challenge, however proliferative responses following stimulation with the strong iNKT agonist α-Galactosylceramide (α-GalCer) were impaired. Recovery of the proliferative response at the 4 week time point was observed in some animals, but due to the small cohort size no correlations could be made with lung iNKT frequency, bacteriology and pathology scores at the time of necropsy. Finally, I demonstrate the generation of Cynomolgus macaque CD1c tetramers (mCD1c). In comparison to human CD1c tetramers, positive staining of macaque T cells was observed with the mCD1c tetramer. Further validation of this tool is required in order to utilise these tetramers to study CD1c-restricted T cells in future M.tb in vivo challenge studies
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